IndraLab

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USP12 deubiquitinates PHLPP2. 4 / 4
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"we demonstrate that Usp12, in complex with Uaf-1 and WDR20, directly deubiquitinates and stabilises the Akt phosphatases PHLPP and PHLPPL resulting in decreased levels of active pAkt."
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"Further analysis using denaturing immunoprecipitation experiments revealed that Usp12 can also deubiquitinate and stabilise both PHLPP and PHLPPL."
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"Secondly, Usp12 deubiquitinates and stabilises PHLPP and PHLPPL proteins which enhances dephosphorylation and deactivation of Akt."
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"Usp12 deubiquitinates and stabilises PHLPP and PHLPPL and controls Akt activation status."
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