IndraLab

Statements

USP38 affects Zika Virus Infection
| 4 2
USP38 inhibits Zika Virus Infection. 6 / 6
| 4 2
eidos
"USP38 Inhibits Zika Virus Infection by Removing Envelope Protein Ubiquitination ."
34696459
reach
"In addition, we found that the deubiquitinase activity of USP38 was essential to inhibit ZIKV infection, and the mutant that lacked the deubiquitinase activity of USP38 lost the ability to inhibit infection."
34696459
eidos
"USP38 Inhibits Zika Virus Infection by Removing Envelope Protein Ubiquitination Zika virus ( ZIKV ) is a mosquito-borne flavivirus , and its infection may cause severe neurodegenerative diseases ."
| PMC
reach
"USP38 Inhibits Zika Virus Infection by Removing Envelope Protein Ubiquitination."
34696459
eidos
"These results demonstrate that ZIKV infection was repressed by USP38 ."
| PMC
eidos
"USP38 Binds to E Protein through Its C-Terminal Domain Next , the mechanism by which USP38 represses ZIKV infection was explored ."
| PMC
USP38 affects Histone
| 5
USP38 acetylates Histone.
| 3
USP38 leads to the acetylation of Histone. 3 / 3
| 3
reach
"Hence, our data indicated that USP38 functions as a deubiquitinase of HDAC3 to modulate the acetylation of histones and regulate gene expression."
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reach
"USP38 modulates histone acetylation."
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"Taken together, our data indicated that USP38 modulates histone acetylation via regulating histone deacetylases."
32404892
USP38 activates Histone.
| 2
USP38 activates Histone. 2 / 2
| 2
reach
"Taken together, our data demonstrated that HDAC3 is functional responsible for USP38 mediated histone modifications, which further controls the expression of cancer stem cell related genes."
32404892
reach
"Next, we analyzed the expression level of HDACs in control, USP38 knockdown, and overexpressing HCT116 cells to determine which HDAC is responsible for USP38 mediated histone modification."
32404892
USP38 activates cell population proliferation. 4 / 4
| 1 3
reach
"The deubiquitinase USP38 promotes cell proliferation through stabilizing c-Myc."
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reach
"Functionally, USP38 is able to promote cell proliferation via a c-Myc dependent manner."
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eidos
"Functionally , USP38 is able to promote cell proliferation via a c-Myc dependent manner ."
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reach
"In this research, we found that USP38 was overexpressed in GC tissues, and USP38 contributed to GC cell proliferation, migration and tumorigenesis."
35812059
USP38 affects TBK1
1 | 2
USP38 ubiquitinates TBK1.
| 1
USP38 ubiquitinates TBK1. 1 / 1
| 1
reach
"The Ub-specific protease 38 (USP38), TRAF-interacting protein (TRIP), Nod-like receptor (NLR) family pyrin domain containing 4 (NLRP4), and DTX4 complex polyubiquitinates TBK1, thereby degrading it to limit the virus-induced IFN-I signaling pathway (Cui et al., 2012)."
34513839
USP38 inhibits TBK1.
| 1
USP38 inhibits TBK1. 1 / 1
| 1
reach
"Similarly, USP38 negatively regulates IFN-I signaling by targeting the active form of TBK1 for degradation in vitro and in vivo (101)."
34707613
USP38 deubiquitinates TBK1.
1 |
USP38 deubiquitinates TBK1. 1 / 1
1 |
ubibrowser
"Here we report that USP38 negatively regulates type I IFN signaling by targeting the active form of TBK1 for degradation in vitro and in vivo."
27692986
USP38 affects HDAC1
| 3
USP38 inhibits HDAC1.
| 1
Modified USP38 inhibits HDAC1. 1 / 1
| 1
reach
"Importantly, we found that USP38 overexpression significantly decreased the ubiquitination level of HDAC3 but not HDAC1 and had no effect on the overall protein level of HDAC3 and HDAC1."
32404892
USP38 binds HDAC1.
| 1
USP38 binds HDAC1 and K63. 1 / 1
| 1
reach
"In response to DNA damage, USP38 interacted with HDAC1 and specifically removed the K63 linked ubiquitin chain promoting the deacetylase activity of HDAC1."
31874856
USP38 activates HDAC1.
| 1
USP38 bound to K63 and HDAC1 activates HDAC1. 1 / 1
| 1
reach
"In response to DNA damage, USP38 interacted with HDAC1 and specifically removed the K63 linked ubiquitin chain promoting the deacetylase activity of HDAC1."
31874856
USP38 affects FBW7alpha
| 3
USP38 inhibits FBW7alpha.
| 2
USP38 inhibits FBW7alpha. 1 / 1
| 1
reach
"Furthermore, USP38 can restore the inhibitory effect of FBW7alpha on proliferation."
34102342
USP38 bound to FBW7alpha inhibits FBW7alpha. 1 / 1
| 1
reach
"Mechanistically, USP38 physically interacts with FBW7alpha and abolishes FBW7alpha mediated degradation of c-Myc."
