IndraLab

Statements

STAMBPL1 affects Ubiquitin
| 1 12
STAMBPL1 binds Ubiquitin.
| 12
sparser
"It is known that Val328 and Phe332 of AMSH-LP interact with ubiquitin Ile44, but structural comparison shows that the equivalent positions in Rpn11 (Val83 and Phe87) are oriented in an opposite direction from AMSH-LP ( xref B)."
33498168
sparser
"Cys282 is next to the active site, and in fact it makes a van der Waals contact with Leu73 of the distal ubiquitin in the structure of AMSH-LP DUB domain bound to Lys63-linked ubiquitin dimer. xref In the disulfide orientation, however, as seen in the model of AMSH244 bound to Lys63-linked diubiquitin (please see below), the contact is lost."
21888914
sparser
"Interestingly, in the structure of AMSH-LP DUB domain bound to Lys63-linked ubiquitin dimer, the corresponding residue pair is still seen in a similar position as the substrate-free form, xref suggesting that these residues close the active site during catalysis as well, perhaps to help position the scissile peptide bond or stabilize the transition state or both."
21888914
sparser
"The Oγ atom of AMSH’s Ser346 is pointing away from Glu64 of the proximal ubiquitin ( xref ), contrary to the equivalent residue in both free and ubiquitin-bound AMSH-LP, which are at distances of 2.4Å and 2.6Å from proximal ubiquitin’s Glu64, respectively."
21888914
sparser
"The structural basis for this recognition was elucidated with the homologous protein, AMSH-LP, bound to Lys63-linked dimer of ubiquitin ( xref )."
24151880
Ubiquitin binds STAMBPL1 and K63. 4 / 4
| 4
sparser
"Proximal ubiquitin binding is similar to that observed in the crystal structure of AMSH-LP bound to K63-Ub 2 ."
24787148
sparser
"Figure xref d shows the superposition of Sst2 Δ220 –K63-Ub 2 and AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV( xref ))."
24787148
sparser
"The structure was determined by molecular replacement using a model of Sst2–K63-Ub 2 generated by superimposition of Sst2 cat with the structure of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV( xref )) and refined yielding satisfactory crystallographic, free R factors and good stereochemistry (Table xref )."
24787148
sparser
"The overall three-dimensional fold of Sst2 Δ220 –K63-Ub 2 is highly similar to the structure of the DUB domain of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) with an rmsd of 1.19 Å of Cα atoms over 266 residues from both Sst2 and K63-Ub 2 ."
24787148
Ubiquitin binds STAMBPL1 and rpn11. 1 / 1
| 1
sparser
"Rpn11 and AMSH-LP bind ubiquitin in a similar orientation, but their interaction with the Ile44 hydrophobic patch is quite different."
33498168
Ubiquitin binds STAMBPL1, K63, and BRCC36. 1 / 1
| 1
sparser
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly."
28587922
Ubiquitin binds STAMBPL1 and PTCH1. 1 / 1
| 1
sparser
"AMSH-LP binds the distal ubiquitin via its Leu8/Ile44/Val70 hydrophobic patch conserved in NEDD8."
21288713
STAMBPL1 increases the amount of Ubiquitin.
| 1
STAMBPL1 increases the amount of Ubiquitin. 1 / 1
| 1
reach
"Since our data clearly indicate that STAMBPL1 affects Snail stability via the proteasome, we assessed if the levels of the main ubiquitin ligases or DUBs involved in the regulation of Snail half-life are modulated by STAMBPL1."
32636467
STAMBPL1 affects BIRC5
| 8 4
STAMBPL1 binds BIRC5.
| 1 4
STAMBPL1 binds BIRC5. 3 / 3
| 1 2
reach
"STAMBPL1 interacted with survivin and c-FLIP, resulted in reduction of ubiquitination."
31817770
sparser
"However, although cepharanthine reduces STAMBPL1 expression and overexpression of STAMBPL1 inhibits cepharanthine-mediated downregulation of survivin, interaction between STAMBPL1 and survivin was not investigated."
31817770
sparser
"As shown in xref C, we detected the interaction between STAMBPL1 and survivin."
31817770
CFLAR binds STAMBPL1 and BIRC5. 2 / 2
| 2
sparser
"STAMBPL1 interacted with survivin and c-FLIP, resulted in reduction of ubiquitination."
31817770
sparser
"Thus, these data reveal that STAMBPL1 directly interacts with survivin and c-FLIP, resulting in stabilization of proteins."
31817770
STAMBPL1 inhibits BIRC5.
| 3
STAMBPL1 inhibits BIRC5. 3 / 3
| 3
reach
"Ectopic expression of STAMBPL1 significantly inhibited CEP induced survivin downregulation (XREF_FIG F)."
30360403
reach
"Next, we investigated whether overexpression of STAMBPL1 prevents CEP induced survivin downregulation."
30360403
reach
"Honokiol Enhances TRAIL Mediated Apoptosis through STAMBPL1 Induced Survivin and c-FLIP Degradation."
31817770
STAMBPL1 activates BIRC5.
| 2
STAMBPL1 activates BIRC5. 2 / 2
| 2
reach
"Knockdown of STAMBPL1 reduced survivin and c-FLIP protein levels, while overexpression of STAMBPL1 inhibited honokinol induced survivin and c-FLIP degradation."
31817770
reach
"Our findings provided that honokiol could overcome TRAIL resistance through survivin and c-FLIP degradation induced by inhibition of STAMBPL1 expression."
31817770
STAMBPL1 increases the amount of BIRC5.
| 1
STAMBPL1 increases the amount of BIRC5. 1 / 1
| 1
reach
"Cepharanthine Enhances TRAIL Mediated Apoptosis Through STAMBPL1 Mediated Downregulation of Survivin Expression in Renal Carcinoma Cells."
30360403
STAMBPL1 decreases the amount of BIRC5.
| 1
STAMBPL1 decreases the amount of BIRC5. 1 / 1
| 1
reach
"Knockdown of STAMBPL1 reduced survivin and c-FLIP protein levels, while overexpression of STAMBPL1 inhibited honokinol induced survivin and c-FLIP degradation."
31817770
UBD affects STAMBPL1
| 3 7
UBD binds STAMBPL1. 9 / 9
| 2 7
sparser
"The crystal structure of the catalytic domain of AMSH-LP bound to its substrate Lys63-linked diubiquitin (PBD ID: 2ZNV) reveals the flap adopting a closed position over the active site ( xref )."
26368668
sparser
"The crystal structure of the catalytic core domain of AMSH-LP bound to K63-linked diubiquitin has provided a molecular description of this specificity xref ."
19243136
sparser
"Only recently was Lys63-linkage specificity understood from the structural analysis of the DUB domain of AMSH-LP bound Lys63-linked diubiquitin. xref This structure reveals interactions between the enzyme and both the distal and proximal ubiquitins, but the basis for specificity arises from residues in the proximal site of the enzyme interacting with the proximal ubiquitin, despite a more extensive interaction with the distal ubiquitin (a significantly more accessible surface area is buried upon interaction with distal than proximal ubiquitin). xref Overall, AMSH adopts very similar interactions when modeled according to the ubiquitin-bound structure of AMSH-LP."
21888914
sparser
"The structure of AMSH-LP bound to K63-linked diubiquitin demonstrates that the recognition of the proximal ubiquitin in diubiquitin determines AMSH-LP linkage selectivity xref ."
19243136
sparser
"However, this residue, in fact, the two-residue turn segment, Leu402-Phe403, needs to move apart relative to Thr316 to make room for the diubiquitin substrate to position itself correctly in the active site. (These observations are also true in the structure of AMSH-LP bound to diubiquitin.) It seems likely that the β-turn segment is dynamic, fluctuating between open and closed forms; the substrate binds to the open form, perhaps by conformational selection."
24787148
sparser
"Modeling of the catalytic domain of AMSH onto the structure of AMSH-LP bound to Lys63-linked diubiquitin revealed four residues within AMSH (Thr341, Phe343, Ser346, and Phe395) that could determine its specificity for Lys63-linked polyubiquitin chains by recognizing the tri-peptide sequence motif Gln62-Lys63-Glu64 within the proximal ubiquitin, which encompasses the acceptor Lys63 and its two immediate flanking residues."
24151880
sparser
"How JAMM/MPNDUBs cleave ubiquitin chains with K63-linkage specificity has been explained by the crystal structure of AMSH-LP bound to K63-linked di-ubiquitin: Two insertion loops orient the distal and proximal ubiquitin in order to place the isopeptide bond at lysine 63 in direct proximity to the active site [ xref ]."
33142801
reach
"Recent structure determination of the K63 linked diubiquitin bound to AMSH-LP revealed specific interactions between the proximal ubiquitin and the DUB catalytic core as well as an inserted motif."
22118673
reach
"(These observations are also true in the structure of AMSH-LP bound to diubiquitin.)"
24787148
UBD binds STAMBPL1 and Phe403. 1 / 1
| 1
reach
"X-ray crystal structures of the DUB domains of both AMSH-LP and Sst2 bound to diubiquitin shows Phe403 collapsed onto the Lys63 side chain of the proximal ubiquitin; however, the flap residues appear to retain their mobility even in presence of bound substrate or product (indicated by relatively weak electron density enveloping these residues and higher B-factors than internal residues)."
26368668
STAMBPL1 affects STAMBP
1 | 3 6
STAMBPL1 binds STAMBP.
