IndraLab

Statements

"Consistent with this notion, the DNA damage sensitivity of USP45 knockout cells is only rescued by wild-type USP45 and not by an active USP45 [Asp25Ala, Glu26Ala] mutant that is unable to bind ERCC1 (Fig xref C) or catalytically inactive USP45 [Cys199Ala] (Fig xref A)."

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"This observation, together with the findings that USP45 co-precipitates with XPF-ERCC1 in Slx4 null cells and that ERCC1 interacts with USP45 in a yeast two-hybrid assay, indicate that USP45 interacts directly with ERCC1."

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"Both mass spectrometry and yeast two-hybrid system identify that USP45 interacts with ERCC1, and it was also demonstrated that USP45 deubiquitinates ERCC1 [55]."

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"USP45 interacts with ERCC1."

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"Another study [ xref ] demonstrated a direct interaction between the deubiquitylase USP45 and ERCC1, which may control its ubiquitylation."

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"Importantly, we find that the USP45 mutant [Asp25Ala, Glu26Ala] that is catalytically active but that cannot bind to ERCC1 (Supplementary Fig S5A) failed to deubiquitylate ERCC1 in vitro , indicating that specific interaction between ERCC1 and USP45 is essential to trigger deubiquitylation."

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"Both mass spectrometry and yeast two-hybrid system identify that USP45 interacts with ERCC1, and it was also demonstrated that USP45 deubiquitinates ERCC1 [XREF_BIBR]."

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USP45 binds ERCC1 and ERCC4. 4 / 4

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"Upon UV exposure, USP45 interacts with ERCC1–XPF but the USP45 mutant (Asp25Ala, Glu26Ala) that is catalytically active but that cannot bind to ERCC1 failed to deubiquitinate ERCC1."

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"USP45 interacts specifically with ERCC1–XPF via its N-terminal 61 residues."

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"These data suggested that USP45 interacts directly with XPF–ERCC1 and not with SLX4."

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"USP45 associates with the ERCC1–XPF endonuclease."

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USP45 deubiquitinates ERCC1.

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USP45 deubiquitinates ERCC1. 10 / 12

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"It was shown that USP45 interacts with and deubiquitinates the excision repair cross complementation group 1 (ERCC1) subunit of the XPF-ERCC1 DNA repair nuclease which has role in the TC-NER of UV induced DNA damage [XREF_BIBR, XREF_BIBR]."

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"As expected, the catalytically inactive USP45 [Cys199Ala] mutant also failed to deubiquitylate ERCC1 (Fig XREF_FIG C, XREF_SUPPLEMENTARY)."

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"Upon UV exposure, USP45 interacts with ERCC1-XPF but the USP45 mutant (Asp25Ala, Glu26Ala) that is catalytically active but that can not bind to ERCC1 failed to deubiquitinate ERCC1."

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"USP45 targeting ERCC1"

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"This, coupled with the report that inactivating the USP45 protein that deubiquitinates ERCC1 in human myelogenous leukaemia and osteosarcoma cells leads to reduced levels of NER and increased sensitivity to UV irradiation [XREF_BIBR], suggests that our therapeutic strategy is likely applicable to a wide range of human cancers."

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"Furthermore, USP45 can deubiquitylate ERCC1 in a manner that requires association of USP45 and ERCC1."

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"These data therefore indicate that likely the ubiquitylation of ERCC1, which is reversed by USP45, controls an aspect of ERCC1 function other than regulating its stability."

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"In this light, we observed that 5 other DUBs tested (AMSH, Cezanne, OTUB1, UCHL1 and USP27X) failed to deubiquitylate ERCC1 under conditions that wild-type USP45 deubiquitylated ERCC1 (Supplementary Fig S5C)."

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"The major role of ERCC1 deubiquitination by USP45 has been speculated to enable ERCC1-XPF to gain access to DNA damage sites."

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"Both mass spectrometry and yeast two-hybrid system identify that USP45 interacts with ERCC1, and it was also demonstrated that USP45 deubiquitinates ERCC1 [55]."

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Mutated USP45 deubiquitinates ERCC1. 2 / 2

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"Importantly, we find that the USP45 mutant [Asp25Ala, Glu26Ala] that is catalytically active but that can not bind to ERCC1 (Supplementary Fig S5A) failed to deubiquitylate ERCC1 in vitro, indicating that specific interaction between ERCC1 and USP45 is essential to trigger deubiquitylation."

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"Importantly, the USP45 mutant [Asp25Ala, Glu26Ala] that displays the same intrinsic catalytic activity as wild-type USP45 when assayed using a generic ubiquitin-rhodamine substrate (XREF_SUPPLEMENTARY), but that can not bind ERCC1, failed to deubiquitylate ERCC1 in parallel experiments (Fig XREF_FIG C, XREF_SUPPLEMENTARY)."

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USP45 deubiquitinates ERCC1 on lysine. 1 / 1

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No evidence text available

USP45 activates ERCC1.

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USP45 activates ERCC1. 3 / 4

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"Moreover, expression of wild-type USP45, but not catalytically deficient USP45 [Cys199Ala] mutant in these cells, restored the number of spontaneous ERCC1 foci almost to the level seen in wild-type U2OS cells (Fig XREF_FIG A and B)."

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"USP45 targeting ERCC1."

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"Expression of wild-type USP45, but not the catalytically deficient USP45 [Cys199Ala] mutant in USP45 knockout U2OS cells, restored the number of DNA damage induced ERCC1 foci to levels observed in wild-type cells (Fig XREF_FIG A and B)."

