IndraLab

Statements

USP21 affects NANOG
8 1 | 1
USP21 binds NANOG.
8 |
USP21 binds NANOG. 8 / 10
8 |
biogrid
No evidence text available
27956178
biogrid
No evidence text available
27956178
biogrid
No evidence text available
27886188
biogrid
No evidence text available
27956178
biogrid
No evidence text available
27956178
biogrid
No evidence text available
27886188
biogrid
No evidence text available
27886188
biogrid
No evidence text available
27886188
USP21 deubiquitinates NANOG.
1 | 1
USP21 deubiquitinates NANOG. 2 / 2
1 | 1
reach
"For example, Oct4 and Sox2 protein levels are regulated by the E3 ligase WWP2, and ubiquitin-specific-processing protease 21 (Usp21) deubiquitinates and stabilizes Nanog, which maintains pluripotency, while FBXW8, an E3 ligase, ubiquitinates and destabilizes Nanog, thereby promoting ESC differentiation."
30891497
ubibrowser
"Review"
28279784
USP21 is modified
8 | 1 3
USP21 is phosphorylated.
6 | 3
USP21 is phosphorylated on S116. 2 / 2
2 |
hprd
No evidence text available
19413330
hprd
No evidence text available
19413330
USP21 is phosphorylated on T132. 2 / 2
2 |
hprd
No evidence text available
19413330
hprd
No evidence text available
19413330
USP21 is phosphorylated. 2 / 2
| 2
rlimsp
"p38 inhibition provides anti-DNA virus immunity by regulation of USP21 phosphorylation and STING activation."
28254948
rlimsp
"Thus, our study reveals a critical role of p38-mediated USP21 phosphorylation in regulating STING-mediated antiviral functions and identifies p38-USP21 axis as an important pathway that DNA virus adopts to avoid innate immunity responses."
28254948
USP21 is phosphorylated on S140. 2 / 2
2 |
hprd
No evidence text available
19413330
hprd
No evidence text available
19413330
USP21 is phosphorylated on S538. 1 / 1
| 1
rlimsp
"HSV-1 infection recruited USP21 to STING at late stage by p38-mediated phosphorylation of USP21 at Ser538."
28254948
USP21 is acetylated.
2 |
USP21 is acetylated on S113. 2 / 2
2 |
hprd
No evidence text available
19413330
hprd
No evidence text available
19413330
USP21 is deubiquitinated.
| 1
USP21 is deubiquitinated. 1 / 1
| 1
trips
"Deubiquitinating enzyme USP21 inhibits HIV-1 replication by downregulating Tat expression."
33827943
eidos
"USP21 Regulates the Expression of MAPK1 Through GATA3 and Affects Cell Proliferation , Migration , Invasion , and Stemness of GC Since USP21 stimulated cell proliferation , migration , invasion , and stemness of GC , and could stabilize the expression of GATA3 by deubiquitinating GATA3 , while MAPK1 was the transcription target of GATA3 , it was further verified whether USP21 could play its oncogenic effect in GC through the GATA3 / MAPK1 axis ."
33791299
eidos
"USP21 promotes cell proliferation via Cys-221 ."
33389794
eidos
"Furthermore , USP21 has been shown to associate with both centrosomes and microtubules to regulate cell motility in three-dimensional matrices [ 29-33 ] , and promotes cell proliferation and metastasis in kinds of cancer [ 34-37 ] ."
31253698
reach
"Besides, Qian et al. showed that the downregulation of USP16 mediated by carboxyl-terminal truncated HBx mutants promotes the proliferation of HCC cells [88]."
31146743
eidos
"USP21 promotes cell proliferation by maintaining the EZH2 level in diffuse large B-cell lymphoma MA et al. Abstract Background Diffuse large B-cell lymphoma ( DLBCL ) is the most common category of non-Hodgkin lymphoma ( NHL ) ."
33389794
eidos
"Therefore , USP21 stimulates cell proliferation but cannot cause cell death ."
33389794
eidos
"We identify that knockdown of USP21 inhibits cell proliferation , and overexpression of USP21 promotes cell growth ."
33389794
eidos
"These data demonstrate that USP21 promotes cell proliferation via its deubiquitinating active site ."
33389794
eidos
"USP21 promotes cell proliferation , tumor progression , and colony formation , and enhances cancer stem cell self-renewal ."
32784507
eidos
"These results demonstrated that USP21 stimulated cell proliferation , migration , invasion , and stemness of GC cells ."
33791299
NANOG affects USP21
8 |
USP21 binds NANOG. 8 / 10
8 |
biogrid
No evidence text available
27956178
biogrid
No evidence text available
27956178
biogrid
No evidence text available
27886188
biogrid
No evidence text available
27956178
biogrid
No evidence text available
27956178
biogrid
No evidence text available
27886188
biogrid
No evidence text available
27886188
biogrid
No evidence text available
27886188
USP21 affects UBC
8 |
UBC binds USP21. 8 / 8
8 |
biogrid
No evidence text available
25527291
biogrid
No evidence text available
20622874
biogrid
No evidence text available
22626734
biogrid
No evidence text available
22298430
biogrid
No evidence text available
22195557
biogrid
No evidence text available
21399617
biogrid
No evidence text available
21399617
biogrid
No evidence text available
23287719
USP21 affects DDX58
3 1 | 1
USP21 binds DDX58.
3 |
USP21 binds DDX58. 3 / 4
3 |
biogrid
No evidence text available
24493797
biogrid
No evidence text available
24493797
biogrid
No evidence text available
24493797
USP21 activates DDX58.
| 1
USP21 activates DDX58. 1 / 2
| 1
eidos
"Ubiquitylation events are reversible processes , and , accordingly , severaldeubiquitylating enzymes , in particular ubiquitin specific peptidase 3 ( USP3 ) , USP21 and CYLD lysine 63 deubiquitinase ( CYLD ) , modulate RIG-I signalling by removing K63-polyubiquitin chains , although with unique kinetics ( reviewed elsewhere112 ,118 ) ."
31792373
USP21 deubiquitinates DDX58.
1 |
USP21 deubiquitinates DDX58. 1 / 1
1 |
ubibrowser
"Another study demonstrated that USP21 deubiquitinates RIG‐1, an essential protein in antiviral immune defense."
27341175
USP21 affects migration
| 6
USP21 activates migration.
| 5
USP21 activates migration. 5 / 5
| 5
eidos
"In non-small cell lung cancer , USP21 promotes tumor cell proliferation , migration , and invasion through the YY1 / SNHG16 axis ( Xu et al ., 2020 ) ."
33791299
eidos
"We reported that USP21 promoted GC cell proliferation , migration , invasion , and stemness in vitro , and regulated GC tumor growth and cell stemness in mice in vivo ."
33791299
eidos
"USP21 Regulates the Expression of MAPK1 Through GATA3 and Affects Cell Proliferation , Migration , Invasion , and Stemness of GC Since USP21 stimulated cell proliferation , migration , invasion , and stemness of GC , and could stabilize the expression of GATA3 by deubiquitinating GATA3 , while MAPK1 was the transcription target of GATA3 , it was further verified whether USP21 could play its oncogenic effect in GC through the GATA3 / MAPK1 axis ."
33791299
eidos
"USP21 amplification can increase proliferation , migration , and invasion [ 64 ] ."
32784507
eidos
"These results demonstrated that USP21 stimulated cell proliferation , migration , invasion , and stemness of GC cells ."
33791299
USP21 inhibits migration.
| 1
USP21 inhibits migration. 1 / 1
| 1
eidos
"Our results suggest that USP21 probably influence the function of GSC and further decrease the viability , migration , and function of chondrocytes , verifying the results of previous studies that indicated [ 5,13 ] ."
31253698
USP21 affects KCTD6
3 |
USP21 binds KCTD6. 3 / 6
3 |
biogrid
No evidence text available
27621083
biogrid
No evidence text available
27621083
biogrid
No evidence text available
27621083
USP21 affects GLI1
2 |
USP21 binds GLI1. 2 / 6
2 |
biogrid
No evidence text available
27621083
biogrid
No evidence text available
27621083
KCTD6 affects USP21
3 |
USP21 binds KCTD6. 3 / 6
3 |
biogrid
No evidence text available
27621083
biogrid
No evidence text available
27621083
biogrid
No evidence text available
27621083
GLI1 affects USP21
2 |
USP21 binds GLI1. 2 / 6
2 |
biogrid
No evidence text available
27621083
biogrid
No evidence text available
27621083
USP21 affects RIPK1
1 2 1 |
USP21 binds RIPK1.
2 |
RIPK1 binds USP21. 2 / 3
2 |
biogrid
No evidence text available
19910467
biogrid
No evidence text available
19910467
USP21 deubiquitinates RIPK1.
1 1 |
USP21 deubiquitinates RIPK1. 1 / 1
1 |
ubibrowser
"The contrast in the phenotype of the Usp21-knockout line with the previously characterized GATA3 and RIPK1 knockout mice strongly indicates that USP21 is redundant for the regulation of GATA3 and RIPK1 activity during mouse development, in hematopoietic stem cells, and in lymphocyte differentiation."
25680095
USP21 deubiquitinates RIPK1 on K377. 1 / 1
1 |
biopax:reactome
No evidence text available
eidos
"These results demonstrated that USP21 stimulated cell proliferation , migration , invasion , and stemness of GC cells ."
33791299
eidos
"We reported that USP21 promoted GC cell proliferation , migration , invasion , and stemness in vitro , and regulated GC tumor growth and cell stemness in mice in vivo ."
33791299
eidos
"USP21 amplification can increase proliferation , migration , and invasion [ 64 ] ."
32784507
eidos
"USP21 Regulates the Expression of MAPK1 Through GATA3 and Affects Cell Proliferation , Migration , Invasion , and Stemness of GC Since USP21 stimulated cell proliferation , migration , invasion , and stemness of GC , and could stabilize the expression of GATA3 by deubiquitinating GATA3 , while MAPK1 was the transcription target of GATA3 , it was further verified whether USP21 could play its oncogenic effect in GC through the GATA3 / MAPK1 axis ."
33791299
eidos
"USP21 inhibition suppressed AMC-HN-8 and TU686 cell proliferation , migration and invasion ."