34102342
USP38 binds FBW7alpha.
| 1
USP38 binds FBW7alpha. 1 / 1
| 1
reach
"Mechanistically, USP38 physically interacts with FBW7alpha and abolishes FBW7alpha mediated degradation of c-Myc."
34102342
Valproic acid affects USP38
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Valproic acid increases the amount of USP38.
1 |
Valproic acid increases the amount of USP38. 1 / 1
1 |
ctd
No evidence text available
29154799
Valproic acid demethylates USP38.
1 |
Valproic acid demethylates USP38. 1 / 1
1 |
ctd
No evidence text available
29154799
Pirinixic acid affects USP38
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Pirinixic acid increases the amount of USP38. 2 / 2
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ctd
No evidence text available
18301758
ctd
No evidence text available
21318169
Methylmercury chloride increases the amount of USP38.
1 |
Methylmercury chloride increases the amount of USP38. 1 / 1
1 |
ctd
No evidence text available
20061341
Methylmercury chloride decreases the amount of USP38.
1 |
Methylmercury chloride decreases the amount of USP38. 1 / 1
1 |
ctd
No evidence text available
28001369
Bisphenol A affects USP38
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Bisphenol A increases the amount of USP38. 2 / 2
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ctd
No evidence text available
30816183
ctd
No evidence text available
26063408
USP38 affects cell growth
| 2
USP38 inhibits cell growth.
| 1
USP38 inhibits cell growth. 1 / 1
| 1
reach
"USP38 inhibits colorectal cancer cell growth in vivo and in vitro."
32404892
USP38 activates cell growth.
| 1
USP38 activates cell growth. 1 / 1
| 1
reach
"Furthermore, FASN was critical for GC cell growth, migration and tumor development triggered by USP38 overexpression because its inhibitor orilistat reversed phenotypes in USP38 overexpressed GC cells."
35812059
USP38 affects Stomach Neoplasms
| 1 1
eidos
"Ubiquitin specific peptidase 38 promotes the progression of gastric cancer through upregulation of fatty acid synthase ."
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reach
"Furthermore, FASN was critical for GC cell growth, migration and tumor development triggered by USP38 overexpression because its inhibitor orilistat reversed phenotypes in USP38 overexpressed GC cells."
35812059
USP38 affects MYC
| 2
USP38 inhibits MYC.
| 1
USP38 bound to FBW7alpha inhibits MYC. 1 / 1
| 1
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"Mechanistically, USP38 physically interacts with FBW7alpha and abolishes FBW7alpha mediated degradation of c-Myc."
34102342
USP38 deubiquitinates MYC.
| 1
USP38 leads to the deubiquitination of MYC. 1 / 1
| 1
reach
"USP38 can inhibit the polyubiquitination of c-Myc, thereby increasing c-Myc stability."
34102342
USP38 affects KDM1A
| 2
KDM1A binds USP38. 2 / 2
| 2
sparser
"Therefore, we could not perform pull-down test to prove the direct interaction between USP38 and LSD1."
30497519
sparser
"Thus, USP38 promotes the colony formation ability of HCT116 cells through the interaction between USP38 and LSD1."
30497519
USP38 affects JUNB
| 2
USP38 activates JUNB. 2 / 2
| 2
reach
"USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein."
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reach
"Mechanistically, USP38 directly associated with JunB, deubiquitinated Lys-48-linked poly-ubiquitination of JunB, and consequently blocked TCR induced JunB turnover."
30224386
USP38 affects Interferon
| 2
USP38 inhibits Interferon. 2 / 2
| 2
reach
"USP38 Inhibits Type I Interferon Signaling by Editing TBK1Ubiquitination through NLRP4 Signalosome."
27692986
reach
"Here we report that USP38 negatively regulates type I IFN signaling by targeting the active form of TBK1 for degradation invitro and invivo."
27692986
USP38 affects H1-3
2 |
USP38 binds H1-3. 2 / 2
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biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
USP38 affects GST
| 2
GST binds USP38. 2 / 2
| 2
sparser
"The molecular weight of USP38 is 116 kDa, making the molecular weight of the fusion protein GST-USP38 larger, approximately 137 kDa, and thus it is very difficult for bacteria to express GST-USP38 ectopically."
30497519
sparser
"However, we do not know whether this interaction is direct or indirect, because we could not induce the prokaryote Escherichia coli to express the fusion protein GST-USP38."