1 | 1 5
STAMBP binds STAMBPL1. 5 / 5
1 | 1 3
sparser
"To quantify the interaction of the UbVs with STAMBP and STAMBPL1 and to validate the key residues responsible for the tight binding, we used isothermal titration calorimetry (ITC) to measure the interaction thermodynamics (Fig. 3)."
34425109
reach
"Both STAMBP and STAMBPL1 localize to early endosomes by binding to clathrin (31); however, STAMBPL1 fails to bind to STAM due to residue substitutions in the SBM-like motif, suggesting it may function in different signaling pathway from that of STAMBP (30) ."
| DOI
sparser
"Hameed et al. developed a zinc chelating ABP that forms a tight complex with STAMBP and STAMBPL1 and inhibits the activity of the proteasomal DUB Rpn11 (PSMD14 in humans)."
35625630
sparser
"Hence, it is possible that AMSH and AMSH-LP might be associated with a proteasome or other unknown large protein complex in the nucleus through their MPN domain."
12810066
biogrid
No evidence text available
28514442
SHBG binds STAMBP and STAMBPL1. 1 / 1
| 1
sparser
"Hameed et al. developed a zinc chelating ABP that forms a tight complex with STAMBP and STAMBPL1 and inhibits the activity of the proteasomal DUB Rpn11 (PSMD14 in humans)."
35625630
Clathrin binds STAMBP, CLTC, and STAMBPL1. 1 / 1
| 1
sparser
"We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins."
16716190
STAMBPL1 inhibits STAMBP.
| 2
STAMBPL1 inhibits STAMBP. 2 / 2
| 2
reach
"Next, we compared the K63-diUb (FRET) cleavage inhibition by the UbVs with STAMBP JAMM to the inhibition of fulllength STAMBP activated by STAM protein and full-length STAMBPL1."
| DOI
reach
"Next, we compared the K63-diUb (FRET) cleavage inhibition by the UbVs with STAMBPJAMM to the inhibition of full-length STAMBP activated by STAM protein and full-length STAMBPL1."
34425109
STAMBPL1 activates STAMBP.
| 1
STAMBPL1 activates STAMBP. 1 / 1
| 1
sparser
"Next, we compared the K63-diUb (FRET) cleavage inhibition by the UbVs with STAMBPJAMM to the inhibition of full-length STAMBP activated by STAM protein and full-length STAMBPL1."
34425109
STAMBPL1 affects SNAI1
| 2 6
STAMBPL1 binds SNAI1.
| 6
SNAI1 binds STAMBPL1. 6 / 6
| 6
sparser
"Hence, we analysed 35 additional human tumour types for a STAMBPL1-SNAI1 co-signature (Fig.  xref )."
32636467
sparser
"A significant STAMBPL1-SNAI1 co-signature was observed across multiple tumour types."
32636467
sparser
"Prevalence of a STAMBPL1-SNAI1 co-signature across a spectrum of tumour types."
32636467
sparser
"Altogether, these data highlight the prevalence of the identified STAMBPL1-SNAI1 association across an extensive number of tumours types."
32636467
sparser
"While our study does not address the mechanistic details on this regulation, we uncover a substantial STAMBPL1-SNAI1 link across multiple human tumours."
32636467
sparser
"Importantly, we found that 24 tumour types showed a positive correlation, out of which >4000 samples in 12 TCGA tumours displayed a significant STAMBPL1-SNAI1 co-expression profile (Fig.  xref )."
32636467
STAMBPL1 inhibits SNAI1.
| 1
STAMBPL1 inhibits SNAI1. 1 / 1
| 1
reach
"By downregulating the level of Ubiquitin using RNA interference-mediated knockdown of Ubb and Ubc, we found that knockdown of UbC that instructs tandem units of ubiquitin with nine repeats resulted in more efficient attenuation of both K48 and total and mono-Ub levels without affecting STAMBPL1 levels (Supplementary Fig. S3e) and that downregulation of UbC effectively hindered STAMBPL1-mediated Snail protein reduction (Fig. 4i)."
32636467
STAMBPL1 activates SNAI1.
| 1
STAMBPL1 activates SNAI1. 1 / 1
| 1
reach
"Since STAMBPL1 has been shown to be an indirect activator of nuclear factor-κB) (NF-κB) signalling, and given that this pathway promotes Snail stabilisation through the synthesis of COP9 signalosome 2 protein (CSN2), we assessed if CSN2 is relevant for STAMBPL1 effect on Snail."
32636467
STAMBPL1 is modified
6 | 2
STAMBPL1 is phosphorylated.
6 |
STAMBPL1 is phosphorylated on S242. 3 / 3
3 |
hprd
No evidence text available
18669648
hprd
No evidence text available
20068231
hprd
No evidence text available
17322306
STAMBPL1 is phosphorylated on S400. 1 / 1
1 |
hprd
No evidence text available
20068231
STAMBPL1 is phosphorylated on T392. 1 / 1
1 |
hprd
No evidence text available
20068231
STAMBPL1 is phosphorylated on S25. 1 / 1
1 |
hprd
No evidence text available
18669648
STAMBPL1 is methylated.
| 2
STAMBPL1 is methylated. 2 / 2
| 2
sparser
"We found that dysregulation of miR-29C, miR-34A, miR-98, and miR-215; and methylation of ANKRD1, ARID5B, CDCA2, PIF1, STAMBPL1, TROAP, ZNF165 , and HIST1H2AJ in HeLa cells could result in cell proliferation and anti-apoptosis through NFκB, TGF-β, and PI3K pathways."
27295129
sparser
"It has been reported that NUF2, TROAP, STAMBPL1 , and ARID5B can be methylated in cancers. xref Furthermore, we used the DNA methylation profile of human cervical cancer and ESCs to validate our findings."
27295129
STAMBPL1 affects CFLAR
| 4 3
STAMBPL1 binds CFLAR.
| 1 3
CFLAR binds STAMBPL1 and BIRC5. 2 / 2
| 2
sparser
"STAMBPL1 interacted with survivin and c-FLIP, resulted in reduction of ubiquitination."
31817770
sparser
"Thus, these data reveal that STAMBPL1 directly interacts with survivin and c-FLIP, resulting in stabilization of proteins."
31817770
CFLAR binds STAMBPL1. 2 / 2
| 1 1
sparser
"In addition, STAMBPL1 also bound endogenous c-FLIP in Caki cells ( xref D)."
31817770
reach
"STAMBPL1 interacted with survivin and c-FLIP, resulted in reduction of ubiquitination."
31817770
STAMBPL1 activates CFLAR.
| 2
STAMBPL1 activates CFLAR. 2 / 2
| 2
reach
"Our findings provided that honokiol could overcome TRAIL resistance through survivin and c-FLIP degradation induced by inhibition of STAMBPL1 expression."
31817770
reach
"Knockdown of STAMBPL1 reduced survivin and c-FLIP protein levels, while overexpression of STAMBPL1 inhibited honokinol induced survivin and c-FLIP degradation."
31817770
STAMBPL1 decreases the amount of CFLAR.
| 1
STAMBPL1 decreases the amount of CFLAR. 1 / 1
| 1
reach
"Knockdown of STAMBPL1 reduced survivin and c-FLIP protein levels, while overexpression of STAMBPL1 inhibited honokinol induced survivin and c-FLIP degradation."
31817770
STAMBP affects STAMBPL1
1 | 1 5
STAMBP binds STAMBPL1. 5 / 5
1 | 1 3
sparser
"To quantify the interaction of the UbVs with STAMBP and STAMBPL1 and to validate the key residues responsible for the tight binding, we used isothermal titration calorimetry (ITC) to measure the interaction thermodynamics (Fig. 3)."
34425109
reach
"Both STAMBP and STAMBPL1 localize to early endosomes by binding to clathrin (31); however, STAMBPL1 fails to bind to STAM due to residue substitutions in the SBM-like motif, suggesting it may function in different signaling pathway from that of STAMBP (30) ."
| DOI
sparser
"Hameed et al. developed a zinc chelating ABP that forms a tight complex with STAMBP and STAMBPL1 and inhibits the activity of the proteasomal DUB Rpn11 (PSMD14 in humans)."
35625630
sparser
"Hence, it is possible that AMSH and AMSH-LP might be associated with a proteasome or other unknown large protein complex in the nucleus through their MPN domain."
12810066
biogrid
No evidence text available
28514442
SHBG binds STAMBP and STAMBPL1. 1 / 1
| 1
sparser
"Hameed et al. developed a zinc chelating ABP that forms a tight complex with STAMBP and STAMBPL1 and inhibits the activity of the proteasomal DUB Rpn11 (PSMD14 in humans)."
35625630
Clathrin binds STAMBP, CLTC, and STAMBPL1. 1 / 1
| 1
sparser
"We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins."
16716190
SNAI1 affects STAMBPL1
| 1 6
SNAI1 binds STAMBPL1.
| 6
SNAI1 binds STAMBPL1. 6 / 6
| 6
sparser
"Hence, we analysed 35 additional human tumour types for a STAMBPL1-SNAI1 co-signature (Fig.  xref )."
32636467
sparser
"A significant STAMBPL1-SNAI1 co-signature was observed across multiple tumour types."
32636467
sparser
"Prevalence of a STAMBPL1-SNAI1 co-signature across a spectrum of tumour types."
32636467
sparser
"Altogether, these data highlight the prevalence of the identified STAMBPL1-SNAI1 association across an extensive number of tumours types."
32636467
sparser
"While our study does not address the mechanistic details on this regulation, we uncover a substantial STAMBPL1-SNAI1 link across multiple human tumours."
