IndraLab

Statements

USP38 deubiquitinates TBK1. 2 / 2

1 | 1

"Here we report that <span class="match term0">USP38</span> negatively regulates type I IFN signaling by targeting the active form of <span class="match term1">TBK1</span> for degradation in vitro and in vivo"

27692986

➶

reach

"Conversely, the K48-linked polyubiquitination level of TBK1 was obviously decreased after AdUSP38 transduced NRCMs (Figure 7B), These findings strongly indicate that USP38 interacts with and deubiquitinates TBK1 in hypertrophied cardiomyocytes."

38481817

INDRA sources:

Colored badges next to statement headings correspond to evidence counts from knowledge sources, as shown below. Badges to the left of the | separator correspond to curated knowledge base sources, and badges to the right of it correspond to machine reading systems.

IndraLab

Statements

USP38 deubiquitinates TBK1. 2 / 2

INDRA sources:

Databases

Reading