30497519
USP38 affects E
| 2
E binds USP38. 2 / 2
| 2
sparser
"More detailed truncation results showed that USP38 binds to 132–193aa of E protein ( xref I)."
| PMC
sparser
"Collectively, our results suggested that USP38 binds to the 132–193aa of E protein through its C-terminal domain."
| PMC
USP38 affects E protein polyubiquitination
| 2
USP38 inhibits E protein polyubiquitination. 2 / 2
| 2
eidos
"Notably , ZIKV E protein polyubiquitination was catalyzed significantly by Myc-UB , catalyzed slightly by K48R or K63R , and the levels of E protein polyubiquitination were repressed by USP38 ( Figure 3D ) ."
| PMC
eidos
"Meanwhile , USP38 decreased E protein polyubiquitination ."
| PMC
USP38 affects Carcinogenesis
| 1 1
USP38 activates Carcinogenesis. 2 / 2
| 1 1
reach
"In this research, we found that USP38 was overexpressed in GC tissues, and USP38 contributed to GC cell proliferation, migration and tumorigenesis."
35812059
eidos
"In this research , we found that USP38 was overexpressed in GC tissues , and USP38 contributed to GC cell proliferation , migration and tumorigenesis ."
35812059
USP38 affects CD133
| 2
USP38 inhibits CD133.
| 1
USP38 inhibits CD133. 1 / 1
| 1
reach
"In both HCT116 and SW620 cells, simultaneous knockdown of USP38 and HDAC3 attenuated the decreased H3K27ac level and increased CD44 and CD133."
32404892
USP38 activates CD133.
| 1
USP38 activates CD133. 1 / 1
| 1
reach
"Surprisingly, our results showed that Aza treatment had no effect on USP38 mediated regulation of genes, while TSA treatment abolished USP38 mediated CD133, SOX2, and NANOG inhibition, suggesting that USP38 regulates CD133 via histone acetylation."
32404892
USP38 affects AHSG
2 |
USP38 binds AHSG. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
USP38 affects ADAR
2 |
USP38 binds ADAR. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
METTL14 affects USP38
| 2
METTL14 inhibits USP38.
| 1
METTL14 inhibits USP38. 1 / 1
| 1
reach
"METTL14 represses BCa cell migration, invasion and EMT via USP38."
36288387
METTL14 activates USP38.
| 1
METTL14 activates USP38. 1 / 1
| 1
reach
"METTL14 stabilizes USP38 mRNA by inducing N6-methyladenosine (m6A) modification and enhances USP38 mRNA stability in YTHDF2-dependent manner."
36288387
KDM1A affects USP38
| 2
KDM1A binds USP38. 2 / 2
| 2
sparser
"Therefore, we could not perform pull-down test to prove the direct interaction between USP38 and LSD1."
30497519
sparser
"Thus, USP38 promotes the colony formation ability of HCT116 cells through the interaction between USP38 and LSD1."
30497519
H1-3 affects USP38
2 |
USP38 binds H1-3. 2 / 2
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biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
GST affects USP38
| 2
GST binds USP38. 2 / 2
| 2
sparser
"The molecular weight of USP38 is 116 kDa, making the molecular weight of the fusion protein GST-USP38 larger, approximately 137 kDa, and thus it is very difficult for bacteria to express GST-USP38 ectopically."
30497519
sparser
"However, we do not know whether this interaction is direct or indirect, because we could not induce the prokaryote Escherichia coli to express the fusion protein GST-USP38."
30497519
E affects USP38
| 2
E binds USP38. 2 / 2
| 2
sparser
"More detailed truncation results showed that USP38 binds to 132–193aa of E protein ( xref I)."
| PMC
sparser
"Collectively, our results suggested that USP38 binds to the 132–193aa of E protein through its C-terminal domain."
| PMC
AHSG affects USP38
2 |
USP38 binds AHSG. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
ADAR affects USP38
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USP38 binds ADAR. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
1,2-dichloroethane decreases the amount of USP38. 2 / 2
2 |
ctd
No evidence text available
28189721
ctd
No evidence text available
28960355
Urethane affects USP38
1 |
Urethane increases the amount of USP38. 1 / 1
1 |
ctd
No evidence text available
28818685
Trimellitic anhydride increases the amount of USP38. 1 / 1
1 |
ctd
No evidence text available
19042947
Topotecan affects USP38
1 |
Topotecan decreases the amount of USP38. 1 / 1
1 |
ctd
No evidence text available
25729387
Tetrachloromethane decreases the amount of USP38. 1 / 1
1 |
ctd
No evidence text available
30723492
Sunitinib affects USP38
1 |
Sunitinib increases the amount of USP38. 1 / 1
1 |
ctd
No evidence text available
31533062
Sodium arsenite affects USP38
1 |
Sodium arsenite increases the amount of USP38. 1 / 1
1 |
ctd
No evidence text available
29361514
Silver(0) affects USP38
1 |
Silver(0) decreases the amount of USP38. 1 / 1
1 |
ctd
No evidence text available
27131904
Pirimiphos-methyl affects USP38
1 |
Pirimiphos-methyl decreases the amount of USP38. 1 / 1
1 |
ctd
No evidence text available
27845199
Perfluorooctane-1-sulfonic acid decreases the amount of USP38. 1 / 1
1 |
ctd
No evidence text available
27153767
Oxaliplatin affects USP38
1 |
Oxaliplatin decreases the amount of USP38. 1 / 1
1 |
ctd
No evidence text available