32636467
sparser
"Importantly, we found that 24 tumour types showed a positive correlation, out of which >4000 samples in 12 TCGA tumours displayed a significant STAMBPL1-SNAI1 co-expression profile (Fig.  xref )."
32636467
SNAI1 inhibits STAMBPL1.
| 1
SNAI1 inhibits STAMBPL1. 1 / 1
| 1
reach
"By genetically depleting STAMBPL1 in these cells, we observed a primary effect on Snail protein levels (Fig. 4b)."
32636467
STAMBPL1 affects apoptotic process
| 2 4
STAMBPL1 inhibits apoptotic process.
| 2 2
STAMBPL1 inhibits apoptotic process. 4 / 4
| 2 2
eidos
"Recently , we reported the depletion of STAMBPL1 increases apoptotic cell death through accumulation of intracellular ROS and lysosome-dependent XIAP degradation in prostate cancer cells [ 34 ] , and we also reported that levels of STAMBPL1 is correlated with the expression of survivin in cepharanthine treated renal cancer cells [ 35 ] ."
31817770
eidos
"In response to genotoxic stress , the degradation of STAMBPL1 augments apoptotic cell death ."
35066747
reach
"Targeting the Deubiquitinase STAMBPL1 Triggers Apoptosis in Prostate Cancer Cells by Promoting XIAP Degradation."
31004702
reach
"In response to genotoxic stress, the degradation of STAMBPL1 augments apoptotic cell death."
35066747
STAMBPL1 activates apoptotic process.
| 2
STAMBPL1 activates apoptotic process. 2 / 2
| 2
reach
"STAMBPL1 RNAi depletion triggered caspase-3/-7-dependent apoptosis in PC3 and DU145 cells."
31004702
reach
"Taken together, these studies show that STAMBPL1 depletion induces apoptosis by promoting XIAP lysosomal degradation, and suggest that targeting deubiquitinase STAMBPL1 might offer promising therapeutic strategy for prostate cancer."
31004702
STAMBPL1 affects K63-Ub 2
| 6
STAMBPL1 binds K63-Ub 2. 5 / 5
| 5
reach
"Figure XREF_FIG d shows the superposition of Sst2 Delta220 -K63-Ub 2 and AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV)."
24787148
reach
"Proximal ubiquitin binding is similar to that observed in the crystal structure of AMSH-LP bound to K63-Ub 2."
24787148
reach
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly.Comparison of the BRCC36 homodimer and heterodimer structures suggests an explanation for the loss of catalytic activity in the homod[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28587922
reach
"The structure was determined by molecular replacement using a model of Sst2-K63-Ub 2 generated by superimposition of Sst2 cat with the structure of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) and refined yielding satisfactory crystallographic, free R factors and good stereochemistry."
24787148
reach
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly."
28587922
STAMBPL1 binds DUB domain and K63-Ub 2. 1 / 1
| 1
reach
"The overall three-dimensional fold of Sst2 Delta220 -K63-Ub 2 is highly similar to the structure of the DUB domain of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) with an rmsd of 1.19 A of Calpha atoms over 266 residues from both Sst2 and K63-Ub 2."
24787148
STAMBPL1 affects K63
| 6
Ubiquitin binds STAMBPL1 and K63. 4 / 4
| 4
sparser
"Proximal ubiquitin binding is similar to that observed in the crystal structure of AMSH-LP bound to K63-Ub 2 ."
24787148
sparser
"Figure xref d shows the superposition of Sst2 Δ220 –K63-Ub 2 and AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV( xref ))."
24787148
sparser
"The structure was determined by molecular replacement using a model of Sst2–K63-Ub 2 generated by superimposition of Sst2 cat with the structure of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV( xref )) and refined yielding satisfactory crystallographic, free R factors and good stereochemistry (Table xref )."
24787148
sparser
"The overall three-dimensional fold of Sst2 Δ220 –K63-Ub 2 is highly similar to the structure of the DUB domain of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) with an rmsd of 1.19 Å of Cα atoms over 266 residues from both Sst2 and K63-Ub 2 ."
24787148
Ubiquitin binds STAMBPL1, K63, and BRCC36. 1 / 1
| 1
sparser
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly."
28587922
STAMBPL1 binds K63 and sst2. 1 / 1
| 1
sparser
"In contrast, AMSH-LP and its yeast homolog Sst2 bind K63 diUb with K M of ~ 50 μM and k cat of ~ 1 s − 1 , substantiall[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28587922
K63-Ub 2 affects STAMBPL1
| 6
STAMBPL1 binds K63-Ub 2. 5 / 5
| 5
reach
"Figure XREF_FIG d shows the superposition of Sst2 Delta220 -K63-Ub 2 and AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV)."
24787148
reach
"Proximal ubiquitin binding is similar to that observed in the crystal structure of AMSH-LP bound to K63-Ub 2."
24787148
reach
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly.Comparison of the BRCC36 homodimer and heterodimer structures suggests an explanation for the loss of catalytic activity in the homod[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28587922
reach
"The structure was determined by molecular replacement using a model of Sst2-K63-Ub 2 generated by superimposition of Sst2 cat with the structure of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) and refined yielding satisfactory crystallographic, free R factors and good stereochemistry."
24787148
reach
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly."
28587922
STAMBPL1 binds DUB domain and K63-Ub 2. 1 / 1
| 1
reach
"The overall three-dimensional fold of Sst2 Delta220 -K63-Ub 2 is highly similar to the structure of the DUB domain of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) with an rmsd of 1.19 A of Calpha atoms over 266 residues from both Sst2 and K63-Ub 2."
24787148
K63 affects STAMBPL1
| 6
Ubiquitin binds STAMBPL1 and K63. 4 / 4
| 4
sparser
"Proximal ubiquitin binding is similar to that observed in the crystal structure of AMSH-LP bound to K63-Ub 2 ."
24787148
sparser
"Figure xref d shows the superposition of Sst2 Δ220 –K63-Ub 2 and AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV( xref ))."
24787148
sparser
"The structure was determined by molecular replacement using a model of Sst2–K63-Ub 2 generated by superimposition of Sst2 cat with the structure of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV( xref )) and refined yielding satisfactory crystallographic, free R factors and good stereochemistry (Table xref )."
24787148
sparser
"The overall three-dimensional fold of Sst2 Δ220 –K63-Ub 2 is highly similar to the structure of the DUB domain of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) with an rmsd of 1.19 Å of Cα atoms over 266 residues from both Sst2 and K63-Ub 2 ."
24787148
Ubiquitin binds STAMBPL1, K63, and BRCC36. 1 / 1
| 1
sparser
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly."
28587922
STAMBPL1 binds K63 and sst2. 1 / 1
| 1
sparser
"In contrast, AMSH-LP and its yeast homolog Sst2 bind K63 diUb with K M of ~ 50 μM and k cat of ~ 1 s − 1 , substantiall[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28587922
Valproic acid affects STAMBPL1
5 |
Valproic acid decreases the amount of STAMBPL1.
4 |
Valproic acid decreases the amount of STAMBPL1. 4 / 4
4 |
ctd
No evidence text available
24935251
ctd
No evidence text available
27188386
ctd
No evidence text available
26272509
ctd
No evidence text available
23179753
Valproic acid increases the amount of STAMBPL1.
1 |
Valproic acid increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
29154799
Ubiquitin affects K63
| 5
Ubiquitin binds STAMBPL1 and K63. 4 / 4
| 4
sparser
"Proximal ubiquitin binding is similar to that observed in the crystal structure of AMSH-LP bound to K63-Ub 2 ."
24787148
sparser
"Figure xref d shows the superposition of Sst2 Δ220 –K63-Ub 2 and AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV( xref ))."
24787148
sparser
"The structure was determined by molecular replacement using a model of Sst2–K63-Ub 2 generated by superimposition of Sst2 cat with the structure of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV( xref )) and refined yielding satisfactory crystallographic, free R factors and good stereochemistry (Table xref )."
24787148
sparser
"The overall three-dimensional fold of Sst2 Δ220 –K63-Ub 2 is highly similar to the structure of the DUB domain of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) with an rmsd of 1.19 Å of Cα atoms over 266 residues from both Sst2 and K63-Ub 2 ."
24787148
Ubiquitin binds STAMBPL1, K63, and BRCC36. 1 / 1
| 1
sparser
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly."
28587922
STAMBPL1 affects STAM
| 5
STAM binds STAMBPL1. 3 / 3
| 3
sparser
"These results indicate that, unlike AMSH, AMSH-LP cannot bind to the STAMs."
12810066
sparser
"We observed a significant enhancement of IL-2-mediated c- myc induction in AMSH-LP-transfected cells as well as AMSH-transfected cells, although AMSH-LP did not associate physically with either STAM [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12810066
sparser
"We addressed whether the SBM-like motif of AMSH-LP could bind STAM1."
12810066
STAM binds STAM2, STAMBPL1, and GRB2. 1 / 1
| 1
sparser
"Consistent with this, coimmunoprecipitation analyses revealed that AMSH-LP could not bind to STAM1, STAM2, or Grb2, all of which contain an SH3 domain that interacts with AMSH [2,3,11] ."
12810066
STAM binds STAM2 and STAMBPL1. 1 / 1
| 1
sparser
"Another STAM family protein, STAM2, did not bind to AMSH-LP either, although AMSH strongly binds to STAM2 (data not shown)."