25538220

USP45 inhibits ERCC1.

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USP45 inhibits ERCC1. 1 / 2

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"Restoring expression of wild-type USP45 in knockout U2OS cells markedly lowered the high molecular weight species of ERCC1 (Fig XREF_FIG B)."

25538220

ERCC1 affects USP45

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ERCC1 binds USP45.

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USP45 binds ERCC1. 10 / 33

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"Both mass spectrometry and yeast two-hybrid system identify that USP45 interacts with ERCC1, and it was also demonstrated that USP45 deubiquitinates ERCC1 [55]."

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"USP45 interacts with ERCC1."

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"Another study [ xref ] demonstrated a direct interaction between the deubiquitylase USP45 and ERCC1, which may control its ubiquitylation."

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"Both mass spectrometry and yeast two-hybrid system identify that USP45 interacts with ERCC1, and it was also demonstrated that USP45 deubiquitinates ERCC1 [XREF_BIBR]."

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No evidence text available

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USP45 binds ERCC1 and ERCC4. 4 / 4

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"Upon UV exposure, USP45 interacts with ERCC1–XPF but the USP45 mutant (Asp25Ala, Glu26Ala) that is catalytically active but that cannot bind to ERCC1 failed to deubiquitinate ERCC1."

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"USP45 interacts specifically with ERCC1–XPF via its N-terminal 61 residues."

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"These data suggested that USP45 interacts directly with XPF–ERCC1 and not with SLX4."

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"USP45 associates with the ERCC1–XPF endonuclease."

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ERCC1 ubiquitinates USP45.

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ERCC1 ubiquitinates USP45. 1 / 1

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"ERCC1 binds to the USP45 deubiquitylase, and ERCC1 ubiquitination was increased in USP45 knockout cells ( Perez-Oliva et al., 2015 )."

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Peptide affects USP45

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Peptide activates USP45. 10 / 17

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"To overcome this inconvenience, we then constructed a novel recombinant strain, L. lactis MG1363 harboring an expression plasmid pSECN, in which the n gene was fused with the coding sequence of USP45 signal peptide and was controlled by the constitutive L. lactis promoter P59."

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"Our data confirmed that the use of sp6 anchor in addition to usp45 signal peptide and interval sequence can efficiently display LTB on the surface of L. lactis."

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"shuttle vector: 1) L. lactis expressing secreted proteins was constructed with recombinant pTRKH2 (secreted-protein plasmid) carrying the Usp45 signal peptide (SPUsp45), nontoxic adjuvanted tetanus toxin fragment C (TETC), and 14 of the 38 C-terminal repeats (14CDTA) of nontoxic C. difficile toxin A (TcdA); and 2) L. lactis expressing secreted and membrane proteins was constructed with recombinant pTRKH2 (membrane-anchored plasmid) carrying SPUsp45, TETC, 14CDTA, and the cell wall-anchored sequence of protein M6 (cwaM6)."

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"P1 represents the constitutive promoter; SD, Shine-Dalgarno sequence; SS, first codons of the Usp45 signal peptide fused to the psaA gene."

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"P1 represents the constitutive promoter; SD, Shine-Dalgarno sequence; SS, first codons of the Usp45 signal peptide fused to the psaA gene.Fig."

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"The psaA gene was cloned into the pT1NX vector PstI site, which produced a fusion of a truncated usp45 signal peptide carried by the vector to the PsaA sequence (Fig. 1), under the control of a constitutive promoter."

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"To calculate the efficacy of hsTRAIL secretion, when pNZ8124 plasmid vector with sequence for usp45 leader peptide was used, we performed ELISA and quantified the concentration of the protein both in crude supernatants and cell lysates after 4 h upon the nisin-induction."

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"In early work in the field, Dieye et al. [27] showed that replacement of the M6 signal peptide with the Usp45 signal peptide from L. lactis doubled the amount of a staphylococcal nuclease reporter protein (NucA) that was successfully anchored to the cell wall [27] ."

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"A cassette consisting of USP45 fused with LEISSTCDA propeptide to increase secretion efficiency, pNZ8048 multiple cloning sites (MCS) modified to include more RE sites, pNZ8048 terminator (T), and TP901–1 bacteriophage attachment site (attP) was synthesized by Integrated DNA Technologies (Singapore) and denoted as attP cassette.The vectors constructions strategy was divided into four phases; Phase I) Construction of PZatt cassette composed of the P promoter, USP45 signal peptide, LEISSTCDA propeptide and attP sequence; Phase II) Construction of the secretion integrative vectors (pS1–4); (a) Plasmid circularisation by incorporation of erythromycin resistant gene and E. coli replication origin into the PZatt cassette, denoted as pS1; (b) Replacement of P promoter with P promoter to produce pS3 plasmid; (c) Replacement of USP45-LEISSTCDA fusion with SPK1 signal peptide into each pS1 and pS3 plasmids to produce pS2 and pS4 plasmids (Additional file 3: Figure S1); Phase III) Construction of the surface display integrative vectors (pSD1–4) by incorporation of PrtP anchor domain into each secretion integrative vector; Phase IV) Cloning of reporter gene, nuclease (Additional file 4: Figure S2)."

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"As for the surface display integrative vector, all systems developed were comparable with the exception of the combination of P 170 promoter with USP45 signal peptide which gave very low signals in whole cell ELISA."

