IndraLab

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USP12 deubiquitinates PPM1B. 4 / 4
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"The interaction between PPM1B and USP12 was then validated (Fig. 4c), raising the question of whether USP12 deubiquitinates PPM1B."
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"USP12 regulates chemokine production by deubiquitinating PPM1B."
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"We found that USP12 downregulation caused insufficient deubiquitination of PPM1B and thereby facilitated tumour growth by promoting the generation of the protumourigenic milieu."
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"The ubiquitination experiments showed that ectopic expression of USP12 but not the C48S mutant decreased the levels of PPM1B polyubiquitination (Fig. 4d)."
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