12810066
STAMBPL1 affects CLTC
4 | 1
CLTC binds STAMBPL1. 4 / 4
4 |
biogrid
No evidence text available
26496610
biogrid
No evidence text available
28514442
biogrid
No evidence text available
16716190
biogrid
No evidence text available
16716190
Clathrin binds STAMBP, CLTC, and STAMBPL1. 1 / 1
| 1
sparser
"We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins."
16716190
STAM affects STAMBPL1
| 5
STAM binds STAMBPL1. 3 / 3
| 3
sparser
"These results indicate that, unlike AMSH, AMSH-LP cannot bind to the STAMs."
12810066
sparser
"We observed a significant enhancement of IL-2-mediated c- myc induction in AMSH-LP-transfected cells as well as AMSH-transfected cells, although AMSH-LP did not associate physically with either STAM [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12810066
sparser
"We addressed whether the SBM-like motif of AMSH-LP could bind STAM1."
12810066
STAM binds STAM2, STAMBPL1, and GRB2. 1 / 1
| 1
sparser
"Consistent with this, coimmunoprecipitation analyses revealed that AMSH-LP could not bind to STAM1, STAM2, or Grb2, all of which contain an SH3 domain that interacts with AMSH [2,3,11] ."
12810066
STAM binds STAM2 and STAMBPL1. 1 / 1
| 1
sparser
"Another STAM family protein, STAM2, did not bind to AMSH-LP either, although AMSH strongly binds to STAM2 (data not shown)."
12810066
K63 affects Ubiquitin
| 5
Ubiquitin binds STAMBPL1 and K63. 4 / 4
| 4
sparser
"Proximal ubiquitin binding is similar to that observed in the crystal structure of AMSH-LP bound to K63-Ub 2 ."
24787148
sparser
"Figure xref d shows the superposition of Sst2 Δ220 –K63-Ub 2 and AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV( xref ))."
24787148
sparser
"The structure was determined by molecular replacement using a model of Sst2–K63-Ub 2 generated by superimposition of Sst2 cat with the structure of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV( xref )) and refined yielding satisfactory crystallographic, free R factors and good stereochemistry (Table xref )."
24787148
sparser
"The overall three-dimensional fold of Sst2 Δ220 –K63-Ub 2 is highly similar to the structure of the DUB domain of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) with an rmsd of 1.19 Å of Cα atoms over 266 residues from both Sst2 and K63-Ub 2 ."
24787148
Ubiquitin binds STAMBPL1, K63, and BRCC36. 1 / 1
| 1
sparser
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly."
28587922
CLTC affects STAMBPL1
4 | 1
CLTC binds STAMBPL1. 4 / 4
4 |
biogrid
No evidence text available
26496610
biogrid
No evidence text available
28514442
biogrid
No evidence text available
16716190
biogrid
No evidence text available
16716190
Clathrin binds STAMBP, CLTC, and STAMBPL1. 1 / 1
| 1
sparser
"We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins."
16716190
BIRC5 affects STAMBPL1
| 1 4
STAMBPL1 binds BIRC5. 3 / 3
| 1 2
reach
"STAMBPL1 interacted with survivin and c-FLIP, resulted in reduction of ubiquitination."
31817770
sparser
"However, although cepharanthine reduces STAMBPL1 expression and overexpression of STAMBPL1 inhibits cepharanthine-mediated downregulation of survivin, interaction between STAMBPL1 and survivin was not investigated."
31817770
sparser
"As shown in xref C, we detected the interaction between STAMBPL1 and survivin."
31817770
CFLAR binds STAMBPL1 and BIRC5. 2 / 2
| 2
sparser
"STAMBPL1 interacted with survivin and c-FLIP, resulted in reduction of ubiquitination."
31817770
sparser
"Thus, these data reveal that STAMBPL1 directly interacts with survivin and c-FLIP, resulting in stabilization of proteins."
31817770
K63 affects STAMBPL1, and Ubiquitin
| 4
Ubiquitin binds STAMBPL1 and K63. 4 / 4
| 4
sparser
"Proximal ubiquitin binding is similar to that observed in the crystal structure of AMSH-LP bound to K63-Ub 2 ."
24787148
sparser
"Figure xref d shows the superposition of Sst2 Δ220 –K63-Ub 2 and AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV( xref ))."
24787148
sparser
"The structure was determined by molecular replacement using a model of Sst2–K63-Ub 2 generated by superimposition of Sst2 cat with the structure of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV( xref )) and refined yielding satisfactory crystallographic, free R factors and good stereochemistry (Table xref )."
24787148
sparser
"The overall three-dimensional fold of Sst2 Δ220 –K63-Ub 2 is highly similar to the structure of the DUB domain of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) with an rmsd of 1.19 Å of Cα atoms over 266 residues from both Sst2 and K63-Ub 2 ."
24787148
Honokiol affects STAMBPL1
| 4
Honokiol inhibits STAMBPL1. 4 / 4
| 4
eidos
"In our study , the honokiol inhibited STAMBPL1 expression ( Figure 5B ) ."
31817770
eidos
"Honokiol induced STAMBPL1 downregulation in tested cancer cells ( ACHN , A498 , A549 , and Hela cells ) ( Figure 6E ) ."
31817770
eidos
"Therefore , we tested alteration of various DUBs expression and discovered that honokiol only decreased STAMBPL1 which is classified as JAMM family ( Figure 5B ) ."
31817770
eidos
"Honokiol decreased STAMBPL1 expression , resulting in degradation of survivin and c-FLIP protein ."
31817770
CFLAR affects STAMBPL1
| 1 3
CFLAR binds STAMBPL1 and BIRC5. 2 / 2
| 2
sparser
"STAMBPL1 interacted with survivin and c-FLIP, resulted in reduction of ubiquitination."
31817770
sparser
"Thus, these data reveal that STAMBPL1 directly interacts with survivin and c-FLIP, resulting in stabilization of proteins."
31817770
CFLAR binds STAMBPL1. 2 / 2
| 1 1
sparser
"In addition, STAMBPL1 also bound endogenous c-FLIP in Caki cells ( xref D)."
31817770
reach
"STAMBPL1 interacted with survivin and c-FLIP, resulted in reduction of ubiquitination."
31817770
Cyclosporin A affects STAMBPL1
3 |
Cyclosporin A increases the amount of STAMBPL1. 3 / 3
3 |
ctd
No evidence text available
25562108
ctd
No evidence text available
20106945
ctd
No evidence text available
27989131
TP53 affects STAMBPL1
| 2 1
TP53 activates STAMBPL1.
| 1 1
Mutated TP53 activates STAMBPL1. 1 / 1
| 1
reach
"Thus, the mechanism by which mutant p53 might activate STAMBPL1 is therefore likely through its interaction with these TFs, which possess responsive to mutant p53."
32636467
TP53 activates STAMBPL1. 1 / 1
| 1
sparser
"Thus, the mechanism by which mutant p53 might activate STAMBPL1 is therefore likely through its interaction with these TFs, which possess responsive to mutant p53. xref – xref Although future studies are needed to delineate whether other DUBs are involved in mutant p53-induced EMT or to other mutant p53-mediated oncogenic pro-survival benefits (ref. xref , xref ), our findings suggest an involvement of mutant p53 in driving the expression of STAMBPL1 as a novel pro-EMT GOF, providing further rationale to investigate DUB expression by other oncoproteins."
32636467
TP53 increases the amount of STAMBPL1.
| 1
TP53 increases the amount of STAMBPL1. 1 / 1
| 1
reach
"While ChIP assay revealed p53 enrichment on MDM2 and CDKN1A promoters in p53 -expressing cells (up to ~4% and ~10% of input), no significant (>1%) occupancy on any of the six predicted was detected for either WT or p53 (Supplementary Fig. S5c), indicating that the expression of STAMBPL1 gene is not directly regulated by p53 ."
32636467
STAMBPL1 affects Tax
| 3
STAMBPL1 activates Tax.
| 2
STAMBPL1 activates Tax. 2 / 2
| 2
reach
"Furthermore, overexpression of STAMBPL1 enhances the stability of Tax by blocking its proteasomal degradation, whereas siRNA silencing of STAMBPL1 promotes Tax degradation."
| PMC
reach
"Silencing of STAMBPL1 with siRNA inhibits Tax activation of both the canonical and noncanonical NF-kappaB signaling pathways."
| PMC
STAMBPL1 deubiquitinates Tax.
| 1
STAMBPL1 leads to the deubiquitination of Tax. 1 / 1
| 1
reach
"Importantly, STAMBPL1 does not induce Tax de-ubiquitination but protects Tax from degradation."
22035054
STAMBPL1 affects SMAD7
1 | 1 1
STAMBPL1 binds SMAD7.
1 | 1
STAMBPL1 binds SMAD2 and SMAD7. 1 / 1
| 1
sparser
"Previous studies reported that although they did not investigate the DUB activity of STAMBPL1, STAMBPL1 interact with Smad2 and Smad7, followed by induction of TGF-β-mediated transcriptional activity [ xref ]."
31817770
STAMBPL1 binds SMAD7. 1 / 1
1 |
hprd
No evidence text available
14728725
STAMBPL1 inhibits SMAD7.
| 1
STAMBPL1 inhibits SMAD7. 1 / 1
| 1
reach
"Similarly, AMSH-LP has been reported to sequester SMAD7, thereby exerting a positive impact on the TGFbeta pathway (XREF_FIG C) XREF_BIBR."
