IndraLab

Statements

USP50 activates WEE1. 5 / 5
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"USP50 (ubiquitin specific protease 50), a deubiqitinating enzyme (DUB), prevents Wee1 degradation, thereby repressing entry into mitosis following activation of the G2/M DNA damage checkpoint."
26358502
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"In response to DNA damage, USP50 accumulates in the nucleus and may act through an HSP90 dependent mechanism to counteract CDC25B mitotic inducing activity and prevent Wee1 degradation, thereby repressing entry into mitosis following activation of the DNA damage checkpoint [XREF_BIBR]."
28031783
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"HSP90 regulates the DUB activity of USP19 and promotes USP50-mediated Wee1 stability ; however, a DUB for HSP90 has not been reported."
38307937
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"USP50 engages with HSP90 and modulates the protein abundance of Wee1, a pivotal element in G2/M cell cycle arrest (19)."
38469295
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"We propose that USP50 may act through a HSP90 dependent mechanism to counteract CDC25B mitotic inducing activity and prevent Wee1 degradation, thereby repressing entry into mitosis following activation of the DNA damage checkpoint."
20930503