IndraLab

Statements

USP50 affects PYCARD
2 1 | 12 6
USP50 binds PYCARD.
2 | 1 6
PYCARD binds USP50. 9 / 12
2 | 1 6
sparser
"A recent report further suggested that USP50 binds ASC and deubiquitinates K63-linked polyubiquitin chains on ASC (citation)."
29031697
biogrid
No evidence text available
28094437
sparser
"Therefore, these results show that the binding of USP50 with ASC protein to deubiquitinate K63‐linked polyubiquitination is a crucial step for inflammasome activation."
28094437
sparser
"We here demonstrate that the deubiquitinating enzyme USP50 binds to the ASC protein and subsequently regulates the inflammasome signaling pathway by deubiquitinating the lysine 63-linked polyubiquitination of ASC."
28094437
reach
"Therefore, these results show that the binding of USP50 with ASC protein to deubiquitinate K63 linked polyubiquitination is a crucial step for inflammasome activation."
28094437
sparser
"Coimmunoprecipitation assays indicated that USP50 strongly binds to the ASC adaptor protein, although it also interacted weakly with NLRP3 (Fig. xref A)."
28094437
sparser
"Based on the interaction between USP50 and ASC protein, we next investigated whether USP50 knockdown affects inflammasome activation by analyzing the formation of ASC specks."
28094437
sparser
"USP50 binds to the ASC adaptor protein and is required for NLRP3‐induced ASC speck formation and oligomerization."
28094437
biogrid
No evidence text available
28094437
USP50 deubiquitinates PYCARD.
1 | 9
USP50 deubiquitinates PYCARD. 7 / 7
1 | 6
reach
"USP50 deubiquitinates the ASC protein."
28094437
ubibrowser
"The deubiquitinating enzyme, ubiquitin-specific peptidase 50, regulates inflammasome activation by targeting the ASC adaptor protein"
28094437
reach
"To further confirm our finding that USP50 deubiquitinates the ASC protein, we performed in vitro deubiquitination assays."
28094437
reach
"In conclusion, we here demonstrate a novel regulatory mechanism regarding the ASC protein which is deubiquitinated by USP50 and provide experimental evidence emphasizing the importance of a regulatory mechanism mediated by ubiquitination and deubiquitination in inflammasome activation."
28094437
reach
"However, the Flag-USP50 (C53S) mutant, did not affect polyubiquitination of the ASC protein, indicating that the Cys residue at position 53 is critical for the catalytic activity of USP50 deubiquitination of the ASC protein."
28094437
reach
"Ubiquitination of Flag-ASC proteins was significantly decreased in the presence of Flag-USP50 protein, indicating that USP50 directly deubiquitinates the polyubiquitination of the ASC protein."
28094437
reach
"Wild-type USP50 and the Flag-USP50 (H322A) mutant significantly deubiquitinated the ASC protein."
28094437
USP50 deubiquitinates PYCARD on lysine. 1 / 1
| 1
reach
"Lee et al.66 showed that the deubiquitinating enzyme, USP50, binds to and deubiquitinates lysine 63‐linked polyubiquitin chains of ASC and that this is required for NLRP3 inflammasome activation, since USP50‐deficient cells show impaired inflammasome activation."
31679183
USP50 deubiquitinates PYCARD at position 63. 1 / 1
| 1
reach
"Lee et al.66 showed that the deubiquitinating enzyme, USP50, binds to and deubiquitinates lysine 63‐linked polyubiquitin chains of ASC and that this is required for NLRP3 inflammasome activation, since USP50‐deficient cells show impaired inflammasome activation."
31679183
USP50-H322A deubiquitinates PYCARD. 1 / 1
| 1
reach
"Wild-type USP50 and the Flag-USP50 (H322A) mutant significantly deubiquitinated the ASC protein."
28094437
USP50 inhibits PYCARD.
| 2
USP50 inhibits PYCARD. 2 / 3
| 2
reach
"Taken together with our results that USP50 depletion decreases the formation of ASC specks as well as the secretion of IL-lbeta, our findings strongly suggest the possibility that removal of these polyubiquitin chains from ASC protein by USP50 is a crucial step for inflammasome activation."
28094437
reach
"USP50 depletion markedly impedes the formation of ASC oligomer and IL-1beta secretion in both human THP-1 macrophages and mouse BMDMs."
