IndraLab

Statements


USP50 inhibits PYCARD. 2 / 3
| 2

reach
"Taken together with our results that USP50 depletion decreases the formation of ASC specks as well as the secretion of IL-lbeta, our findings strongly suggest the possibility that removal of these polyubiquitin chains from ASC protein by USP50 is a crucial step for inflammasome activation."

reach
"USP50 depletion markedly impedes the formation of ASC oligomer and IL-1beta secretion in both human THP-1 macrophages and mouse BMDMs."