IndraLab

Statements

USP34 is modified

22 | 1

USP34 is phosphorylated on S3406. 2 / 2

2 |

➶

hprd

No evidence text available

18669648

➶

hprd

No evidence text available

18452278

USP34 is phosphorylated on S1377. 1 / 1

1 |

➶

hprd

No evidence text available

20068231

USP34 is phosphorylated on T188. 1 / 1

1 |

➶

hprd

No evidence text available

18077418

USP34 is phosphorylated on T3385. 1 / 1

1 |

➶

hprd

No evidence text available

19651622

USP34 is phosphorylated on T679. 1 / 1

1 |

➶

hprd

No evidence text available

20068231

USP34 is phosphorylated on S3358. 1 / 1

1 |

➶

hprd

No evidence text available

18669648

USP34 is phosphorylated on S3384. 1 / 1

1 |

➶

hprd

No evidence text available

19651622

USP34 is phosphorylated. 1 / 1

| 1

➶

sparser

"M1320T, and ubiquitin specific peptidase 34 ( USP34 ) p."

33886505

USP34 is phosphorylated on S352. 1 / 1

1 |

➶

hprd

No evidence text available

18669648

USP34 is phosphorylated on S1469. 1 / 1

1 |

➶

hprd

No evidence text available

18669648

USP34 is phosphorylated on S3411. 1 / 1

1 |

➶

hprd

No evidence text available

18669648

USP34 is phosphorylated on S2488. 1 / 1

1 |

➶

hprd

No evidence text available

15345747

USP34 is phosphorylated on T3383. 1 / 1

1 |

➶

hprd

No evidence text available

19651622

USP34 is phosphorylated on S1461. 1 / 1

1 |

➶

hprd

No evidence text available

18669648

USP34 is phosphorylated on T667. 1 / 1

1 |

➶

hprd

No evidence text available

20068231

USP34 is phosphorylated on S681. 1 / 1

1 |

➶

hprd

No evidence text available

20068231

USP34 is phosphorylated on S3410. 1 / 1

1 |

➶

hprd

No evidence text available

18669648

USP34 is phosphorylated on S355. 1 / 1

1 |

➶

hprd

No evidence text available

18669648

USP34 is phosphorylated on S1473. 1 / 1

1 |

➶

hprd

No evidence text available

18669648

USP34 is phosphorylated on Y3415. 1 / 1

1 |

➶

hprd

No evidence text available

18669648

USP34 is phosphorylated on S3359. 1 / 1

1 |

➶

hprd

No evidence text available

18669648

USP34 is phosphorylated on S1472. 1 / 1

1 |

➶

hprd

No evidence text available

18669648

USP34 deubiquitinates NFIC.

| 5

USP34 deubiquitinates NFIC. 5 / 5

| 5

➶

reach

"USP34 deubiquitinates and stabilizes NFIC."

33686052

➶

reach

"Mechanically, we demonstrated that USP34 deubiquitinates and stabilizes NFIC during odontoblast differentiation."

33686052

➶

reach

"To test whether USP34 dependent deubiquitination of NFIC is involved in odontogenic differentiation of DPCs, DPCs were infected with Lv-NFIC, or Lv-GFP as control."

33686052

➶

reach

"XREF_BIBR, XREF_BIBR Our research identified that USP34 deubiquitinates and stabilizes NFIC to promote odontoblast differentiation and thus regulates root formation."

33686052

➶

reach

"Ubiquitination assay showed increased ubiquitination level of NFIC in USP34 deficient 293T cells, indicating the presence of USP34 dependent deubiquitination of NFIC."

33686052

USP34 binds NFIC. 1 / 1

| 1

➶

sparser

"To uncover the molecular interaction between USP34 and NFIC, we transduced 293 T cells with Lv-NFIC and then performed co-IP analysis."

33686052

USP34 binds NFIC and 293T. 1 / 1

| 1

➶

reach

"To uncover the molecular interaction between USP34 and NFIC, we transduced 293T cells with Lv-NFIC and then performed co-IP analysis."

33686052

USP34 inhibits NFIC.

| 1

USP34 inhibits NFIC. 1 / 1

| 1

➶

reach

"Furthermore, we treated 293T cells with cycloheximide (CHX), a protein translation inhibitor, and observed that depletion of USP34 accelerated the degradation of NFIC."

33686052

USP34 activates NFIC.

| 1

USP34 activates NFIC. 1 / 1

| 1

➶

eidos

"Furthermore , we treated 293 T cells with cycloheximide ( CHX ) , a protein translation inhibitor , and observed that depletion of USP34 accelerated the degradation of NFIC ( Fig. 4b , d ) ."

33686052

USP34 binds RNF168. 3 / 3

| 2 1

➶

reach

"USP34 also associates and stabilizes RNF168 especially after IR, thereby enhancing H2A and gammaH2AX ubiquitylation."

28764946

➶

reach

"As USP34 interacted with RNF168, but not RNF8 (XREF_FIG C and D), we focused our attention to dissect the functional interaction of USP34 and RNF168, although we are fully aware of the possibility that RNF8 may also transiently associate with USP34 and may represent a bona fide target of USP34."

23863847

➶

sparser

"As USP34 interacted with RNF168, but not RNF8 ( xref C and D), we focused our attention to dissect the functional interaction of USP34 and RNF168, although we are fully aware of the possibility that RNF8 may also transiently associate with USP34 and may represent a bona fide target of USP34."

23863847

USP34 deubiquitinates RNF168.

1 | 1

USP34 deubiquitinates RNF168. 2 / 2

1 | 1

➶

reach

"A similar observation was seen when we immunoblotted immunoprecipitated RNF168 proteins with antibodies specific for lys48-ubiquitin linkages (XREF_FIG D), suggesting that USP34 may deubiquitylate and stablize RNF168."

23863847

➶

ubibrowser

"Review"

28031783

USP34 activates RNF168.

| 2

USP34 activates RNF168. 2 / 2

| 2

➶

reach

"Specifically, USP34 promotes RNF168 dependent functions at DSBs."

30831436

➶

reach

"We concluded that USP34 promotes RNF168 dependent ubiquitylation events at DSBs."

23863847

USP34 inhibits RNF168.

| 1

USP34 inhibits RNF168. 1 / 1

| 1

➶

reach

"Another DUB, USP7, has also been shown to deubiquitinate and stabilize RNF168 [XREF_BIBR]; however, RNF168 is itself polyubiquitinated and destabilized upon IR treatment, which is reversed by USP34, suggesting that USP34 specifically stabilizes RNF168 when DNA becomes damaged [XREF_BIBR]."

30831436

ATM affects USP34

2 1 | 3 1

ATM binds USP34.

1 | 2 1

USP34 binds ATM. 4 / 4

1 | 2 1

➶

biogrid

No evidence text available

17478428

➶

sparser

"Immunoprecipitation demonstrated the interaction between USP34 and ATM."

37043976

➶

reach

"Immunoprecipitation demonstrated the interaction between USP34 and ATM."

37043976

➶

reach

"USP34 deficiency in macrophages promotes the onset of vitiligo with increased PMEL CD8 + T cell enrichment, and USP34/ATM complex can be considered as a therapy target."

37043976

ATM phosphorylates USP34.