33627128
USP50 affects CPT1A
| 3 6
USP50 binds CPT1A.
| 6
USP50 binds CPT1A. 6 / 6
| 6
sparser
"Additionally, CPT1a interacted with USP50 in 293T cells transfected with flag-USP50 (Figure 7B)."
34976224
sparser
"These observations suggest that upon LPS treatment, mitochondrial STAT3 could induce CPT1a-USP50 binding by mediating USP50 expression, leading to CPT1a stabilization, an increase in FAO and higher ATP production."
34976224
sparser
"In comparison, in the LPS-treatedRosa26 LSL-MLS-mSTAT3 macrophage lysates, CPT1a pulled down much less USP50 (Figure xref C, IP Lane 1, xref A), suggesting that mitochondrial STAT3 could contribute to CPT1a stabilization by influencing CPT1a-USP50 binding, at least partially."
34976224
sparser
"Upon the LPS stimulation, mitochondrial STAT3 could induce CPT1a stabilization by promoting USP50 expression and facilitating CPT1a-USP50 binding, leading to a switch from glucose to an increased reliance on FAO for ATP production, which, in turn, further enhanced NF-κB nuclear localization, leading to a great amount of cytokine production."
34976224
sparser
"Additionally, CPT1a interacted with USP50 in 293T cells transfected with flag-USP50 (Figure xref B)."
34976224
sparser
"In comparison, in the LPS-treated Rosa26LSL-MLS-mSTAT3 macrophage lysates, CPT1a pulled down much less USP50 (Figure 7C, IP Lane 1, Figure S5A), suggesting that mitochondrial STAT3 could contribute to CPT1a stabilization by influencing CPT1a-USP50 binding, at least partially."
34976224
USP50 activates CPT1A.
| 3
USP50 activates CPT1A. 3 / 3
| 3
reach
"Curcumin alleviated LPS-mediated sepsis by suppressing the activities of mitochondrial STAT3 and NF-κB. Conclusion: Our findings reveal that mitochondrial STAT3 could trigger FAO by inducing CPT1a stabilization mediated by USP50 in macrophages, at least partially."
34976224
reach
"Our study results further suggest that the pharmacological blockade of mitochondrial STAT3 function by curcumin could be a promising treatment strategy for sepsis, metabolic disorders, and other inflammatory diseases.Although our study demonstrates that in the presence of LPS, mitochondrial STAT3 drives FAO by inducing CPT1a stabilization mediated by USP50 in macrophages, several questions emerge from our study."
34976224
reach
"Curcumin alleviated LPS-mediated sepsis by suppressing the activities of mitochondrial STAT3 and NF-κB. Conclusion: Our findings reveal that mitochondrial STAT3 could trigger FAO by inducing CPT1a stabilization mediated by USP50 in macrophages, at least partially.Sepsis is a life-threatening condition with limited therapeutic options and is characterized by excessive systemic inflammation and multiple organ failure [1] ."
34976224
USP50 affects XRCC6
| 6
USP50 inhibits XRCC6.
| 4
USP50 inhibits XRCC6. 4 / 4
| 4
reach
"Interestingly, USP50 associates with the Ku70 protein and reduces the half-life of Ku70 protein."
29101126
reach
"These data suggest that USP50 reduces Ku70 protein stability."
29101126
reach
"Thus, we hypothesize that USP50 mediated Ku70 degradation might be through targeting a ubiquitin E3 ligase that ubiquitinates and degrades Ku70."
29101126
reach
"USP50 reduces Ku70 protein stability without affecting its mRNA levels."
29101126
USP50 binds XRCC6.
| 1
USP50 binds XRCC6. 1 / 1
| 1
reach
"This is also the first study to demonstrate an interaction between USP50 and Ku70."
29101126
USP50 activates XRCC6.
| 1
USP50 activates XRCC6. 1 / 1
| 1
reach
"Additional studies are necessary to elucidate the molecular mechanisms of USP50 mediated destabilization of Ku70 protein."
29101126
CPT1A affects USP50
| 6
USP50 binds CPT1A. 6 / 6
| 6
sparser
"Additionally, CPT1a interacted with USP50 in 293T cells transfected with flag-USP50 (Figure 7B)."
34976224
sparser
"These observations suggest that upon LPS treatment, mitochondrial STAT3 could induce CPT1a-USP50 binding by mediating USP50 expression, leading to CPT1a stabilization, an increase in FAO and higher ATP production."