36919585
USP21 affects cell growth
| 3 1
USP21 activates cell growth.
| 3
USP21 activates cell growth. 3 / 3
| 3
eidos
"Mechanistically , USP21 promotes cell growth by maintaining the EZH2 protein level ."
33389794
eidos
"In vitro and in vivo experiments showed that USP21 promotes cell growth , while its knock down had the opposite effect ."
32201366
eidos
"Mechanistically , USP21 promotes cell growth by maintaining EZH2 protein level ."
33389794
USP21 inhibits cell growth.
| 1
USP21 inhibits cell growth. 1 / 1
| 1
reach
"In addition, USP16 overexpression in normal human fibroblasts and neural progenitors led to reduced cell expansion , which was similar to the strong proliferation defects observed in fibroblasts from individuals with Down syndrome ."
28959952
USP21 affects IL33
2 1 |
USP21 binds IL33.
2 |
USP21 binds IL33. 2 / 3
2 |
biogrid
No evidence text available
25197364
biogrid
No evidence text available
25197364
USP21 deubiquitinates IL33.
1 |
USP21 deubiquitinates IL33. 1 / 1
1 |
ubibrowser
"Furthermore, depletion of USP21 reduces IL-33 protein levels and IL-33-mediated NF-kappaB p65 promoter activity."
25197364
USP21 affects CUL3
2 |
USP21 binds CUL3. 2 / 4
2 |
biogrid
No evidence text available
27621083
biogrid
No evidence text available
27621083
DDX58 affects USP21
3 |
USP21 binds DDX58. 3 / 4
3 |
biogrid
No evidence text available
24493797
biogrid
No evidence text available
24493797
biogrid
No evidence text available
24493797
CUL3 affects USP21
2 |
USP21 binds CUL3. 2 / 4
2 |
biogrid
No evidence text available
27621083
biogrid
No evidence text available
27621083
Pirinixic acid affects USP21
3 |
Pirinixic acid increases the amount of USP21.
1 |
Pirinixic acid increases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
19710929
Pirinixic acid decreases the amount of USP21.
1 |
Pirinixic acid decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
21318169
Pirinixic acid activates USP21.
1 |
Pirinixic acid activates USP21. 1 / 1
1 |
ctd
No evidence text available
19710929
USP21 affects MARK2
3 |
USP21 binds MARK2. 3 / 3
3 |
biogrid
No evidence text available
22298430
biogrid
No evidence text available
19615732
biogrid
No evidence text available
22298430
USP21 affects GATA3
2 1 |
USP21 binds GATA3.
2 |
USP21 binds GATA3. 2 / 2
2 |
biogrid
No evidence text available
23395819
biogrid
No evidence text available
23395819
USP21 deubiquitinates GATA3.
1 |
USP21 deubiquitinates GATA3. 1 / 1
1 |
USP21 affects FOXM1
1 | 2
USP21 deubiquitinates FOXM1.
1 | 1
USP21 deubiquitinates FOXM1. 2 / 2
1 | 1
reach
"HDACi treatment increased the ubiquitination level of FOXM1 by suppressing ubiquitin-specific peptidase 21 (USP21), which deubiquitinates FOXM1."
34335925
ubibrowser
"We identified USP21 in an RNAi-based screen for deubiquitinases that control FOXM1 abundance."
30865895
USP21 decreases the amount of FOXM1.
| 1
USP21 decreases the amount of FOXM1. 1 / 1
| 1
reach
"HDACi treatment increased the ubiquitination level of FOXM1 by suppressing ubiquitin-specific peptidase 21 (USP21), which deubiquitinates FOXM1."
34335925
USP21 affects BAZ2A
1 2 |
USP21 deubiquitinates BAZ2A.
2 |
USP21 deubiquitinates BAZ2A. 2 / 2
2 |
ubibrowser
"Deubiquitinates BAZ2A/TIP5 leading to its stabilization"
26100909
ubibrowser
No evidence text available
USP21 binds BAZ2A.
1 |
USP21 binds BAZ2A. 1 / 1
1 |
biogrid
No evidence text available
26100909
RIPK1 affects USP21
2 |
RIPK1 binds USP21. 2 / 3
2 |
biogrid
No evidence text available
19910467
biogrid
No evidence text available
19910467
MARK2 affects USP21
3 |
USP21 binds MARK2. 3 / 3
3 |
biogrid
No evidence text available
22298430
biogrid
No evidence text available
19615732
biogrid
No evidence text available
22298430
IL33 affects USP21
2 |
USP21 binds IL33. 2 / 3
2 |
biogrid
No evidence text available
25197364
biogrid
No evidence text available
25197364
Valproic acid affects USP21
2 |
Valproic acid methylates USP21.
1 |
Valproic acid methylates USP21. 1 / 1
1 |
ctd
No evidence text available
29154799
Valproic acid decreases the amount of USP21.
1 |
Valproic acid decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
23179753
Bisphenol A affects USP21
2 |
Bisphenol A methylates USP21.
1 |
Bisphenol A methylates USP21. 1 / 1
1 |
ctd
No evidence text available
30906313
Bisphenol A decreases the amount of USP21.
1 |
Bisphenol A decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
25181051
USP28 affects USP21
2 |
USP21 binds USP28. 2 / 2
2 |
biogrid
No evidence text available
22626734
biogrid
No evidence text available
22626734
USP21
1 | 1
USP21 translocates.
| 1
USP21 translocates from the cytoplasm to the nucleus. 1 / 1
| 1
reach
"SNHG5 inhibits ubiquitination and degradation of FOXO3 by recruiting Ubiquitin Specific Peptidase 21 (USP21), then promotes the translocation of FOXO3 from cytoplasm to nucleus."
35338124
USP21 binds.
1 |
USP21 binds USP21. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP21 affects tumor cell
| 2
USP21 activates tumor cell. 2 / 2
| 2
eidos
"In non-small cell lung cancer , USP21 promotes tumor cell proliferation , migration , and invasion through the YY1 / SNHG16 axis ( Xu et al ., 2020 ) ."
33791299
eidos
"Phenotypically , USP21 depletion leads to a decrease in HR efficiency and impairs tumor cell proliferation , both in vitro as well as in animal models ."
32201366
USP21 activates transcription, DNA-templated. 2 / 2
| 1 1
reach
"Expressing an siRNA-resistant USP16 restored transcription levels in this system, implicating USP16 in H2AK119ub1-mediated transcriptional regulation at DSB sites."
32708614
eidos
"Besides , USP21 could promote transcription by deubiquitylating ubH2A in vitro [ 46 ] ."
33546726
USP21 affects USP28
2 |
USP21 binds USP28. 2 / 2
2 |
biogrid
No evidence text available
22626734
biogrid
No evidence text available
22626734
USP21 affects USP20
2 |
USP20 binds USP21. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
22626734
USP21 affects USP15
2 |
USP15 binds USP21. 2 / 2
2 |
biogrid
No evidence text available
22626734
biogrid
No evidence text available
22626734
USP21 affects UCHL1
2 |
UCHL1 binds USP21. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
22626734
USP21 affects Neoplasms
| 1
USP21 activates Neoplasms. 1 / 2
| 1
eidos
"USP21 promotes cell proliferation , tumor progression , and colony formation , and enhances cancer stem cell self-renewal ."
32784507
USP21 affects MARK3
2 |
USP21 binds MARK3. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
22298430
USP21 affects MARK1
2 |
USP21 binds MARK1. 2 / 2
2 |
biogrid
No evidence text available
22298430
biogrid
No evidence text available
19615732
USP21 affects Interferon
| 1
USP21 inhibits Interferon. 1 / 2
| 1
eidos
"USP21 can interact directly with STING and remove the K27 and K63 Ub chains on STING , thereby inhibiting the production of type I interferons ."
32140262
USP21 affects HIV-1
| 2
USP21 inhibits HIV-1. 2 / 2
| 2
eidos
"Here , we demonstrate that the deubiquitinase , USP21 , potently inhibits HIV-1 production by indirectly downregulating the expression of HIV-1 trans-activator of transcription ( Tat ) , which is essential for transcriptional elongation in HIV-1 ."
33827943
eidos
"Here , we screened a series of USP members and found that USP21 inhibits HIV-1 production by specifically targeting Tat , but not the other HIV-1 accessory proteins ."
33827943
USP21 affects FOXP3
1 | 1
USP21 inhibits FOXP3.
| 1
USP21 inhibits FOXP3. 1 / 1
| 1
eidos
"USP21 prevents FOXP3 degradation through deubiquination , thus stabilizing Treg phenotype and antagonizing the development of Th1-like Tregs [ 65 ] ."
28624966
USP21 deubiquitinates FOXP3.
1 |
USP21 deubiquitinates FOXP3. 1 / 1
1 |
ubibrowser
"USP21 stabilizes FOXP3 protein by mediating its deubiquitination and maintains the expression of Treg signature genes."
27857073
USP21 affects EXOSC10
1 1 |
USP21 binds EXOSC10. 2 / 2
1 1 |
hprd
No evidence text available
15231747
biogrid
No evidence text available
15231747
USP21 affects BEND3
2 |
USP21 binds BEND3. 2 / 2
2 |
biogrid
No evidence text available
26100909
biogrid
No evidence text available
19615732
USP21 affects AURKA
1 | 1
USP21 binds AURKA.
1 |
AURKA binds USP21. 1 / 1
1 |
biogrid
No evidence text available
26446837
USP21 activates AURKA.
| 1
USP21 activates AURKA. 1 / 1
| 1
eidos
"Knockdown of USP21 markedly increased the ubiquitination level of AURKA , and USP21 restored AURKA activity through deubiquitination ."
36919585
USP20 affects USP21
2 |
USP20 binds USP21. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
22626734
USP15 affects USP21
2 |
USP15 binds USP21. 2 / 2
2 |
biogrid
No evidence text available
22626734
biogrid
No evidence text available
22626734
UCHL1 affects USP21
2 |
UCHL1 binds USP21. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
22626734
Rac5c affects USP21
| 2
Rac5c inhibits USP21. 2 / 2
| 2
eidos
"Rac5c was specific for SARS2 PLpro and did not inhibit USP21 even at the highest concentration of 100 muM ."