25007997
STAMBPL1 affects NFkappaB
| 2
STAMBPL1 activates NFkappaB. 1 / 2
| 1
reach
"Silencing of STAMBPL1 with siRNA inhibits Tax activation of both the canonical and noncanonical NF-kappaB signaling pathways."
| PMC
Modified STAMBPL1 activates NFkappaB. 1 / 1
| 1
reach
"Overexpression of wild-type STAMBPL1, but not a catalytically inactive mutant, enhances Tax mediated NF-kappaB activation and the induction of NF-kappaB target genes."
| PMC
STAMBPL1 affects DUSP1
| 2 1
STAMBPL1 binds DUSP1.
| 1 1
STAMBPL1 binds DUSP1. 2 / 2
| 1 1
reach
"STAMBPL1 interacts with MKP-1 and stabilizes MKP-1 via deubiquitination."
35236965
sparser
"STAMBPL1 interacts with MKP-1 and stabilizes MKP-1 via deubiquitination."
35236965
STAMBPL1 increases the amount of DUSP1.
| 1
STAMBPL1 increases the amount of DUSP1. 1 / 1
| 1
reach
"STAMBPL1 promotes breast cancer cell resistance to cisplatin partially by stabilizing MKP-1 expression."
35236965
Sst2 affects STAMBPL1
| 1 1
STAMBPL1 binds sst2. 1 / 1
| 1
reach
"In contrast, AMSH-LP and its yeast homologue Sst2 bind K63 diUb with K M ~ 50 muM, and k cat ~ 1 s -1, substantially below the catalytic proficiency associated with cleavage of some small peptides by thermolysin."
28587922
STAMBPL1 binds K63 and sst2. 1 / 1
| 1
sparser
"In contrast, AMSH-LP and its yeast homolog Sst2 bind K63 diUb with K M of ~ 50 μM and k cat of ~ 1 s − 1 , substantiall[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28587922
Silicon dioxide increases the amount of STAMBPL1.
1 |
Silicon dioxide increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
25895662
Silicon dioxide decreases the amount of STAMBPL1.
1 |
Silicon dioxide decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
23806026
DiUb affects STAMBPL1
| 2
STAMBPL1 binds diUb. 2 / 2
| 2
reach
"(E) A comparison of the diUb/STAMBPL1 complex structure (left) and UbV/STAMBPL1 structure overlaid with diUb (right)."
| DOI
reach
"E, a comparison of the diUb/STAMBPL1 complex structure (left) and UbV/STAMBPL1 structure overlaid with diUb (right)."
34425109
Cisplatin affects STAMBPL1
2 |
Cisplatin increases the amount of STAMBPL1.
1 |
Cisplatin increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
27594783
Cisplatin decreases the amount of STAMBPL1.
1 |
Cisplatin decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
27392435
Bisphenol A affects STAMBPL1
2 |
Bisphenol A increases the amount of STAMBPL1.
1 |
Bisphenol A increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
25181051
Bisphenol A decreases the amount of STAMBPL1.
1 |
Bisphenol A decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
29275510
Aflatoxin B1 affects STAMBPL1
2 |
Aflatoxin B1 methylates STAMBPL1.
1 |
Aflatoxin B1 methylates STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
27153756
Aflatoxin B1 increases the amount of STAMBPL1.
1 |
Aflatoxin B1 increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
22100608
UbVSP.1 affects STAMBPL1
| 2
UbVSP.1 inhibits STAMBPL1.
| 1
UbVSP.1 inhibits STAMBPL1. 1 / 1
| 1
reach
"In addition, UbVSP.1 appeared to inhibit STAMBPL1 to some extent, whereas UbVSP.3 showed no inhibitory effect with STAMBPL1 (Fig. S2A)."
34425109
UbVSP.1 binds STAMBPL1.
| 1
STAMBPL1 binds UbVSP.1. 1 / 1
| 1
reach
"A strong hydrogen bond network is then formed between the Arg72 guanidinium and the backbone carbonyl group of Glu326 in ins-1 and between the amide group of Gln49 of UbVSP.1 with the backbone carbonyl and amide of Val328 and Glu326, thus stabilizing the interaction between the STAMBPL1 and UbVSP.1 (Fig. 2G)."
34425109
TRIP13 affects STAMBPL1
1 1 |
TRIP13 binds STAMBPL1. 2 / 2
1 1 |
hprd
No evidence text available
16189514
biogrid
No evidence text available
16189514
STAMBPL1 affects sst2
| 1 1
STAMBPL1 binds sst2. 1 / 1
| 1
reach
"In contrast, AMSH-LP and its yeast homologue Sst2 bind K63 diUb with K M ~ 50 muM, and k cat ~ 1 s -1, substantially below the catalytic proficiency associated with cleavage of some small peptides by thermolysin."
28587922
STAMBPL1 binds K63 and sst2. 1 / 1
| 1
sparser
"In contrast, AMSH-LP and its yeast homolog Sst2 bind K63 diUb with K M of ~ 50 μM and k cat of ~ 1 s − 1 , substantiall[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28587922
STAMBPL1 affects diUb
| 2
STAMBPL1 binds diUb. 2 / 2
| 2
reach
"(E) A comparison of the diUb/STAMBPL1 complex structure (left) and UbV/STAMBPL1 structure overlaid with diUb (right)."
| DOI
reach
"E, a comparison of the diUb/STAMBPL1 complex structure (left) and UbV/STAMBPL1 structure overlaid with diUb (right)."
34425109
STAMBPL1 affects TRIP13
1 1 |
TRIP13 binds STAMBPL1. 2 / 2
1 1 |
hprd
No evidence text available
16189514
biogrid
No evidence text available
16189514
STAMBPL1 affects STAM2
| 2
STAM binds STAM2, STAMBPL1, and GRB2. 1 / 1
| 1
sparser
"Consistent with this, coimmunoprecipitation analyses revealed that AMSH-LP could not bind to STAM1, STAM2, or Grb2, all of which contain an SH3 domain that interacts with AMSH [2,3,11] ."
12810066
STAM binds STAM2 and STAMBPL1. 1 / 1
| 1
sparser
"Another STAM family protein, STAM2, did not bind to AMSH-LP either, although AMSH strongly binds to STAM2 (data not shown)."
12810066
STAMBPL1 affects SMAD2
1 | 1
STAMBPL1 binds SMAD2 and SMAD7. 1 / 1
| 1
sparser
"Previous studies reported that although they did not investigate the DUB activity of STAMBPL1, STAMBPL1 interact with Smad2 and Smad7, followed by induction of TGF-β-mediated transcriptional activity [ xref ]."
31817770
hprd
No evidence text available
14728725
STAMBPL1 affects RNF32
2 |
biogrid
No evidence text available
21163940
biogrid
No evidence text available
21163940
STAMBPL1 affects RAB2A
2 |
STAMBPL1 binds RAB2A. 2 / 2
2 |
biogrid
No evidence text available
21516116
biogrid
No evidence text available
25416956
STAMBPL1 affects MTOR
| 2
STAMBPL1 activates MTOR. 2 / 2
| 2
reach
"We talk to first authors Dong Wang and Chenchen Xu about their paper, "E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression," and group leader Ying Liu about how the research in her lab in Beijing has evolved, how curiosity is key, and the guilt involved with being a female scientist and mother and how reprioritizing helps her juggle."
35180426
reach
"E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression."
35114100
STAMBPL1 affects GTSE1
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26496610
STAMBPL1 affects GAK
2 |
STAMBPL1 binds GAK. 2 / 2
2 |
biogrid
No evidence text available
26496610
biogrid
No evidence text available
28514442
STAMBPL1 affects FAS
| 2
FAS binds STAMBPL1. 2 / 2
| 2
sparser
"STAMBPL1-FAS fusion isoform was identified in sample 1 M (metastasis cancer) and 2 M (the metastasis cancer): XM_011539985 from STAMBPL1 and XM_011539766.2 from FAS (Fig.  xref )."
33907296
sparser
"However, subsequent analysis using Taqman qPCR showed that the STAMBPL1-FAS fusion isoform can be found in all 6 cancer samples (Supplementary Fig.  xref ), implying a wider distribution of this gene fusion in colon cancers."
33907296
STAMBPL1 affects Clathrin
| 1 1
reach
"Both STAMBP and STAMBPL1 localize to early endosomes by binding to clathrin (31); however, STAMBPL1 fails to bind to STAM due to residue substitutions in the SBM-like motif, suggesting it may function in different signaling pathway from that of STAMBP (30) ."
| DOI
Clathrin binds STAMBP, CLTC, and STAMBPL1. 1 / 1
| 1
sparser
"We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins."
16716190
STAMBPL1 affects CLINT1
2 |
CLINT1 binds STAMBPL1. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
28514442
STAM2 affects STAMBPL1
| 2
STAM binds STAM2, STAMBPL1, and GRB2. 1 / 1
| 1
sparser
"Consistent with this, coimmunoprecipitation analyses revealed that AMSH-LP could not bind to STAM1, STAM2, or Grb2, all of which contain an SH3 domain that interacts with AMSH [2,3,11] ."
12810066
STAM binds STAM2 and STAMBPL1. 1 / 1
| 1
sparser
"Another STAM family protein, STAM2, did not bind to AMSH-LP either, although AMSH strongly binds to STAM2 (data not shown)."
