IndraLab

Statements

USP50 binds CPT1A. 6 / 6
| 6
sparser
"Additionally, CPT1a interacted with USP50 in 293T cells transfected with flag-USP50 (Figure 7B)."
34976224
sparser
"These observations suggest that upon LPS treatment, mitochondrial STAT3 could induce CPT1a-USP50 binding by mediating USP50 expression, leading to CPT1a stabilization, an increase in FAO and higher ATP production."
34976224
sparser
"In comparison, in the LPS-treatedRosa26 LSL-MLS-mSTAT3 macrophage lysates, CPT1a pulled down much less USP50 (Figure xref C, IP Lane 1, xref A), suggesting that mitochondrial STAT3 could contribute to CPT1a stabilization by influencing CPT1a-USP50 binding, at least partially."
34976224
sparser
"Upon the LPS stimulation, mitochondrial STAT3 could induce CPT1a stabilization by promoting USP50 expression and facilitating CPT1a-USP50 binding, leading to a switch from glucose to an increased reliance on FAO for ATP production, which, in turn, further enhanced NF-κB nuclear localization, leading to a great amount of cytokine production."
34976224
sparser
"Additionally, CPT1a interacted with USP50 in 293T cells transfected with flag-USP50 (Figure xref B)."
34976224
sparser
"In comparison, in the LPS-treated Rosa26LSL-MLS-mSTAT3 macrophage lysates, CPT1a pulled down much less USP50 (Figure 7C, IP Lane 1, Figure S5A), suggesting that mitochondrial STAT3 could contribute to CPT1a stabilization by influencing CPT1a-USP50 binding, at least partially."
34976224