IndraLab

Statements

USP38 binds ADAR. 9 / 9
3 | 6
biogrid
No evidence text available
33961781
reach
"To further confirm the interaction between USP38 and ADAR, we coexpressed USP38 and ADAR proteins tagged with different tags in HEK293T cells and then analyzed the interaction between USP38 and ADAR through IP."
39303916
reach
"The interaction between USP38 and ADAR depends on its enzymatic active region."
39303916
reach
"To clarify the structural domains involved in the USP38 and ADAR interaction, a series of deletion mutants of USP38 (WT (1-1042AA), N-term (1-400AA), C-term (401-1042AA)) and ADAR (WT (1-931AA), ΔZD (deletion of 1-71AA), ΔRBD (deletion of 207-499AA), and ΔDD (deletion of 591-926AA)) were used for IP analyses."
39303916
reach
"Subsequently, we used the online web tool DMFold (https://zhanggroup.org/DMFold/) to predict the structure of the USP38 and ADAR complex."
39303916
reach
"DMFold predicted five structures for the USP38–ADAR complex."
39303916
reach
"These findings demonstrate that the interaction between USP38 and ADAR is mediated through their C-terminal enzymatic catalytic regions."
39303916
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194