31775775

USP45 affects SPDL1

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USP45 binds SPDL1. 5 / 5

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"This could be explained if the interaction is through the ubiquitin motif as data from the yeast two hybrid assay reveals that the interaction between USP45 and Spindly is not direct or could be through a third, unknown ubiquitylated protein in the complex."

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"Given that USP45 is a DUB, we decided to explore the ubiquitylation in the Spindly-USP45 complex."

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"To validate the data of mass spectrometry, co-immunoprecipitation assays were performed using endogenous USP45 followed by immunoblot that validated the interaction between endogenous Spindly and endogenous USP45 (Fig. xref )."

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"These results further underline the importance of DUB enzymatic activity in the interaction between USP45 and Spindly."

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"In order to map the region of USP45 interacting with Spindly, we performed co-immunoprecipitation studies from HEK293 cells transiently expressing different USP45 fragments GFP tagged (Fig. xref )."

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USP45 binds SPDL1 and FlaG. 1 / 1

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"This suggests that Spindly could be potentially be mono-ubiquitylated instead of poly-ubiquitylated: Treatment of the IP of Spindly-FLAG with recombinant USP45 WT showed a removal of the potential Spindly mono-ubiquitylation band (Fig. xref , right panel)."

30258100

USP45 affects ERCC4

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USP45 binds ERCC1 and ERCC4. 4 / 4

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"Upon UV exposure, USP45 interacts with ERCC1–XPF but the USP45 mutant (Asp25Ala, Glu26Ala) that is catalytically active but that cannot bind to ERCC1 failed to deubiquitinate ERCC1."

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"USP45 interacts specifically with ERCC1–XPF via its N-terminal 61 residues."

25538220

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"These data suggested that USP45 interacts directly with XPF–ERCC1 and not with SLX4."

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"USP45 associates with the ERCC1–XPF endonuclease."

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USP45 binds ERCC4. 2 / 2

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SPDL1 affects USP45

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USP45 binds SPDL1. 5 / 5

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"Given that USP45 is a DUB, we decided to explore the ubiquitylation in the Spindly-USP45 complex."

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"These results further underline the importance of DUB enzymatic activity in the interaction between USP45 and Spindly."

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"In order to map the region of USP45 interacting with Spindly, we performed co-immunoprecipitation studies from HEK293 cells transiently expressing different USP45 fragments GFP tagged (Fig. xref )."

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ERCC4 affects USP45

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USP45 binds ERCC1 and ERCC4. 4 / 4

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"Upon UV exposure, USP45 interacts with ERCC1–XPF but the USP45 mutant (Asp25Ala, Glu26Ala) that is catalytically active but that cannot bind to ERCC1 failed to deubiquitinate ERCC1."

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"USP45 interacts specifically with ERCC1–XPF via its N-terminal 61 residues."

25538220

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"These data suggested that USP45 interacts directly with XPF–ERCC1 and not with SLX4."

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"USP45 associates with the ERCC1–XPF endonuclease."

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USP45 binds ERCC4. 2 / 2

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No evidence text available

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No evidence text available

25538220

Bisphenol A affects USP45

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Bisphenol A methylates USP45.

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Bisphenol A methylates USP45. 1 / 1

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ctd

No evidence text available

28505145

Bisphenol A increases the amount of USP45.

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Bisphenol A increases the amount of USP45. 1 / 1

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No evidence text available

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Bisphenol A demethylates USP45.

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ctd

No evidence text available

30906313

Bisphenol A decreases the amount of USP45.

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ctd

No evidence text available

30816183

USP45 affects SLX4

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"In agreement with USP45 associating with SLX4 indirectly through its ability to bind ERCC1, we found that USP45 did not co-immunoprecipitate with SLX4 from ERCC1 knockout mouse embryonic fibroblasts (MEFs) (Fig xref D; McWhir et al , xref ; Melton et al , xref )."

25538220

ERCC4 affects ERCC1

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USP45 binds ERCC1 and ERCC4. 4 / 4

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"Upon UV exposure, USP45 interacts with ERCC1–XPF but the USP45 mutant (Asp25Ala, Glu26Ala) that is catalytically active but that cannot bind to ERCC1 failed to deubiquitinate ERCC1."

27827925

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"USP45 interacts specifically with ERCC1–XPF via its N-terminal 61 residues."

25538220

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"These data suggested that USP45 interacts directly with XPF–ERCC1 and not with SLX4."

25538220

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"USP45 associates with the ERCC1–XPF endonuclease."

25538220

Valproic acid affects USP45

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Valproic acid increases the amount of USP45.

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Valproic acid increases the amount of USP45. 2 / 2

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ctd

No evidence text available

29154799

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No evidence text available

24935251

Valproic acid demethylates USP45.

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Valproic acid demethylates USP45. 1 / 1

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ctd

No evidence text available

29154799

USP45 affects SP

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"SP Usp45 ::GroEL might undergo rapid folding right after their synthesis, which interferes with (or hampers) the secretion process."

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"Analysis of induced NZ(pSEC:groEL) samples revealed only one band in the C fraction, with an expected size of around 60 kDa, which corresponds to the GroEL precursor (SP Usp45 ::GroEL) (Figure 2 )."

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"Similar results were obtained when pCYT and pSEC vectors were used to produce the B. abortus GroEL chaperone protein: only pSEC:GroEL plasmid was obtained and subsequently the fusion SP Usp45 :GroEL was detected in Western blot experiments (V. Azevedo, unpublished data)."