34976224
sparser
"In comparison, in the LPS-treatedRosa26 LSL-MLS-mSTAT3 macrophage lysates, CPT1a pulled down much less USP50 (Figure xref C, IP Lane 1, xref A), suggesting that mitochondrial STAT3 could contribute to CPT1a stabilization by influencing CPT1a-USP50 binding, at least partially."
34976224
sparser
"Upon the LPS stimulation, mitochondrial STAT3 could induce CPT1a stabilization by promoting USP50 expression and facilitating CPT1a-USP50 binding, leading to a switch from glucose to an increased reliance on FAO for ATP production, which, in turn, further enhanced NF-κB nuclear localization, leading to a great amount of cytokine production."
34976224
sparser
"Additionally, CPT1a interacted with USP50 in 293T cells transfected with flag-USP50 (Figure xref B)."
34976224
sparser
"In comparison, in the LPS-treated Rosa26LSL-MLS-mSTAT3 macrophage lysates, CPT1a pulled down much less USP50 (Figure 7C, IP Lane 1, Figure S5A), suggesting that mitochondrial STAT3 could contribute to CPT1a stabilization by influencing CPT1a-USP50 binding, at least partially."
34976224
USP50 affects WEE1
1 | 4
USP50 activates WEE1.
| 3
USP50 activates WEE1. 3 / 3
| 3
reach
"We propose that USP50 may act through a HSP90 dependent mechanism to counteract CDC25B mitotic inducing activity and prevent Wee1 degradation, thereby repressing entry into mitosis following activation of the DNA damage checkpoint."
20930503
reach
"USP50 (ubiquitin specific protease 50), a deubiqitinating enzyme (DUB), prevents Wee1 degradation, thereby repressing entry into mitosis following activation of the G2/M DNA damage checkpoint."
26358502
reach
"In response to DNA damage, USP50 accumulates in the nucleus and may act through an HSP90 dependent mechanism to counteract CDC25B mitotic inducing activity and prevent Wee1 degradation, thereby repressing entry into mitosis following activation of the DNA damage checkpoint [XREF_BIBR]."
28031783
USP50 inhibits WEE1.
| 1
USP50 inhibits WEE1. 1 / 1
| 1
reach
"We also demonstrate USP50 depletion causes a loss in accumulation of the HSP90 client Wee1, which is an essential component of the G2/M cell cycle arrest."
20930503
USP50 deubiquitinates WEE1.
1 |
USP50 deubiquitinates WEE1. 1 / 1
1 |
ubibrowser
"USP50 regulates HSP90-dependent Wee1 stability preventing mitotic entry, acting as another G2/M checkpoint"
25121098
USP50 affects Ku-70
| 5
USP50 binds Ku-70. 4 / 4
| 4
sparser
"Interestingly, Ku70 has been implicated in the deubiquitination and stabilization of Mcl-1, which is an antiapoptotic member of the BCL-2 protein family. xref Mcl-1 plays a critical role as a suppressor of apoptosis during erythropoiesis. xref These observations suggest that the interaction of Ku70 with USP50 may play a critical role in stabilizing Mcl-1 and controlling apoptosis during erythropoiesis."
29101126
sparser
"Interestingly, USP50 associates with the Ku70 protein and reduces the half-life of Ku70 protein."
29101126
sparser
"The Ku70 forms a heterodimer with Ku80, which binds to chromosomal replication origins xref and plays a critical role in cell cycle and DNA replication. xref The current study reveals that USP50 is associated with Ku70 and overexpression of USP50 reduces Ku70 protein stability."
29101126
sparser
"Coimmunoprecipitation and proteomics analyses reveal that Ku70, a DNA-binding protein, is associated with USP50."
29101126
FBXO22 binds USP50 and Ku-70. 1 / 1
| 1
sparser
"Future studies will investigate USP50–FBXO22–Ku70 interactions."
29101126
USP50 affects NLRP3 inflammasome
| 1
USP50 inhibits NLRP3 inflammasome. 1 / 2
| 1
eidos
"In addition , USP50 can also inhibit NLRP3 inflammasome degradation through the autophagy pathway as mentioned above ( Lee et al ., 2017 ) ."
34966378
USP50 affects MYC
| 2
USP50 binds MYC. 2 / 2
| 2
sparser
"However, the levels of polyubiquitinated CPT1a protein were decreased in the 293T cells transfected with flag-CPT1a, myc-USP50 and HA-ubiquitin (Figure xref E)."
34976224
sparser
"However, the levels of polyubiquitinated CPT1a protein were decreased in the 293T cells transfected with flag-CPT1a, myc-USP50 and HA-ubiquitin (Figure 7E)."