2 |

ATM phosphorylates USP34 on S718. 1 / 1

1 |

➶

biopax:phosphositeplus

No evidence text available

ATM phosphorylates USP34 on S1751. 1 / 1

1 |

➶

biopax:phosphositeplus

No evidence text available

ATM activates USP34.

| 1

ATM activates USP34. 1 / 1

| 1

➶

reach

"As chemical inhibition of ATM using KU55933 inhibited USP34 IRIF, we examined whether DSB association of USP34 may require an intact H2AX dependent DNA damage signaling pathway."

23863847

USP34 affects Wnt

| 5 1

USP34 activates Wnt.

| 4

USP34 activates Wnt. 4 / 4

| 4

➶

reach

"For example, Christodoulides et al. reported that mutation C256Y in WNT10B was associated with overweight or obesity because the mutation was unable to activate canonical Wnt pathway [XREF_BIBR]; and Choi et al. found that indirubin-3 '-oxime (I3O), also an activator of the Wnt signaling like USP34, inhibited the development of obesity in high-fat diet fed mice [XREF_BIBR]."

25975428

➶

reach

"Finally, we found the SNORA70B and its hose gene USP34 might directly regulate Wnt signalling pathway to promote tumorigenesis in ccRCC."

31943775

➶

reach

"Moreover, USP34 positively regulates Wnt signaling pathway [XREF_BIBR] and plays a role in DNA damage response control [XREF_BIBR]."

28493913

➶

reach

"Moreover, USP34 positively regulates Wnt signaling pathway [XREF_BIBR], which plays an important role in gender differentiation, folliculogenesis, ovulation and other biological processes in reproduction [XREF_BIBR]."

25975428

USP34 inhibits Wnt.

| 1

USP34 inhibits Wnt. 1 / 1

| 1

➶

reach

"This indicates that USP34 suppresses Wnt and beta-catenin signaling, due to degradation of beta-catenin resulting from increased stability of AXIN1 [XREF_BIBR]."

32486158

USP34 binds Wnt.

| 1

Wnt binds USP34. 1 / 1

| 1

➶

sparser

"Lasted studies have reported that snoRNAs could directly bind to functional protein to promote tumorigenesis. xref , xref Therefore, we inferred that USP34 or SNORA70B might bind WNT pathway–related protein to activate it."

31943775

USP34 affects NFkappaB

| 4 1

USP34 activates NFkappaB.

| 3

USP34 activates NFkappaB. 3 / 3

| 3

➶

reach

"We present evidence that knockdown of Ubiquitin Specific Protease 34 (USP34) selectively enhanced NF-kappaB activation driven by TCR engagement, similarly to siRNA against the well characterized DUB cylindromatosis (CYLD)."

23590831

➶

reach

"Hence, our results suggest that USP34 likely functions downstream of the CBM-IKK nexus to enhance NF-kappaB activation."

23590831

➶

reach

"Combined, these results indicate that USP34 shares some functional similarities with CYLD and selectively targets the NF-kappaB signaling pathway."

23590831

USP34 inhibits NFkappaB.

| 1

USP34 inhibits NFkappaB. 1 / 1

| 1

➶

reach

"USP34 also suppresses NFkappaB activation."

24712463

USP34 binds NFkappaB.

| 1

NFkappaB binds USP34. 1 / 1

| 1

➶

sparser

"Given that USP34 does not bind to the NF-κB core components (our unpublished results), we favor a model in which USP34 impacts on the activity of a cytosolic co-activator to ensure IκBα fine-tuning [ xref , xref ]."

23590831

USP34 affects AXIN1

1 1 | 3

USP34 deubiquitinates AXIN1.

1 1 | 1

USP34 leads to the deubiquitination of AXIN1. 2 / 2

1 | 1

➶

ubibrowser

No evidence text available

➶

reach

"USP34 reduced the ubiquitination of AXIN1, but the catalytic mutant of USP34 does not reduce the ubiquitination of AXIN1."

32486158

USP34 deubiquitinates AXIN1 on lysine. 1 / 1

1 |

➶

biopax:reactome

No evidence text available

USP34 ubiquitinates AXIN1.

| 1

Mutated USP34 leads to the ubiquitination of AXIN1. 1 / 1

| 1

➶

reach

"USP34 reduced the ubiquitination of AXIN1, but the catalytic mutant of USP34 does not reduce the ubiquitination of AXIN1."

32486158

USP34 inhibits AXIN1.

| 1

USP34 inhibits AXIN1. 1 / 1

| 1

➶

reach

"Inhibition of USP34 in NMuMG cells induced EMT, as evidenced by the upregulation of EMT markers including N-cadherin, phospho-Smad3, Snail and active-beta-catenin, as well as the downregulation of Axin 1 and E-cadherin."

28499884

Benzo[a]pyrene affects USP34

4 |

Benzo[a]pyrene decreases the amount of USP34.

3 |

Benzo[a]pyrene decreases the amount of USP34. 3 / 3

3 |

➶

ctd

No evidence text available

26001963

➶

ctd

No evidence text available

21632981

➶

ctd

No evidence text available

20106945

Benzo[a]pyrene increases the amount of USP34.

1 |

Benzo[a]pyrene increases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

26238291

USP34 affects cell population proliferation

| 4

USP34 inhibits cell population proliferation.

| 2

USP34 inhibits cell population proliferation. 2 / 2

| 2

➶

reach

"In this study, downregulation of USP34 markedly inhibited proliferation and migration, and induced apoptosis in PANC-1 cells."

32110045

➶

reach

"Downregulation of USP34 could inhibit proliferation and migration in PANC-1 cells via inhibiting PRR11, and inactivating p38 MAPK signaling."

32110045

USP34 activates cell population proliferation.

| 2

USP34 activates cell population proliferation. 2 / 2

| 2

➶

reach

"PLAGL2 also activates the expression of USP34 deubiqutinase that in turn stabilizes Snail1 and promotes proliferation and migration of gastric cancer cells [63]."

35563824

➶

reach

"In addition, USP34 overexpression promoted PANC-1 cell proliferation and migration via up-regulating the proteins of p-AKT and p-PKC."

30686807

USP34 affects AXIN

| 4

USP34 activates AXIN.

| 2

USP34 activates AXIN. 2 / 2

| 2

➶

reach

"In colon carcinoma cell lines that show activation of Wnt and beta-catenin signaling downstream of the DC, Axin and USP34 were found to positively regulate beta-catenin-dependent transcription [XREF_BIBR] whereby USP34 supported the nuclear accumulation of Axin [XREF_BIBR]."

24975604

➶

reach

"For example, USP34 increases the stability of Axin, thereby promoting its nuclear accumulation (Lui et al., 2011)."

26189775

USP34 deubiquitinates AXIN.

| 1

USP34 deubiquitinates AXIN. 1 / 1

| 1

➶

reach

"UBPY and USP8 positively regulates the pathway by modifying Frizzled (Mukai et al., 2010), whereas USP34 deubiquitinates Axin and consequently works as a negative regulator of the WNT pathway (Lui et [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

26189775

USP34 binds AXIN.

| 1

AXIN binds USP34. 1 / 1

| 1

➶

reach

"XREF_BIBR - XREF_BIBR In addition, the deubiquitinating enzymes USP34 and USP7, CYLD and USP9X and USP4 can bind to Axin, Dvl and beta-catenin, respectively, thereby promoting the nuclear localization of beta-catenin and the Wnt signaling pathway by inhibiting their ubiquitination."