32845033
eidos
"Rac5c was specific for SARS2 PLpro and did not inhibit USP21 551 even at the highest concentration of 100 muM ."
| DOI
Plant Extracts affects USP21
2 |
Plant Extracts increases the amount of USP21.
1 |
Plant Extracts increases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
23557933
Plant Extracts decreases the amount of USP21.
1 |
Plant Extracts decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
23557933
MARK3 affects USP21
2 |
USP21 binds MARK3. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
22298430
MARK1 affects USP21
2 |
USP21 binds MARK1. 2 / 2
2 |
biogrid
No evidence text available
22298430
biogrid
No evidence text available
19615732
GATA3 affects USP21
2 |
USP21 binds GATA3. 2 / 2
2 |
biogrid
No evidence text available
23395819
biogrid
No evidence text available
23395819
EXOSC10 affects USP21
1 1 |
USP21 binds EXOSC10. 2 / 2
1 1 |
hprd
No evidence text available
15231747
biogrid
No evidence text available
15231747
BEND3 affects USP21
2 |
USP21 binds BEND3. 2 / 2
2 |
biogrid
No evidence text available
26100909
biogrid
No evidence text available
19615732
2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP21.
1 |
2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
17942748
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of USP21.
1 |
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
21215274
Vinclozolin affects USP21
1 |
Vinclozolin increases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
23034163
Tert-butyl hydroperoxide decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
15336504
Rotenone affects USP21
1 |
Rotenone decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
23186747
Rac5c affects USP21
| 1
Rac5c inhibits USP21. 1 / 1
| 1
eidos
"This contrasted with rac5c , which inhibited PLpro , 197 but did not inhibit USP21 even at 100 muM concentration ( Figure 3b ) .7 SARS PLpro inhibitors against SARS2 PLpro206 SARS PLpro has been the focus of academic drug discovery efforts in the last two 207 decades 3 ."
| DOI
Phorbol 13-acetate 12-myristate decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
25613284
Pentabromodiphenyl ether decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
23948077
Paracetamol affects USP21
1 |
Paracetamol decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
26690555
Overexpression myristoylated Akt affects USP21
| 1
Overexpression myristoylated Akt activates USP21. 1 / 1
| 1
eidos
"Additionally , overexpression of myristoylated Akt increased USP2-1 expression in hepatoma , which was accompanied by high levels of expression of lipogenic proteins including FASN , acetyl-CoA carboxylase , and adenosine triphosphate citrate lyase [ 19 ] ."
33530560
Methylazoxymethanol increases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
17107856
Ionomycin affects USP21
1 |
Ionomycin decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
25613284
Immune activation affects USP21
| 1
Immune activation activates USP21. 1 / 1
| 1
eidos
"Alternatively , immune activation could activate USP21 post-translationally , thereby providing an activated feedback ."
33808506
Hsa-miR-93-5p affects USP21
1 |
Hsa-miR-93-5p decreases the amount of USP21. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-744-5p affects USP21
1 |
Hsa-miR-744-5p decreases the amount of USP21. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-671-5p affects USP21
1 |
Hsa-miR-671-5p decreases the amount of USP21. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-331-3p affects USP21
1 |
Hsa-miR-331-3p decreases the amount of USP21. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-32-5p affects USP21
1 |
Hsa-miR-32-5p decreases the amount of USP21. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hexabromocyclododecane increases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
29177809
Folic acid affects USP21
1 |
Folic acid methylates USP21. 1 / 1
1 |
ctd
No evidence text available
20938992
Doxorubicin affects USP21
1 |
Doxorubicin decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
29803840
Dibutyl phthalate affects USP21
1 |
Dibutyl phthalate decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
21266533
Choline affects USP21
1 |
Choline methylates USP21. 1 / 1
1 |
ctd
No evidence text available
20938992
Carboxyl-terminal truncated HBx mutants affects USP21
| 1
Carboxyl-terminal truncated HBx mutants activates USP21. 1 / 1
| 1
reach
"Besides, Qian et al. showed that the downregulation of USP16 mediated by carboxyl-terminal truncated HBx mutants promotes the proliferation of HCC cells [88]."
31146743
Cadmium dichloride demethylates USP21. 1 / 1
1 |
ctd
No evidence text available
22457795
Butanal affects USP21
1 |
Butanal decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
26079696
Atrazine affects USP21
1 |
Atrazine increases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
22378314
Assays affects USP21
| 1
Assays activates USP21. 1 / 1
| 1
eidos
"In addition , we tested USP14 because it can antagonize proteasomal degradation ( Lee et al ., 2010 ) , as well as USP21 because it is highly active in many in vitro assays ."
33417828
Aflatoxin B1 affects USP21
1 |
Aflatoxin B1 methylates USP21. 1 / 1
1 |
ctd
No evidence text available
27153756
Abrine affects USP21
1 |
Abrine increases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
31054353
ZNF638 affects USP21
1 |
USP21 binds ZNF638. 1 / 1
1 |
biogrid
No evidence text available
27173435
ZNF350 affects USP21
1 |
USP21 binds ZNF350. 1 / 1
1 |
biogrid
No evidence text available
27621083
ZIC1 affects USP21
1 |
ZIC1 decreases the amount of USP21. 1 / 1
1 |
biopax:msigdb
No evidence text available
ZBTB21 affects USP21
1 |
USP21 binds ZBTB21. 1 / 1
1 |
biogrid
No evidence text available
27173435
YOD1 affects USP21
1 |
USP21 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
22626734
XPO1 affects USP21
1 |
USP21 binds XPO1. 1 / 1
1 |
biogrid
No evidence text available
21888622
WDR47 affects USP21
1 |
USP21 binds WDR47. 1 / 1
1 |
biogrid
No evidence text available
27621083
UTRN affects USP21
1 |
USP21 binds UTRN. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP8 affects USP21
1 |
USP21 binds USP8. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP7 affects USP21
1 |
USP21 binds USP7. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP51 affects USP21
1 |
USP21 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP48 affects USP21
1 |
USP21 binds USP48. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP4 affects USP21
1 |
USP21 binds USP4. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP33 affects USP21
1 |
USP21 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP21 affects viability
| 1
USP21 inhibits viability. 1 / 1
| 1
eidos
"Our results suggest that USP21 probably influence the function of GSC and further decrease the viability , migration , and function of chondrocytes , verifying the results of previous studies that indicated [ 5,13 ] ."
31253698
USP21 affects viability colony MKN-45 cells
| 1
USP21 inhibits viability colony MKN-45 cells. 1 / 1
| 1
eidos
"The results exhibited that overexpression of USP21 notably improved the viability and colony forming ability of AGS cells while inhibiting the expression of USP21 conspicuously reduced the viability and colony forming ability of MKN-45 cells ( Figures 2C , D ) ."
33791299
USP21 affects ubiquitination FOXM1
| 1
USP21 inhibits ubiquitination FOXM1. 1 / 1
| 1
eidos
"HDACi treatment increased the ubiquitination level of FOXM1 by suppressing ubiquitin-specific peptidase 21 ( USP21 ) , which deubiquitinates FOXM1 ."
34335925
USP21 affects tumorigenicity cells
| 1
USP21 activates tumorigenicity cells. 1 / 1
| 1
eidos
"Moreover , USP21 could promote the malignant transformation of the normal human hepatocytes and increased the tumorigenicity of the HCC cells by activating the ERK signaling through the stabilization of MEK2 ( 11 ) ."
33718205
USP21 affects tumor growth
| 1
USP21 activates tumor growth. 1 / 1
| 1
eidos
"USP21 increases DNA repair and tumor growth by stabilizing BRCA2 [ 97 ] ."
31133011
USP21 affects transcriptional program
| 1
USP21 activates transcriptional program. 1 / 1
| 1
eidos
"In this study , we showed that USP21 binds and regulates FoxM1 stability , and accordingly , modulates its transcriptional program ."
32201366
USP21 affects transcription nuclear factor-kappaB p65
| 1
USP21 activates transcription nuclear factor-kappaB p65. 1 / 1
| 1
eidos
"USP21 was shown to modulate the transcription of nuclear factor-kappaB p65 by deubiquitinating and stabilising interleukin-33 in the nucleus [ 25 ] , and interacts with both nuclear and cytoplasmic proteins including GATA3 , receptor-interacting serine / threonine-protein kinase 1 , and Nanog [ 14,19,26,27 ] ."
31253698
USP21 affects stemness
| 1
USP21 activates stemness. 1 / 1
| 1
eidos
"We reported that USP21 promoted GC cell proliferation , migration , invasion , and stemness in vitro , and regulated GC tumor growth and cell stemness in mice in vivo ."
33791299
USP21 affects stemness pancreatic cancer cells
| 1
USP21 activates stemness pancreatic cancer cells. 1 / 1
| 1
eidos
"For instance , USP21 stimulates the stemness of pancreatic cancer cells by activating the Wnt pathway ( Hou et al ., 2019 ) ."
33791299
USP21 affects stemness GC
| 1
USP21 activates stemness GC. 1 / 1
| 1
eidos
"USP21 Regulates the Expression of MAPK1 Through GATA3 and Affects Cell Proliferation , Migration , Invasion , and Stemness of GC Since USP21 stimulated cell proliferation , migration , invasion , and stemness of GC , and could stabilize the expression of GATA3 by deubiquitinating GATA3 , while MAPK1 was the transcription target of GATA3 , it was further verified whether USP21 could play its oncogenic effect in GC through the GATA3 / MAPK1 axis ."
33791299
USP21 affects stemness GC cells
| 1
USP21 activates stemness GC cells. 1 / 1
| 1
eidos
"These results demonstrated that USP21 stimulated cell proliferation , migration , invasion , and stemness of GC cells ."
33791299
reach
"It has been shown that upregulation of USP16 in the Ts65Dn mouse model and primary human fibroblasts results in downregulation of the Wnt pathway and reduces stem cell renewal."
31683073
USP21 affects stabilizing
| 1
USP21 inhibits stabilizing. 1 / 1
| 1
eidos
"USP21 prevents FOXP3 degradation through deubiquination , thus stabilizing Treg phenotype and antagonizing the development of Th1-like Tregs [ 65 ] ."
28624966
USP21 affects stability Nanog
| 1
USP21 activates stability Nanog. 1 / 1
| 1
eidos
"USP21 could significantly enhance the stability of Nanog and then maintain the self-renewal of stem cells ."
