IndraLab

Statements

USP50 binds Ku-70. 4 / 4
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"Interestingly, Ku70 has been implicated in the deubiquitination and stabilization of Mcl-1, which is an antiapoptotic member of the BCL-2 protein family. xref Mcl-1 plays a critical role as a suppressor of apoptosis during erythropoiesis. xref These observations suggest that the interaction of Ku70 with USP50 may play a critical role in stabilizing Mcl-1 and controlling apoptosis during erythropoiesis."
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"Interestingly, USP50 associates with the Ku70 protein and reduces the half-life of Ku70 protein."
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"The Ku70 forms a heterodimer with Ku80, which binds to chromosomal replication origins xref and plays a critical role in cell cycle and DNA replication. xref The current study reveals that USP50 is associated with Ku70 and overexpression of USP50 reduces Ku70 protein stability."
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"Coimmunoprecipitation and proteomics analyses reveal that Ku70, a DNA-binding protein, is associated with USP50."
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