32140262

USP34 affects ATM

1 | 2 1

USP34 binds ATM. 4 / 4

1 | 2 1

➶

biogrid

No evidence text available

17478428

➶

sparser

"Immunoprecipitation demonstrated the interaction between USP34 and ATM."

37043976

➶

reach

"Immunoprecipitation demonstrated the interaction between USP34 and ATM."

37043976

➶

reach

"USP34 deficiency in macrophages promotes the onset of vitiligo with increased PMEL CD8 + T cell enrichment, and USP34/ATM complex can be considered as a therapy target."

37043976

Trichostatin A affects USP34

3 |

Trichostatin A decreases the amount of USP34.

2 |

Trichostatin A decreases the amount of USP34. 2 / 2

2 |

➶

ctd

No evidence text available

27188386

➶

ctd

No evidence text available

26272509

Trichostatin A increases the amount of USP34.

1 |

Trichostatin A increases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

24935251

USP34 affects SOX2

1 | 2

USP34 binds SOX2.

1 | 1

SOX2 binds USP34. 2 / 2

1 | 1

➶

biogrid

No evidence text available

23667531

➶

reach

"Moreover, USP34, as a deubiquitinase, could interact with SOX2, and reduce the polyubiquitination of SOX2."

32783291

USP34 decreases the amount of SOX2.

| 1

USP34 decreases the amount of SOX2. 1 / 1

| 1

➶

reach

"Usp9x KD but not Usp34 KD (XREF_FIG) reduced SOX2 levels in both BRAF mutant A375, SK-Mel28 (XREF_FIG), and NRAS-mutant SK-Mel147 (XREF_FIG) melanoma cell lines."

33613844

USP34 affects CTNNB1

| 3

USP34 inhibits CTNNB1.

| 1

USP34 inhibits CTNNB1. 1 / 1

| 1

➶

reach

"This indicates that USP34 suppresses Wnt and beta-catenin signaling, due to degradation of beta-catenin resulting from increased stability of AXIN1 [XREF_BIBR]."

32486158

USP34 decreases the amount of CTNNB1.

| 1

Modified USP34 decreases the amount of CTNNB1. 1 / 1

| 1

➶

reach

"Also, decreased USP34 expression resulted in decreased expression of AXIN1, and increased expression of beta-catenin."

32486158

USP34 binds CTNNB1.

| 1

USP34 binds CTNNB1. 1 / 1

| 1

➶

reach

32140262

RNF168 affects USP34

| 2 1

USP34 binds RNF168. 3 / 3

| 2 1

➶

reach

"USP34 also associates and stabilizes RNF168 especially after IR, thereby enhancing H2A and gammaH2AX ubiquitylation."

28764946

➶

reach

23863847

➶

sparser

23863847

NFIC affects USP34

| 2 1

NFIC binds USP34.

| 1 1

USP34 binds NFIC. 1 / 1

| 1

➶

sparser

"To uncover the molecular interaction between USP34 and NFIC, we transduced 293 T cells with Lv-NFIC and then performed co-IP analysis."

33686052

USP34 binds NFIC and 293T. 1 / 1

| 1

➶

reach

"To uncover the molecular interaction between USP34 and NFIC, we transduced 293T cells with Lv-NFIC and then performed co-IP analysis."

33686052

NFIC activates USP34.

| 1

NFIC activates USP34. 1 / 1

| 1

➶

reach

"Overexpression of NFIC partially rescues the odontogenic potential of USP34 deficient DPCs."

33686052

MYC affects USP34

3 |

MYC decreases the amount of USP34. 3 / 3

3 |

➶

biopax:msigdb

No evidence text available

➶

biopax:msigdb

No evidence text available

➶

biopax:msigdb

No evidence text available

CEBPA affects USP34

3 |

CEBPA decreases the amount of USP34. 3 / 3

3 |

➶

biopax:msigdb

No evidence text available

➶

biopax:msigdb

No evidence text available

➶

biopax:msigdb

No evidence text available

Valproic acid affects USP34

2 |

Valproic acid decreases the amount of USP34. 2 / 2

2 |

➶

ctd

No evidence text available

25192806

➶

ctd

No evidence text available

23179753

Succimer affects USP34

2 |

Succimer decreases the amount of USP34. 2 / 2

2 |

➶

ctd

No evidence text available

26378955

➶

ctd

No evidence text available

21641980

Magnetite nanoparticle affects USP34

2 |

Magnetite nanoparticle decreases the amount of USP34. 2 / 2

2 |

➶

ctd

No evidence text available

26378955

➶

ctd

No evidence text available

21641980

Formaldehyde affects USP34

2 |

Formaldehyde increases the amount of USP34.

1 |

Formaldehyde increases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

23649840

Formaldehyde decreases the amount of USP34.

1 |

Formaldehyde decreases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

20655997

Bisphenol A affects USP34

2 |

Bisphenol A methylates USP34.

1 |

Bisphenol A methylates USP34. 1 / 1

1 |

➶

ctd

No evidence text available

28505145

Bisphenol A decreases the amount of USP34.

1 |

Bisphenol A decreases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

30816183

Benzo[a]pyrene diol epoxide I affects USP34

2 |

Benzo[a]pyrene diol epoxide I decreases the amount of USP34. 2 / 2

2 |

➶

ctd

No evidence text available

19150397

➶

ctd

No evidence text available

20018196

Aflatoxin B1 affects USP34

2 |

Aflatoxin B1 increases the amount of USP34.

1 |

Aflatoxin B1 increases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

19770486

Aflatoxin B1 demethylates USP34.

1 |

Aflatoxin B1 demethylates USP34. 1 / 1

1 |

➶

ctd

No evidence text available

27153756

ZNF707 affects USP34

2 |

USP34 binds ZNF707. 2 / 2

2 |

➶

biogrid

No evidence text available

26186194

➶

biogrid

No evidence text available

28514442

Vehicle Emissions affects USP34

2 |

Vehicle Emissions increases the amount of USP34.

1 |

Vehicle Emissions increases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

27809917

Vehicle Emissions demethylates USP34.

1 |

Vehicle Emissions demethylates USP34. 1 / 1

1 |

➶

ctd

No evidence text available

25560391

USP34 affects tpa-1

| 2

Modified USP34 increases the amount of tpa-1. 1 / 1

| 1

➶

reach

"On the other hand, USP34 overexpressing remarkably up-regulated the expression of p-AKT and p-PKC in cells."

30686807

USP34 increases the amount of tpa-1. 1 / 1

| 1

➶

reach

"Subsequently, western blotting assay indicated that USP34 silencing significantly down-regulated the expression of p-AKT and p-PKC in cells."

30686807

USP34 affects cell differentiation

| 2

USP34 inhibits cell differentiation.

| 1

USP34 inhibits cell differentiation. 1 / 1

| 1

➶

reach

"The expression of USP34 in human MSCs increases after osteogenic induction while depletion of USP34 inhibits osteogenic differentiation."

30181118

USP34 activates cell differentiation.

| 1

USP34 activates cell differentiation. 1 / 1

| 1

➶

reach

"Importantly, USP34 modulates osteogenic differentiation and bone formation by regulating BMP2 signaling gradients (Guo et al., 2018)."

