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CPT1A binds USP50. 3 / 6
3 | 3
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"Additionally, CPT1a interacted with USP50 in 293T cells transfected with flag-USP50 (Figure xref B)."
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"These observations suggest that upon LPS treatment, mitochondrial STAT3 could induce CPT1a-USP50 binding by mediating USP50 expression, leading to CPT1a stabilization, an increase in FAO and higher ATP production."
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sparser
"In comparison, in the LPS-treatedRosa26 LSL-MLS-mSTAT3 macrophage lysates, CPT1a pulled down much less USP50 (Figure xref C, IP Lane 1, xref A), suggesting that mitochondrial STAT3 could contribute to CPT1a stabilization by influencing CPT1a-USP50 binding, at least partially."
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