IndraLab

Statements


USP5 deubiquitinates HDAC2. 7 / 8
1 | 7

reach
"USP5 inhibits cell cycle arrest by deubiquitinates HDAC2."

reach
"Ubiquitin specific peptidase 5 promotes ovarian cancer cell proliferation through deubiquitinating HDAC2."

reach
"Moreover, USP5 interacted with HDAC2, and disruption of USP5 enhanced the ubiquitination of HDAC2."

reach
"Immunoprecipiation experiments with antibody against USP5 or HDAC2 showed the interaction between USP5 and HDAC2 in OVCAR3 cells (Figure 5B), and that USP5 knockdown induced the ubiquitination of HDAC2 (Figure 5C)."

reach
"USP5 stimulates ovarian cancer cell proliferation via the deubiquitination of HDAC2 (histone deacetylase 2) [45] or the modulation of cycle regulators in pancreatic cancer cells [46] ."

reach
"HDAC2 interacted with USP5, and USP5 knockdown induced the ubiquitination of HDAC2."

reach
"Moreover, USP5 positively regulates the stability and deubiquitinates HDAC2, of which the mutation or loss of function acts as an oncogene (Figure 2A) [95,121]."