12810066
SMAD7 affects STAMBPL1
1 | 1
STAMBPL1 binds SMAD2 and SMAD7. 1 / 1
| 1
sparser
"Previous studies reported that although they did not investigate the DUB activity of STAMBPL1, STAMBPL1 interact with Smad2 and Smad7, followed by induction of TGF-β-mediated transcriptional activity [ xref ]."
31817770
STAMBPL1 binds SMAD7. 1 / 1
1 |
hprd
No evidence text available
14728725
SMAD2 affects STAMBPL1
1 | 1
STAMBPL1 binds SMAD2 and SMAD7. 1 / 1
| 1
sparser
"Previous studies reported that although they did not investigate the DUB activity of STAMBPL1, STAMBPL1 interact with Smad2 and Smad7, followed by induction of TGF-β-mediated transcriptional activity [ xref ]."
31817770
hprd
No evidence text available
14728725
RNF32 affects STAMBPL1
2 |
biogrid
No evidence text available
21163940
biogrid
No evidence text available
21163940
RAB2A affects STAMBPL1
2 |
STAMBPL1 binds RAB2A. 2 / 2
2 |
biogrid
No evidence text available
21516116
biogrid
No evidence text available
25416956
NFkappaB affects STAMBPL1
| 2
NFkappaB inhibits STAMBPL1.
| 1
NFkappaB inhibits STAMBPL1. 1 / 1
| 1
reach
"Overexpression of wild-type STAMBPL1, but not a catalytically inactive mutant, enhanced Tax mediated NF-kappaB activation, whereas silencing of STAMBPL1 with siRNA impaired Tax activation of both the canonical and noncanonical NF-kappaB signaling pathways."
22258247
NFkappaB activates STAMBPL1.
| 1
NFkappaB activates STAMBPL1. 1 / 1
| 1
reach
"Overexpression of wild-type STAMBPL1, but not a catalytically inactive mutant, enhanced Tax mediated NF-kappaB activation, whereas silencing of STAMBPL1 with siRNA impaired Tax activation of both the canonical and noncanonical NF-kappaB signaling pathways."
22258247
GTSE1 affects STAMBPL1
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26496610
GAK affects STAMBPL1
2 |
STAMBPL1 binds GAK. 2 / 2
2 |
biogrid
No evidence text available
26496610
biogrid
No evidence text available
28514442
FAS affects STAMBPL1
| 2
FAS binds STAMBPL1. 2 / 2
| 2
sparser
"STAMBPL1-FAS fusion isoform was identified in sample 1 M (metastasis cancer) and 2 M (the metastasis cancer): XM_011539985 from STAMBPL1 and XM_011539766.2 from FAS (Fig.  xref )."
33907296
sparser
"However, subsequent analysis using Taqman qPCR showed that the STAMBPL1-FAS fusion isoform can be found in all 6 cancer samples (Supplementary Fig.  xref ), implying a wider distribution of this gene fusion in colon cancers."
33907296
DUSP1 affects STAMBPL1
| 1 1
STAMBPL1 binds DUSP1. 2 / 2
| 1 1
reach
"STAMBPL1 interacts with MKP-1 and stabilizes MKP-1 via deubiquitination."
35236965
sparser
"STAMBPL1 interacts with MKP-1 and stabilizes MKP-1 via deubiquitination."
35236965
Clathrin affects STAMBPL1
| 1 1
reach
"Both STAMBP and STAMBPL1 localize to early endosomes by binding to clathrin (31); however, STAMBPL1 fails to bind to STAM due to residue substitutions in the SBM-like motif, suggesting it may function in different signaling pathway from that of STAMBP (30) ."
| DOI
Clathrin binds STAMBP, CLTC, and STAMBPL1. 1 / 1
| 1
sparser
"We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins."
16716190
CLINT1 affects STAMBPL1
2 |
CLINT1 binds STAMBPL1. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
28514442
CFLAR affects BIRC5
| 2
CFLAR binds STAMBPL1 and BIRC5. 2 / 2
| 2
sparser
"STAMBPL1 interacted with survivin and c-FLIP, resulted in reduction of ubiquitination."
31817770
sparser
"Thus, these data reveal that STAMBPL1 directly interacts with survivin and c-FLIP, resulting in stabilization of proteins."
31817770
BRCC3 affects STAMBPL1
| 2
BRCC3 deubiquitinates STAMBPL1.
| 1
BRCC3 deubiquitinates STAMBPL1. 1 / 1
| 1
reach
"To identify the DUB associated with NALP7, we over-expressed plasmids expressing several candidate DUBs including BRCC3, which deubiquitinates NALP3, COPS5, STAMBPL1, USP7 and the endosome associated DUBs, STAMBP and USP8."
28492230
BRCC3 binds STAMBPL1.
| 1
STAMBPL1 binds BRCC3. 1 / 1
| 1
reach
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly.Comparison of the BRCC36 homodimer and heterodimer structures suggests an explanation for the loss of catalytic activity in the homod[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28587922
BIRC5 affects CFLAR, and STAMBPL1
| 2
CFLAR binds STAMBPL1 and BIRC5. 2 / 2
| 2
sparser
"STAMBPL1 interacted with survivin and c-FLIP, resulted in reduction of ubiquitination."
31817770
sparser
"Thus, these data reveal that STAMBPL1 directly interacts with survivin and c-FLIP, resulting in stabilization of proteins."
31817770
(+)-JQ1 compound decreases the amount of STAMBPL1. 2 / 2
2 |
ctd
No evidence text available
25307878
ctd
No evidence text available
27432991
Vincristine affects STAMBPL1
1 |
Vincristine decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
23649840
Urethane affects STAMBPL1
1 |
Urethane decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
28818685
Tunicamycin affects STAMBPL1
1 |
Tunicamycin increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
22378314
Triadimefon affects STAMBPL1
1 |
Triadimefon increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
28263823
Topotecan affects STAMBPL1
1 |
Topotecan decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
25729387
Thapsigargin affects STAMBPL1
1 |
Thapsigargin increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
22378314
Sulforaphane affects STAMBPL1
1 |
Sulforaphane increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
31838189
Sst2 affects K63
| 1
STAMBPL1 binds K63 and sst2. 1 / 1
| 1
sparser
"In contrast, AMSH-LP and its yeast homolog Sst2 bind K63 diUb with K M of ~ 50 μM and k cat of ~ 1 s − 1 , substantiall[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28587922
Rpn11 affects Ubiquitin
| 1
Ubiquitin binds STAMBPL1 and rpn11. 1 / 1
| 1
sparser
"Rpn11 and AMSH-LP bind ubiquitin in a similar orientation, but their interaction with the Ile44 hydrophobic patch is quite different."
33498168
Resveratrol affects STAMBPL1
1 |
Resveratrol increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
25505154
Propiconazole affects STAMBPL1
1 |
Propiconazole increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
28970091
Progesterone affects STAMBPL1
1 |
Progesterone decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
20660070
Potassium chromate decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
22079256
Polyubiquitin affects STAMBPL1
| 1
STAMBPL1 binds polyubiquitin. 1 / 1
| 1
sparser
"Thus, the structure of the AMSH-LP domain bound to K63-linked polyubiquitin reveals one mode by which DUBs discriminate between polyubiquitin isoforms."
19243136
Phorbol 13-acetate 12-myristate increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
25613284
Paracetamol affects STAMBPL1
1 |
Paracetamol decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
21420995
Oxaliplatin affects STAMBPL1
1 |
Oxaliplatin decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
25729387
Nickel sulfate affects STAMBPL1
1 |
Nickel sulfate decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
22714537
Nickel atom affects STAMBPL1
1 |
Nickel atom increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
25583101
Methyl methanesulfonate decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
23649840
Methamphetamine decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
29802913
Melphalan affects STAMBPL1
1 |
Melphalan decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
22363485
Lead diacetate affects STAMBPL1
1 |
Lead diacetate decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
21829687
Jinfukang affects STAMBPL1
1 |
Jinfukang decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
27392435
Ionomycin affects STAMBPL1
1 |
Ionomycin increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
25613284
Hsa-miR-941 affects STAMBPL1
1 |
Hsa-miR-941 decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-885-5p affects STAMBPL1
1 |
Hsa-miR-885-5p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-766-3p affects STAMBPL1
1 |
Hsa-miR-766-3p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-6868-3p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-6849-3p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-6837-3p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-6754-3p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-6720-5p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-6512-3p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-548p affects STAMBPL1
1 |
Hsa-miR-548p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-5197-5p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-508-5p affects STAMBPL1
1 |
Hsa-miR-508-5p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-4778-3p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-4633-5p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-412-3p affects STAMBPL1
1 |
Hsa-miR-412-3p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-23c affects STAMBPL1
1 |
Hsa-miR-23c decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-23b-3p affects STAMBPL1
1 |
Hsa-miR-23b-3p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-23a-3p affects STAMBPL1
1 |
Hsa-miR-23a-3p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-215-5p affects STAMBPL1
1 |
Hsa-miR-215-5p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19074876
Hsa-miR-192-5p affects STAMBPL1
1 |
Hsa-miR-192-5p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19074876
Hsa-miR-130a-5p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-1248 affects STAMBPL1
1 |
Hsa-miR-1248 decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-1237-3p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-103a-3p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hexabromocyclododecane decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
29177809
Formaldehyde affects STAMBPL1
1 |
Formaldehyde decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
23649840
Folic acid affects STAMBPL1
1 |
Folic acid increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
20938992
Flutamide affects STAMBPL1
1 |
Flutamide increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
24136188
Flusilazole affects STAMBPL1
1 |
Flusilazole increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
28263823
Fluoranthene affects STAMBPL1
1 |
Fluoranthene increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
28329830
Fenarimol affects STAMBPL1
1 |
Fenarimol increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
28970091
Ethyl methanesulfonate decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
23649840
Ethanol affects STAMBPL1
1 |
Ethanol increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
19167417
Entinostat affects STAMBPL1
1 |
Entinostat decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
27188386
Endosulfan affects STAMBPL1
1 |
Endosulfan increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
26615145
Ectopic following affects STAMBPL1
| 1
Ectopic following activates STAMBPL1. 1 / 1
| 1
eidos
"A 137 number of novel host factors have been confirmed to facilitate SARS-CoV-2 pseudovirus entry ,138 151HEK293T cells , besides ACE2 and CTSL , the ectopic expression of any of the following genes could 152 effectively enable SARS-CoV-2 infection , CLEC4G , CPLX1 , LDLRAD3 , TMEM30A , and STAMBPL1 153 ( Fig. 3B ) ."