25729387
Leflunomide affects USP38
1 |
Leflunomide increases the amount of USP38. 1 / 1
1 |
ctd
No evidence text available
28988120
Jinfukang affects USP38
1 |
Jinfukang decreases the amount of USP38. 1 / 1
1 |
ctd
No evidence text available
27392435
Hsa-miR-98-5p affects USP38
1 |
Hsa-miR-98-5p decreases the amount of USP38. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-7856-5p affects USP38
1 |
Hsa-miR-7856-5p decreases the amount of USP38. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-6831-5p affects USP38
1 |
Hsa-miR-6831-5p decreases the amount of USP38. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-590-3p affects USP38
1 |
Hsa-miR-590-3p decreases the amount of USP38. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-587 affects USP38
1 |
Hsa-miR-587 decreases the amount of USP38. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-5581-3p affects USP38
1 |
Hsa-miR-5581-3p decreases the amount of USP38. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-548e-5p affects USP38
1 |
Hsa-miR-548e-5p decreases the amount of USP38. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4694-3p affects USP38
1 |
Hsa-miR-4694-3p decreases the amount of USP38. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4500 affects USP38
1 |
Hsa-miR-4500 decreases the amount of USP38. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4458 affects USP38
1 |
Hsa-miR-4458 decreases the amount of USP38. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-3927-3p affects USP38
1 |
Hsa-miR-3927-3p decreases the amount of USP38. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-376a-2-5p affects USP38
1 |
Hsa-miR-376a-2-5p decreases the amount of USP38. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-3658 affects USP38
1 |
Hsa-miR-3658 decreases the amount of USP38. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-17-5p affects USP38
1 |
Hsa-miR-17-5p decreases the amount of USP38. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-148a-3p affects USP38
1 |
Hsa-miR-148a-3p decreases the amount of USP38. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-124-3p affects USP38
1 |
Hsa-miR-124-3p decreases the amount of USP38. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
18668037
Hsa-let-7i-5p affects USP38
1 |
Hsa-let-7i-5p decreases the amount of USP38. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-let-7g-5p affects USP38
1 |
Hsa-let-7g-5p decreases the amount of USP38. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-let-7f-5p affects USP38
1 |
Hsa-let-7f-5p decreases the amount of USP38. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-let-7e-5p affects USP38
1 |
Hsa-let-7e-5p decreases the amount of USP38. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-let-7d-5p affects USP38
1 |
Hsa-let-7d-5p decreases the amount of USP38. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-let-7c-5p affects USP38
1 |
Hsa-let-7c-5p decreases the amount of USP38. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-let-7b-5p affects USP38
1 |
Hsa-let-7b-5p decreases the amount of USP38. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-let-7a-5p affects USP38
1 |
Hsa-let-7a-5p decreases the amount of USP38. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Formaldehyde affects USP38
1 |
Formaldehyde decreases the amount of USP38. 1 / 1
1 |
ctd
No evidence text available
20655997
Folic acid affects USP38
1 |
Folic acid demethylates USP38. 1 / 1
1 |
ctd
No evidence text available
20938992
Fenofibrate affects USP38
1 |
Fenofibrate increases the amount of USP38. 1 / 1
1 |
ctd
No evidence text available
21318169
Copper(II) sulfate increases the amount of USP38. 1 / 1
1 |
ctd
No evidence text available
19549813
Cobalt dichloride affects USP38
1 |
Cobalt dichloride increases the amount of USP38. 1 / 1
1 |
ctd
No evidence text available
19320972
Choline affects USP38
1 |
Choline demethylates USP38. 1 / 1
1 |
ctd
No evidence text available
20938992
Cadmium dichloride increases the amount of USP38. 1 / 1
1 |
ctd
No evidence text available
20061341
Bis(2-ethylhexyl) phthalate increases the amount of USP38. 1 / 1
1 |
ctd
No evidence text available
21318169
Benzo[a]pyrene diol epoxide I decreases the amount of USP38. 1 / 1
1 |
ctd
No evidence text available
20018196
Atrazine affects USP38
1 |
Atrazine decreases the amount of USP38. 1 / 1
1 |
ctd
No evidence text available
22378314
VAV2 affects USP38
1 |
VAV2 binds USP38. 1 / 1
1 |
biogrid
No evidence text available
18654987
USP38 affects www.frontiersin.org ubiquitination K33-linkage poly-ubiquitin chains
| 1
USP38 inhibits www.frontiersin.org ubiquitination K33-linkage poly-ubiquitin chains. 1 / 1
| 1
eidos
"USP38 knockdown has enhanced the Frontiers in Microbiology | www.frontiersin.org ubiquitination of K33-linkage poly-ubiquitin chains , but the formation of the k48-linked ubiquitin chain and the degradation of TBK1 are disrupted , indicating that the effects of DTX4 and TRIP on TBK1 depend on the presence of USP38 ."
