IndraLab

Statements

USP5 deubiquitinates TP53. 3 / 4
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"USP5 deubiquitinates p53 [XREF_BIBR], while USP2a acts on Mdm2 [XREF_BIBR], and differences in the levels of the two proteases can affect p53 levels."
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"In hepatocellular carcinoma, USP5 promotes cell proliferation by deubiquitinating and inhibiting p53‐induced apoptosis [21]."
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"Additionally, ablation of USP5 or BECN1 significantly decreased the ubiquitination of p53, which could be rescued by ectopic expression of MDM2 (Supplementary Fig. S4i, j)."
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