IndraLab

Statements

USP12 affects AR
1 | 5
USP12 deubiquitinates AR. 6 / 6
1 | 5
reach
"USP12 in the presence of its cofactors Uaf-1 and WDR20 deubiquitinates AR to enhance AR protein stability and transcriptional activity [71] USP12 in complex with Uaf-1 and WDR20 also abrogates phospho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30217566
ubibrowser
"The AR is known to be regulated by a number of post-translational modifications and we have recently identified the deubiquitinating enzyme Usp12 as a positive regulator of AR."
26462181
reach
"We determined that Usp12 deubiquitinates the AR resulting in elevated receptor stability and activity."
26462181
reach
"We have recently reported that AR is deubiquitinated and stabilised by Usp12 resulting in increased transcriptional activity."
25216524
reach
"We find that USP12 deubiquitinates MDM2 and AR, which in turn controls the levels of the TP53 tumour suppressor and AR oncogene in prostate cancer."
29755129
reach
"In this report we demonstrate that Usp12, in complex with Uaf-1 and WDR20, deubiquitinates the AR to enhance receptor stability and transcriptional activity."
24056413
USP12 affects Histone_H2B
| 5
USP12 deubiquitinates Histone_H2B. 5 / 5
| 5
reach
"Both USP12 and USP46 deubiquitinate histone H2A and H2B, affecting Xenopus development (Joo et al., 2011), and, unlike USP1, these smaller USPs can simultaneously bind WDR20 in addition to WDR48 (Joo [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26388029
reach
"It has also been reported that USP12 and USP46 deubiquitinate histone H2A and H2B thereby playing a role in Xenopus development."
27650958
reach
"USP12 and USP46 prefer nucleosomal substrates and deubiquitinate both histone H2A and H2B in vitro and in vivo."
21183687
reach
"Usp12 and Usp46 deubiquitinate both H2A and H2B and Uaf-1 is required for this reaction [XREF_BIBR]."
25962961
reach
"Joo et al. demonstrated that USP46 and USP12 containing fractions from HeLa cells can deubiquitinate histones H2A and H2B to control cell fate and gastrulation during Xenopus development [XREF_BIBR]."
23316392
USP12 affects PPM1B
| 4
USP12 deubiquitinates PPM1B. 4 / 4
| 4
reach
"The interaction between PPM1B and USP12 was then validated (Fig. 4c), raising the question of whether USP12 deubiquitinates PPM1B."
34381028
reach
"USP12 regulates chemokine production by deubiquitinating PPM1B."
34381028
reach
"We found that USP12 downregulation caused insufficient deubiquitination of PPM1B and thereby facilitated tumour growth by promoting the generation of the protumourigenic milieu."
34381028
reach
"The ubiquitination experiments showed that ectopic expression of USP12 but not the C48S mutant decreased the levels of PPM1B polyubiquitination (Fig. 4d)."
34381028
USP12 affects PHLPP2
1 | 3
USP12 deubiquitinates PHLPP2. 4 / 4
1 | 3
ubibrowser
"we demonstrate that Usp12, in complex with Uaf-1 and WDR20, directly deubiquitinates and stabilises the Akt phosphatases PHLPP and PHLPPL resulting in decreased levels of active pAkt."
25216524
reach
"Further analysis using denaturing immunoprecipitation experiments revealed that Usp12 can also deubiquitinate and stabilise both PHLPP and PHLPPL."
25216524
reach
"Secondly, Usp12 deubiquitinates and stabilises PHLPP and PHLPPL proteins which enhances dephosphorylation and deactivation of Akt."
25216524
reach
"Usp12 deubiquitinates and stabilises PHLPP and PHLPPL and controls Akt activation status."
25216524
USP12 affects PHLPP1
1 | 3
USP12 deubiquitinates PHLPP1. 4 / 4
1 | 3
reach
"Usp12 deubiquitinates and stabilises PHLPP and PHLPPL and controls Akt activation status."
25216524
reach
"Further analysis using denaturing immunoprecipitation experiments revealed that Usp12 can also deubiquitinate and stabilise both PHLPP and PHLPPL."
25216524
ubibrowser
"USP11 stabilizes IKK-α?to stabilize and activate p53"
25121098
reach
"Secondly, Usp12 deubiquitinates and stabilises PHLPP and PHLPPL proteins which enhances dephosphorylation and deactivation of Akt."
25216524
USP12 affects MDM2
1 | 1
USP12 deubiquitinates MDM2. 2 / 2
1 | 1
reach
"We find that USP12 deubiquitinates MDM2 and AR, which in turn controls the levels of the TP53 tumour suppressor and AR oncogene in prostate cancer."
29755129
ubibrowser
"We find that USP12 deubiquitinates MDM2 and AR, which in turn controls the levels of the TP53 tumour suppressor and AR oncogene in prostate cancer."
29755129
USP12 affects EP300
| 1 1
USP12 deubiquitinates EP300. 2 / 2
| 1 1
reach
"De-ubiquitination of p300 by USP12 Critically Enhances METTL3 Expression and Ang II induced Cardiac Hypertrophy."