32582299

USP34 affects ZNF707

2 |

USP34 binds ZNF707. 2 / 2

2 |

➶

biogrid

No evidence text available

26186194

➶

biogrid

No evidence text available

28514442

USP34 affects Vitiligo

| 2

USP34 inhibits Vitiligo. 2 / 2

| 2

➶

reach

"USP34 deficiency in macrophages promotes the onset of vitiligo with increased PMEL CD8 + T cell enrichment, and USP34/ATM complex can be considered as a therapy target."

37043976

➶

reach

"It further revealed that USP34 deficiency promoted the development of vitiligo with increased PMEL CD8 + T cell enrichment, which was not affected by KU-55933 administration."

37043976

USP34 affects PNN

| 2

USP34 decreases the amount of PNN.

| 1

USP34 decreases the amount of PNN. 1 / 1

| 1

➶

reach

"Similarly as observed for Dpt, overexpressing USP34 significantly reduced Drs expression at 12 and 24hours after infection with the non pathogenic Gram positive bacteria Micrococcus luteus."

25027767

USP34 activates PNN.

| 1

USP34 activates PNN. 1 / 1

| 1

➶

reach

"However, while USP2 is also required to prevent excessive activation of the Imd pathway in infected flies, USP34 displays differential requirement depending on the antimicrobial peptide gene analysed : silencing Usp34 enhanced the activation of AttA, Drs and IM1."

25027767

USP34 affects PMEL

| 2

USP34 inhibits PMEL. 2 / 2

| 2

➶

reach

"USP34 deficiency in macrophages promotes the onset of vitiligo with increased PMEL CD8 + T cell enrichment, and USP34/ATM complex can be considered as a therapy target."

37043976

➶

reach

"It further revealed that USP34 deficiency promoted the development of vitiligo with increased PMEL CD8 + T cell enrichment, which was not affected by KU-55933 administration."

37043976

USP34 affects Histone

| 1 1

USP34 leads to the ubiquitination of Histone. 2 / 2

| 1 1

➶

reach

"USP34 promotes DNA damage induced histone ubiquitylation."

23863847

➶

sparser

"USP34 promotes DNA damage-induced histone ubiquitylation."

23863847

USP34 affects EIF3M

2 |

USP34 binds EIF3M. 2 / 2

2 |

➶

biogrid

No evidence text available

28514442

➶

biogrid

No evidence text available

26186194

USP34 affects CSNK1A1

2 |

USP34 binds CSNK1A1. 2 / 2

2 |

➶

biogrid

No evidence text available

23455922

➶

biogrid

No evidence text available

28514442

USP34 affects AXIN2

1 1 |

USP34 deubiquitinates AXIN2. 1 / 1

1 |

➶

ubibrowser

No evidence text available

USP34 deubiquitinates AXIN2 on lysine. 1 / 1

1 |

➶

biopax:reactome

No evidence text available

USP34 affects AKT

| 2

Modified USP34 increases the amount of phosphorylated AKT. 1 / 1

| 1

➶

reach

"On the other hand, USP34 overexpressing remarkably up-regulated the expression of p-AKT and p-PKC in cells."

30686807

USP34 increases the amount of phosphorylated AKT. 1 / 1

| 1

➶

reach

"Subsequently, western blotting assay indicated that USP34 silencing significantly down-regulated the expression of p-AKT and p-PKC in cells."

30686807

SOX2 affects USP34

1 | 1

SOX2 binds USP34. 2 / 2

1 | 1

➶

biogrid

No evidence text available

23667531

➶

reach

"Moreover, USP34, as a deubiquitinase, could interact with SOX2, and reduce the polyubiquitination of SOX2."

32783291

MAX affects USP34

2 |

MAX decreases the amount of USP34. 2 / 2

2 |

➶

biopax:msigdb

No evidence text available

➶

biopax:msigdb

No evidence text available

LEF1 affects USP34

2 |

LEF1 decreases the amount of USP34. 2 / 2

2 |

➶

biopax:msigdb

No evidence text available

➶

biopax:msigdb

No evidence text available

EIF3M affects USP34

2 |

USP34 binds EIF3M. 2 / 2

2 |

➶

biogrid

No evidence text available

28514442

➶

biogrid

No evidence text available

26186194

CTNNB1 affects USP34

| 2

CTNNB1 increases the amount of USP34.

| 1

CTNNB1 increases the amount of USP34. 1 / 1

| 1

➶

reach

"However, the authors also suggest that loss of USP34 inhibited beta-catenin mediated transcription indicating that USP34 may function downstream of beta-catenin to regulate nuclear accumulation of AXI[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

28923280

CTNNB1 binds USP34.

| 1

USP34 binds CTNNB1. 1 / 1

| 1

➶

reach

32140262

CSNK1A1 affects USP34

2 |

USP34 binds CSNK1A1. 2 / 2

2 |

➶

biogrid

No evidence text available

23455922

➶

biogrid

No evidence text available

28514442

3,4-methylenedioxymethamphetamine affects USP34

2 |

3,4-methylenedioxymethamphetamine decreases the amount of USP34. 2 / 2

2 |

➶

ctd

No evidence text available

20188158

➶

ctd

No evidence text available

26251327

2,3,7,8-tetrachlorodibenzodioxine affects USP34

2 |

2,3,7,8-tetrachlorodibenzodioxine decreases the amount of USP34. 2 / 2

2 |

➶

ctd

No evidence text available

21215274

➶

ctd

No evidence text available

19770486

Zinc protoporphyrin affects USP34

1 |

Zinc protoporphyrin increases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

22839698

Vorinostat affects USP34

1 |

Vorinostat decreases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

27188386

Vincristine affects USP34

1 |

Vincristine increases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

23649840

Tunicamycin affects USP34

1 |

Tunicamycin decreases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

17127020

Tungsten affects USP34

1 |

Tungsten decreases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

30912803

Topotecan affects USP34

1 |

Topotecan decreases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

25729387

Sunitinib affects USP34

1 |

Sunitinib increases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

31533062

Potassium dichromate affects USP34

1 |

Potassium dichromate decreases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

23608068

Potassium chromate affects USP34

1 |

Potassium chromate decreases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

22079256

Oxaliplatin affects USP34

1 |

Oxaliplatin decreases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

25729387

Miconazole affects USP34

1 |

Miconazole decreases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

27462272

Methylmercury chloride affects USP34

1 |

Methylmercury chloride decreases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

26272509

Methyl methanesulfonate affects USP34

1 |

Methyl methanesulfonate increases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

23649840

Lipopolysaccharide, E coli O55-B5 affects USP34

1 |

Lipopolysaccharide, E coli O55-B5 decreases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

24972896

Lead diacetate affects USP34

1 |

Lead diacetate increases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

22839698

Jinfukang affects USP34

1 |

Jinfukang decreases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

27392435

Indometacin affects USP34

1 |

Indometacin decreases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

28628672

Hsa-miR-485-5p affects USP34

1 |

Hsa-miR-485-5p decreases the amount of USP34. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24374217

Hsa-miR-23a-3p affects USP34

1 |

Hsa-miR-23a-3p decreases the amount of USP34. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23622248

Hsa-miR-218-5p affects USP34

1 |

Hsa-miR-218-5p decreases the amount of USP34. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23212916

Hsa-miR-21-5p affects USP34

1 |

Hsa-miR-21-5p decreases the amount of USP34. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

18591254

Hsa-miR-19b-3p affects USP34

1 |

Hsa-miR-19b-3p decreases the amount of USP34. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

22382630

Hsa-miR-192-5p affects USP34

1 |

Hsa-miR-192-5p decreases the amount of USP34. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

19074876

Hsa-miR-127-5p affects USP34

1 |

Hsa-miR-127-5p decreases the amount of USP34. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

24374217

Etoposide affects USP34

| 1

Etoposide activates USP34. 1 / 1

| 1

➶

reach

"Paralleling the situation with TCR, knocking down USP34 markedly increased NF-kappaB in cells treated with TNFalpha or etoposide."

