IndraLab

Statements

PYCARD binds USP50. 9 / 12
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sparser
"A recent report further suggested that USP50 binds ASC and deubiquitinates K63-linked polyubiquitin chains on ASC (citation)."
29031697
biogrid
No evidence text available
28094437
sparser
"Therefore, these results show that the binding of USP50 with ASC protein to deubiquitinate K63‐linked polyubiquitination is a crucial step for inflammasome activation."
28094437
sparser
"We here demonstrate that the deubiquitinating enzyme USP50 binds to the ASC protein and subsequently regulates the inflammasome signaling pathway by deubiquitinating the lysine 63-linked polyubiquitination of ASC."
28094437
reach
"Therefore, these results show that the binding of USP50 with ASC protein to deubiquitinate K63 linked polyubiquitination is a crucial step for inflammasome activation."
28094437
sparser
"Coimmunoprecipitation assays indicated that USP50 strongly binds to the ASC adaptor protein, although it also interacted weakly with NLRP3 (Fig. xref A)."
28094437
sparser
"Based on the interaction between USP50 and ASC protein, we next investigated whether USP50 knockdown affects inflammasome activation by analyzing the formation of ASC specks."
28094437
sparser
"USP50 binds to the ASC adaptor protein and is required for NLRP3‐induced ASC speck formation and oligomerization."
28094437
biogrid
No evidence text available
28094437