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"USP21 was shown to modulate the transcription of nuclear factor-kappaB p65 by deubiquitinating and stabilising interleukin-33 in the nucleus [ 25 ] , and interacts with both nuclear and cytoplasmic proteins including GATA3 , receptor-interacting serine / threonine-protein kinase 1 , and Nanog [ 14,19,26,27 ] ."