34976224
USP50 affects IL1B
| 2
USP50 inhibits IL1B. 2 / 2
| 2
reach
"USP50 depletion markedly impedes the formation of ASC oligomer and IL-1beta secretion in both human THP-1 macrophages and mouse BMDMs."
33627128
reach
"In contrast, USP50 depletion significantly decreased IL-1beta secretion, suggesting the possibility that USP50 is a positive regulator in inflammasome activation."
28094437
USP50 affects HSP90AB1
2 |
biogrid
No evidence text available
20930503
biogrid
No evidence text available
20930503
USP50 affects FBXO22
| 2
FBXO22 binds USP50 and Ku-70. 1 / 1
| 1
sparser
"Future studies will investigate USP50–FBXO22–Ku70 interactions."
29101126
FBXO22 binds USP50. 1 / 1
| 1
sparser
"This is an unusual function for a DUB, but it is possible that USP50 stabilizes an unknown E3 ligase that targets Ku70 for degradation. xref shows that USP50 is associated with the FBXO22, a subunit of a nuclear ubiquitin E3 ligase."
29101126
MYC affects USP50
| 2
USP50 binds MYC. 2 / 2
| 2
sparser
"However, the levels of polyubiquitinated CPT1a protein were decreased in the 293T cells transfected with flag-CPT1a, myc-USP50 and HA-ubiquitin (Figure xref E)."
34976224
sparser
"However, the levels of polyubiquitinated CPT1a protein were decreased in the 293T cells transfected with flag-CPT1a, myc-USP50 and HA-ubiquitin (Figure 7E)."
34976224
HSP90AB1 affects USP50
2 |
biogrid
No evidence text available
20930503
biogrid
No evidence text available
20930503
FBXO22 affects USP50
| 2
FBXO22 binds USP50 and Ku-70. 1 / 1
| 1
sparser
"Future studies will investigate USP50–FBXO22–Ku70 interactions."
29101126
FBXO22 binds USP50. 1 / 1
| 1
sparser
"This is an unusual function for a DUB, but it is possible that USP50 stabilizes an unknown E3 ligase that targets Ku70 for degradation. xref shows that USP50 is associated with the FBXO22, a subunit of a nuclear ubiquitin E3 ligase."
29101126
Leflunomide affects USP50
1 |
Leflunomide decreases the amount of USP50. 1 / 1
1 |
ctd
No evidence text available
28988120
Jinfukang affects USP50
1 |
Jinfukang decreases the amount of USP50. 1 / 1
1 |
ctd
No evidence text available
27392435
Cadmium atom affects USP50
1 |
Cadmium atom decreases the amount of USP50. 1 / 1
1 |
ctd
No evidence text available
24376830
Butanal affects USP50
1 |
Butanal decreases the amount of USP50. 1 / 1
1 |
ctd
No evidence text available
26079696
Bisphenol A affects USP50
1 |
Bisphenol A decreases the amount of USP50. 1 / 1
1 |
ctd
No evidence text available
25181051
XRCC6 affects USP50
| 1
USP50 binds XRCC6. 1 / 1
| 1
reach
"This is also the first study to demonstrate an interaction between USP50 and Ku70."
29101126
USP50 affects oligomer IL-1beta secretion human THP-1 macrophages mouse BMDMs
| 1
USP50 activates oligomer IL-1beta secretion human THP-1 macrophages mouse BMDMs. 1 / 1
| 1
eidos
"USP50 depletion markedly impedes the formation of ASC oligomer and IL-1beta secretion in both human THP-1 macrophages and mouse BMDMs ."
33627128
USP50 affects apoptotic process
| 1
USP50 inhibits apoptotic process. 1 / 1
| 1
reach
"Taken together, these findings suggest a model where USP50 and Ku70 may stabilize Mcl-1 and prevent apoptosis in the late stages of erythropoiesis."
29101126
USP50 affects UMPS
1 |
UMPS binds USP50. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP50 affects TUBA1A
1 |
USP50 binds TUBA1A. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP50 affects STING1
1 |
USP50 binds STING1. 1 / 1
1 |
biogrid
No evidence text available
27801882
USP50 affects SRPRB
1 |
USP50 binds SRPRB. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP50 affects SLC25A13
1 |
SLC25A13 binds USP50. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP50 affects SLC1A5
1 |
SLC1A5 binds USP50. 1 / 1
1 |
biogrid
No evidence text available
19615732
reach
"Furthermore, silencing USP50 suppressed the OCR (Figure 7F)."
