IndraLab

Statements

USP5 deubiquitinates FOXM1. 5 / 7
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"In contrast, USP5 deubiquitinates and stabilizes FOXM1 upon Wnt3a stimulation."
32723561
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"Additionally, two other studies demonstrated that deubiquitylation and stabilization of FoxM1 by USP5 and USP28 contribute to its nuclear accumulation, which facilitates the recruitment of β-catenin to the Wnt target gene promoter and activates the Wnt signaling pathway (Chen et al., 2016; Chen L. et al., 2021)."
35846989
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"Overexpression of USP5 impairs the ubiquitination of FOXM1 and depletion of USP5 diminishes the ability of Wnt3a to reduce the ubiquitination of FOXM1."
32723561
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"Thus, FOXM1 is deubiquitinated and stabilized by USP5 upon wnt3a stimulation."
32723561
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"In conclusion, these results demonstrate that deubiquitination of FoxM1 by USP5 can activate Wnt/β-catenin signaling and is clinically relevant to glioblastomas."
32723561