IndraLab

Statements

USP12 deubiquitinates PPM1B. 6 / 6
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"Yang et al. found that USP12 and USP46 deubiquitinates and stabilizes PPM1B to regulate chemokine production in tumor cells ( Yang et al., 2021 )."
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"USP12 regulates chemokine production by deubiquitinating PPM1B."
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"The interaction between PPM1B and USP12 was then validated (Fig. 4c), raising the question of whether USP12 deubiquitinates PPM1B."
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"The ubiquitination experiments showed that ectopic expression of USP12 but not the C48S mutant decreased the levels of PPM1B polyubiquitination (Fig. 4d)."
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"We found that USP12 downregulation caused insufficient deubiquitination of PPM1B and thereby facilitated tumour growth by promoting the generation of the protumourigenic milieu."
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"For example, USP12 is described above as promoting NF-κB activation for NLRP3 inflammatory microsome production, but in NSCLC it inhibits NF-κB signaling activity and regulates chemokine secretion by deubiquitinating and stabilizing PPM1B."
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