15631634

USP45 affects MYC

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USP45 binds MYC.

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USP45 binds MYC. 2 / 2

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"Herein we report our discoveries in this research area, and we have found that deubiquitinase USP45 can directly bind with MYC, resulting in its deubiquitination and stabilization."

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"Herein we report our discoveries in this research area, and we have found that deubiquitinase USP45 can directly bind with MYC, resulting in its deubiquitination and stabilization."

36765885

USP45 activates MYC.

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USP45 activates MYC. 1 / 1

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"Further, USP45 overexpressing can upregulate MYC, and this overexpressing can significantly enhance cancer development, cancer cell stemness and drug resistance."

36765885

USP45 affects HSPD1

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USP45 binds HSPD1 and SP. 3 / 3

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"SP Usp45 ::GroEL might undergo rapid folding right after their synthesis, which interferes with (or hampers) the secretion process."

16556312

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"Analysis of induced NZ(pSEC:groEL) samples revealed only one band in the C fraction, with an expected size of around 60 kDa, which corresponds to the GroEL precursor (SP Usp45 ::GroEL) (Figure 2 )."

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USP45 affects FBXL7

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"For example, Fbxl7 directly associates to USP1 and USP45, and indirectly is linked to USP12."

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USP1 binds FBXL7 and USP45. 1 / 1

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"For example, Fbxl7 directly associates to USP1 and USP45, and indirectly is linked to USP12. xref These deubiquitylation enzymes could counteract SCF Fbxl18 to remove ubiquitin from Fbxl7 to prevent its degradation."

25654763

SP affects USP45

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"SP Usp45 ::GroEL might undergo rapid folding right after their synthesis, which interferes with (or hampers) the secretion process."

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"Analysis of induced NZ(pSEC:groEL) samples revealed only one band in the C fraction, with an expected size of around 60 kDa, which corresponds to the GroEL precursor (SP Usp45 ::GroEL) (Figure 2 )."

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15631634

MYC affects USP45

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MYC binds USP45.

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USP45 binds MYC. 2 / 2

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"Herein we report our discoveries in this research area, and we have found that deubiquitinase USP45 can directly bind with MYC, resulting in its deubiquitination and stabilization."

36765885

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"Herein we report our discoveries in this research area, and we have found that deubiquitinase USP45 can directly bind with MYC, resulting in its deubiquitination and stabilization."

36765885

MYC inhibits USP45.

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MYC inhibits USP45. 1 / 1

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"Interestingly, without enhancing cancer development, MYC silencing with shRNA can only suppress USP45-induced stemness and drug resistance."

36765885

HSPD1 affects USP45

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USP45 binds HSPD1 and SP. 3 / 3

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"SP Usp45 ::GroEL might undergo rapid folding right after their synthesis, which interferes with (or hampers) the secretion process."

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"Analysis of induced NZ(pSEC:groEL) samples revealed only one band in the C fraction, with an expected size of around 60 kDa, which corresponds to the GroEL precursor (SP Usp45 ::GroEL) (Figure 2 )."

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FBXL7 affects USP45

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FBXL7 binds USP45. 1 / 2

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"For example, Fbxl7 directly associates to USP1 and USP45, and indirectly is linked to USP12."

25654763

USP1 binds FBXL7 and USP45. 1 / 1

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25654763

Doxorubicin affects USP45

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Doxorubicin inhibits USP45.

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Doxorubicin inhibits USP45. 1 / 1

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"Since USP45 is significantly expressed in cervical tumors, we have discovered that the combination of α-mangostin and doxorubicin can significantly inhibit USP45-induced cervical tumorigenesis in an animal model."

36765885

Doxorubicin decreases the amount of USP45.

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Doxorubicin decreases the amount of USP45. 1 / 1

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ctd

No evidence text available

29803840

Aflatoxin B1 affects USP45

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Aflatoxin B1 methylates USP45.

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Aflatoxin B1 methylates USP45. 1 / 1

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ctd

No evidence text available

30157460

Aflatoxin B1 increases the amount of USP45.

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Aflatoxin B1 increases the amount of USP45. 1 / 1

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ctd

No evidence text available

19770486

ZFR affects USP45

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ZFR binds USP45. 2 / 2

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biogrid

No evidence text available

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biogrid

No evidence text available

25538220

USP45 affects response to drug

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USP45 inhibits response to drug.

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USP45 bound to natural small molecule inhibits response to drug. 1 / 1

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"Moreover, we have identified that USP45 can be specifically bound and inhibited by a natural small molecule (α-mangostin), in turn significantly suppressing USP45-induced stemness and drug resistance."

36765885

USP45 activates response to drug.

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USP45 activates response to drug. 1 / 1

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"Suppression of Cancer Cell Stemness and Drug Resistance via MYC Destabilization by Deubiquitinase USP45 Inhibition with a Natural Small Molecule."

36765885

USP45 affects ZFR

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ZFR binds USP45. 2 / 2

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biogrid

No evidence text available

19615732

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biogrid

No evidence text available

25538220

USP45 affects RBMX

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USP45 binds RBMX. 2 / 2

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biogrid

No evidence text available

25538220

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biogrid

No evidence text available

19615732

USP45 affects MYL12B

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USP45 binds MYL12B. 2 / 2

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biogrid

No evidence text available

25538220

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biogrid

No evidence text available

19615732

USP45 affects MYH9

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USP45 binds MYH9. 2 / 2

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biogrid

No evidence text available

25538220

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biogrid

No evidence text available

19615732

USP45 affects MYH10

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USP45 binds MYH10. 2 / 2

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biogrid

No evidence text available

19615732

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biogrid

No evidence text available

25538220

USP45 affects ERCC1-XPF

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USP45 binds ERCC1-XPF. 2 / 2

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"USP45 interacts specifically with ERCC1-XPF via its N-terminal 61 residues."