34966378
USP38 affects ubiquitination over-expressed E protein
| 1
USP38 inhibits ubiquitination over-expressed E protein. 1 / 1
| 1
eidos
"The results indicated that USP38 could strongly reduce the ubiquitination level of over-expressed E protein ( Figure 3A ) ."
| PMC
USP38 affects ubiquitination ZIKV E protein infected cells
| 1
USP38 inhibits ubiquitination ZIKV E protein infected cells. 1 / 1
| 1
eidos
"Similarly , the results showed that USP38 also significantly attenuated the ubiquitination level of ZIKV E protein in infected cells ( Figure 3B ) ."
| PMC
USP38 affects ubiquitination K33-linkage poly-ubiquitin chains
| 1
USP38 inhibits ubiquitination K33-linkage poly-ubiquitin chains. 1 / 1
| 1
eidos
"USP38 knockdown has enhanced the ubiquitination of K33-linkage poly-ubiquitin chains , but the formation of the k48-linked ubiquitin chain and the degradation of TBK1 are disrupted , indicating that the effects of DTX4 and TRIP on TBK1 depend on the presence of USP38 ."
34966378
USP38 affects ubiquitination E protein
| 1
USP38 inhibits ubiquitination E protein. 1 / 1
| 1
eidos
"We overexpressed USP38 in HEK293T cells and found that USP38 notably reduced the ubiquitination of E protein ."
| PMC
USP38 affects synthesis IFN
| 1
USP38 inhibits synthesis IFN. 1 / 1
| 1
eidos
"USP38 Inhibits ZIKV Infection Previous studies determined that , during viral infection , USP38 inhibits type I interferon pathway by degrading TBK1 , thereby inhibiting the synthesis of type I IFN [ 15 ] ."
| PMC
reach
"USP38 Inhibits Zika Virus Infection by Removing Envelope Protein Ubiquitination."
34696459
USP38 affects polyubiquitination
| 1
USP38 inhibits polyubiquitination. 1 / 1
| 1
eidos
"USP38 can inhibit the polyubiquitination of c-Myc , thereby increasing c-Myc stability ."
34102342
USP38 affects migration
| 1
USP38 activates migration. 1 / 1
| 1
eidos
"In this research , we found that USP38 was overexpressed in GC tissues , and USP38 contributed to GC cell proliferation , migration and tumorigenesis ."
35812059
USP38 affects interferon pathway
| 1
USP38 inhibits interferon pathway. 1 / 1
| 1
eidos
"USP38 Inhibits ZIKV Infection Previous studies determined that , during viral infection , USP38 inhibits type I interferon pathway by degrading TBK1 , thereby inhibiting the synthesis of type I IFN [ 15 ] ."
| PMC
USP38 affects inhibitory FBW7alpha
| 1
USP38 activates inhibitory FBW7alpha. 1 / 1
| 1
eidos
"Furthermore , USP38 can restore the inhibitory effect of FBW7alpha on proliferation ."
34102342
USP38 affects deacetylase
| 1
USP38 bound to K63 and HDAC1 activates deacetylase. 1 / 1
| 1
reach
"In response to DNA damage, USP38 interacted with HDAC1 and specifically removed the K63 linked ubiquitin chain promoting the deacetylase activity of HDAC1."
31874856
USP38 affects cell adhesion
| 1
USP38 inhibits cell adhesion. 1 / 1
| 1
reach
"We further noticed that elevated expression of USP38 reduced the expression and secretion of cell adhesion-related molecules with the elevation in expression of pro-apoptotic proteins, and these effects might be mediated by inhibition of JAK2/STAT3 signalling pathway as USP38 is the upstream regulator of STAT3 and inhibition of cellular adhesion process."
35114776
USP38 affects c-Myc stability
| 1
USP38 activates c-Myc stability. 1 / 1
| 1
eidos
"USP38 can inhibit the polyubiquitination of c-Myc , thereby increasing c-Myc stability ."
34102342
USP38 affects bleomycin-induced pulmonary fibrosis
| 1
USP38 inhibits bleomycin-induced pulmonary fibrosis. 1 / 1
| 1
eidos
"USP38 deficiency aggravates IL-33-induced lung inflammatory response and bleomycin-induced pulmonary fibrosis ."
35238669
USP38 affects activation IFN signaling pathways
| 1
USP38 inhibits activation IFN signaling pathways. 1 / 1
| 1
eidos
"For example , USP3 , USP38 , and USP19 target RIG-I , TBK1 , and TRAF3 for deubiquitination , respectively , thereby blocking the activation of type I IFN signaling pathways ( Cui et al ., 2014 ; Gu et al ., 2017 ; Lin et al ., 2016 ) ."
