IndraLab

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USP50 inhibits PYCARD. 2 / 3

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"Taken together with our results that USP50 depletion decreases the formation of ASC specks as well as the secretion of IL-lbeta, our findings strongly suggest the possibility that removal of these polyubiquitin chains from ASC protein by USP50 is a crucial step for inflammasome activation."

28094437

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reach

"USP50 depletion markedly impedes the formation of ASC oligomer and IL-1beta secretion in both human THP-1 macrophages and mouse BMDMs."

33627128

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IndraLab

Statements

USP50 inhibits PYCARD. 2 / 3

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