IndraLab
Statements
reach
"It is therefore still unclear whether the ZnF domain of USP16 binds free ISG15 in the same mode as free Ub, and if it plays a regulatory role in ISG15-dependent processes in cells.The specificity of mouse USP18 for mouse ISG15 is mediated by interaction between a hydrophobic patch in USP18 and a hydrophobic region in the C-terminal domain of ISG15."