| DOI
Doxorubicin affects STAMBPL1
1 |
Doxorubicin decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
29803840
Dorsomorphin affects STAMBPL1
1 |
Dorsomorphin decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
27188386
Choline affects STAMBPL1
1 |
Choline increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
20938992
Cepharanthine affects STAMBPL1
| 1
eidos
"However , although cepharanthine reduces STAMBPL1 expression and overexpression of STAMBPL1 inhibits cepharanthine-mediated downregulation of survivin , interaction between STAMBPL1 and survivin was not investigated ."
31817770
Camptothecin affects STAMBPL1
1 |
Camptothecin methylates STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
30720231
Calcitriol affects STAMBPL1
1 |
Calcitriol increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
16002434
Butanal affects STAMBPL1
1 |
Butanal increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
26079696
Bis(2-ethylhexyl) phthalate decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
31163220
Benzo[a]pyrene affects STAMBPL1
1 |
Benzo[a]pyrene increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
22228805
Benzo[a]pyrene diol epoxide I decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
19150397
Atrazine affects STAMBPL1
1 |
Atrazine decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
29505797
All-trans-retinoic acid increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
21934132
Acetamide affects STAMBPL1
1 |
Acetamide increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
31881176
Abrine affects STAMBPL1
1 |
Abrine increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
31054353
ZNF106 affects STAMBPL1
1 |
ZNF106 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
28514442
YPEL3 affects STAMBPL1
| 1
CEP55 binds YPEL3, STAMBPL1, and IGFBP1. 1 / 1
| 1
sparser
"These data suggest that STAMBPL1, CEP55, YPEL3 and IGFBP1 may be associated with the prognosis of patients with PAAD."
32565937
WNK1 affects STAMBPL1
1 |
WNK1 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
28514442
VTI1B affects STAMBPL1
1 |
biogrid
No evidence text available
28514442
Ubiquitin affects rpn11
| 1
Ubiquitin binds STAMBPL1 and rpn11. 1 / 1
| 1
sparser
"Rpn11 and AMSH-LP bind ubiquitin in a similar orientation, but their interaction with the Ile44 hydrophobic patch is quite different."
33498168
Ubiquitin affects PTCH1
| 1
Ubiquitin binds STAMBPL1 and PTCH1. 1 / 1
| 1
sparser
"AMSH-LP binds the distal ubiquitin via its Leu8/Ile44/Val70 hydrophobic patch conserved in NEDD8."
21288713
Ubiquitin affects BRCC36
| 1
Ubiquitin binds STAMBPL1, K63, and BRCC36. 1 / 1
| 1
sparser
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly."
28587922
UbV SP.1 affects STAMBPL1
| 1
UbV SP.1 inhibits STAMBPL1. 1 / 1
| 1
reach
"In addition, UbV SP.1 appeared to inhibit STAMBPL1 to some extent, whereas UbV SP.3 showed no inhibitory effect with STAMBPL1 (Fig. S2A) ."
| DOI
USP49 affects STAMBPL1
1 |
USP49 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
19615732
UBE2N affects STAMBPL1
1 |
biogrid
No evidence text available
19615732
UBD affects Phe403
| 1
UBD binds STAMBPL1 and Phe403. 1 / 1
| 1
reach
"X-ray crystal structures of the DUB domains of both AMSH-LP and Sst2 bound to diubiquitin shows Phe403 collapsed onto the Lys63 side chain of the proximal ubiquitin; however, the flap residues appear to retain their mobility even in presence of bound substrate or product (indicated by relatively weak electron density enveloping these residues and higher B-factors than internal residues)."
26368668
UBC affects STAMBPL1
1 |
UBC binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
18758443
Tobacco Smoke Pollution decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
28065790
TRIM27 affects STAMBPL1
1 |
STAMBPL1 binds TRIM27. 1 / 1
1 |
biogrid
No evidence text available
25416956
TCF4 affects STAMBPL1
1 |
TCF4 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
25416956
STX8 affects STAMBPL1
1 |
STX8 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
28514442
STAMBPL1 inhibits transcription, DNA-templated. 1 / 1
| 1
reach
"As a result, viral transcription and replication are greatly suppressed by either LEF1 or STAMBPL1, resulting in selective viral replication in LEF1 and STAMPBPL1 low expressing cells."
27901484
STAMBPL1 affects survivin c-FLIP protein
| 1
STAMBPL1 activates survivin c-FLIP protein. 1 / 1
| 1
eidos
"Knockdown of STAMBPL1 reduced survivin and c-FLIP protein levels , while overexpression of STAMBPL1 inhibited honokinol-induced survivin and c-FLIP degradation ."
31817770
STAMBPL1 affects rpn11
| 1
Ubiquitin binds STAMBPL1 and rpn11. 1 / 1
| 1
sparser
"Rpn11 and AMSH-LP bind ubiquitin in a similar orientation, but their interaction with the Ile44 hydrophobic patch is quite different."
33498168
STAMBPL1 affects polyubiquitin
| 1
STAMBPL1 binds polyubiquitin. 1 / 1
| 1
sparser
"Thus, the structure of the AMSH-LP domain bound to K63-linked polyubiquitin reveals one mode by which DUBs discriminate between polyubiquitin isoforms."
19243136
STAMBPL1 affects messenger RNA
| 1
STAMBPL1 increases the amount of messenger RNA. 1 / 1
| 1
reach
"qPCR results revealed, beyond the knockdown efficiency, that depletion of STAMBPL1 causes an elevation of CDH1 and a reduction of VIM messenger RNA (mRNA) levels (Fig. 2b)."
32636467
reach
"STAMBPL1 expression contributes to EMT."
32636467
STAMBPL1 affects cepharanthine-mediated survivin
| 1
STAMBPL1 activates cepharanthine-mediated survivin. 1 / 1
| 1
eidos
"However , although cepharanthine reduces STAMBPL1 expression and overexpression of STAMBPL1 inhibits cepharanthine-mediated downregulation of survivin , interaction between STAMBPL1 and survivin was not investigated ."
31817770
STAMBPL1 affects breast cancer cell resistance cisplatin
| 1
STAMBPL1 activates breast cancer cell resistance cisplatin. 1 / 1
| 1
eidos
"STAMBPL1 promotes breast cancer cell resistance to cisplatin partially by stabilizing MKP-1 expression ."
35236965
STAMBPL1 affects ZNF106
1 |
ZNF106 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
28514442
STAMBPL1 affects YPEL3
| 1
CEP55 binds YPEL3, STAMBPL1, and IGFBP1. 1 / 1
| 1
sparser
"These data suggest that STAMBPL1, CEP55, YPEL3 and IGFBP1 may be associated with the prognosis of patients with PAAD."
32565937
STAMBPL1 affects XIAP
| 1
STAMBPL1 inhibits XIAP. 1 / 1
| 1
reach
"Taken together, these studies show that STAMBPL1 depletion induces apoptosis by promoting XIAP lysosomal degradation, and suggest that targeting deubiquitinase STAMBPL1 might offer promising therapeutic strategy for prostate cancer."
31004702
STAMBPL1 affects WNK1
1 |
WNK1 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
28514442
STAMBPL1 affects VTI1B
1 |
biogrid
No evidence text available
28514442
STAMBPL1 affects VIM
| 1
STAMBPL1 increases the amount of VIM. 1 / 1
| 1
reach
"qPCR results revealed, beyond the knockdown efficiency, that depletion of STAMBPL1 causes an elevation of CDH1 and a reduction of VIM messenger RNA (mRNA) levels (Fig. 2b)."
32636467
STAMBPL1 affects Ubiquitin, and rpn11
| 1
Ubiquitin binds STAMBPL1 and rpn11. 1 / 1
| 1
sparser
"Rpn11 and AMSH-LP bind ubiquitin in a similar orientation, but their interaction with the Ile44 hydrophobic patch is quite different."
33498168
STAMBPL1 affects UbVSP.1
| 1
STAMBPL1 binds UbVSP.1. 1 / 1
| 1
reach
"A strong hydrogen bond network is then formed between the Arg72 guanidinium and the backbone carbonyl group of Glu326 in ins-1 and between the amide group of Gln49 of UbVSP.1 with the backbone carbonyl and amide of Val328 and Glu326, thus stabilizing the interaction between the STAMBPL1 and UbVSP.1 (Fig. 2G)."