25538220

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"Upon UV exposure, USP45 interacts with ERCC1-XPF but the USP45 mutant (Asp25Ala, Glu26Ala) that is catalytically active but that can not bind to ERCC1 failed to deubiquitinate ERCC1."

27827925

RBMX affects USP45

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USP45 binds RBMX. 2 / 2

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biogrid

No evidence text available

25538220

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biogrid

No evidence text available

19615732

MYL12B affects USP45

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USP45 binds MYL12B. 2 / 2

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biogrid

No evidence text available

25538220

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biogrid

No evidence text available

19615732

MYH9 affects USP45

2 |

USP45 binds MYH9. 2 / 2

2 |

➶

biogrid

No evidence text available

25538220

➶

biogrid

No evidence text available

19615732

MYH10 affects USP45

2 |

USP45 binds MYH10. 2 / 2

2 |

➶

biogrid

No evidence text available

19615732

➶

biogrid

No evidence text available

25538220

ERCC1-XPF affects USP45

| 2

USP45 binds ERCC1-XPF. 2 / 2

| 2

➶

reach

"USP45 interacts specifically with ERCC1-XPF via its N-terminal 61 residues."

25538220

➶

reach

"Upon UV exposure, USP45 interacts with ERCC1-XPF but the USP45 mutant (Asp25Ala, Glu26Ala) that is catalytically active but that can not bind to ERCC1 failed to deubiquitinate ERCC1."

27827925

17alpha-ethynylestradiol affects USP45

2 |

17alpha-ethynylestradiol increases the amount of USP45.

1 |

17alpha-ethynylestradiol increases the amount of USP45. 1 / 1

1 |

➶

ctd

No evidence text available

29097150

17alpha-ethynylestradiol decreases the amount of USP45.

1 |

17alpha-ethynylestradiol decreases the amount of USP45. 1 / 1

1 |

➶

ctd

No evidence text available

23129252

Α-mangostin affects USP45

| 1

Α-mangostin inhibits USP45. 1 / 1

| 1

➶

reach

36765885

Vorinostat affects USP45

1 |

Vorinostat increases the amount of USP45. 1 / 1

1 |

➶

ctd

No evidence text available

27188386

Vinclozolin affects USP45

1 |

Vinclozolin increases the amount of USP45. 1 / 1

1 |

➶

ctd

No evidence text available

23034163

Tris(1,3-dichloro-2-propyl)phosphate affects USP45

1 |

Tris(1,3-dichloro-2-propyl)phosphate increases the amount of USP45. 1 / 1

1 |

➶

ctd

No evidence text available

26179874

Trichostatin A affects USP45

1 |

Trichostatin A increases the amount of USP45. 1 / 1

1 |

➶

ctd

No evidence text available

24935251

Sunitinib affects USP45

1 |

Sunitinib increases the amount of USP45. 1 / 1

1 |

➶

ctd

No evidence text available

31533062

Pirinixic acid affects USP45

1 |

Pirinixic acid decreases the amount of USP45. 1 / 1

1 |

➶

ctd

No evidence text available

18445702

Phorbol 13-acetate 12-myristate affects USP45

1 |

Phorbol 13-acetate 12-myristate increases the amount of USP45. 1 / 1

1 |

➶

ctd

No evidence text available

25613284

Phlorizin affects USP45

1 |

Phlorizin decreases the amount of USP45. 1 / 1

1 |

➶

ctd

No evidence text available

22538082

Paracetamol affects USP45

1 |

Paracetamol increases the amount of USP45. 1 / 1

1 |

➶

ctd

No evidence text available

26690555

Natural small molecule affects USP45

| 1

USP45 binds natural small molecule. 1 / 1

| 1

➶

reach

36765885

Mono(2-ethylhexyl) phthalate affects USP45

1 |

Mono(2-ethylhexyl) phthalate decreases the amount of USP45. 1 / 1

1 |

➶

ctd

No evidence text available

31059758

Mitomycin C affects USP45

| 1

Mitomycin C activates USP45. 1 / 1

| 1

➶

reach

"We also explored how USP45 knockout impacts on gamma-H2AX foci induced by MMC."

25538220

Methylmercury chloride affects USP45

1 |

Methylmercury chloride decreases the amount of USP45. 1 / 1

1 |

➶

ctd

No evidence text available

28001369

Methyl methanesulfonate affects USP45

1 |

Methyl methanesulfonate increases the amount of USP45. 1 / 1

1 |

➶

ctd

No evidence text available

23649840

Methapyrilene affects USP45

1 |

Methapyrilene methylates USP45. 1 / 1

1 |

➶

ctd

No evidence text available

30157460

Manganese(II) chloride affects USP45

1 |

Manganese(II) chloride decreases the amount of USP45. 1 / 1

1 |

➶

ctd

No evidence text available

17175027

Manganese atom affects USP45

1 |

Manganese atom decreases the amount of USP45. 1 / 1

1 |

➶

ctd

No evidence text available

17175027

Lactacystin affects USP45

| 1

Lactacystin inhibits USP45. 1 / 1

| 1

➶

reach

"To explore whether USP45 can directly catalyse deubiquitylation of ERCC1, we isolated ubiquitylated Flag-ERCC1 (Fig XREF_FIG C) or GFP-ERCC1 (XREF_SUPPLEMENTARY), expressed in USP45 knockout U2OS cells treated with lactacystin proteasomal inhibitor."