34976224
USP50 affects NUP205
1 |
NUP205 binds USP50. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP50 affects NLRP3
1 |
NLRP3 binds USP50. 1 / 1
1 |
biogrid
No evidence text available
28094437
USP50 activates NLRP3 inflammasome complex assembly. 1 / 1
| 1
reach
"The deubiquitinase USP50 also contributes to NLRP3 inflammasome activation through ASC deubiquitination."
31679183
USP50 affects NFkappaB
| 1
NFkappaB binds USP50. 1 / 1
| 1
sparser
"The ChIP assays revealed that NF-κB bound the USP50 promoter."
34976224
USP50 affects MTHFD1L
1 |
USP50 binds MTHFD1L. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP50 affects LUC7L
1 |
USP50 binds LUC7L. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP50 affects IPO5
1 |
USP50 binds IPO5. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP50 affects IL-lbeta
| 1
USP50 inhibits IL-lbeta. 1 / 1
| 1
reach
"Taken together with our results that USP50 depletion decreases the formation of ASC specks as well as the secretion of IL-lbeta, our findings strongly suggest the possibility that removal of these polyubiquitin chains from ASC protein by USP50 is a crucial step for inflammasome activation."
28094437
USP50 affects IGF2R
1 |
USP50 binds IGF2R. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP50 affects HUWE1
1 |
USP50 binds HUWE1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP50 affects HSPA8
1 |
USP50 binds HSPA8. 1 / 1
1 |
biogrid
No evidence text available
20930503
USP50 affects HSPA1A
1 |
USP50 binds HSPA1A. 1 / 1
1 |
biogrid
No evidence text available
20930503
USP50 affects HSP90AA1
1 |
biogrid
No evidence text available
20930503
USP50 affects GNB2
1 |
USP50 binds GNB2. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP50 affects DYNC2H1
1 |
USP50 binds DYNC2H1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP50 affects CPT1a-USP50 binding
| 1
USP50 activates CPT1a-USP50 binding. 1 / 1
| 1
eidos
"These observations suggest that upon LPS treatment , mitochondrial STAT3 could induce CPT1a-USP50 binding by mediating USP50 expression , leading to CPT1a stabilization , an increase in FAO and higher ATP production ."
34976224
USP50 affects CPT1a stabilization
| 1
USP50 activates CPT1a stabilization. 1 / 1
| 1
eidos
"Upon the LPS stimulation , mitochondrial STAT3 could induce CPT1a stabilization by promoting USP50 expression and facilitating CPT1a-USP50 binding , leading to a switch from glucose to an increased reliance on FAO for ATP production , which , in turn , further enhanced NF-kappaB nuclear localization , leading to a great amount of cytokine production ."
34976224
USP50 affects CKAP4
1 |
CKAP4 binds USP50. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP50 affects BSG
1 |
BSG binds USP50. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP50 affects AMBRA1
1 |
USP50 binds AMBRA1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP50 affects ALDH3A2
1 |
USP50 binds ALDH3A2. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP50 affects AFG3L2
1 |
USP50 binds AFG3L2. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP50 affects ACE2
| 1
ACE2 binds USP50. 1 / 1
| 1
sparser
"VitC blocks the USP50-ACE2 interaction, thus promoting K48-linked polyubiquitination of ACE2 at Lys788 and subsequent degradation of ACE2 without affecting its transcriptional expression."
36876523
USP50 affects ACADM
1 |
USP50 binds ACADM. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP50 affects ABCE1
1 |
USP50 binds ABCE1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP50 affects ABCD3
1 |
USP50 binds ABCD3. 1 / 1
1 |
biogrid
No evidence text available
19615732
UMPS affects USP50
1 |
UMPS binds USP50. 1 / 1
1 |
biogrid
No evidence text available
19615732
TUBA1A affects USP50
1 |
USP50 binds TUBA1A. 1 / 1
1 |
biogrid
No evidence text available
19615732
STING1 affects USP50
1 |
USP50 binds STING1. 1 / 1
1 |
biogrid
No evidence text available
27801882
STAT3 affects USP50
| 1
STAT3 increases the amount of USP50. 1 / 1
| 1
reach
"Upon the LPS stimulation, mitochondrial STAT3 could induce CPT1a stabilization by promoting USP50 expression and facilitating CPT1a-USP50 binding, leading to a switch from glucose to an increased reliance on FAO for ATP production, which, in turn, further enhanced NF-κB nuclear localization, leading to a great amount of cytokine production."