30408499
USP38 affects ZIKV structural protein E non-structural protein
| 1
USP38 inhibits ZIKV structural protein E non-structural protein. 1 / 1
| 1
eidos
"The results indicated that , in Hela cells transfected with HA-USP38 and infected with ZIKV , the production of ZIKV structural protein E and non-structural protein 5 ( NS5 ) ( Figure 1A ) , the expression of E mRNA and NS5 mRNA ( Figure 1B ) , and the level of ZIKV mRNA ( Figure 1C ) were significantly attenuated by USP38 ."
| PMC
USP38 affects ZIKV mRNA
| 1
USP38 inhibits ZIKV mRNA. 1 / 1
| 1
eidos
"The results indicated that , in Hela cells transfected with HA-USP38 and infected with ZIKV , the production of ZIKV structural protein E and non-structural protein 5 ( NS5 ) ( Figure 1A ) , the expression of E mRNA and NS5 mRNA ( Figure 1B ) , and the level of ZIKV mRNA ( Figure 1C ) were significantly attenuated by USP38 ."
| PMC
USP38 affects ZIKV invasion
| 1
USP38 activates ZIKV invasion. 1 / 1
| 1
eidos
"Here , we demonstrate that , overexpression of USP38 in Hela cells markedly inhibited ZIKV infection , while deficient of USP38 increased ZIKV invasion ."
| PMC
USP38 affects ZIKV dsRNA
| 1
USP38 activates ZIKV dsRNA. 1 / 1
| 1
eidos
"Furthermore , immunofluorescence analyses indicated that the levels of ZIKV dsRNA were repressed by USP38 , but not by the mutant protein ( Figure 4E ) , suggesting that unlike USP38 , the mutant protein USP38-MUT failed to repress ZIKV infection ."
| PMC
USP38 affects ZIKV RNA
| 1
USP38 inhibits ZIKV RNA. 1 / 1
| 1
eidos
"Immunoblot analyses indicated that the levels of ZIKV E protein and NS5 protein were significantly attenuated by USP38 , but not by USP38-MUT ( Figure 4B ) , and similarly , qPCR results revealed that the levels of ZIKV N mRNA and NS5 mRNA ( Figure 4C ) as well as ZIKV RNA ( Figure 4D ) were significantly reduced by USP38 , but relatively unaffected by USP38-MUT ."
| PMC
USP38 affects ZIKV N mRNA NS5 mRNA
| 1
USP38 inhibits ZIKV N mRNA NS5 mRNA. 1 / 1
| 1
eidos
"Immunoblot analyses indicated that the levels of ZIKV E protein and NS5 protein were significantly attenuated by USP38 , but not by USP38-MUT ( Figure 4B ) , and similarly , qPCR results revealed that the levels of ZIKV N mRNA and NS5 mRNA ( Figure 4C ) as well as ZIKV RNA ( Figure 4D ) were significantly reduced by USP38 , but relatively unaffected by USP38-MUT ."
| PMC
USP38 affects ZIKV Infection Previous determined
| 1
USP38 inhibits ZIKV Infection Previous determined. 1 / 1
| 1
eidos
"USP38 Inhibits ZIKV Infection Previous studies determined that , during viral infection , USP38 inhibits type I interferon pathway by degrading TBK1 , thereby inhibiting the synthesis of type I IFN [ 15 ] ."
| PMC
USP38 affects VAV2
1 |
VAV2 binds USP38. 1 / 1
1 |
biogrid
No evidence text available
18654987
USP38 affects TLR
| 1
USP38 inhibits TLR. 1 / 1
| 1
reach
"We found that USP38 could also negatively regulate TLR and RIG-I signaling through different mechanisms (213, 214) ."
35309296
USP38 affects TBK1 proteasome
| 1
USP38 inhibits TBK1 proteasome. 1 / 1
| 1
eidos
"Collectively , USP38 could promotes TBK1 proteasome degradation and maintains the homeostasis of the antiviral response ( Lin et al ., 2016a ) ."
34966378
USP38 affects SOX2
| 1
USP38 activates SOX2. 1 / 1
| 1
reach
"Furthermore, we examined the protein levels of cancer stem cell related genes and found that downregulation of USP38 caused significant upregulation of cancer stem cell marker genes SOX2, NANOG, OCT4, BIM1, SNAIL, CD133, ABCG2, and CD44, suggesting that USP38 restrains cancer stem cell population of colorectal cancer cells."
32404892
USP38 affects SEM1
1 |
SEM1 binds USP38. 1 / 1
1 |
biogrid
No evidence text available
24811749
USP38 affects RPS12
1 |
RPS12 binds USP38. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP38 affects RPL7
1 |
RPL7 binds USP38. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP38 affects Neoplasms
| 1
USP38 activates Neoplasms. 1 / 1
| 1
reach
"Furthermore, FASN was critical for GC cell growth, migration and tumor development triggered by USP38 overexpression because its inhibitor orilistat reversed phenotypes in USP38 overexpressed GC cells."
35812059
USP38 affects NHEJ repair
| 1
USP38 activates NHEJ repair. 1 / 1
| 1
reach
"The deubiquitinase USP38 promotes NHEJ repair through regulation of HDAC1 activity and regulates cancer cell response to genotoxic insults."
