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USP21 deubiquitinates NANOG. 2 / 3

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"Ubiquitin-specific peptidase 21 (USP21) deubiquitylates NANOG but not OCT4 or SOX2."

37047234

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"For example, Oct4 and Sox2 protein levels are regulated by the E3 ligase WWP2, and ubiquitin-specific-processing protease 21 (Usp21) deubiquitinates and stabilizes Nanog, which maintains pluripotency, while FBXW8, an E3 ligase, ubiquitinates and destabilizes Nanog, thereby promoting ESC differentiation."

30891497

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USP21 deubiquitinates NANOG. 2 / 3

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