34339675
trips
"De-ubiquitination of p300 by USP12 Critically Enhances METTL3 Expression and Ang II-induced Cardiac Hypertrophy."
34339675
USP12 affects WDR48
| 1
USP12 deubiquitinates WDR48. 1 / 1
| 1
reach
"Usp12 and Usp46 deubiquitinate both H2A and H2B and Uaf-1 is required for this reaction [XREF_BIBR]."
25962961
USP12 affects TCR
| 1
USP12 deubiquitinates TCR. 1 / 1
| 1
reach
"Similarly, the ubiquitin specific peptidase 12 (USP12) can deubiquitinate LAT at the proximal TCR (Figure 2), to protect it from ubiquitin-dependent lysosomal degradation [146]."
| PMC
USP12 affects RRM2
| 1
USP12 deubiquitinates RRM2. 1 / 1
| 1
reach
"Here we showed that ubiquitin-specific peptidase 12 (USP12) directly interacts with and deubiquitinates RRM2 in non-small cell lung cancer (NSCLC) cells."
37341611
USP12 affects RELA
| 1
USP12 deubiquitinates RELA. 1 / 1
| 1
reach
"Furthermore, USP12 deficiency inhibited the suppressor function of M-MDSCs by downregulating the negative regulatory molecules iNOS and PD-L1, through deubiquitinating and stabilizing p65."
35898171
USP12 affects Notch
| 1
USP12 deubiquitinates Notch. 1 / 1
| 1
reach
"At the biochemical level, USP12 with its activator UAF1 deubiquitinate the nonactivated form of Notch in cell culture and in vitro."
22778262
USP12 affects MDK
| 1
USP12 deubiquitinates MDK. 1 / 1
| 1
reach
"Collectively, our study identified that USP12 is responsible for deubiquitinating and stabilizing MDK and leads to metastasis by promoting angiogenesis."
34759262
USP12 affects LAT
| 1
USP12 deubiquitinates LAT. 1 / 1
| 1
reach
"Similarly, the ubiquitin specific peptidase 12 (USP12) can deubiquitinate LAT at the proximal TCR (Figure 2), to protect it from ubiquitin-dependent lysosomal degradation [146]."
| PMC
USP12 affects IFI16
| 1
USP12 deubiquitinates IFI16. 1 / 1
| 1
reach
"USP12 promotes antiviral responses by deubiquitinating and stabilizing IFI16."
37410794
USP12 affects Histone
| 1
USP12 deubiquitinates Histone-H2A. 1 / 1
| 1
reach
"Joo et al. demonstrated that USP46 and USP12 containing fractions from HeLa cells can deubiquitinate histones H2A and H2B to control cell fate and gastrulation during Xenopus development [XREF_BIBR]."
23316392
USP12 affects H2BK120ub
| 1
USP12 deubiquitinates H2BK120ub. 1 / 1
| 1
reach
"Other major DUBs with specificity for histone H2AK119ub over H2BK120ub are BAP1 and USP16, while USP3, USP12, USP22, and USP44 deubiquitinate both H2AK119ub and H2BK120ub, as well as different non histone substrates [XREF_BIBR]."
32344625
USP12 affects H2BC21
1 |
USP12 deubiquitinates H2BC21. 1 / 1
1 |
ubibrowser
"USP12 and USP46 prefer nucleosomal substrates and deubiquitinate both histone H2A and H2B in vitro and in vivo."
21183687
USP12 affects H2BC10
1 |
USP12 deubiquitinates H2BC10. 1 / 1
1 |
ubibrowser
"It was shown that USP12 deubiquitinates histones H2A and H2B both in vitro and in vivo"
28063927
USP12 affects H2AK119ub
| 1
USP12 deubiquitinates H2AK119ub. 1 / 1
| 1
reach
"Other major DUBs with specificity for histone H2AK119ub over H2BK120ub are BAP1 and USP16, while USP3, USP12, USP22, and USP44 deubiquitinate both H2AK119ub and H2BK120ub, as well as different non histone substrates [XREF_BIBR]."
32344625
USP12 affects H2AC20
1 |
USP12 deubiquitinates H2AC20. 1 / 1
1 |
ubibrowser
"USP12 and USP46 prefer nucleosomal substrates and deubiquitinate both histone H2A and H2B in vitro and in vivo."
21183687
USP12 affects H2AC17
1 |
USP12 deubiquitinates H2AC17. 1 / 1
1 |
ubibrowser
"It was shown that USP12 deubiquitinates histones H2A and H2B both in vitro and in vivo"
28063927
USP12 affects GRIA
| 1
USP12 deubiquitinates GRIA. 1 / 1
| 1
reach
"Knock-down of USP46, but not USP12, results in increased levels of ubiquitinated GluA1, decreased surface and total levels of GluA1, and reduced mEPSC amplitudes, consistent with a role for USP46 in deubiquitinating mammalian AMPARs (Huo et al., 2015)."
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