IndraLab

Statements

USP12 deubiquitinates EP300. 4 / 4
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trips
"De-ubiquitination of p300 by USP12 Critically Enhances METTL3 Expression and Ang II-induced Cardiac Hypertrophy."
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"Third, the knockdown of USP12 significantly increased levels of p300 ubiquitination, whereas overexpression of USP12 reduced p300 ubiquitination."
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"USP12 deubiquitinated p300 to activate the transcription of methyltransferase-like 3 (METTL3), which resulted in the abnormal m6A RNA methylation in cardiomyocyte and exacerbated cardiac hypertrophy (Ref."
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"Next, we tested whether USP12 inhibited the ubiquitination of p300."
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