IndraLab

Statements

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"These results demonstrated that USP21 stimulated cell proliferation , migration , invasion , and stemness of GC cells ."
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"Knockdown of USP16 in prostate cancer cell lines reduces cell proliferation and suppresses xenograft tumor growth."
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"For instance, USP16, known as a deubiquitinase, was strongly associated with the c-Myc gene signature to serve as a novel deubiquitinase of c-Myc, thereby enhancing the castration-resistant prostate cancer cell proliferation [16]."
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"We identify that knockdown of USP21 inhibits cell proliferation , and overexpression of USP21 promotes cell growth ."
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"Besides, Qian et al. showed that the downregulation of USP16 mediated by carboxyl-terminal truncated HBx mutants promotes the proliferation of HCC cells [88]."
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"USP21 promotes cell proliferation by maintaining the EZH2 level in diffuse large B-cell lymphoma MA et al. Abstract Background Diffuse large B-cell lymphoma ( DLBCL ) is the most common category of non-Hodgkin lymphoma ( NHL ) ."
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"In human tissues, overexpression of Usp16 reduces the expansion of normal fibroblasts and post-natal neural progenitors, while downregulation of Usp16 partially rescues the proliferation defects of fibroblasts and expands the stem cell compartment in blood, mammary epithelial tissue, and brain."
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"Furthermore , USP21 has been shown to associate with both centrosomes and microtubules to regulate cell motility in three-dimensional matrices [ 29-33 ] , and promotes cell proliferation and metastasis in kinds of cancer [ 34-37 ] ."
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"USP21 Regulates the Expression of MAPK1 Through GATA3 and Affects Cell Proliferation , Migration , Invasion , and Stemness of GC Since USP21 stimulated cell proliferation , migration , invasion , and stemness of GC , and could stabilize the expression of GATA3 by deubiquitinating GATA3 , while MAPK1 was the transcription target of GATA3 , it was further verified whether USP21 could play its oncogenic effect in GC through the GATA3 / MAPK1 axis ."
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"USP21 knockdown or overexpression in the DLBCL cell line shows that USP21 promotes cell proliferation ."
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"USP16 can promote the cellular proliferation and growth of PCa (Ge et al., 2021)."
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"It has demonstrated that USP16 promotes the proliferation and differentiation of T cells, thereby increasing CD4 T cell infiltration and aggravating IBD (66)."
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"USP21 promotes cell proliferation , tumor progression , and colony formation , and enhances cancer stem cell self-renewal ."
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"Therefore , USP21 stimulates cell proliferation but cannot cause cell death ."
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"It is important to note that USP16 reduction also reduced astrocyte proliferation and restored cognitive function as measured by the NOR and Barnes Maze tests, independently of plaques and widespread inflammation."
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"These data demonstrate that USP21 promotes cell proliferation via its deubiquitinating active site ."
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"USP21 promotes cell proliferation via Cys-221 ."
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