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USP12 deubiquitinates IFI16. 8 / 8
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"In this study, we found that USP12 significantly inhibited IFI16 ubiquitination and degradation, stabilized and extended the half-life of IFI16, and subsequently induced the STING-dependent expressions of IFN-β, CCL-5, IL-6, and downstream ISGs, which makes the host more resistant to DNA virus (S11 Fig)."
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"Our results showed that USP12 inhibited IFI16 ubiquitination and degradation through its deubiquitinase activity, thereby promoting IFI16-STING mediated antiviral response."
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"However, USP12 may positively regulate the IFI16-STING-mediated IFN-I antiviral response by deubiquitinating and stabilizing IFI16."
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"[56] USP12 promotes antiviral responses by deubiquitinating and stabilizing IFI16 [31]."
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"USP12 promotes antiviral responses by deubiquitinating and stabilizing IFI16."
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"Correction: USP12 promotes antiviral responses by deubiquitinating and stabilizing IFI16."
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"These results demonstrated that USP12 deubiquitinates and stabilizes IFI16 during DNA virus infection."
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"We found that USP12, but not USP12 , reduced the IFI16 degradation rate (Fig 6A) and ubiquitination level (Fig 6B) in HEK293T cells, which indicated that USP12 stabilized IFI16 and reversed IFI16 ubiquitination by its deubiquitinase activity."
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