IndraLab

Statements

USP5 deubiquitinates FOXM1. 7 / 7
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reach
"In contrast, USP5 deubiquitinates and stabilizes FOXM1 upon Wnt3a stimulation."
32723561
reach
"Additionally, two other studies demonstrated that deubiquitylation and stabilization of FoxM1 by USP5 and USP28 contribute to its nuclear accumulation, which facilitates the recruitment of β-catenin to the Wnt target gene promoter and activates the Wnt signaling pathway (Chen et al., 2016; Chen L. et al., 2021)."
35846989
signor
"Wnt signaling activation inhibits FoxM1 phosphorylation by GSK3-Axin complex and leads to interaction between FoxM1 and deubiquitinating enzyme USP5, thereby deubiquitination and stabilization of FoxM1."
26912724
reach
"Overexpression of USP5 impairs the ubiquitination of FOXM1 and depletion of USP5 diminishes the ability of Wnt3a to reduce the ubiquitination of FOXM1."
32723561
reach
"Thus, FOXM1 is deubiquitinated and stabilized by USP5 upon wnt3a stimulation."
32723561
reach
"In conclusion, these results demonstrate that deubiquitination of FoxM1 by USP5 can activate Wnt/β-catenin signaling and is clinically relevant to glioblastomas."
32723561
ubibrowser
"27775833"
27775833