IndraLab

Statements

USP45 binds MYC. 12 / 12
3 | 3 6
sparser
"Therefore, we explored the regulatory mechanism of USP45-MYC in cervical cancer."
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sparser
"Co-IP assays demonstrated that USP45 interacted directly with MYC, and the interaction was independent to the USP45 catalytic activity ( xref A–C)."
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"Curiously, in different situations, USP45 forms a connection with ERCC1 through its brief acidic motif that is positioned outside of the catalytic domain. [ xref ] Similarly, the binding of USP45 to MYC in cervical cancer cells is also independent of its catalytic domain. [ xref ] The specific domain responsible for the USP45–Snail interaction remains unknown."
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biogrid
No evidence text available
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sparser
"The purified USP45 was incubated with purified MYC from HEK293T cells, followed by the pulling down experiments, which demonstrated the direct interaction between USP45 and MYC ( xref F)."
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biogrid
No evidence text available
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biogrid
No evidence text available
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sparser
"Herein we report our discoveries in this research area, and we have found that deubiquitinase USP45 can directly bind with MYC, resulting in its deubiquitination and stabilization."
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reach
"Herein we report our discoveries in this research area, and we have found that deubiquitinase USP45 can directly bind with MYC, resulting in its deubiquitination and stabilization."
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sparser
"Co-IP assays confirmed that USP45 binds directly to MYC, selectively removing K48-linked ubiquitin chains from MYC, thereby intensifying Dox resistance in cancer cells."
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reach
"USP45 Interacts with and Deubiquitinates MYC."
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reach
"The purified USP45 was incubated with purified MYC from HEK293T cells, followed by the pulling down experiments, which demonstrated the direct interaction between USP45 and MYC (Figure 5F)."
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