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USP12 deubiquitinates AR. 7 / 8
1 | 7
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"We find that USP12 deubiquitinates MDM2 and AR, which in turn controls the levels of the TP53 tumour suppressor and AR oncogene in prostate cancer."
29755129
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"USP12 binds to Uaf-1 and WDR20 to form a complex to deubiquitinate AR, thereby increasing AR protein stability and transcriptional activity, while the depletion of WDR20 and Uaf-1 displays the opposite effect."
37752518
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"We have recently reported that AR is deubiquitinated and stabilised by Usp12 resulting in increased transcriptional activity."
25216524
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"In this report we demonstrate that Usp12, in complex with Uaf-1 and WDR20, deubiquitinates the AR to enhance receptor stability and transcriptional activity."
24056413
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"We determined that Usp12 deubiquitinates the AR resulting in elevated receptor stability and activity."
26462181
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"USP12 in the presence of its cofactors Uaf-1 and WDR20 deubiquitinates AR to enhance AR protein stability and transcriptional activity [71] USP12 in complex with Uaf-1 and WDR20 also abrogates phospho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30217566
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"For example, USP12 plays a crucial role in prostate cancer (PC) by deubiquitinating the androgen receptor (AR) and the Akt phosphatases, PH domain leucine-rich repeat protein phosphatase (PHLPP) and P[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26680102