IndraLab

Statements

USP12 deubiquitinates LAT. 4 / 4
| 4
reach
"Similarly, the ubiquitin specific peptidase 12 (USP12) can deubiquitinate LAT at the proximal TCR (Figure 2), to protect it from ubiquitin-dependent lysosomal degradation [146]."
| PMC
reach
"Mechanistically, USP12 deubiquitinates LAT and Trat1, and inhibits lysosomal degradation of LAT and Trat1 to maintain the proximal TCR complex for the duration of signaling, which is the first time fo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31078284
reach
"Further experiments indicated that USP12 deubiquitinates LAT and TRAT1 to prevent their monoubiquitination and lysosomal degradation, leading to the stabilization of the TCR complex at the cell surfac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35181195
reach
"Recently, USP12 was shown to stabilize the TCR complex at the cell surface by deubiquitinating TCR adaptor proteins LAT and Trat1."
31078284