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TCR increases the amount of USP38. 3 / 3
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"Here we found that TCR activation induced expression of ubiquitin-specific peptidase 38 (USP38), whose gene has been recently reported to be in a chromosome locus associated with human asthma in a genome-wide association study (GWAS; Hirota et al., 2011)."
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"We further found that the mRNA level of usp38 did not show statistic difference in different CD4 T cell subsets (Fig. S3 A) and was not induced by the subset-specific cytokines, including IL-2, IL-4, IL-6, IFN, and TGF-β in primary CD4 T cells (Fig. S3 B), suggesting that usp38 expression is directly regulated by TCR signal rather than by cytokines downstream of TCR signaling."
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"178 In the pathogenesis of allergic asthma, TCR signaling can upregulate the levels of the deubiquitinase USP38, which, in turn, stabilizes the TH2 development factor JunB, ultimately promoting asthma."
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