23590831

Ethanol affects USP34

1 |

Ethanol decreases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

29018328

Doxorubicin affects USP34

1 |

Doxorubicin decreases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

29803840

Dorsomorphin affects USP34

1 |

Dorsomorphin decreases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

27188386

Dexamethasone affects USP34

1 |

Dexamethasone decreases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

28628672

Deubiquitinase affects USP34

| 1

USP34 binds deubiquitinase. 1 / 1

| 1

➶

isi

"Moreover, USP34, as a deubiquitinase, could interact with SOX2, and reduce the polyubiquitination of SOX2."

32783291

Decabromodiphenyl ether affects USP34

1 |

Decabromodiphenyl ether decreases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

23640034

Clobetasol affects USP34

1 |

Clobetasol decreases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

27462272

Cisplatin affects USP34

1 |

Cisplatin decreases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

27594783

Chlorpyrifos affects USP34

1 |

Chlorpyrifos decreases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

29156651

Cadmium dichloride affects USP34

1 |

Cadmium dichloride decreases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

24982889

Bisphenol F affects USP34

1 |

Bisphenol F decreases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

28628672

Bis(2-ethylhexyl) phthalate affects USP34

| 1

Bis(2-ethylhexyl) phthalate inhibits USP34. 1 / 1

| 1

➶

eidos

"In the present study , multiplex RT-PCR results showed that USP34 was downregulated by DEHP in OVCAR5 cells , which suggests a diminished ability to repair DNA damage and increase the risk of POF due to reductions in follicle numbers ."

32143396

Abrine affects USP34

1 |

Abrine decreases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

31054353

ZRANB2 affects USP34

1 |

ZRANB2 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

ZNRD2 affects USP34

1 |

ZNRD2 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

ZNF785 affects USP34

1 |

USP34 binds ZNF785. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

ZNF764 affects USP34

1 |

USP34 binds ZNF764. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

ZNF669 affects USP34

1 |

USP34 binds ZNF669. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

ZNF550 affects USP34

1 |

USP34 binds ZNF550. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

ZNF354C affects USP34

1 |

ZNF354C binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

ZNF214 affects USP34

1 |

ZNF214 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

ZNF211 affects USP34

1 |

ZNF211 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

ZHX2 affects USP34

1 |

ZHX2 decreases the amount of USP34. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

ZFYVE19 affects USP34

1 |

USP34 binds ZFYVE19. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

YP_009227205 affects USP34

1 |

USP34 binds YP_009227205. 1 / 1

1 |

➶

virhostnet

No evidence text available

30037810

Wnt affects USP34

| 1

Wnt binds USP34. 1 / 1

| 1

➶

sparser

31943775

WNT pathway–related protein affects USP34

| 1

USP34 binds WNT pathway–related protein. 1 / 1

| 1

➶

reach

"Lasted studies have reported that snoRNAs could directly bind to functional protein to promote tumorigenesis.48, 49 Therefore, we inferred that USP34 or SNORA70B might bind WNT pathway–related protein to activate it.In general, we identified a six‐snoRNA signature as an independent and specific indicator to diagnose and predict prognosis of ccRCC patients, providing a prospective diagnostic and prognostic biomarker and potential therapeutic targets for ccRCC."

31943775

WASHC4 affects USP34

1 |

USP34 binds WASHC4. 1 / 1

1 |

➶

biogrid

No evidence text available

22863883

VPS4B affects USP34

1 |

VPS4B binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP9X affects USP34

1 |

USP9X binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP8 affects USP34

| 1

USP8 binds USP34, Plasticin-L1, and ORF102. 1 / 1

| 1

➶

sparser

"Notably, SARS-CoV-2 ORF3 and ORF7a proteins interacted with USP8 and USP34, respectively [158]."

35625630

USP34-shRNA1 affects USP34

| 1

USP34-shRNA1 decreases the amount of USP34. 1 / 1

| 1

➶

reach

"According to the result of qRT-PCR and western blotting, USP34-shRNA1 significantly downregulated USP34 gene level in PANC-1 cell."

30686807

USP34 affects transcription, DNA-templated

| 1

USP34 inhibits transcription, DNA-templated. 1 / 1

| 1

➶

sparser

"However, the authors also suggest that loss of USP34 inhibited β-catenin mediated transcription indicating that USP34 may function downstream of β-catenin to regulate nuclear accumulation of AXIN ."

28923280

USP34 affects titanium

| 1

USP34 activates titanium. 1 / 1

| 1

➶

reach

"Taken together, our data demonstrate that specific deletion of Usp34 in mesenchymal stem cells impairs fixation of titanium implants in mice."

32363724

USP34 affects thrombin-p38

| 1

USP34 activates thrombin-p38. 1 / 1

| 1

➶

reach

"Currently, I am examining the impact of USP34-mediated modulation of thrombin-p38 signaling on endothelial inflammatory responses."

35554628

USP34 affects stemness

| 1

USP34 inhibits stemness. 1 / 1

| 1

➶

eidos

"Inhibition of USP34 induces EMT and stemness in mammary epithelial cells [ 63 ] ."

31133011

USP34 affects signal transduction

| 1

USP34 activates signal transduction. 1 / 1

| 1

➶

reach

"Finally, we found the SNORA70B and its hose gene USP34 might directly regulate Wnt signalling pathway to promote tumorigenesis in ccRCC."

31943775

USP34 affects polyubiquitination SOX2

| 1

USP34 inhibits polyubiquitination SOX2. 1 / 1

| 1

➶

eidos

"Moreover , USP34 , as a deubiquitinase , could interact with SOX2 , and reduce the polyubiquitination of SOX2 ."

32783291

USP34 affects osteogenic differentiation

| 1

USP34 activates osteogenic differentiation. 1 / 1

| 1

➶

eidos

"A study has shown that USP34 promotes osteogenic differentiation by activating Smad1 / 5/8 and stabilizing the transcription factor RUNX2 ( Guo et al ., 2020 ) ."

36340031

USP34 affects ossification

| 1

USP34 activates ossification. 1 / 1

| 1

➶

reach

"Importantly, USP34 modulates osteogenic differentiation and bone formation by regulating BMP2 signaling gradients (Guo et al., 2018)."

32582299

USP34 affects more resistance drug treatment

| 1

USP34 activates more resistance drug treatment. 1 / 1

| 1

➶

eidos

"USP34 inhibits EMT and cancer stemness and may therefore induce more resistance to the drug treatment [ 102 ] ."

31133011

USP34 affects epithelial to mesenchymal transition

| 1

USP34 inhibits epithelial to mesenchymal transition. 1 / 1

| 1

➶

eidos

"Inhibition of USP34 induces EMT and stemness in mammary epithelial cells [ 63 ] ."

