IndraLab

Statements

USP45 binds SPDL1. 11 / 11
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reach
"Conte identified hSpindly as a new target of the ubiquitin-specific protease USP45; hSpindly and USP45 can form a complex whose interaction is specifically related to the catalytic activity of USP45 [38]."
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biogrid
No evidence text available
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sparser
"Conte identified hSpindly as a new target of the ubiquitin-specific protease USP45; hSpindly and USP45 can form a complex whose interaction is specifically related to the catalytic activity of USP45 [ xref ]."
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sparser
"These results further underline the importance of DUB enzymatic activity in the interaction between USP45 and Spindly."
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biogrid
No evidence text available
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sparser
"Given that USP45 is a DUB, we decided to explore the ubiquitylation in the Spindly-USP45 complex."
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biogrid
No evidence text available
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sparser
"To validate the data of mass spectrometry, co-immunoprecipitation assays were performed using endogenous USP45 followed by immunoblot that validated the interaction between endogenous Spindly and endogenous USP45 (Fig.  xref )."
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sparser
"This could be explained if the interaction is through the ubiquitin motif as data from the yeast two hybrid assay reveals that the interaction between USP45 and Spindly is not direct or could be through a third, unknown ubiquitylated protein in the complex."
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sparser
"In order to map the region of USP45 interacting with Spindly, we performed co-immunoprecipitation studies from HEK293 cells transiently expressing different USP45 fragments GFP tagged (Fig.  xref )."
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biogrid
No evidence text available
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