34976224
SRPRB affects USP50
1 |
USP50 binds SRPRB. 1 / 1
1 |
biogrid
No evidence text available
19615732
SLC25A13 affects USP50
1 |
SLC25A13 binds USP50. 1 / 1
1 |
biogrid
No evidence text available
19615732
SLC1A5 affects USP50
1 |
SLC1A5 binds USP50. 1 / 1
1 |
biogrid
No evidence text available
19615732
PAX4 affects USP50
1 |
PAX4 decreases the amount of USP50. 1 / 1
1 |
biopax:msigdb
No evidence text available
NUP205 affects USP50
1 |
NUP205 binds USP50. 1 / 1
1 |
biogrid
No evidence text available
19615732
NLRP3 affects USP50
1 |
NLRP3 binds USP50. 1 / 1
1 |
biogrid
No evidence text available
28094437
NFkappaB affects USP50
| 1
NFkappaB binds USP50. 1 / 1
| 1
sparser
"The ChIP assays revealed that NF-κB bound the USP50 promoter."
34976224
MTHFD1L affects USP50
1 |
USP50 binds MTHFD1L. 1 / 1
1 |
biogrid
No evidence text available
19615732
LUC7L affects USP50
1 |
USP50 binds LUC7L. 1 / 1
1 |
biogrid
No evidence text available
19615732
Ku-70 affects FBXO22
| 1
FBXO22 binds USP50 and Ku-70. 1 / 1
| 1
sparser
"Future studies will investigate USP50–FBXO22–Ku70 interactions."
29101126
IPO5 affects USP50
1 |
USP50 binds IPO5. 1 / 1
1 |
biogrid
No evidence text available
19615732
IGF2R affects USP50
1 |
USP50 binds IGF2R. 1 / 1
1 |
biogrid
No evidence text available
19615732
HUWE1 affects USP50
1 |
USP50 binds HUWE1. 1 / 1
1 |
biogrid
No evidence text available
19615732
HSPA8 affects USP50
1 |
USP50 binds HSPA8. 1 / 1
1 |
biogrid
No evidence text available
20930503
HSPA1A affects USP50
1 |
USP50 binds HSPA1A. 1 / 1
1 |
biogrid
No evidence text available
20930503
HSP90AA1 affects USP50
1 |
biogrid
No evidence text available
20930503
GNB2 affects USP50
1 |
USP50 binds GNB2. 1 / 1
1 |
biogrid
No evidence text available
19615732
FOXO4 affects USP50
1 |
FOXO4 decreases the amount of USP50. 1 / 1
1 |
biopax:msigdb
No evidence text available
FBXO22 affects Ku-70, and USP50
| 1
FBXO22 binds USP50 and Ku-70. 1 / 1
| 1
sparser
"Future studies will investigate USP50–FBXO22–Ku70 interactions."
29101126
DYNC2H1 affects USP50
1 |
USP50 binds DYNC2H1. 1 / 1
1 |
biogrid
No evidence text available
19615732
CKAP4 affects USP50
1 |
CKAP4 binds USP50. 1 / 1
1 |
biogrid
No evidence text available
19615732
BSG affects USP50
1 |
BSG binds USP50. 1 / 1
1 |
biogrid
No evidence text available
19615732
AMBRA1 affects USP50
1 |
USP50 binds AMBRA1. 1 / 1
1 |
biogrid
No evidence text available
19615732
ALDH3A2 affects USP50
1 |
USP50 binds ALDH3A2. 1 / 1
1 |
biogrid
No evidence text available
19615732
AFG3L2 affects USP50
1 |
USP50 binds AFG3L2. 1 / 1
1 |
biogrid
No evidence text available
19615732
ACE2 affects USP50
| 1
ACE2 binds USP50. 1 / 1
| 1
sparser
"VitC blocks the USP50-ACE2 interaction, thus promoting K48-linked polyubiquitination of ACE2 at Lys788 and subsequent degradation of ACE2 without affecting its transcriptional expression."
36876523
ACADM affects USP50
1 |
USP50 binds ACADM. 1 / 1
1 |
biogrid
No evidence text available
19615732
ABCE1 affects USP50
1 |
USP50 binds ABCE1. 1 / 1
1 |
biogrid
No evidence text available
19615732
ABCD3 affects USP50
1 |
USP50 binds ABCD3. 1 / 1
1 |
biogrid
No evidence text available
19615732