IndraLab

Statements

USP5 deubiquitinates CTNNB1. 15 / 15
1 | 14
ubibrowser
"Mechanistically, we found that <span class="match term0">USP5</span> deubiquitinated <span class="match term1">BETA-CATENIN</span>, prevented ubiquitination mediated <span class="match term1">BETA-CATENIN</span> degradation and promoted <span class="match term1">BETA-CATENIN</span> nuclear accumulation, leading to the activation of Wnt/<span class="match term1">BETA-CATENIN</span> signal pathway in NSCLC cells"
30555744
reach
"Ubiquitin-specific peptidase 5 facilitates cancer stem cell-like properties in lung cancer by deubiquitinating beta-catenin."
37726816
reach
"USP5 promotes stemness properties by deubiquitinating beta-catenin."
37726816
reach
"Ma et al. [ 38 ] found that USP5 could activate the Wnt/β-catenin pathway by deubiquitinating and stabilizing β-catenin protein in non-small cell lung cancer, which results in promotion of cell prolif[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31756387
reach
"Collectively, these data suggest that USP5 deubiquitinates β-catenin, promotes β-catenin stability, and subsequently promotes Wnt signaling pathway activity in lung cancer cells.To confirm the role of β-catenin in USP5-mediated stemness, we silenced the β-catenin expression in USP5-overexpressing A549 cells and determined the sphere-forming ability (Additional file 1: Figure S5D)."
37726816
reach
"Inhibition of USP5 by small molecules enhances beta-catenin ubiquitination and suppresses stemness properties and cell motility."
37726816
reach
"Mechanistically, Wnt signaling signatures were identified to be clinically related to USP5 expression, and our data showed that USP5 physically interacted with β-catenin to cause β-catenin deubiquitination and stabilization, thereby stimulating Wnt signaling."
37726816
reach
"Here, our findings provide new insights indicating that USP5 interacts with β-catenin, causes β-catenin deubiquitination, prolongs the β-catenin protein half-life, and thus increases the expression of Wnt/β-catenin downstream target genes in lung cancer.Our study showed WP1130 inhibited cell motility and cancer stemness in lung cancer."
37726816
reach
"Mechanistically, we found that USP5 deubiquitinated beta-catenin, prevented ubiquitination mediated beta-catenin degradation and promoted beta-catenin nuclear accumulation, leading to the activation of Wnt and beta-catenin signal pathway in NSCLC cells."
30555744
reach
"DEPDC1B-mediated USP5 deubiquitination of beta-catenin promotes breast cancer metastasis by activating the wnt/beta-catenin pathway."
37642235
reach
"Furthermore, we also revealed a novel mechanism in DEPDC1B-mediated USP5 deubiquitination of β-catenin, which led to the activation of the wnt/β-catenin signaling pathway and ultimately promoted breast cancer cell metastasis."
37642235
reach
"In non-small-cell lung cancer and trophoblast cells, USP5 can deubiquitinate and stabilize β-catenin and activate the wnt/β-catenin signaling pathway (43–45)."
37642235
reach
"First, mechanistically, how DEPDC1B, USP5, and β-catenin interact, the location of the binding sites, how DEPDC1B mediates the deubiquitination of β-catenin by USP5, and whether DEPDC1B has enzyme activity remain to be further explored."
37642235
reach
"As previously described, USP5 can deubiquitinate and stabilize β-catenin, leading to β-catenin nuclear accumulation and activation ( Fig. 3 b) [ 38 ]."
31756387
reach
"Finally, we found that in breast cancer cells DEPDC1B mediates the deubiquitination of β-catenin by USP5, stabilizes the β-catenin protein level, promotes nuclear translocation, activates the wnt/β-catenin signaling pathway, and ultimately promotes the transfer of breast cancer cells (Fig. 8)."
37642235