32140262
USP21 affects self-renewal tumorigenicity mesenchymal glioblastoma stem cells
| 1
USP21 activates self-renewal tumorigenicity mesenchymal glioblastoma stem cells. 1 / 1
| 1
eidos
"USP21 promotes self-renewal and tumorigenicity of mesenchymal glioblastoma stem cells by deubiquitinating and stabilizing FOXD1 ."
35974001
USP21 affects reporter induced SeV RIG-I-CARD TANK-binding kinase TBK1 mouse embryonic fibroblasts
| 1
USP21 inhibits reporter induced SeV RIG-I-CARD TANK-binding kinase TBK1 mouse embryonic fibroblasts. 1 / 1
| 1
eidos
"They unveiled that USP21 inhibited ISRE reporter activity induced by SeV and RIG-I-CARD , but not by TANK-binding kinase 1 ( TBK1 ) in mouse embryonic fibroblasts ( MEF ) cells [ 24 ] ."
31208841
USP21 affects reporter assay131
| 1
USP21 activates reporter assay131. 1 / 1
| 1
eidos
"In a search for DUBs that contribute to GATA3 stabilization in FOXP3-expressing cells , both USP7 and USP21 were shown to upregulate GATA3-mediated activity using a reporter assay131 ."
28959952
USP21 affects reporter assay
| 1
USP21 activates reporter assay. 1 / 1
| 1
eidos
"In a search for DUBs that contribute to GATA3 stabilization in FOXP3-expressing cells , both USP7 and USP21 were shown to upregulate GATA3-mediated activity using a reporter assay 131 ."
28959952
USP21 affects radio-sensitivity CC cells
| 1
USP21 inhibits radio-sensitivity CC cells. 1 / 1
| 1
eidos
"Knockdown of USP21 enhanced the radio-sensitivity of CC cells in vivo ."
34825342
USP21 affects radio-resistance CC cells
| 1
USP21 activates radio-resistance CC cells. 1 / 1
| 1
eidos
"In summary , USP21 contributed to the radio-resistance of CC cells via FOXM1 / Hippo signaling , and may serve as a promising target for radio-sensitizers in the radiotherapy of CC ."
34825342
USP21 activates protein deubiquitination. 1 / 1
| 1
eidos
"USP21 interacted with GSC to promote GSC deubiquitination while having no effect on GSC protein stability ."
31253698
USP21 affects protein EZH2
| 1
USP21 activates protein EZH2. 1 / 1
| 1
eidos
"Furthermore , we then identify USP21 modulates the protein level of EZH2 , a key regulatory gene of DLBCL growth ."
33389794
USP21 affects polyubiquitination mediated RNF135 TRIM25
| 1
USP21 inhibits polyubiquitination mediated RNF135 TRIM25. 1 / 1
| 1
eidos
"] Interestingly , USP21 presumably removes polyubiquitin chains from more than one lysine sites in either CARD or CTD domain , since USP21 can reverse the polyubiquitination mediated by both RNF135 and TRIM25 ."
33511009
USP21 affects non-small-cell lung cancer
| 1
USP21 activates non-small-cell lung cancer. 1 / 1
| 1
eidos
"For instance , USP10 and USP21 could promote hepatocellular carcinoma and non-small-cell lung cancer proliferation , respectively [ 36 , 37 ] ."
34261480
USP21 affects mitotic entry delay sensitivity paclitaxel cell culture animal xenografts
| 1
USP21 activates mitotic entry delay sensitivity paclitaxel cell culture animal xenografts. 1 / 1
| 1
eidos
"Suppression of USP21 causes a mitotic entry delay to slow proliferation and sensitivity to paclitaxel in cell culture and animal xenografts ( 50 ) ."
33643919
USP21 affects mitotic MIA PaCa-2 pancreatic carcinoma cells
| 1
USP21 activates mitotic MIA PaCa-2 pancreatic carcinoma cells. 1 / 1
| 1
eidos
"Shi et al. demonstrated that USP2-1 directly deubiquitinates Aurora-A , and thus stimulates mitotic progression of MIA PaCa-2 pancreatic carcinoma cells [ 46 ] ."
33530560
USP21 affects mitosis pancreatic carcinoma
| 1
USP21 activates mitosis pancreatic carcinoma. 1 / 1
| 1
eidos
"Thus , USP2-1 seems to stimulate mitosis in pancreatic carcinoma by stabilizing Aurora-A ."
33530560
USP21 affects migration invasion stemness GC cells
| 1
USP21 activates migration invasion stemness GC cells. 1 / 1
| 1
eidos
"USP21 promotes the proliferation , migration , invasion , and stemness of GC cells ."
33791299
USP21 affects migration invasion MKN-45 cells
| 1
USP21 activates migration invasion MKN-45 cells. 1 / 1
| 1
eidos
"Afterward , the role of USP21 in cell migration and invasion was evaluated through Transwell assay , and the data in Figures 2E , F showed that overexpression of USP21 accelerated the migration and invasion of AGS cells , whereas knockdown of USP21 pronouncedly reduced the migration and invasion of MKN-45 cells ."
33791299
USP21 affects miR-34b c
| 1
USP21 inhibits miR-34b c. 1 / 1
| 1
eidos
"USP2-1 downregulates miR-34b / c , which leads to the increase in c-Myc in prostate cancer cells and prostate epithelial cells [ 71,72 ] ."
33530560
USP21 affects metastasis bladder cancer cells
| 1
USP21 activates metastasis bladder cancer cells. 1 / 1
| 1
eidos
"In bladder cancer , USP21 is highly expressed and patients with high expression levels have poor survival , and USP21 can accelerate the proliferation and metastasis of bladder cancer cells via inhibiting EZH2 ubiquitination ( Chen et al ., 2017 ) ."
33791299
USP21 affects matrix secretion ATDC5
| 1
USP21 inhibits matrix secretion ATDC5. 1 / 1
| 1
eidos
"For the toluidine blue staining , USP21 decreased the matrix secretion of ATDC5 significantly and no obvious difference exists in the other three groups ( Figure 6G ) ."
31253698
USP21 affects malignant transformation human hepatocytes
| 1
USP21 activates malignant transformation human hepatocytes. 1 / 1
| 1
eidos
"Moreover , USP21 could promote the malignant transformation of the normal human hepatocytes and increased the tumorigenicity of the HCC cells by activating the ERK signaling through the stabilization of MEK2 ( 11 ) ."
33718205
USP21 affects mRNA cyclin T1
| 1
USP21 inhibits mRNA cyclin T1. 1 / 1
| 1
eidos
"First , USP21 deubiquitinates polyubiquitinated Tat causing Tat instability , and second USP21 reduces the mRNA levels of cyclin T1 ( CycT1 ) , an important component of P-TEFb , that leads 56 to Tat downregulation ."
33827943
USP21 affects localization
| 1
USP21 activates localization. 1 / 1
| 1
reach
"USP16 aids the correct alignment of chromosomes by promoting the localization and maintenance of polo-like kinase 1 (PLK1) on kinetochores [71]."
35406655
USP21 affects isopeptide bond hydrolysis
| 1
USP21 activates isopeptide bond hydrolysis. 1 / 1
| 1
eidos
"USP21 as an effective DUB can catalyze isopeptide bond hydrolysis between ubiquitin and histone H2A ( Okuda et al ., 2013 ) ."
33791299
USP21 affects invasion YY1 SNHG16 axis
| 1
USP21 activates invasion YY1 SNHG16 axis. 1 / 1
| 1
eidos
"In non-small cell lung cancer , USP21 promotes tumor cell proliferation , migration , and invasion through the YY1 / SNHG16 axis ( Xu et al ., 2020 ) ."
33791299
eidos
"We noted the upregulation of usp21 , which modulates the innate immune responses through inhibition of the NF-kappaB-signaling cascade , which leads to down-regulation of TNFalpha ( 69 ) ."
32528473
USP21 affects hyperactivation mesangial cells
| 1
USP21 inhibits hyperactivation mesangial cells. 1 / 1
| 1
eidos
"Because the expressed USP2-1 was primarily observed in the mesangium of the glomeruli , USP2-1 may suppress the hyperactivation of mesangial cells [ 48 ] ."
33530560
eidos
"For instance , USP10 and USP21 could promote hepatocellular carcinoma and non-small-cell lung cancer proliferation , respectively [ 36 , 37 ] ."
34261480
USP21 affects function
| 1
USP21 activates function. 1 / 1
| 1
eidos
"These findings suggest that USP21 modulates GSC function through deubiquitination ."
31253698
USP21 affects function chondrocytes
| 1
USP21 inhibits function chondrocytes. 1 / 1
| 1
eidos
"Our results suggest that USP21 probably influence the function of GSC and further decrease the viability , migration , and function of chondrocytes , verifying the results of previous studies that indicated [ 5,13 ] ."
31253698
USP21 affects efficiency interaction
| 1
USP21 activates efficiency interaction. 1 / 1
| 1
eidos
"Furthermore , Ubiquitin-specific protease 21 ( USP21 ) enhances the efficiency of interaction between BRCA2 and RAD51at the DNA damage site through deubiquitylating and stabilization of BRCA2 ."
33013205
USP21 affects deubiquitination determine
| 1
USP21 activates deubiquitination determine. 1 / 1
| 1
eidos
"USP21 promotes GSC deubiquitination To determine whether USP21 is a DUB of GSC , HEK 293T cells were co-transfected with Flag-GSC and HA-ubiquitin-K0 ( HA-Ub-K0 ) , with or without Myc-USP21 and Myc-WWP2 ; after 2 days , immunoprecipitation was performed using an anti-Flag antibody , and immunoblotting was performed with anti-HA and anti-Flag antibodies ."
31253698
USP21 affects deubiquitination RIP1
| 1
USP21 inhibits deubiquitination RIP1. 1 / 1
| 1
eidos
"Ubv.21.4 blocked the deubiquitination of RIP1 by USP21 and restored NF-kappaB activation , showing that it acts as an inhibitor of USP21 in cells ."