31874856
USP38 affects LGALS7
1 |
USP38 binds LGALS7. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP38 affects KDM5B
| 1
KDM5B binds USP38. 1 / 1
| 1
reach
"Furthermore, USP38 can bind to KDM5B and prevent it from proteasomal degradation, which further enhances the function of KDM5B in the regulation of inflammation related genes."
33240782
USP38 affects K63-linked ubiquitination E protein
| 1
USP38 inhibits K63-linked ubiquitination E protein. 1 / 1
| 1
eidos
"USP38 was capable to attenuate both K48 - and K63-linked ubiquitination of E protein to prevent ZIKV infection ."
| PMC
USP38 affects K63-linked polyubiquitination ZIKV E protein
| 1
USP38 inhibits K63-linked polyubiquitination ZIKV E protein. 1 / 1
| 1
eidos
"In summary , USP38 impairs both K48-linked polyubiquitination and K63-linked polyubiquitination of ZIKV E protein ."
| PMC
USP38 affects K63
| 1
USP38 binds HDAC1 and K63. 1 / 1
| 1
reach
"In response to DNA damage, USP38 interacted with HDAC1 and specifically removed the K63 linked ubiquitin chain promoting the deacetylase activity of HDAC1."
31874856
USP38 affects K48-linked polyubiquitination
| 1
USP38 inhibits K48-linked polyubiquitination. 1 / 1
| 1
eidos
"In summary , USP38 impairs both K48-linked polyubiquitination and K63-linked polyubiquitination of ZIKV E protein ."
| PMC
USP38 affects IL-33-induced lung inflammatory response
| 1
USP38 inhibits IL-33-induced lung inflammatory response. 1 / 1
| 1
eidos
"USP38 deficiency aggravates IL-33-induced lung inflammatory response and bleomycin-induced pulmonary fibrosis ."
35238669
USP38 affects IFN-I
| 1
USP38 inhibits IFN-I. 1 / 1
| 1
reach
"Similarly, USP38 negatively regulates IFN-I signaling by targeting the active form of TBK1 for degradation in vitro and in vivo (101)."
34707613
USP38 affects HSPB1
1 |
USP38 binds HSPB1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP38 affects HMX3
1 |
USP38 binds HMX3. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP38 affects HDAC3
| 1
Modified USP38 decreases the amount of HDAC3. 1 / 1
| 1
reach
"Importantly, we found that USP38 overexpression significantly decreased the ubiquitination level of HDAC3 but not HDAC1 and had no effect on the overall protein level of HDAC3 and HDAC1."
32404892
USP38 affects HDAC
| 1
USP38 activates HDAC. 1 / 1
| 1
reach
"Hence, we detected the global histone deacetylase (HDAC) activity in HCT116 cells with downregulated, normal, and upregulated levels of USP38, respectively and found that the global HDAC activities were significantly induced by downregulation of USP38 in HCT116 cells and SW620 cells while the global HDAC activities were inhibited in USP38 overexpressing HCT116 cells."
32404892
USP38 affects Glioma
| 1
USP38 inhibits Glioma. 1 / 1
| 1
reach
"In this study, we firstly constructed a USP38 overexpression and inhibition model in 2 cell lines and found that overexpression of USP38 inhibits the viability rate and migration ability of glioma cells."
35114776
USP38 inhibits Genomic Instability. 1 / 1
| 1
eidos
"It has been shown that USP38 affects DNA damage repair by regulating the activity of HDAC1 , meanwhile , a low expression of USP38 causes genome instability , which may lead to tumorigenesis [ 18 ] ."
| PMC
USP38 affects GNB5
1 |
USP38 binds GNB5. 1 / 1
1 |
biogrid
No evidence text available
26186194
USP38 affects GC cell
| 1
USP38 activates GC cell. 1 / 1
| 1
eidos
"In this research , we found that USP38 was overexpressed in GC tissues , and USP38 contributed to GC cell proliferation , migration and tumorigenesis ."
35812059
USP38 affects Frontiers
| 1
USP38 inhibits Frontiers. 1 / 1
| 1
eidos
"USP38 knockdown has enhanced the Frontiers in Microbiology | www.frontiersin.org ubiquitination of K33-linkage poly-ubiquitin chains , but the formation of the k48-linked ubiquitin chain and the degradation of TBK1 are disrupted , indicating that the effects of DTX4 and TRIP on TBK1 depend on the presence of USP38 ."
