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USP45 inhibits ERCC1. 3 / 4
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"Restoring expression of wild-type USP45 in knockout U2OS cells markedly lowered the high molecular weight species of ERCC1 (Fig XREF_FIG B)."
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"It was shown that USP45 could inhibit the ubiquitin-proteasome degradation pathway of ERCC1 protein, a DNA repair-related nucleic acid endonuclease, thereby enhancing the ability of tumor cells to repair DNA damage. xref KEGG pathway analysis showed that USP45 may be associated with the MAPK signaling pathway, AMPK signaling pathway, Hippo signaling pathway, cell cycle, p53 signaling pathway, and TGF-β signaling pathway ( xref N and xref )."
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"It was shown that USP45 could inhibit the ubiquitin-proteasome degradation pathway of ERCC1 protein, a DNA repair-related nucleic acid endonuclease, thereby enhancing the ability of tumor cells to repair DNA damage.4 KEGG pathway analysis showed that USP45 may be associated with the MAPK signaling pathway, AMPK signaling pathway, Hippo signaling pathway, cell cycle, p53 signaling pathway, and TGF-β signaling pathway (Fig. 1N and Table S5)."
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