IndraLab

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USP45 activates localization. 4 / 4
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"Interestingly, the ablation of USP45 significantly enhanced the localization of the V-ATPase V0 subunit d (ATP6V0D) at late endosomes (Rab 7) and lysosomes (LAMP2), while having no effects on its localization at early endosomes (EEA1) (Fig. 4, E and F)."
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"We then investigated whether USP45 could modulate the localization of V-ATPase on endolysosomes."
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"dUsp45/USP45 impairs lysosomal acidification and disrupts the localization of V-ATPases to lysosomes by modulating actin structures."
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"The Usp45 secretion and spaX (S. aureus protein A) anchor signals efficiently promote the localization of FNIII 7-10 in the bacterial membrane."
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