25538220

Ionomycin affects USP45

1 |

Ionomycin increases the amount of USP45. 1 / 1

1 |

➶

ctd

No evidence text available

25613284

Hsa-miR-6873-5p affects USP45

1 |

Hsa-miR-6873-5p decreases the amount of USP45. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-6783-5p affects USP45

1 |

Hsa-miR-6783-5p decreases the amount of USP45. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-665 affects USP45

1 |

Hsa-miR-665 decreases the amount of USP45. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

27292025

Hsa-miR-630 affects USP45

1 |

Hsa-miR-630 decreases the amount of USP45. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-526a affects USP45

1 |

Hsa-miR-526a decreases the amount of USP45. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-523-5p affects USP45

1 |

Hsa-miR-523-5p decreases the amount of USP45. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-522-5p affects USP45

1 |

Hsa-miR-522-5p decreases the amount of USP45. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-520g-5p affects USP45

1 |

Hsa-miR-520g-5p decreases the amount of USP45. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-520c-5p affects USP45

1 |

Hsa-miR-520c-5p decreases the amount of USP45. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-519c-5p affects USP45

1 |

Hsa-miR-519c-5p decreases the amount of USP45. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-519b-5p affects USP45

1 |

Hsa-miR-519b-5p decreases the amount of USP45. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-519a-5p affects USP45

1 |

Hsa-miR-519a-5p decreases the amount of USP45. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-518f-5p affects USP45

1 |

Hsa-miR-518f-5p decreases the amount of USP45. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-518e-5p affects USP45

1 |

Hsa-miR-518e-5p decreases the amount of USP45. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-518d-5p affects USP45

1 |

Hsa-miR-518d-5p decreases the amount of USP45. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-4777-5p affects USP45

1 |

Hsa-miR-4777-5p decreases the amount of USP45. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-4668-5p affects USP45

1 |

Hsa-miR-4668-5p decreases the amount of USP45. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-3662 affects USP45

1 |

Hsa-miR-3662 decreases the amount of USP45. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-32-5p affects USP45

1 |

Hsa-miR-32-5p decreases the amount of USP45. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-3149 affects USP45

1 |

Hsa-miR-3149 decreases the amount of USP45. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-3148 affects USP45

1 |

Hsa-miR-3148 decreases the amount of USP45. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-3145-3p affects USP45

1 |

Hsa-miR-3145-3p decreases the amount of USP45. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-192-5p affects USP45

1 |

Hsa-miR-192-5p decreases the amount of USP45. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

19074876

Hsa-let-7f-5p affects USP45

1 |

Hsa-let-7f-5p decreases the amount of USP45. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23622248

Galactose affects USP45

| 1

Galactose activates USP45. 1 / 1

| 1

➶

sparser

"We also show that the usp45 promoter is highly activated by galactose."

32532874

Formaldehyde affects USP45

1 |

Formaldehyde decreases the amount of USP45. 1 / 1

1 |

➶

ctd

No evidence text available

23649840

Folic acid affects USP45

1 |

Folic acid decreases the amount of USP45. 1 / 1

1 |

➶

ctd

No evidence text available

20938992

Dioxygen affects USP45

1 |

Dioxygen increases the amount of USP45. 1 / 1

1 |

➶

ctd

No evidence text available

22629407

Choline affects USP45

1 |

Choline decreases the amount of USP45. 1 / 1

1 |

➶

ctd

No evidence text available

20938992

Cadmium dichloride affects USP45

1 |

Cadmium dichloride demethylates USP45. 1 / 1

1 |

➶

ctd

No evidence text available

22457795

Bortezomib affects USP45

1 |

Bortezomib increases the amount of USP45. 1 / 1

1 |

➶

ctd

No evidence text available

20977926

Benzo[e]pyrene affects USP45

1 |

Benzo[e]pyrene methylates USP45. 1 / 1

1 |

➶

ctd

No evidence text available

30157460

Alpha-D-galactose affects USP45

| 1

Alpha-D-galactose activates USP45. 1 / 1

| 1

➶

reach

"We also show that the usp45 promoter is highly activated by galactose."

32532874

Aflatoxin B2 affects USP45

1 |

Aflatoxin B2 methylates USP45. 1 / 1

1 |

➶

ctd

No evidence text available

30157460

YLPM1 affects USP45

1 |

YLPM1 binds USP45. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

XPF-ERCC1 affects USP45

| 1

XPF-ERCC1 activates USP45. 1 / 1

| 1

➶

reach

"On this basis, we speculate that is likely that XPF-ERCC1 is the major target of USP45 in controlling DNA repair."

25538220

WIZ affects USP45

1 |

USP45 binds WIZ. 1 / 1

1 |

➶

biogrid

No evidence text available

26496610

USP45 affects secretion heterologous protein L. lactis

| 1

USP45 activates secretion heterologous protein L. lactis. 1 / 1

| 1

➶

eidos

"One report concluded that usp45 could enhance secretion to increase heterologous protein production in L. lactis [ 21 ] ."

31015862

USP45 affects sacA

| 1

USP45 activates sacA. 1 / 1

| 1

➶

reach

"Removal of the USP45 secretion peptide allowed a soluble and functional invertase to be expressed intracellularly in L. lactis."