31133011

USP34 affects drug sensitivity cisplatin resistant cells

| 1

USP34 inhibits drug sensitivity cisplatin resistant cells. 1 / 1

| 1

➶

eidos

"Finally , we also found that USP34 and SOX2 were upregulated in cisplatin-resistant LSCC cells , but knockdown of USP34 could enhance the drug sensitivity of cisplatin in the resistant cells ."

32783291

USP34 affects disulfur

| 1

USP34 inhibits disulfur. 1 / 1

| 1

➶

reach

"USP34 inhibits the Toll pathway in S2 cells."

25027767

USP34 affects deubiquitination remains uncharacterized

| 1

USP34 activates deubiquitination remains uncharacterized. 1 / 1

| 1

➶

eidos

"Despite its functional importance , how USP34 recognizes ubiquitin and catalyzes deubiquitination remains structurally uncharacterized ."

35588869

USP34 affects deubiquitinase

| 1

USP34 binds deubiquitinase. 1 / 1

| 1

➶

isi

"Moreover, USP34, as a deubiquitinase, could interact with SOX2, and reduce the polyubiquitination of SOX2."

32783291

USP34 affects dental mesenchymal cells undergo odontogenic differentiation deubiquitination

| 1

USP34 activates dental mesenchymal cells undergo odontogenic differentiation deubiquitination. 1 / 1

| 1

➶

eidos

"Conclusion In summary , we showed that USP34 regulates root morphogenesis and promotes dental mesenchymal cells to undergo odontogenic differentiation through deubiquitination and stabilizes NFIC ."

33686052

USP34 affects cell growth

| 1

USP34 activates cell growth. 1 / 1

| 1

➶

reach

"In addition, knockdown of USP34 could significantly inhibit LSCC cell growth, but overexpression of SOX2 could reverse this effect."

32783291

USP34 affects apoptotic process

| 1

USP34 activates apoptotic process. 1 / 1

| 1

➶

reach

"In this study, downregulation of USP34 markedly inhibited proliferation and migration, and induced apoptosis in PANC-1 cells."

32110045

USP34 affects ZRANB2

1 |

ZRANB2 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects ZNRD2

1 |

ZNRD2 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects ZNF785

1 |

USP34 binds ZNF785. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

USP34 affects ZNF764

1 |

USP34 binds ZNF764. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

USP34 affects ZNF669

1 |

USP34 binds ZNF669. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

USP34 affects ZNF550

1 |

USP34 binds ZNF550. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

USP34 affects ZNF354C

1 |

ZNF354C binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

USP34 affects ZNF214

1 |

ZNF214 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

USP34 affects ZNF211

1 |

ZNF211 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

USP34 affects ZFYVE19

1 |

USP34 binds ZFYVE19. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects YP_009227205

1 |

USP34 binds YP_009227205. 1 / 1

1 |

➶

virhostnet

No evidence text available

30037810

USP34 affects Wnt beta-catenin signaling

| 1

USP34 activates Wnt beta-catenin signaling. 1 / 1

| 1

➶

eidos

"USP34 has been shown to promote Wnt / beta-catenin signaling , which has an important role in several human cancers ( Lui et al ., 2011 ) ."

31410080

USP34 affects WNT pathway–related protein

| 1

USP34 binds WNT pathway–related protein. 1 / 1

| 1

➶

reach

31943775

USP34 affects WASHC4

1 |

USP34 binds WASHC4. 1 / 1

1 |

➶

biogrid

No evidence text available

22863883

USP34 affects VPS4B

1 |

VPS4B binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects USP9X

1 |

USP9X binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects USP8

| 1

USP8 binds USP34, Plasticin-L1, and ORF102. 1 / 1

| 1

➶

sparser

"Notably, SARS-CoV-2 ORF3 and ORF7a proteins interacted with USP8 and USP34, respectively [158]."

35625630

USP34 affects UNK

1 |

USP34 binds UNK. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects UFM1

1 |

USP34 binds UFM1. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects UFC1

1 |

USP34 binds UFC1. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects UCHL3

1 |

UCHL3 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects UBXN7

1 |

USP34 binds UBXN7. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects UBXN1

1 |

UBXN1 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects UBQLN4

1 |

UBQLN4 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects UBQLN2

1 |

UBQLN2 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects UBQLN1

1 |

UBQLN1 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects UBL7

1 |

USP34 binds UBL7. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects UBE4B

1 |

UBE4B binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects UBE2V2

1 |

UBE2V2 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects UBE2V1

1 |

UBE2V1 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects UBE2L3

1 |

UBE2L3 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects UBE2D1

1 |

UBE2D1 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects UBE2C

1 |

UBE2C binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects UBA2

1 |

USP34 binds UBA2. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects Toll

| 1

USP34 inhibits Toll. 1 / 1

| 1

➶

reach

"Moreover, USP34 is also necessary to prevent constitutive activation of the Toll pathway."

25027767

USP34 affects TTLL12

1 |

USP34 binds TTLL12. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects TSPYL6

1 |

TSPYL6 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

USP34 affects TRIM25

1 |

TRIM25 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

29117863

USP34 affects TCR

| 1

USP34 inhibits TCR. 1 / 1

| 1

➶

reach

"Another deubiquitinase, USP34, has been shown to inhibit TCR and CD28 stimulated NF-kappaB activation in the Jurkat T-cell line."

26260210

USP34 affects SUV39H1

1 |

SUV39H1 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

USP34 affects SULT1A1

1 |

SULT1A1 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects STAM

1 |

STAM binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects SRXN1

1 |

SRXN1 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects SP7

| 1

USP34 activates SP7. 1 / 1

| 1

➶

eidos

"Depletion of USP34 in DPCs also led to decreased expression of SP7 and DSPP , the downstream targets of NFIC ( Fig. 3d ) ."

33686052

USP34 affects SNRNP200

1 |

USP34 binds SNRNP200. 1 / 1

1 |

➶

biogrid

No evidence text available

22863883

USP34 affects SMAD1

| 1

USP34 activates SMAD1. 1 / 1

| 1

➶

eidos

"USP34 can activate Smad1 / 5/8 to enhance BMP signaling ."

36340031

USP34 affects SLPI

| 1

USP34 inhibits SLPI. 1 / 1

| 1

➶

reach

"Depeletion of USP34 inhibited the ALP activity and ARS staining."

33686052

USP34 affects SIRT7

1 |

SIRT7 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22586326

USP34 affects SEC24A

1 |

SEC24A binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects Radiation, Ionizing

| 1

USP34 inhibits Radiation, Ionizing. 1 / 1

| 1

➶

reach

30831436

USP34 affects RNF8

| 1

RNF8 binds USP34. 1 / 1

| 1

➶

sparser

23863847

USP34 affects RIEG2

| 1

USP34 inhibits RIEG2. 1 / 1

| 1

➶

reach

"Depeletion of USP34 inhibited the ALP activity and ARS staining."

