IndraLab

Statements

USP50 activates CPT1A. 3 / 3
| 3
reach
"Curcumin alleviated LPS-mediated sepsis by suppressing the activities of mitochondrial STAT3 and NF-κB. Conclusion: Our findings reveal that mitochondrial STAT3 could trigger FAO by inducing CPT1a stabilization mediated by USP50 in macrophages, at least partially."
34976224
reach
"Our study results further suggest that the pharmacological blockade of mitochondrial STAT3 function by curcumin could be a promising treatment strategy for sepsis, metabolic disorders, and other inflammatory diseases.Although our study demonstrates that in the presence of LPS, mitochondrial STAT3 drives FAO by inducing CPT1a stabilization mediated by USP50 in macrophages, several questions emerge from our study."
34976224
reach
"Curcumin alleviated LPS-mediated sepsis by suppressing the activities of mitochondrial STAT3 and NF-κB. Conclusion: Our findings reveal that mitochondrial STAT3 could trigger FAO by inducing CPT1a stabilization mediated by USP50 in macrophages, at least partially.Sepsis is a life-threatening condition with limited therapeutic options and is characterized by excessive systemic inflammation and multiple organ failure [1] ."
34976224