28155177

USP45 affects plasmin

| 1

USP45 increases the amount of plasmin. 1 / 1

| 1

➶

reach

"Expression of the plasmin gene driven by the promoter and complete signal sequence of the lactococcal usp45 gene resulted in efficient plasmin secretion in strain BPL420."

9352676

USP45 affects peptide

| 1

USP45 activates peptide. 1 / 1

| 1

➶

reach

"Analysis of the amino acid sequences performed on the two hsTRAIL protein bands showed that the upper (larger) band represents a slightly truncated form of hsTRAIL containing 160 amino acid (aa) residues, while the lower (smaller) band represents a more truncated form of hsTRAIL deprived of 37 aa residues from the N-terminus of the protein, both having the bacterial usp45 leading peptide cut off."

30446013

USP45 affects natural small molecule

| 1

USP45 binds natural small molecule. 1 / 1

| 1

➶

reach

36765885

USP45 affects migration velocity

| 1

USP45 activates migration velocity. 1 / 1

| 1

➶

eidos

"Our data indicate that the lack of USP45 reduces migration velocity compared to wild-type cells ."

30258100

USP45 affects miR-30e-5p

| 1

USP45 activates miR-30e-5p. 1 / 1

| 1

➶

reach

"Furthermore, Usp45 is also potential target of miR-30e-5p which is a regulator of XPF-ERCC1 crucial for efficient DNA repair [XREF_BIBR]."

26439850

USP45 affects localization

| 1

USP45 activates localization. 1 / 1

| 1

➶

reach

"The Usp45 secretion and spaX (S. aureus protein A) anchor signals efficiently promote the localization of FNIII 7-10 in the bacterial membrane."

25068919

USP45 affects dimer

| 1

USP45 activates dimer. 1 / 1

| 1

➶

reach

"Fig. 2D indicate that recombinant USP45 WT is able to mediate the cleavage of 100% of the K6, K48 and K63 dimer in 60 min."

30258100

USP45 affects cell migration

| 1

USP45 inhibits cell migration. 1 / 1

| 1

➶

reach

"USP45 depleted cells were defective in cell migration and the defects observed were not produced by off-target effects: phenotypic rescue could be achieved only by re-expressing the catalytically active USP45 and not with the inactive mutant C199A, suggesting a potential interplay of Spindly and USP45 in cell migration (Fig. 5C)."

30258100

USP45 affects alpha-amylase

| 1

USP45 activates alpha-amylase. 1 / 1

| 1

➶

reach

"Fusion of the usp45 promoter region and various parts of the leader sequence to an amyS gene devoid of its signal sequence, showed that in Escherichia coli the first 19, 20, and 27 residues of the Usp45 leader are able to direct alpha-amylase secretion."

8413193

USP45 affects acmA

| 1

USP45 activates acmA. 1 / 1

| 1

➶

reach

"To verify whether IL-23-specific ILP protein binders can be produced in L. lactis host cells, DNA sequences coding for ILP proteins (ILP030, ILP317 and ILP323 variants) were genetically fused to Usp45 secretion signal and C-terminal domain of AcmA protein (cA) containing LysM repeats (LysM) for peptidoglycan anchoring."

29966384

USP45 affects YLPM1

1 |

YLPM1 binds USP45. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP45 affects WIZ

1 |

USP45 binds WIZ. 1 / 1

1 |

➶

biogrid

No evidence text available

26496610

USP45 affects USP1

| 1

USP1 binds FBXL7 and USP45. 1 / 1

| 1

➶

sparser

25654763

USP45 affects TMOD3

1 |

TMOD3 binds USP45. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP45 affects TGFBR1

1 |

TGFBR1 binds USP45. 1 / 1

1 |

➶

hprd

No evidence text available

15761153

USP45 affects SRBD1

1 |

USP45 binds SRBD1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP45 affects SMURF1

1 |

SMURF1 binds USP45. 1 / 1

1 |

➶

hprd

No evidence text available

15761153

USP45 affects SMAD1

1 |

USP45 binds SMAD1. 1 / 1

1 |

➶

hprd

No evidence text available

15761153

USP45 affects SF3A2

1 |

SF3A2 binds USP45. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP45 affects SAFB

1 |

SAFB binds USP45. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP45 affects RTCA

1 |

RTCA binds USP45. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP45 affects RBM7

1 |

USP45 binds RBM7. 1 / 1

1 |

➶

biogrid

No evidence text available

26496610

USP45 affects RALY

1 |

RALY binds USP45. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP45 affects PPP5C

1 |

USP45 binds PPP5C. 1 / 1

1 |

➶

biogrid

No evidence text available

26496610

USP45 affects POLR2G

1 |

USP45 binds POLR2G. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP45 affects PIK3CG

1 |

USP45 binds PIK3CG. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP45 affects NOP53

1 |

USP45 binds NOP53. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP45 affects MYL6

1 |

USP45 binds MYL6. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP45 affects LiaRS

| 1

USP45 activates LiaRS. 1 / 1

| 1

➶

reach

"Usp45 and TEM-1 IA (2)-lactamase specifically induce the LiaRS dependent response."

22624725

USP45 affects LCN2

| 1

USP45 activates LCN2. 1 / 1

| 1

➶

reach

"Construction of Lcn2 under the P1 promoter allows for constitutive expression, whereas USP45 encodes for the sequence signal to drive the secretion of Lcn2 from L. lactis."