33686052

USP34 affects RBM3

1 |

USP34 binds RBM3. 1 / 1

1 |

➶

biogrid

No evidence text available

26472337

USP34 affects Plasticin-L1

| 1

USP8 binds USP34, Plasticin-L1, and ORF102. 1 / 1

| 1

➶

sparser

"Notably, SARS-CoV-2 ORF3 and ORF7a proteins interacted with USP8 and USP34, respectively [158]."

35625630

USP34 affects Pdfr

| 1

USP34 binds Pdfr. 1 / 1

| 1

➶

sparser

"USP34 gene polymorphisms (rs17008097 and rs17008940) may not be associated with PCOS in the Han Chinese women."

25975428

USP34 affects PRR11

| 1

USP34 increases the amount of PRR11. 1 / 1

| 1

➶

reach

"Moreover, silencing of USP34 obviously downregulated the levels of PRR11 and p-p38 in PANC-1 cells."

32110045

USP34 affects PP38

| 1

USP34 increases the amount of PP38. 1 / 1

| 1

➶

reach

"Moreover, silencing of USP34 obviously downregulated the levels of PRR11 and p-p38 in PANC-1 cells."

32110045

USP34 affects POU5F1

1 |

USP34 binds POU5F1. 1 / 1

1 |

➶

biogrid

No evidence text available

26687479

USP34 affects PCGF1

1 |

PCGF1 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

26687479

USP34 affects ORF102

| 1

USP8 binds USP34, Plasticin-L1, and ORF102. 1 / 1

| 1

➶

sparser

"Notably, SARS-CoV-2 ORF3 and ORF7a proteins interacted with USP8 and USP34, respectively [158]."

35625630

USP34 affects NFKBIA

| 1

USP34 activates NFKBIA. 1 / 1

| 1

➶

reach

"USP34 knockdown in Jurkat cells promotes mitogen stimulated IkappaBalpha degradation without enhancing IKK activation, suggesting that this deubiquitinase may modulate the proteolytic process involved in IkappaBalpha degradation."

26260210

USP34 affects NANOG

1 |

USP34 binds NANOG. 1 / 1

1 |

➶

biogrid

No evidence text available

26687479

USP34 affects MTNR1B

1 |

USP34 binds MTNR1B. 1 / 1

1 |

➶

biogrid

No evidence text available

26514267

USP34 affects MTNR1A

1 |

USP34 binds MTNR1A. 1 / 1

1 |

➶

biogrid

No evidence text available

26514267

USP34 affects M

1 |

USP34 binds M. 1 / 1

1 |

➶

virhostnet

No evidence text available

26789921

USP34 affects LYPD4

1 |

USP34 binds LYPD4. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

USP34 affects LSCC cell growth

| 1

USP34 activates LSCC cell growth. 1 / 1

| 1

➶

eidos

"In addition , knockdown of USP34 could significantly inhibit LSCC cell growth , but overexpression of SOX2 could reverse this effect ."

32783291

USP34 affects LAGE3

1 |

USP34 binds LAGE3. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects Imd

| 1

USP34 inhibits Imd. 1 / 1

| 1

➶

reach

"We report here that USP2 and USP34 and Puf, in addition to the previously described USP36 and Scny, prevent inappropriate activation of Imd dependent immune signal in unchallenged conditions."

25027767

USP34 affects IL12

| 1

USP34 inhibits IL12. 1 / 1

| 1

➶

reach

"USP34 deficiency or KU-55933 administration promoted the induction of Ccl2, Ccl5, Il12α, and p-IKKα/β in LPS or CpG stimulated BMDMs; KU-55933 administration could not affect the expression of the above molecules in USP34 deficient BMDMs."

37043976

USP34 affects HSP90B1

| 1

HSP90B1 binds USP34 and HMGN2. 1 / 1

| 1

➶

sparser

"The expressions of HSP90B1, USP34 and HMGN2 were significantly negatively associated with tumour grade (p<0.001)."

22363530

USP34 affects H4atta

| 1

USP34 activates H4atta. 1 / 1

| 1

➶

reach

25027767

USP34 affects ERMAP

1 |

ERMAP binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

USP34 affects EPHA1

1 |

USP34 binds EPHA1. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

USP34 affects EMT

| 1

USP34 inhibits EMT. 1 / 1

| 1

➶

reach

28499884

USP34 affects EMT cancer stemness

| 1

USP34 inhibits EMT cancer stemness. 1 / 1

| 1

➶

eidos

"USP34 inhibits EMT and cancer stemness and may therefore induce more resistance to the drug treatment [ 102 ] ."

31133011

USP34 affects ELP2

1 |

ELP2 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22863883

USP34 affects EGFR

1 |

USP34 binds EGFR. 1 / 1

1 |

➶

biogrid

No evidence text available

28065597

USP34 affects DVL

| 1

DVL binds USP34. 1 / 1

| 1

➶

reach

32140262

USP34 affects DPPA4

1 |

DPPA4 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

26687479

USP34 affects DNA repair

| 1

USP34 activates DNA repair. 1 / 1

| 1

➶

reach

"Usp5, Usp34, and Otu1 deubiquitylases mediate DNA repair in Drosophila melanogaster."

35393473

USP34 affects DNA Damage

| 1

USP34 activates DNA Damage. 1 / 1

| 1

➶

reach

"USP34 promotes cellular responses to DNA damage."

23863847

USP34 affects Carcinogenesis

| 1

USP34 activates Carcinogenesis. 1 / 1

| 1

➶

reach

"Finally, we found the SNORA70B and its hose gene USP34 might directly regulate Wnt signalling pathway to promote tumorigenesis in ccRCC."

31943775

USP34 affects CFTR

| 1

USP34 deubiquitinates CFTR. 1 / 1

| 1

➶

reach

"For example, in this and a previous study we observed that neither USP34, nor USP8 deubiquitinate CFTR, and only USP10 activity was inhibited by Cif XREF_BIBR, XREF_BIBR."

21455491

USP34 affects CDH1

| 1

USP34 inhibits CDH1. 1 / 1

| 1

➶

reach

28499884

USP34 affects CD2AP

1 |

CD2AP binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22863883

USP34 affects CD28

| 1

USP34 inhibits CD28. 1 / 1

| 1

➶

reach

"Another deubiquitinase, USP34, has been shown to inhibit TCR and CD28 stimulated NF-kappaB activation in the Jurkat T-cell line."

26260210

USP34 affects CCL5

| 1

USP34 inhibits CCL5. 1 / 1

| 1

➶

reach

37043976

USP34 affects CCL2

| 1

USP34 inhibits CCL2. 1 / 1

| 1

➶

reach

37043976

USP34 affects Bom1

| 1

USP34 activates Bom1. 1 / 1

| 1

➶

reach

25027767

USP34 affects ATP6V1B2

1 |

USP34 binds ATP6V1B2. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects AMFR

| 1

USP34 activates AMFR. 1 / 1

| 1

➶

reach

"We demonstrate that knockdown of USP34 facilitates proteasomal degradation of gp78 and consequently impairs the function of gp78 in regulating lipid droplet formation."

30585151

USP34 affects AHCYL1

1 |

USP34 binds AHCYL1. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

USP34 affects 293T

| 1

USP34 binds NFIC and 293T. 1 / 1

| 1

➶

reach

"To uncover the molecular interaction between USP34 and NFIC, we transduced 293T cells with Lv-NFIC and then performed co-IP analysis."