24239534
USP21 affects cyclin T1 mRNA
| 1
USP21 inhibits cyclin T1 mRNA. 1 / 1
| 1
eidos
"Further investigation showed that USP21 downregulates cyclin T1 mRNA levels by increasing methylation of histone K9 in the promoter of cyclin T1 , a subunit of the positive transcription elongation factor b ( P-TEFb ) that interacts with Tat and transactivation response element ( TAR ) and is required for transcription stimulation and Tat stability ."
33827943
USP21 affects colony
| 1
USP21 activates colony. 1 / 1
| 1
eidos
"USP21 promotes cell proliferation , tumor progression , and colony formation , and enhances cancer stem cell self-renewal ."
32784507
USP21 affects colony efficiency
| 1
USP21 activates colony efficiency. 1 / 1
| 1
eidos
"For the colony formation assay , USP21 decreased the colony formation efficiency significantly ( P < 0.01 ) , and that in GSC + USP21 decreased slightly compared with NC group ( P < 0.05 ) ( Figure 6E , F ) ."
31253698
USP21 affects cell metastasis bladder carcinoma
| 1
USP21 activates cell metastasis bladder carcinoma. 1 / 1
| 1
eidos
"45 USP21 could suppress EZH2 ubiquitination and thus promotes cell proliferation and metastasis in bladder carcinoma ."
33389794
USP21 affects cell growth invasion stemness renal cell carcinoma
| 1
USP21 activates cell growth invasion stemness renal cell carcinoma. 1 / 1
| 1
eidos
"Thus far , a study ( Peng et al ., 2016 ) proved that USP21 can accelerate cell growth , invasion , and stemness of renal cell carcinoma ."
33791299
USP21 affects cell examined CCK8 assay
| 1
USP21 activates cell examined CCK8 assay. 1 / 1
| 1
eidos
"USP21 knockdown dramatically decreased cell proliferation rate examined by CCK8 assay ( Figure 2B ) ."
33389794
USP21 affects cell cycle
| 1
USP21 activates cell cycle. 1 / 1
| 1
eidos
"18 , 19 USP21 can modulate cell cycle progression by deubiquitinating Forkhead box M1 ( FOXM1 ) in basal-like breast cancer ."
33389794
USP21 affects cannot cause cell death
| 1
USP21 activates cannot cause cell death. 1 / 1
| 1
eidos
"Therefore , USP21 stimulates cell proliferation but cannot cause cell death ."
33389794
USP21 affects cancer stem cell self-renewal
| 1
USP21 activates cancer stem cell self-renewal. 1 / 1
| 1
eidos
"USP21 promotes cell proliferation , tumor progression , and colony formation , and enhances cancer stem cell self-renewal ."
32784507
USP21 affects apoptotic process
| 1
eidos
"Given the proapoptotic properties of p53 , it can be concluded that USP2-1 abates apoptosis by stabilizing MDM2 , MDMX , MDM4 , and FASN ."
33530560
USP21 affects antagonizing development Th1-like Tregs
| 1
USP21 inhibits antagonizing development Th1-like Tregs. 1 / 1
| 1
eidos
"USP21 prevents FOXP3 degradation through deubiquination , thus stabilizing Treg phenotype and antagonizing the development of Th1-like Tregs [ 65 ] ."
28624966
USP21 affects aging
| 1
USP21 inhibits aging. 1 / 1
| 1
reach
"Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer's model."
35311644
USP21 affects adipose tissue inflammation-related SERPINE1 PAI-1 adipocyte protein aP2 HMGA4high mobility group protein A2 HMGA2 matrix metalloproteases
| 1
USP21 inhibits adipose tissue inflammation-related SERPINE1 PAI-1 adipocyte protein aP2 HMGA4high mobility group protein A2 HMGA2 matrix metalloproteases. 1 / 1
| 1
eidos
"We previously demonstrated that in human macrophage-like HL-60 cells , USP2-1 suppressed the expression of adipose tissue inflammation-related genes for SERPINE1 PAI-1 , adipocyte protein 2 ( aP2 ) , HMGA4high mobility group protein A2 ( HMGA2 ) , and matrix metalloproteases ( MMPs ) [ 9 ] ."
33530560
USP21 affects activation IFNbeta
| 1
USP21 inhibits activation IFNbeta. 1 / 1
| 1
eidos
"Moreover , USP2-4 , but not USP2-1 , attenuated the activation of IFNbeta promoter after SeV infection , indicating a role for USP2 in suppressing viral immunity [ 155 ] ."
33530560
USP21 affects ZNF638
1 |
USP21 binds ZNF638. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects ZNF598-mediated ubiquitylation event
| 1
USP21 activates ZNF598-mediated ubiquitylation event. 1 / 1
| 1
eidos
"Recently , it was shown that the ZNF598-mediated ubiquitylation event can be reversed by USP21 and OTUD3 , probably to avoid the degradation of the 40S subunit , allowing its recycling in further translation rounds [ 98 ] ."
33292102
USP21 affects ZNF350
1 |
USP21 binds ZNF350. 1 / 1
1 |
biogrid
No evidence text available
27621083
USP21 affects ZBTB21
1 |
USP21 binds ZBTB21. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects YOD1
1 |
USP21 binds YOD1. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP21 affects XPO1
1 |
USP21 binds XPO1. 1 / 1
1 |
biogrid
No evidence text available
21888622
USP21 affects WDR47
1 |
USP21 binds WDR47. 1 / 1
1 |
biogrid
No evidence text available
27621083
USP21 affects Ubiquitination
| 1
eidos
"USP3 , USP21 and CYLD inhibit RIG-I K63-linked ubiquitination and activation ."
28744851
USP21 affects UTRN
1 |
USP21 binds UTRN. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP21 affects USP8
1 |
USP21 binds USP8. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP21 affects USP7
1 |
USP21 binds USP7. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP21 affects USP51
1 |
USP21 binds USP51. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP21 affects USP48
1 |
USP21 binds USP48. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP21 affects USP4
1 |
USP21 binds USP4. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP21 affects USP33
1 |
USP21 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP21 affects USP2
1 |
USP2 binds USP21. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP21 affects USP14
1 |
USP14 binds USP21. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP21 affects UPF3B
1 |
USP21 binds UPF3B. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP21 affects UL83
| 1
USP21 increases the amount of UL83. 1 / 1
| 1
reach
"We found that while knockdown of LIN37, TPRG1L and USP16 decreased the level of p65 and p-p65, the knockdown of LIN37, TPRG1L and TYROBP decreased the level of STAT3 and phosphorylated STAT3 (p-STAT3) (Figure 5A, B)."
31294790
USP21 affects UCHL3
1 |
UCHL3 binds USP21. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP21 affects UBE2S
1 |
USP21 binds UBE2S. 1 / 1
1 |
biogrid
No evidence text available
20622874
USP21 affects TRIM9
1 |
USP21 binds TRIM9. 1 / 1
1 |
biogrid
No evidence text available
23105109
USP21 affects TRIM8
1 |
USP21 binds TRIM8. 1 / 1
1 |
biogrid
No evidence text available
23105109
USP21 affects TRIM63
1 |
USP21 binds TRIM63. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP21 affects TRIM54
1 |
USP21 binds TRIM54. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP21 affects TRIM5
1 |
USP21 binds TRIM5. 1 / 1
1 |
biogrid
No evidence text available
23105109
USP21 affects TRIM23
1 |
USP21 binds TRIM23. 1 / 1
1 |
biogrid
No evidence text available
23105109
USP21 affects TRAF6
1 |
TRAF6 binds USP21. 1 / 1
1 |
biogrid
No evidence text available
20622874
USP21 affects TP53
1 |
TP53 binds USP21. 1 / 1
1 |
biogrid
No evidence text available
27561390
USP21 affects TNF-induced cell death
| 1
USP21 activates TNF-induced cell death. 1 / 1
| 1
eidos
"The same authors also demonstrated that the ratio of USP2-1 and TRAF2 determined the apoptosis sensitivity in response to TNF-alpha , whereby high USP2-1 / TRAF2 conditions accelerated TNF-induced cell death , and low USP2-1 / TRAF2 conditions inhibited death [ 78 ] ."
33530560
USP21 affects TNF-alpha-induced NF-kappaB
| 1
USP21 inhibits TNF-alpha-induced NF-kappaB. 1 / 1
| 1
eidos
"Ubiquitinated receptor-interacting protein 1 ( RIP1 ) is a positive regulator of NF-kappaB activation induced by TNF-alpha , and in turn , USP21 has been shown to down-regulate TNF-alpha-induced NF-kappaB activation by deubiquitinating RIP1 [ 138 ] ."
24239534
USP21 affects TIAM1
1 |
TIAM1 binds USP21. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects TESK2
1 |
TESK2 binds USP21. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects TBC1D25
1 |
USP21 binds TBC1D25. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects SYNE1
1 |
USP21 binds SYNE1. 1 / 1
1 |
biogrid
No evidence text available
27621083
USP21 affects SYDE1
1 |
USP21 binds SYDE1. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects STING1
1 |
USP21 deubiquitinates STING1. 1 / 1
1 |
ubibrowser
"In this study, we found that USP21 is an important deubiquitinating enzyme for STING and that it negatively regulates the DNA virus-induced production of type I interferons by hydrolyzing K27/63-linked polyubiquitin chain on STING."
28254948
USP21 affects STAMBP
1 |
USP21 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP21 affects SRSF12
1 |
USP21 binds SRSF12. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects SRGAP2
1 |
USP21 binds SRGAP2. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects SNHG16
| 1
USP21 activates SNHG16. 1 / 1
| 1
eidos
"USP21 can further increase expression of SNHG16 ( Xu P. et al ., 2020 ) ."
34671603
USP21 affects SLF1
1 |
USP21 binds SLF1. 1 / 1
1 |
biogrid
No evidence text available
27621083
USP21 affects SLCO6A1
| 1
USP21 deubiquitinates SLCO6A1. 1 / 1
| 1
reach
"Ub-GST was also efficiently deubiquitinated by USP2-3 incrementSRM."
26484888
USP21 affects SIPA1L1
1 |
USP21 binds SIPA1L1. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects SH3PXD2A
1 |
USP21 binds SH3PXD2A. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects SH3BP4
1 |
SH3BP4 binds USP21. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects SENP8
1 |
USP21 binds SENP8. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP21 affects SENP3
1 |
USP21 binds SENP3. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP21 affects RTKN
1 |
RTKN binds USP21. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects RPS27A
| 1
USP21 leads to the ubiquitination of RPS27A. 1 / 1
| 1
reach
"USP16 de(p)letion leads to RPS27a ubiquitination and 40S biogenesis defects."
