IndraLab

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USP45 activates ERCC1. 3 / 4
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"Moreover, expression of wild-type USP45, but not catalytically deficient USP45 [Cys199Ala] mutant in these cells, restored the number of spontaneous ERCC1 foci almost to the level seen in wild-type U2OS cells (Fig XREF_FIG A and B)."

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"USP45 targeting ERCC1."

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"Expression of wild-type USP45, but not the catalytically deficient USP45 [Cys199Ala] mutant in USP45 knockout U2OS cells, restored the number of DNA damage induced ERCC1 foci to levels observed in wild-type cells (Fig XREF_FIG A and B)."