IndraLab

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USP12 deubiquitinates PHLPP2. 6 / 7
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"Secondly, Usp12 deubiquitinates and stabilises PHLPP and PHLPPL proteins which enhances dephosphorylation and deactivation of Akt."
25216524
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"Usp12 deubiquitinates and stabilises PHLPP and PHLPPL and controls Akt activation status."
25216524
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"Further analysis using denaturing immunoprecipitation experiments revealed that Usp12 can also deubiquitinate and stabilise both PHLPP and PHLPPL."
25216524
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"The deubiquitinating enzyme Usp12 deubiquitinates and stabilizes PHLPP and PHLPPL."
26525204
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"USP12-Uaf-1-WDR20 complex directly deubiquitinates and stabilizes PHLPP and PHLPPL, resulting in a decrease in the active p-Akt level."
37752518
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"For example, USP12 plays a crucial role in prostate cancer (PC) by deubiquitinating the androgen receptor (AR) and the Akt phosphatases, PH domain leucine-rich repeat protein phosphatase (PHLPP) and P[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26680102