32129764
USP21 affects RNF185
1 |
USP21 binds RNF185. 1 / 1
1 |
biogrid
No evidence text available
23105109
USP21 affects RNF144A
1 |
USP21 binds RNF144A. 1 / 1
1 |
biogrid
No evidence text available
23105109
USP21 affects RIG-I-induced IFN-beta
| 1
USP21 inhibits RIG-I-induced IFN-beta. 1 / 1
| 1
eidos
"Fan et al ., knowing that USP21 inhibits RIG-I-induced IFN-beta production , searched for its mechanism [ 24 ] ."
31208841
USP21 affects RBM8A
1 |
USP21 binds RBM8A. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP21 affects RBM45
1 |
USP21 binds RBM45. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP21 affects RBE cell migration
| 1
USP21 activates RBE cell migration. 1 / 1
| 1
eidos
"Wound healing and transwell assays demonstrate that USP21 accelerates RBE cell migration ."
33052017
USP21 affects RBCK1
1 |
USP21 binds RBCK1. 1 / 1
1 |
biogrid
No evidence text available
23105109
USP21 affects RASAL2
1 |
USP21 binds RASAL2. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects RAB3IP
1 |
USP21 binds RAB3IP. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects PRKCI
1 |
USP21 binds PRKCI. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP21 affects PRC1
| 1
USP21 deubiquitinates PRC1. 1 / 1
| 1
reach
"When combined with the protein regulator of cytokinesis 1, USP16 can deubiquitinate histone H2A and control gene expression (PRC1)."
35406655
USP21 affects PPP6R3
1 |
PPP6R3 binds USP21. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP21 affects PPM1H
1 |
USP21 binds PPM1H. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects PPIB
1 |
USP21 binds PPIB. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP21 affects PLK1
| 1
USP21 activates PLK1. 1 / 1
| 1
reach
"USP16 aids the correct alignment of chromosomes by promoting the localization and maintenance of polo-like kinase 1 (PLK1) on kinetochores [71]."
35406655
USP21 affects PLEKHA7
1 |
USP21 binds PLEKHA7. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects PHLDB2
1 |
USP21 binds PHLDB2. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects PCGF6
1 |
USP21 binds PCGF6. 1 / 1
1 |
biogrid
No evidence text available
23105109
USP21 affects OTUB2
1 |
USP21 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP21 affects OTUB1
1 |
USP21 binds OTUB1. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP21 activates Neoplasm Metastasis. 1 / 1
| 1
eidos
"Furthermore , USP21 has been shown to associate with both centrosomes and microtubules to regulate cell motility in three-dimensional matrices [ 29-33 ] , and promotes cell proliferation and metastasis in kinds of cancer [ 34-37 ] ."
31253698
USP21 affects NFkappaB
| 1
USP21 inhibits NFkappaB. 1 / 1
| 1
eidos
"In addition , the ubiquitin-specific peptidase 21 ( USP21 ) inhibits NF-kappaB in the TNF pathway by deubiquitination of RIP1 [ 37 ] ."
33498196
USP21 affects NFAT
| 1
USP21 increases the amount of NFAT. 1 / 1
| 1
reach
"Mechanistically, they found that Usp16-mediated de-ubiquitination of calcineurin A, which is a calcium-activated phosphatase that dephosphorylates members of the nuclear factor of activated T cells (NFAT) family, leads to transcription of NFAT-targeted genes, which helps in the maintenance and proliferation of peripheral T cells [105]."
| PMC
USP21 affects NF1
1 |
USP21 binds NF1. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects NADK
1 |
USP21 binds NADK. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects Migration Invasion abnormal USP21 GC cell lines had USP21 tumor cells were selected relationship
| 1
USP21 inhibits Migration Invasion abnormal USP21 GC cell lines had USP21 tumor cells were selected relationship. 1 / 1
| 1
eidos
"USP21 Promotes the Proliferation , Migration , Invasion , and Stemness of GC Cells Due to the abnormal expression of USP21 in GC , AGS and MKN-45 cell lines which , respectively , had relatively low and high USP21 expression in all tumor cells were selected to study the relationship between USP21 and GC progression ."
33791299
USP21 affects MPP1
1 |
USP21 binds MPP1. 1 / 1
1 |
biogrid
No evidence text available
27621083
USP21 affects MELK
1 |
USP21 binds MELK. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects MAST3
1 |
USP21 binds MAST3. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects MARK4
1 |
USP21 binds MARK4. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP21 affects MAPKAP1
1 |
USP21 binds MAPKAP1. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects MAPK3
1 |
USP21 binds MAPK3. 1 / 1
1 |
biogrid
No evidence text available
27886188
USP21 affects MAP4
1 |
USP21 binds MAP4. 1 / 1
1 |
biogrid
No evidence text available
22298430
USP21 affects MAP3K21
1 |
USP21 binds MAP3K21. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects MAP2K2
1 |
USP21 deubiquitinates MAP2K2. 1 / 1
1 |
ubibrowser
"The deubiquitinase USP21 stabilizes MEK2 to promote tumor growth"
29706623
USP21 affects MAGI1
1 |
USP21 binds MAGI1. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects LRSAM1
1 |
USP21 binds LRSAM1. 1 / 1
1 |
biogrid
No evidence text available
23105109
USP21 affects LRFN1
1 |
USP21 binds LRFN1. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects LIMA1
1 |
USP21 binds LIMA1. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects KSR1
1 |
USP21 binds KSR1. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects KRT40
1 |
USP21 binds KRT40. 1 / 1
1 |
biogrid
No evidence text available
25416956
USP21 affects KIF1C
1 |
USP21 binds KIF1C. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects KIF13B
1 |
USP21 binds KIF13B. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects KCTD3
1 |
USP21 binds KCTD3. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects KCTD11
1 |
USP21 binds KCTD11. 1 / 1
1 |
biogrid
No evidence text available
27621083
USP21 affects JOSD1
1 |
USP21 binds JOSD1. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP21 affects ISG15
1 |
USP21 binds ISG15. 1 / 1
1 |
biogrid
No evidence text available
21399617
USP21 affects IFIH1
1 |
USP21 binds IFIH1. 1 / 1
1 |
biogrid
No evidence text available
24493797
USP21 affects Hippo pathway
| 1
USP21 activates Hippo pathway. 1 / 1
| 1
eidos
"USP21 activated the Hippo pathway by mediating FOXM1 ."
34825342
USP21 affects HERC2
| 1
USP21 binds HERC2. 1 / 1
| 1
reach
"HERC2 also interacts with and stabilises USP16 which is involved in H2A de-ubiquitination in DSB repair [38]."
31769469
USP21 affects HECW2
1 |
USP21 binds HECW2. 1 / 1
1 |
biogrid
No evidence text available
24163370
USP21 affects HDAC4
1 |
USP21 binds HDAC4. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects H2AX
| 1
USP21 deubiquitinates H2AX. 1 / 1
| 1
reach
"USP3, USP51 and USP16 de-ubiquitinate H2A/H2AX with varying degrees of specificity [47–49]."
31769469
USP21 affects H2AW
1 |
USP21 deubiquitinates H2AW on K120. 1 / 1
1 |
biopax:reactome
No evidence text available
USP21 affects H2AC20
1 |
USP21 deubiquitinates H2AC20. 1 / 1
1 |
ubibrowser
"Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator."
21179169
USP21 affects H2AC18
1 |
USP21 binds H2AC18. 1 / 1
1 |
biogrid
No evidence text available
21179169
USP21 affects H2AC17
1 |
USP21 deubiquitinates H2AC17. 1 / 1
1 |
ubibrowser
"In this study, we report that H2Aub markedly decreases in hepatocellular carcinoma. Usp21, a H2A deubiquitinase, is probably responsible for decrease in H2Aub."
27190257
USP21 affects Goosecoid function
| 1
USP21 activates Goosecoid function. 1 / 1
| 1
eidos
"USP21 modulates Goosecoid function through deubiquitination The homeobox gene Goosecoid ( GSC ) , which is known to regulate craniofacial development , is activated by mono-ubiquitination ; however , the deubiquitylase responsible for GSC deubiquitination and inhibition has yet to be identified ."
31253698
USP21 affects GSC-Sox6 reporter
| 1
USP21 inhibits GSC-Sox6 reporter. 1 / 1
| 1
eidos
"USP21 decreased GSC-Sox6 reporter gene activity ."
31253698
USP21 affects GLTSCR2 removal K63-linked polyubiquitin chains
| 1
USP21 activates GLTSCR2 removal K63-linked polyubiquitin chains. 1 / 1
| 1
eidos
"No evidence was presented to support TRIM25 or USP21 mediated GLTSCR2 removal of K63-linked polyubiquitin chains from RIG-I ."
27824081
USP21 affects GLI2
1 |
USP21 binds GLI2. 1 / 1
1 |
biogrid
No evidence text available
27621083
USP21 affects GIGYF1
1 |
USP21 binds GIGYF1. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects GC cell
| 1
USP21 activates GC cell. 1 / 1
| 1
eidos
"We reported that USP21 promoted GC cell proliferation , migration , invasion , and stemness in vitro , and regulated GC tumor growth and cell stemness in mice in vivo ."
33791299
USP21 affects GATA3-mediated
| 1
USP21 activates GATA3-mediated. 1 / 1
| 1
eidos
"In a search for DUBs that contribute to GATA3 stabilization in FOXP3-expressing cells , both USP7 and USP21 were shown to upregulate GATA3-mediated activity using a reporter assay131 ."
28959952
USP21 affects GATA-3
| 1
USP21 binds GATA-3. 1 / 1
| 1
trips
"Here, we show how USP21 interacts with and stabilizes GATA3 by mediating its deubiquitination."
23395819
USP21 affects GAB2
1 |
USP21 binds GAB2. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects FUCA1
1 |
USP21 binds FUCA1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP21 affects FOXP3 protein
| 1
USP21 inhibits FOXP3 protein. 1 / 1
| 1
eidos
"In addition , USP21 prevents the depletion of FOXP3 protein by mediating its deubiquitination and thereby maintaining the expression of Treg signature genes and Treg-specific deficiency of Usp21 contributed to the development of Th1-type inflammation [ 107 ] ."
