IndraLab

Statements

USP5 affects FOXM1
1 | 5
USP5 deubiquitinates FOXM1. 5 / 5
1 | 4
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"Thus, FOXM1 is deubiquitinated and stabilized by USP5 upon wnt3a stimulation."
32723561
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"In conclusion, these results demonstrate that deubiquitination of FoxM1 by USP5 can activate Wnt/β-catenin signaling and is clinically relevant to glioblastomas."
32723561
reach
"In contrast, USP5 deubiquitinates and stabilizes FOXM1 upon Wnt3a stimulation."
32723561
ubibrowser
"Review"
27775833
reach
"Overexpression of USP5 impairs the ubiquitination of FOXM1 and depletion of USP5 diminishes the ability of Wnt3a to reduce the ubiquitination of FOXM1."
32723561
Modified USP5 leads to the deubiquitination of FOXM1. 1 / 1
| 1
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"Overexpression of USP5 reduces the endogenous ubiquitination of FoxM1 and increases FoxM1 expression [25]."
28807830
USP5 affects MAF
1 | 3
USP5 leads to the deubiquitination of MAF. 4 / 4
1 | 3
reach
"Because USP5, as a deubiquitinase of c-Maf, binds to and suppresses c-Maf polyubiquitination, we sought to determine whether mebendazole could interfere with the association of c-Maf and USP5."
31197245
ubibrowser
"Consistent with the high level of c-Maf protein in MM cells, USP5 was also highly expressed."
28933784
reach
"C-Maf ubiquitination can be reversed by the deubiquitinase USP5 because USP5 prevents c-Maf from polyubiquitination and degradation [XREF_BIBR]."
31197245
reach
"C-Maf ubiquitination can be reversed by the deubiquitinase USP5 because USP5 prevents c-Maf from polyubiquitination and degradation [8]."
31197245
USP5 affects HDAC2
| 4
USP5 deubiquitinates HDAC2. 4 / 4
| 4
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"HDAC2 interacted with USP5, and USP5 knockdown induced the ubiquitination of HDAC2."
31727867
reach
"Immunoprecipiation experiments with antibody against USP5 or HDAC2 showed the interaction between USP5 and HDAC2 in OVCAR3 cells (Figure 5B), and that USP5 knockdown induced the ubiquitination of HDAC2 (Figure 5C)."
31727867
reach
"Moreover, USP5 interacted with HDAC2, and disruption of USP5 enhanced the ubiquitination of HDAC2."
31727867
reach
"Ubiquitin specific peptidase 5 promotes ovarian cancer cell proliferation through deubiquitinating HDAC2."
31727867
USP5 affects SNAI2
1 | 2
USP5 leads to the deubiquitination of SNAI2. 3 / 3
1 | 2
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"Collectively, these results indicated that USP5 promotes SLUG stabilization by deubiquitinating SLUG."
30809294
ubibrowser
"USP5 interacts with and stabilizes SLUG to regulate its abundance through USP5 deubiquitination activities in epithelial-mesenchymal transition (EMT) of hepatocellular carcinoma (HCC)."
30809294
reach
"Formononetin targets USP5 to inhibit the deubiquitination of SLUG."
30809294
USP5 affects CACNA1H
1 | 2
USP5 leads to the deubiquitination of CACNA1H. 3 / 3
1 | 2
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"Knockdown of USP5 via shRNA increases Cav3.2 ubiquitination, decreases Cav3.2 protein levels, and reduces Cav3.2 whole-cell currents."
25189210
reach
"As reported, overexpression of USP5 decreases ubiquitination of CaV3.2, which in turn decreases channel internalization [64]."
33422652
ubibrowser
"Review"
27775833
USP5 affects TUFM
| 2
USP5 deubiquitinates TUFM. 2 / 2
| 2
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"Another study showed that EFTU was deubiquitinated by ubiquitin-specific peptidase 5 (USP5), and its level increased in CRC (Xu et al., 2019)."
34277617
reach
"USP5 deubiquitinated TUFM and increased its level in CRC cells."
31281542
USP5 affects TP53
1 | 1
USP5 deubiquitinates TP53. 2 / 2
1 | 1
ubibrowser
"Review"
28801249
reach
"USP5 deubiquitinates p53 [XREF_BIBR], while USP2a acts on Mdm2 [XREF_BIBR], and differences in the levels of the two proteases can affect p53 levels."
24659749
USP5 affects CCND1
| 2
USP5 deubiquitinates CCND1. 2 / 2
| 2
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"Given that USP5 is a deubiquitinating enzyme (24), we wondered whether USP5 could directly interact with and deubiquitinate CCND1 to stabilize CCND1 protein."
34858787
reach
"Further, we found that USP5 could physically interact with and deubiquitinate CCND1, thereby stabilizing the protein level of CCND1 and prolonging its half-life."
34858787
USP5 affects WT1
| 1
USP5 deubiquitinates WT1. 1 / 1
| 1
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"We further identified that USP5 deubiquitinated WT1 and stabilized its expression."
31845546
USP5 affects STING1
1 |
USP5 deubiquitinates STING1. 1 / 1
1 |
ubibrowser
"In addition, the ubiquitination of STING was impaired by USP5, USP13, and USP22."
29732405
USP5 affects Proteasome
| 1
USP5 leads to the deubiquitination of Proteasome. 1 / 1
| 1
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"Interestingly, we also discovered that the human gene encoding the ubiquitin specific peptidase 5 (USP5), which is known to promote cellular deubiquitination and ubiquitin and proteasome dependent proteolysis, was a direct transcriptional target for miR-125a to repress."
31452281
USP5 affects MAFB
1 |
USP5 deubiquitinates MAFB. 1 / 1
1 |
ubibrowser
"USP5 was found to interact with c-Maf and prevented it from degradation by decreasing its polyubiquitination level| Notably, MafA and MafB are also members of the c-Maf family, however, USP5 failed to deubiquitinate MafA, suggesting its substrate specificity."
28933784
USP5 affects MAFA
| 1
USP5 deubiquitinates MAFA. 1 / 1
| 1
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"Notably, MafA and MafB are also members of the c-Maf family, however, USP5 failed to deubiquitinate MafA, suggesting its substrate specificity."
28933784
USP5 affects ERK
| 1
USP5 deubiquitinates ERK. 1 / 1
| 1
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"More recently, USP5 has been shown to deubiquitinate phosphorylated methyltransferase-like 3 (METTL3) and consequently stabilize it in extracellular signal-regulated kinase (ERK)-activated human cancer cells, thereby contributing to tumorigenesis (45)."
34858787
USP5 affects CTNNB1
| 1
USP5 deubiquitinates CTNNB1. 1 / 1
| 1
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"Mechanistically, we found that USP5 deubiquitinated beta-catenin, prevented ubiquitination mediated beta-catenin degradation and promoted beta-catenin nuclear accumulation, leading to the activation of Wnt and beta-catenin signal pathway in NSCLC cells."
30555744
USP5 affects CD274
| 1
USP5 deubiquitinates CD274. 1 / 1
| 1
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"USP5 directly interacted with PD-L1 and deubiquitinated PD-L1, therefore enhances PD-L1 protein stability."
34741014