28445245

USP45 affects IGKV4-1

1 |

USP45 binds IGKV4-1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP45 affects GUCY2D

| 1

USP45 binds GUCY2D. 1 / 1

| 1

➶

sparser

"Our study implicates that biallelic mutations in USP45 are associated with the occurrence of LCA."

30573563

USP45 affects FlaG

| 1

USP45 binds SPDL1 and FlaG. 1 / 1

| 1

➶

sparser

30258100

USP45 affects FLNA

1 |

USP45 binds FLNA. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP45 affects FARS2

1 |

USP45 binds FARS2. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP45 affects DNA Damage

| 1

USP45 activates DNA Damage. 1 / 1

| 1

➶

reach

"Taken together, these data indicate that USP45 localises at sites of UV induced DNA damage, and at intra- and interstrand cross-links, and that USP45 is required, like ERCC1 for efficient NER."

25538220

USP45 affects Carcinogenesis

| 1

USP45 activates Carcinogenesis. 1 / 1

| 1

➶

reach

36765885

USP45 affects CORO1C

1 |

USP45 binds CORO1C. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP45 affects CDK1

1 |

CDK1 binds USP45. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP45 affects BMPR1B

1 |

BMPR1B binds USP45. 1 / 1

1 |

➶

hprd

No evidence text available

15761153

USP45 affects ARID1A

| 1

ARID1A binds USP45. 1 / 1

| 1

➶

reach

"We further investigated shared segments and WES for evidence supporting the complexes USP45 and ARID1A are involved in."

29389935

USP1 affects USP45

| 1

USP1 binds FBXL7 and USP45. 1 / 1

| 1

➶

sparser

25654763

TMOD3 affects USP45

1 |

TMOD3 binds USP45. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

TGFBR1 affects USP45

1 |

TGFBR1 binds USP45. 1 / 1

1 |

➶

hprd

No evidence text available

15761153

SRBD1 affects USP45

1 |

USP45 binds SRBD1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

SPINK1 affects USP45

| 1

SPINK1 activates USP45. 1 / 1

| 1

➶

reach

16549380

SPDL1 affects FlaG

| 1

USP45 binds SPDL1 and FlaG. 1 / 1

| 1

➶

sparser

30258100

SMURF1 affects USP45

1 |

SMURF1 binds USP45. 1 / 1

1 |

➶

hprd

No evidence text available

15761153

SMAD1 affects USP45

1 |

USP45 binds SMAD1. 1 / 1

1 |

➶

hprd

No evidence text available

15761153

SF3A2 affects USP45

1 |

SF3A2 binds USP45. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

SAFB affects USP45

1 |

SAFB binds USP45. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

RTCA affects USP45

1 |

RTCA binds USP45. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

RBM7 affects USP45

1 |

USP45 binds RBM7. 1 / 1

1 |

➶

biogrid

No evidence text available

26496610

RALY affects USP45

1 |

RALY binds USP45. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

PPP5C affects USP45

1 |

USP45 binds PPP5C. 1 / 1

1 |

➶

biogrid

No evidence text available

26496610

POLR2G affects USP45

1 |

USP45 binds POLR2G. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

PIK3CG affects USP45

1 |

USP45 binds PIK3CG. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP45 is modified

| 1

USP45 is ubiquitinated. 1 / 1

| 1

➶

sparser

"Given that USP45 is a DUB, we decided to explore the ubiquitylation in the Spindly-USP45 complex."

30258100

NOP53 affects USP45

1 |

USP45 binds NOP53. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

MYL6 affects USP45

1 |

USP45 binds MYL6. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

Leber Congenital Amaurosis affects USP45

| 1

Leber Congenital Amaurosis activates USP45. 1 / 1

| 1

➶

reach

"Biallelic LoF mutations in USP45 cause Leber congenital amaurosis, a severe form of inherited retinal dystrophies that results in irreversible childhood blindness (45)."

35662507

L-methionine affects USP45

1 |

L-methionine decreases the amount of USP45. 1 / 1

1 |

➶

ctd

No evidence text available

20938992

IGKV4-1 affects USP45

1 |

USP45 binds IGKV4-1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

GUCY2D affects USP45

| 1

USP45 binds GUCY2D. 1 / 1

| 1

➶

sparser

"Our study implicates that biallelic mutations in USP45 are associated with the occurrence of LCA."

30573563

FlaG affects USP45

| 1

USP45 binds SPDL1 and FlaG. 1 / 1

| 1

➶

sparser

30258100

FLNA affects USP45

1 |

USP45 binds FLNA. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

FBXL7 affects USP1, and USP45

| 1

USP1 binds FBXL7 and USP45. 1 / 1

| 1

➶

sparser

25654763

FARS2 affects USP45

1 |

USP45 binds FARS2. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

Cuprizone affects USP45

1 |

Cuprizone decreases the amount of USP45. 1 / 1

1 |

➶

ctd

No evidence text available

26577399

Casp14 affects USP45

| 1

Casp14 activates USP45. 1 / 1

| 1

➶

reach

"In agreement with these clinical findings, the LL-IL35-treated mice had markedly reduced Ly-6G + CD11b + cells (neutrophils) infiltrating the joints (Figure 2A ) representing a 7-and 5-fold reduction compared to The synthetic insert encodes in order: the usp45 secretion peptide genetically fused in-frame to the p35 subunit, a short flexible linker, fused to the EBI3."

30515168