32369982
USP21 affects FK2 foci
| 1
USP21 inhibits FK2 foci. 1 / 1
| 1
reach
"Depletion of USP16 increases FK2 foci."
33797206
USP21 affects FAM53C
1 |
USP21 binds FAM53C. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects FAM126A
| 1
USP21 activates FAM126A. 1 / 1
| 1
reach
"Besides, Qian et al. showed that the downregulation of USP16 mediated by carboxyl-terminal truncated HBx mutants promotes the proliferation of HCC cells [88]."
31146743
USP21 affects FAM110B
1 |
USP21 binds FAM110B. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects FAM110A
1 |
USP21 binds FAM110A. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects Efficiency
| 1
USP21 activates Efficiency. 1 / 1
| 1
eidos
"Phenotypically , USP21 depletion leads to a decrease in HR efficiency and impairs tumor cell proliferation , both in vitro as well as in animal models ."
32201366
USP21 affects EZH2 ubiquitination
| 1
USP21 inhibits EZH2 ubiquitination. 1 / 1
| 1
eidos
"45 USP21 could suppress EZH2 ubiquitination and thus promotes cell proliferation and metastasis in bladder carcinoma ."
33389794
USP21 affects ESPL1
1 |
USP21 binds ESPL1. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP21 affects EIF4E2
1 |
USP21 binds EIF4E2. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects DTX3
1 |
USP21 binds DTX3. 1 / 1
1 |
biogrid
No evidence text available
23105109
USP21 affects DNA repair
| 1
USP21 activates DNA repair. 1 / 1
| 1
eidos
"USP21 increases DNA repair and tumor growth by stabilizing BRCA2 [ 97 ] ."
31133011
USP21 affects DNA damage frequency
| 1
USP21 activates DNA damage frequency. 1 / 1
| 1
eidos
"Deactivation of USP21 reduces the HR activity and increases the DNA damage frequency [ 115 ] ."
33013205
USP21 affects DLBCL oncogenesis
| 1
USP21 activates DLBCL oncogenesis. 1 / 1
| 1
eidos
"Therefore , USP21 may be supposed to modulate DLBCL oncogenesis through this underlying mechanism ."
33389794
USP21 affects DLBCL cell
| 1
USP21 activates DLBCL cell. 1 / 1
| 1
eidos
"The expression of USP21 promoted DLBCL cell proliferation , while it had no obvious effect on cell death ."
33389794
USP21 affects DHX58
1 |
USP21 binds DHX58. 1 / 1
1 |
biogrid
No evidence text available
24493797
USP21 affects DEPDC1B
1 |
USP21 binds DEPDC1B. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects DENND4C
1 |
USP21 binds DENND4C. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects DENND1A
1 |
USP21 binds DENND1A. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects DCLK1
1 |
USP21 binds DCLK1. 1 / 1
1 |
biogrid
No evidence text available
27173435
eidos
"Cell counting and 5-ethynyl-2 ' - deoxyuridine incorporation assays reveal that USP21 promotes the proliferation of cholangiocarcinoma ."
33052017
USP21 affects CKAP5
1 |
USP21 binds CKAP5. 1 / 1
1 |
biogrid
No evidence text available
22298430
USP21 affects CDK16
1 |
USP21 binds CDK16. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects CDC25B
1 |
USP21 binds CDC25B. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects CBY1
1 |
USP21 binds CBY1. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects CBLC
1 |
USP21 binds CBLC. 1 / 1
1 |
biogrid
No evidence text available
23105109
USP21 affects CBL
1 |
USP21 binds CBL. 1 / 1
1 |
biogrid
No evidence text available
23105109
USP21 affects BRCA2
1 |
USP21 deubiquitinates BRCA2. 1 / 1
1 |
ubibrowser
"Together, our findings identify deubiquitination as a means to regulate BRCA2 function and point to USP21 as a potential therapeutic target in BRCA2-proficient tumors."
28743957
USP21 affects BRCA2 cell cycle stage
| 1
USP21 activates BRCA2 cell cycle stage. 1 / 1
| 1
eidos
"BRCA2 expression in the S phase is stabilized by USP21 , as USP21 loss reduces the expression of BRCA2 in this cell cycle stage [ 115 ] ."
33013205
USP21 affects BHLHE40
1 |
BHLHE40 binds USP21. 1 / 1
1 |
biogrid
No evidence text available
25202122
USP21 affects BAP1
1 |
USP21 binds BAP1. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP21 affects ATXN3
1 |
USP21 binds ATXN3. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP21 affects ARHGEF2
1 |
USP21 binds ARHGEF2. 1 / 1
1 |
biogrid
No evidence text available
22298430
USP21 affects ANKRD34A
1 |
USP21 binds ANKRD34A. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects ANKRD28
1 |
USP21 binds ANKRD28. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP21 affects AGAP1
1 |
USP21 binds AGAP1. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP21 affects AFDN
1 |
USP21 binds AFDN. 1 / 1
1 |
biogrid
No evidence text available
27173435
USP2 affects USP21
1 |
USP2 binds USP21. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP14 affects USP21
1 |
USP14 binds USP21. 1 / 1
1 |
biogrid
No evidence text available
22626734
UPF3B affects USP21
1 |
USP21 binds UPF3B. 1 / 1
1 |
biogrid
No evidence text available
19615732
UCHL3 affects USP21
1 |
UCHL3 binds USP21. 1 / 1
1 |
biogrid
No evidence text available
22626734
UBE2S affects USP21
1 |
USP21 binds UBE2S. 1 / 1
1 |
biogrid
No evidence text available
20622874
TRIM9 affects USP21
1 |
USP21 binds TRIM9. 1 / 1
1 |
biogrid
No evidence text available
23105109
TRIM8 affects USP21
1 |
USP21 binds TRIM8. 1 / 1
1 |
biogrid
No evidence text available
23105109
TRIM63 affects USP21
1 |
USP21 binds TRIM63. 1 / 1
1 |
biogrid
No evidence text available
22626734
TRIM54 affects USP21
1 |
USP21 binds TRIM54. 1 / 1
1 |
biogrid
No evidence text available
22626734
TRIM5 affects USP21
1 |
USP21 binds TRIM5. 1 / 1
1 |
biogrid
No evidence text available
23105109
TRIM23 affects USP21
1 |
USP21 binds TRIM23. 1 / 1
1 |
biogrid
No evidence text available
23105109
TRAF6 affects USP21
1 |
TRAF6 binds USP21. 1 / 1
1 |
biogrid
No evidence text available
20622874
TP53 affects USP21
1 |
TP53 binds USP21. 1 / 1
1 |
biogrid
No evidence text available
27561390
TIAM1 affects USP21
1 |
TIAM1 binds USP21. 1 / 1
1 |
biogrid
No evidence text available
27173435
TESK2 affects USP21
1 |
TESK2 binds USP21. 1 / 1
1 |
biogrid
No evidence text available
27173435
TBC1D25 affects USP21
1 |
USP21 binds TBC1D25. 1 / 1
1 |
biogrid
No evidence text available
27173435
SYNE1 affects USP21
1 |
USP21 binds SYNE1. 1 / 1
1 |
biogrid
No evidence text available
27621083
SYDE1 affects USP21
1 |
USP21 binds SYDE1. 1 / 1
1 |
biogrid
No evidence text available
27173435
STAT3 affects USP21
| 1
STAT3 increases the amount of USP21. 1 / 1
| 1
reach
"STAT3 controls protein stability by inducing the expression of the deubiquitinase Ubiquitin Specific Peptidase 21 (USP21), stabilizing NANOG in mouse ES cells."
