IndraLab

Statements


USP12 deubiquitinates PHLPP1. 4 / 4
1 | 3

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"Usp12 deubiquitinates and stabilises PHLPP and PHLPPL and controls Akt activation status."

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"Further analysis using denaturing immunoprecipitation experiments revealed that Usp12 can also deubiquitinate and stabilise both PHLPP and PHLPPL."

"USP11 stabilizes IKK-α?to stabilize and activate p53"

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"Secondly, Usp12 deubiquitinates and stabilises PHLPP and PHLPPL proteins which enhances dephosphorylation and deactivation of Akt."