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USP38 ubiquitinates TBK1. 3 / 3
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"The Ub-specific protease 38 (USP38), TRAF-interacting protein (TRIP), Nod-like receptor (NLR) family pyrin domain containing 4 (NLRP4), and DTX4 complex polyubiquitinates TBK1, thereby degrading it to limit the virus-induced IFN-I signaling pathway (Cui et al., 2012)."
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"To determine how USP38 regulates TBK1 ubiquitination, we transfected 293T cells with FLAG-TBK1, Myc-USP38, HA-tagged K48-linked ubiquitin (K48-Ub), or K63-linked ubiquitin (K63-Ub), and we found that [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP38 overexpression promotes polyubiquitination of TBK1, resulting in the stabilization of p-TBK1 and activation of AKT signaling pathway in Ang II-induced myocardial hypertrophy mouse model."
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