34966378
USP38 affects Flag
| 1
Flag binds USP38. 1 / 1
| 1
sparser
"In addition, A549 cells were transfected with HA-UB, Flag-vector, or Flag-USP38 for 24 h and then infected with ZIKV (1 MOI)."
| PMC
USP38 affects E mRNA NS5 mRNA
| 1
USP38 inhibits E mRNA NS5 mRNA. 1 / 1
| 1
eidos
"The results indicated that , in Hela cells transfected with HA-USP38 and infected with ZIKV , the production of ZIKV structural protein E and non-structural protein 5 ( NS5 ) ( Figure 1A ) , the expression of E mRNA and NS5 mRNA ( Figure 1B ) , and the level of ZIKV mRNA ( Figure 1C ) were significantly attenuated by USP38 ."
| PMC
USP38 affects DDX58
| 1
USP38 inhibits DDX58. 1 / 1
| 1
reach
"We found that USP38 could also negatively regulate TLR and RIG-I signaling through different mechanisms (213, 214) ."
35309296
USP38 affects CD44
| 1
USP38 inhibits CD44. 1 / 1
| 1
reach
"In both HCT116 and SW620 cells, simultaneous knockdown of USP38 and HDAC3 attenuated the decreased H3K27ac level and increased CD44 and CD133."
32404892
TCR affects USP38
| 1
TCR increases the amount of USP38. 1 / 1
| 1
reach
"TCR stimulation up-regulated the USP38 level, and USP38 in turn mediated the protein stabilization of JunB, a transcription factor specific for Th2 development."
30224386
Soman affects USP38
1 |
Soman increases the amount of USP38. 1 / 1
1 |
ctd
No evidence text available
19281266
SEM1 affects USP38
1 |
SEM1 binds USP38. 1 / 1
1 |
biogrid
No evidence text available
24811749
RPS12 affects USP38
1 |
RPS12 binds USP38. 1 / 1
1 |
biogrid
No evidence text available
19615732
RPL7 affects USP38
1 |
RPL7 binds USP38. 1 / 1
1 |
biogrid
No evidence text available
19615732
LGALS7 affects USP38
1 |
USP38 binds LGALS7. 1 / 1
1 |
biogrid
No evidence text available
19615732
L-methionine affects USP38
1 |
L-methionine demethylates USP38. 1 / 1
1 |
ctd
No evidence text available
20938992
KDM5B affects USP38
| 1
KDM5B binds USP38. 1 / 1
| 1
reach
"Furthermore, USP38 can bind to KDM5B and prevent it from proteasomal degradation, which further enhances the function of KDM5B in the regulation of inflammation related genes."
33240782
K63 affects USP38
| 1
USP38 binds HDAC1 and K63. 1 / 1
| 1
reach
"In response to DNA damage, USP38 interacted with HDAC1 and specifically removed the K63 linked ubiquitin chain promoting the deacetylase activity of HDAC1."
31874856
IL1RL1 affects USP38
| 1
IL1RL1 inhibits USP38. 1 / 1
| 1
reach
"In this study, we identified USP38, which negatively regulates IL-33-triggered signaling by mediating K27-linked deubiquitination of IL-33R at K511 and its autophagic degradation."
35238669
HSPB1 affects USP38
1 |
USP38 binds HSPB1. 1 / 1
1 |
biogrid
No evidence text available
19615732
HMX3 affects USP38
1 |
USP38 binds HMX3. 1 / 1
1 |
biogrid
No evidence text available
19615732
HDAC1 affects USP38
| 1
USP38 binds HDAC1 and K63. 1 / 1
| 1
reach
"In response to DNA damage, USP38 interacted with HDAC1 and specifically removed the K63 linked ubiquitin chain promoting the deacetylase activity of HDAC1."
31874856
GNB5 affects USP38
1 |
USP38 binds GNB5. 1 / 1
1 |
biogrid
No evidence text available
26186194
Flag affects USP38
| 1
Flag binds USP38. 1 / 1
| 1
sparser
"In addition, A549 cells were transfected with HA-UB, Flag-vector, or Flag-USP38 for 24 h and then infected with ZIKV (1 MOI)."
| PMC
FBW7alpha affects USP38
| 1
USP38 binds FBW7alpha. 1 / 1
| 1
reach
"Mechanistically, USP38 physically interacts with FBW7alpha and abolishes FBW7alpha mediated degradation of c-Myc."
34102342
CD44 affects USP38
| 1
CD44 inhibits USP38. 1 / 1
| 1
reach
"Importantly, flow cytometry analysis of cell surface markers revealed that the number of CD133 and CD44 double positive cells was significantly elevated in colorectal cancer cells transfected with shRNA targeting USP38 and the number of CD133 and CD44 double positive cells was significantly reduced in colorectal cancer cells overexpressing USP38."
32404892
5-formyluracil affects USP38
| 1
5-formyluracil activates USP38. 1 / 1
| 1
reach
"Firstly, we analyzed the number of apoptotic cells in USP38 knock down and USP38 overexpressing HCT116 cells treated with 5-fluorouracil (5-FU), oxaliplatin (Oxal) or 5-FU plus Oxal (5-FU/Oxal)."
32404892
3,4-methylenedioxymethamphetamine increases the amount of USP38. 1 / 1
1 |
ctd
No evidence text available
20188158
2-hydroxypropanoic acid decreases the amount of USP38. 1 / 1
1 |
ctd
No evidence text available
30851411