31557897
STAMBP affects USP21
1 |
USP21 binds STAMBP. 1 / 1
1 |
biogrid
No evidence text available
22626734
SRSF12 affects USP21
1 |
USP21 binds SRSF12. 1 / 1
1 |
biogrid
No evidence text available
27173435
SRGAP2 affects USP21
1 |
USP21 binds SRGAP2. 1 / 1
1 |
biogrid
No evidence text available
27173435
SP1 affects USP21
1 |
SP1 decreases the amount of USP21. 1 / 1
1 |
biopax:msigdb
No evidence text available
SLF1 affects USP21
1 |
USP21 binds SLF1. 1 / 1
1 |
biogrid
No evidence text available
27621083
SIPA1L1 affects USP21
1 |
USP21 binds SIPA1L1. 1 / 1
1 |
biogrid
No evidence text available
27173435
SH3PXD2A affects USP21
1 |
USP21 binds SH3PXD2A. 1 / 1
1 |
biogrid
No evidence text available
27173435
SH3BP4 affects USP21
1 |
SH3BP4 binds USP21. 1 / 1
1 |
biogrid
No evidence text available
27173435
SENP8 affects USP21
1 |
USP21 binds SENP8. 1 / 1
1 |
biogrid
No evidence text available
22626734
SENP3 affects USP21
1 |
USP21 binds SENP3. 1 / 1
1 |
biogrid
No evidence text available
22626734
RTKN affects USP21
1 |
RTKN binds USP21. 1 / 1
1 |
biogrid
No evidence text available
27173435
RNF185 affects USP21
1 |
USP21 binds RNF185. 1 / 1
1 |
biogrid
No evidence text available
23105109
RNF144A affects USP21
1 |
USP21 binds RNF144A. 1 / 1
1 |
biogrid
No evidence text available
23105109
RBM8A affects USP21
1 |
USP21 binds RBM8A. 1 / 1
1 |
biogrid
No evidence text available
19615732
RBM45 affects USP21
1 |
USP21 binds RBM45. 1 / 1
1 |
biogrid
No evidence text available
19615732
RBCK1 affects USP21
1 |
USP21 binds RBCK1. 1 / 1
1 |
biogrid
No evidence text available
23105109
RASAL2 affects USP21
1 |
USP21 binds RASAL2. 1 / 1
1 |
biogrid
No evidence text available
27173435
RAB3IP affects USP21
1 |
USP21 binds RAB3IP. 1 / 1
1 |
biogrid
No evidence text available
27173435
PRKCI affects USP21
1 |
USP21 binds PRKCI. 1 / 1
1 |
biogrid
No evidence text available
19615732
PPP6R3 affects USP21
1 |
PPP6R3 binds USP21. 1 / 1
1 |
biogrid
No evidence text available
19615732
PPM1H affects USP21
1 |
USP21 binds PPM1H. 1 / 1
1 |
biogrid
No evidence text available
27173435
PPIB affects USP21
1 |
USP21 binds PPIB. 1 / 1
1 |
biogrid
No evidence text available
19615732
PLEKHA7 affects USP21
1 |
USP21 binds PLEKHA7. 1 / 1
1 |
biogrid
No evidence text available
27173435
PHLDB2 affects USP21
1 |
USP21 binds PHLDB2. 1 / 1
1 |
biogrid
No evidence text available
27173435
PCGF6 affects USP21
1 |
USP21 binds PCGF6. 1 / 1
1 |
biogrid
No evidence text available
23105109
PCBP1 affects USP21
1 |
PCBP1 decreases the amount of USP21. 1 / 1
1 |
biopax:msigdb
No evidence text available
OTUB2 affects USP21
1 |
USP21 binds OTUB2. 1 / 1
1 |
biogrid
No evidence text available
22626734
OTUB1 affects USP21
1 |
USP21 binds OTUB1. 1 / 1
1 |
biogrid
No evidence text available
22626734
NF1 affects USP21
1 |
USP21 binds NF1. 1 / 1
1 |
biogrid
No evidence text available
27173435
NADK affects USP21
1 |
USP21 binds NADK. 1 / 1
1 |
biogrid
No evidence text available
27173435
MPP1 affects USP21
1 |
USP21 binds MPP1. 1 / 1
1 |
biogrid
No evidence text available
27621083
MELK affects USP21
1 |
USP21 binds MELK. 1 / 1
1 |
biogrid
No evidence text available
27173435
MAST3 affects USP21
1 |
USP21 binds MAST3. 1 / 1
1 |
biogrid
No evidence text available
27173435
MARK4 affects USP21
1 |
USP21 binds MARK4. 1 / 1
1 |
biogrid
No evidence text available
19615732
MAPKAP1 affects USP21
1 |
USP21 binds MAPKAP1. 1 / 1
1 |
biogrid
No evidence text available
27173435
MAPK3 affects USP21
1 |
USP21 binds MAPK3. 1 / 1
1 |
biogrid
No evidence text available
27886188
MAPK14 affects USP21
1 |
MAPK14 phosphorylates USP21 on S538. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
MAP4 affects USP21
1 |
USP21 binds MAP4. 1 / 1
1 |
biogrid
No evidence text available
22298430
MAP3K21 affects USP21
1 |
USP21 binds MAP3K21. 1 / 1
1 |
biogrid
No evidence text available
27173435
MAGI1 affects USP21
1 |
USP21 binds MAGI1. 1 / 1
1 |
biogrid
No evidence text available
27173435
LRSAM1 affects USP21
1 |
USP21 binds LRSAM1. 1 / 1
1 |
biogrid
No evidence text available
23105109
LRFN1 affects USP21
1 |
USP21 binds LRFN1. 1 / 1
1 |
biogrid
No evidence text available
27173435
LIMA1 affects USP21
1 |
USP21 binds LIMA1. 1 / 1
1 |
biogrid
No evidence text available
27173435
L-methionine affects USP21
1 |
L-methionine methylates USP21. 1 / 1
1 |
ctd
No evidence text available
20938992
KSR1 affects USP21
1 |
USP21 binds KSR1. 1 / 1
1 |
biogrid
No evidence text available
27173435
KRT40 affects USP21
1 |
USP21 binds KRT40. 1 / 1
1 |
biogrid
No evidence text available
25416956
KIF1C affects USP21
1 |
USP21 binds KIF1C. 1 / 1
1 |
biogrid
No evidence text available
27173435
KIF13B affects USP21
1 |
USP21 binds KIF13B. 1 / 1
1 |
biogrid
No evidence text available
27173435
KCTD3 affects USP21
1 |
USP21 binds KCTD3. 1 / 1
1 |
biogrid
No evidence text available
27173435
KCTD11 affects USP21
1 |
USP21 binds KCTD11. 1 / 1
1 |
biogrid
No evidence text available
27621083
JOSD1 affects USP21
1 |
USP21 binds JOSD1. 1 / 1
1 |
biogrid
No evidence text available
22626734
ISG15 affects USP21
1 |
USP21 binds ISG15. 1 / 1
1 |
biogrid
No evidence text available
21399617
IFIH1 affects USP21
1 |
USP21 binds IFIH1. 1 / 1
1 |
biogrid
No evidence text available
24493797
HERC2 affects USP21
| 1
USP21 binds HERC2. 1 / 1
| 1
reach
"HERC2 also interacts with and stabilises USP16 which is involved in H2A de-ubiquitination in DSB repair [38]."
31769469
HECW2 affects USP21
1 |
USP21 binds HECW2. 1 / 1
1 |
biogrid
No evidence text available
24163370
HDAC4 affects USP21
1 |
USP21 binds HDAC4. 1 / 1
1 |
biogrid
No evidence text available
27173435
H2AC18 affects USP21
1 |
USP21 binds H2AC18. 1 / 1
1 |
biogrid
No evidence text available
21179169
GLI2 affects USP21
1 |
USP21 binds GLI2. 1 / 1
1 |
biogrid
No evidence text available
27621083
GIGYF1 affects USP21
1 |
USP21 binds GIGYF1. 1 / 1
1 |
biogrid
No evidence text available
27173435
GATA-3 affects USP21
| 1
USP21 binds GATA-3. 1 / 1
| 1
trips
"Here, we show how USP21 interacts with and stabilizes GATA3 by mediating its deubiquitination."
23395819
GAB2 affects USP21
1 |
USP21 binds GAB2. 1 / 1
1 |
biogrid
No evidence text available
27173435
FUCA1 affects USP21
1 |
USP21 binds FUCA1. 1 / 1
1 |
biogrid
No evidence text available
19615732
FOXP3 affects USP21
1 |
FOXP3 increases the amount of USP21. 1 / 1
1 |
trrust
No evidence text available
23395819
FAM53C affects USP21
1 |
USP21 binds FAM53C. 1 / 1
1 |
biogrid
No evidence text available
27173435
FAM110B affects USP21
1 |
USP21 binds FAM110B. 1 / 1
1 |
biogrid
No evidence text available
27173435
FAM110A affects USP21
1 |
USP21 binds FAM110A. 1 / 1
1 |
biogrid
No evidence text available
27173435
ESPL1 affects USP21
1 |
USP21 binds ESPL1. 1 / 1
1 |
biogrid
No evidence text available
22626734
EIF4E2 affects USP21
1 |
USP21 binds EIF4E2. 1 / 1
1 |
biogrid
No evidence text available
27173435
DTX3 affects USP21
1 |
USP21 binds DTX3. 1 / 1
1 |
biogrid
No evidence text available
23105109
DHX58 affects USP21
1 |
USP21 binds DHX58. 1 / 1
1 |
biogrid
No evidence text available
24493797
DEPDC1B affects USP21
1 |
USP21 binds DEPDC1B. 1 / 1
1 |
biogrid
No evidence text available
27173435
DENND4C affects USP21
1 |
USP21 binds DENND4C. 1 / 1
1 |
biogrid
No evidence text available
27173435
DENND1A affects USP21
1 |
USP21 binds DENND1A. 1 / 1
1 |
biogrid
No evidence text available
27173435
DCLK1 affects USP21
1 |
USP21 binds DCLK1. 1 / 1
1 |
biogrid
No evidence text available
27173435
Cuprizone affects USP21
1 |
Cuprizone increases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
26577399
CKAP5 affects USP21
1 |
USP21 binds CKAP5. 1 / 1
1 |
biogrid
No evidence text available
22298430
CDK16 affects USP21
1 |
USP21 binds CDK16. 1 / 1
1 |
biogrid
No evidence text available
27173435
CDC25B affects USP21
1 |
USP21 binds CDC25B. 1 / 1
1 |
biogrid
No evidence text available
27173435
CBY1 affects USP21
1 |
USP21 binds CBY1. 1 / 1
1 |
biogrid
No evidence text available
27173435
CBLC affects USP21
1 |
USP21 binds CBLC. 1 / 1
1 |
biogrid
No evidence text available
23105109
CBL affects USP21
1 |
USP21 binds CBL. 1 / 1
1 |
biogrid
No evidence text available
23105109
BHLHE40 affects USP21
1 |
BHLHE40 binds USP21. 1 / 1
1 |
biogrid
No evidence text available
25202122
BAZ2A affects USP21
1 |
USP21 binds BAZ2A. 1 / 1
1 |
biogrid
No evidence text available
26100909
BAP1 affects USP21
1 |
USP21 binds BAP1. 1 / 1
1 |
biogrid
No evidence text available
22626734
Antirheumatic Agents increases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
24449571
AZM551248 affects USP21
1 |
AZM551248 decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
22323515
AURKA affects USP21
1 |
AURKA binds USP21. 1 / 1
1 |
biogrid
No evidence text available
26446837
ATXN3 affects USP21
1 |
USP21 binds ATXN3. 1 / 1
1 |
biogrid
No evidence text available
22626734
ARHGEF2 affects USP21
1 |
USP21 binds ARHGEF2. 1 / 1
1 |
biogrid
No evidence text available
22298430
ANKRD34A affects USP21
1 |
USP21 binds ANKRD34A. 1 / 1
1 |
biogrid
No evidence text available
27173435
ANKRD28 affects USP21
1 |
USP21 binds ANKRD28. 1 / 1
1 |
biogrid
No evidence text available
19615732
AGAP1 affects USP21
1 |
USP21 binds AGAP1. 1 / 1
1 |
biogrid
No evidence text available
27173435
AFDN affects USP21
1 |
USP21 binds AFDN. 1 / 1
1 |
biogrid
No evidence text available
27173435
3,4-methylenedioxymethamphetamine increases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
20188158
17alpha-ethynylestradiol increases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
17942748
(+)-JQ1 compound affects USP21
1 |
(+)-JQ1 compound decreases the amount of USP21. 1 / 1
1 |
ctd
No evidence text available
25307878