33686052

UNK affects USP34

1 |

USP34 binds UNK. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

UFM1 affects USP34

1 |

USP34 binds UFM1. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

UFC1 affects USP34

1 |

USP34 binds UFC1. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

UCHL3 affects USP34

1 |

UCHL3 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

UBXN7 affects USP34

1 |

USP34 binds UBXN7. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

UBXN1 affects USP34

1 |

UBXN1 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

UBQLN4 affects USP34

1 |

UBQLN4 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

UBQLN2 affects USP34

1 |

UBQLN2 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

UBQLN1 affects USP34

1 |

UBQLN1 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

UBL7 affects USP34

1 |

USP34 binds UBL7. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

UBE4B affects USP34

1 |

UBE4B binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

UBE2V2 affects USP34

1 |

UBE2V2 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

UBE2V1 affects USP34

1 |

UBE2V1 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

UBE2L3 affects USP34

1 |

UBE2L3 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

UBE2D1 affects USP34

1 |

UBE2D1 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

UBE2C affects USP34

1 |

UBE2C binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

UBA2 affects USP34

1 |

USP34 binds UBA2. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

TTLL12 affects USP34

1 |

USP34 binds TTLL12. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

TSPYL6 affects USP34

1 |

TSPYL6 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

TRIM25 affects USP34

1 |

TRIM25 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

29117863

TCR affects USP34

| 1

TCR activates USP34. 1 / 1

| 1

➶

reach

"Consistent with the primary screening, NF-kappaB reporter activity was similarly boosted upon TCR stimulation in USP34- and CYLD silenced Jurkat when compared to control non targeting siRNA transfected cells."

23590831

TCF4 affects USP34

1 |

TCF4 decreases the amount of USP34. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

SUV39H1 affects USP34

1 |

SUV39H1 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

SULT1A1 affects USP34

1 |

SULT1A1 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

STAM affects USP34

1 |

STAM binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

SRXN1 affects USP34

1 |

SRXN1 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

SNRNP200 affects USP34

1 |

USP34 binds SNRNP200. 1 / 1

1 |

➶

biogrid

No evidence text available

22863883

SIRT7 affects USP34

1 |

SIRT7 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22586326

SEC24A affects USP34

1 |

SEC24A binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

RNF8 affects USP34

| 1

RNF8 binds USP34. 1 / 1

| 1

➶

sparser

23863847

RBM3 affects USP34

1 |

USP34 binds RBM3. 1 / 1

1 |

➶

biogrid

No evidence text available

26472337

Plasticin-L1 affects USP8

| 1

USP8 binds USP34, Plasticin-L1, and ORF102. 1 / 1

| 1

➶

sparser

"Notably, SARS-CoV-2 ORF3 and ORF7a proteins interacted with USP8 and USP34, respectively [158]."

35625630

Phthalic Acids affects USP34

1 |

Phthalic Acids increases the amount of USP34. 1 / 1

1 |

➶

ctd

No evidence text available

21061450

Pdfr affects USP34

| 1

USP34 binds Pdfr. 1 / 1

| 1

➶

sparser

"USP34 gene polymorphisms (rs17008097 and rs17008940) may not be associated with PCOS in the Han Chinese women."

25975428

POU5F1 affects USP34

1 |

USP34 binds POU5F1. 1 / 1

1 |

➶

biogrid

No evidence text available

26687479

PLAGL2 affects USP34

| 1

PLAGL2 increases the amount of USP34. 1 / 1

| 1

➶

reach

"PLAGL2 also activates the expression of USP34 deubiqutinase that in turn stabilizes Snail1 and promotes proliferation and migration of gastric cancer cells [63]."

35563824

PCGF1 affects USP34

1 |

PCGF1 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

26687479

ORF102 affects USP8

| 1

USP8 binds USP34, Plasticin-L1, and ORF102. 1 / 1

| 1

➶

sparser

"Notably, SARS-CoV-2 ORF3 and ORF7a proteins interacted with USP8 and USP34, respectively [158]."

35625630

NR6A1 affects USP34

1 |

NR6A1 decreases the amount of USP34. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

NFkappaB affects USP34

| 1

NFkappaB binds USP34. 1 / 1

| 1

➶

sparser

23590831

NFIC affects 293T

| 1

USP34 binds NFIC and 293T. 1 / 1

| 1

➶

reach

"To uncover the molecular interaction between USP34 and NFIC, we transduced 293T cells with Lv-NFIC and then performed co-IP analysis."

33686052

NFE2L1 affects USP34

1 |

NFE2L1 decreases the amount of USP34. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

NANOG affects USP34

1 |

USP34 binds NANOG. 1 / 1

1 |

➶

biogrid

No evidence text available

26687479

MYCN affects USP34

1 |

MYCN decreases the amount of USP34. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

MTNR1B affects USP34

1 |

USP34 binds MTNR1B. 1 / 1

1 |

➶

biogrid

No evidence text available

26514267

MTNR1A affects USP34

1 |

USP34 binds MTNR1A. 1 / 1

1 |

➶

biogrid

No evidence text available

26514267

MAFG affects USP34

1 |

MAFG decreases the amount of USP34. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

M affects USP34

1 |

USP34 binds M. 1 / 1

1 |

➶

virhostnet

No evidence text available

26789921

LYPD4 affects USP34

1 |

USP34 binds LYPD4. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

LAGE3 affects USP34

1 |

USP34 binds LAGE3. 1 / 1

1 |

➶

biogrid

No evidence text available

22939629

HSP90B1 affects USP34

| 1

HSP90B1 binds USP34 and HMGN2. 1 / 1

| 1

➶

sparser

"The expressions of HSP90B1, USP34 and HMGN2 were significantly negatively associated with tumour grade (p<0.001)."

22363530

HSF1 affects USP34

1 |

HSF1 decreases the amount of USP34. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

HMGN2 affects USP34

| 1

HSP90B1 binds USP34 and HMGN2. 1 / 1

| 1

➶

sparser

"The expressions of HSP90B1, USP34 and HMGN2 were significantly negatively associated with tumour grade (p<0.001)."

22363530

FOXF2 affects USP34

1 |

FOXF2 decreases the amount of USP34. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

FOXD1 affects USP34

1 |

FOXD1 decreases the amount of USP34. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

ERMAP affects USP34

1 |

ERMAP binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

EPHA1 affects USP34

1 |

USP34 binds EPHA1. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

ELP2 affects USP34

1 |

ELP2 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

22863883

EGFR affects USP34

1 |

USP34 binds EGFR. 1 / 1

1 |

➶

biogrid

No evidence text available

28065597

DVL affects USP34

| 1

DVL binds USP34. 1 / 1

| 1

➶

reach

32140262

DPPA4 affects USP34

1 |

DPPA4 binds USP34. 1 / 1

1 |

➶

biogrid

No evidence text available

26687479

DEHP exposure dose-dependent manner affects USP34

| 1

DEHP exposure dose-dependent manner inhibits USP34. 1 / 1

| 1

➶

eidos

"The results showed that the mRNA levels of USP12 , COPS5 , ATXN3L , and USP49 were increased in A2780 cells ( Figure 1 and Figure S1 ) , and that the mRNA level of USP49 was increased and that of USP34 was decreased in OVCAR5 cells ( Figure 2 and Figure S2 ) by DEHP exposure in a dose-dependent manner ."

32143396