34425109
STAMBPL1 affects USP49
1 |
USP49 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
19615732
STAMBPL1 affects UBE2N
1 |
biogrid
No evidence text available
19615732
STAMBPL1 affects UBC
1 |
UBC binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
18758443
STAMBPL1 affects TRIM27
1 |
STAMBPL1 binds TRIM27. 1 / 1
1 |
biogrid
No evidence text available
25416956
STAMBPL1 affects TP53
| 1
STAMBPL1 activates mutated TP53. 1 / 1
| 1
reach
"Concomitantly, we observed that STAMBPL1 expression was elevated in cells with mutant p53-elicited EMT (Fig. 6c)."
32636467
STAMBPL1 affects TGFß
| 1
STAMBPL1 activates TGFß. 1 / 1
| 1
reach
"Leukaemia (2) AMSH-LP Potentiates TGFß signaling through interaction with inihibitory I-SMADs (62) None reportedKidney (2), liver, brain, HNSCC.Brain, testicular, leukaemia, brain."
20073038
STAMBPL1 affects TGFB
| 1
STAMBPL1 activates TGFB. 1 / 1
| 1
reach
"Finally, AMSH-LP and UCHL5 promote TGF-beta responses through their interaction with inhibitory I-SMADs [XREF_BIBR, XREF_BIBR]."
25972356
STAMBPL1 affects TCF4
1 |
TCF4 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
25416956
STAMBPL1 affects STX8
1 |
STX8 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
28514442
STAMBPL1 affects SP1
| 1
SP1 binds STAMBPL1, E2F2, E2F6, and MAFF. 1 / 1
| 1
sparser
"While our study highlights and connect three key signalling pathways: mutant p53, EMT and DUBs, showing that STAMBPL1 is transcriptionally elevated in mutant p53-expressing cells, STAMBPL1 seems not to be under a direct regulation by p53 R175H . However, out of the known TFs that help recruit mutant p53 to the chromatin to upregulate genes, xref we found that E2F2, E2F6, MAFF and SP1 can bind to the core promoter region of STAMBPL1 by their motif search using Eukaryotic promoter database."
32636467
STAMBPL1 affects SNRPA1
1 |
biogrid
No evidence text available
19615732
STAMBPL1 affects SMAP2
1 |
biogrid
No evidence text available
28514442
STAMBPL1 affects SIPA1L1
1 |
biogrid
No evidence text available
28514442
STAMBPL1 affects SHBG
| 1
SHBG binds STAMBP and STAMBPL1. 1 / 1
| 1
sparser
"Hameed et al. developed a zinc chelating ABP that forms a tight complex with STAMBP and STAMBPL1 and inhibits the activity of the proteasomal DUB Rpn11 (PSMD14 in humans)."
35625630
STAMBPL1 affects SESN2
| 1
SESN2 binds STAMBPL1. 1 / 1
| 1
sparser
"Lastly, a cell-permeable peptide that blocks the STAMBPL1-Sestrin2 interaction inhibits mTORC1 and provides a potential option for cancer therapy."
35114100
STAMBPL1 affects RPN11
| 1
STAMBPL1 inhibits RPN11. 1 / 1
| 1
reach
"In fact, whereas the Ins-2 loop of AMSH-LP contacts the proximal ubiquitin, restricting linkage specificity [44], in Rpn11, it anchors the enzyme to the proteasome [45,66]."
28988953
STAMBPL1 affects REPS1
1 |
biogrid
No evidence text available
28514442
STAMBPL1 affects Phe403
| 1
UBD binds STAMBPL1 and Phe403. 1 / 1
| 1
reach
"X-ray crystal structures of the DUB domains of both AMSH-LP and Sst2 bound to diubiquitin shows Phe403 collapsed onto the Lys63 side chain of the proximal ubiquitin; however, the flap residues appear to retain their mobility even in presence of bound substrate or product (indicated by relatively weak electron density enveloping these residues and higher B-factors than internal residues)."
26368668
STAMBPL1 affects PTCH1
| 1
Ubiquitin binds STAMBPL1 and PTCH1. 1 / 1
| 1
sparser
"AMSH-LP binds the distal ubiquitin via its Leu8/Ile44/Val70 hydrophobic patch conserved in NEDD8."
21288713
STAMBPL1 affects PSEN1
1 |
biogrid
No evidence text available
21163940
STAMBPL1 affects PNMA1
1 |
biogrid
No evidence text available
25416956
STAMBPL1 affects PIK3C2A
1 |
STAMBPL1 binds PIK3C2A. 1 / 1
1 |
biogrid
No evidence text available
28514442
STAMBPL1 affects PICALM
1 |
PICALM binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
28514442
STAMBPL1 affects OTUB1
1 |
biogrid
No evidence text available
19615732
STAMBPL1 affects Neoplasms
| 1
STAMBPL1 activates Neoplasms. 1 / 1
| 1
reach
"Knockout of STAMBPL1 or correction of the heterozygous STAMBPL1 mutation in a human colon cancer cell line suppresses xenograft tumor growth."
35114100
STAMBPL1 affects NUMB
1 |
STAMBPL1 binds NUMB. 1 / 1
1 |
biogrid
No evidence text available
28514442
STAMBPL1 affects MYC
| 1
STAMBPL1 decreases the amount of MYC. 1 / 1
| 1
reach
"It is of great interest that the C-terminal-half-deleted mutants of AMSH and AMSH-LP, which lack the JAMM motifs, are unable to induce the IL-2-mediated c- myc expression."
12810066
STAMBPL1 affects MAST1
1 |
MAST1 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
21163940
STAMBPL1 affects MAGEA6
1 |
biogrid
No evidence text available
25416956
STAMBPL1 affects MAFF
| 1
SP1 binds STAMBPL1, E2F2, E2F6, and MAFF. 1 / 1
| 1
sparser
"While our study highlights and connect three key signalling pathways: mutant p53, EMT and DUBs, showing that STAMBPL1 is transcriptionally elevated in mutant p53-expressing cells, STAMBPL1 seems not to be under a direct regulation by p53 R175H . However, out of the known TFs that help recruit mutant p53 to the chromatin to upregulate genes, xref we found that E2F2, E2F6, MAFF and SP1 can bind to the core promoter region of STAMBPL1 by their motif search using Eukaryotic promoter database."
32636467
STAMBPL1 affects LAX1
1 |
STAMBPL1 binds LAX1. 1 / 1
1 |
biogrid
No evidence text available
25416956
STAMBPL1 affects JAB
| 1
STAMBPL1 binds JAB. 1 / 1
| 1
sparser
"1 / STAMBPL1 JAMM complex at 2.0 Å resolution (PDB:7L97, Fig. 2B and Table 1 ) in space group C 2 ."
34425109
STAMBPL1 affects INCA1
1 |
biogrid
No evidence text available
25416956
STAMBPL1 affects IKZF3
1 |
IKZF3 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
25416956
STAMBPL1 affects IGFBP1
| 1
CEP55 binds YPEL3, STAMBPL1, and IGFBP1. 1 / 1
| 1
sparser
"These data suggest that STAMBPL1, CEP55, YPEL3 and IGFBP1 may be associated with the prognosis of patients with PAAD."
32565937
STAMBPL1 affects HMX3
1 |
STAMBPL1 binds HMX3. 1 / 1
1 |
biogrid
No evidence text available
19615732
STAMBPL1 affects HIP1R
1 |
biogrid
No evidence text available
28514442
STAMBPL1 affects GRB2
| 1
STAM binds STAM2, STAMBPL1, and GRB2. 1 / 1
| 1
sparser
"Consistent with this, coimmunoprecipitation analyses revealed that AMSH-LP could not bind to STAM1, STAM2, or Grb2, all of which contain an SH3 domain that interacts with AMSH [2,3,11] ."
12810066
STAMBPL1 affects GPRIN1
1 |
STAMBPL1 binds GPRIN1. 1 / 1
1 |
biogrid
No evidence text available
28514442
STAMBPL1 affects GOLGA2
1 |
biogrid
No evidence text available
25416956
STAMBPL1 affects GNPTAB
1 |
biogrid
No evidence text available
25416956
STAMBPL1 affects EPS15
1 |
STAMBPL1 binds EPS15. 1 / 1
1 |
biogrid
No evidence text available
28514442
STAMBPL1 affects ECSIT
1 |
STAMBPL1 binds ECSIT. 1 / 1
1 |
biogrid
No evidence text available
21163940
STAMBPL1 affects E7
1 |
STAMBPL1 binds E7. 1 / 1
1 |
virhostnet
No evidence text available
22810586
STAMBPL1 affects E2F6
| 1
SP1 binds STAMBPL1, E2F2, E2F6, and MAFF. 1 / 1
| 1
sparser
"While our study highlights and connect three key signalling pathways: mutant p53, EMT and DUBs, showing that STAMBPL1 is transcriptionally elevated in mutant p53-expressing cells, STAMBPL1 seems not to be under a direct regulation by p53 R175H . However, out of the known TFs that help recruit mutant p53 to the chromatin to upregulate genes, xref we found that E2F2, E2F6, MAFF and SP1 can bind to the core promoter region of STAMBPL1 by their motif search using Eukaryotic promoter database."
32636467
STAMBPL1 affects DUB domain
| 1
STAMBPL1 binds DUB domain and K63-Ub 2. 1 / 1
| 1
reach
"The overall three-dimensional fold of Sst2 Delta220 -K63-Ub 2 is highly similar to the structure of the DUB domain of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) with an rmsd of 1.19 A of Calpha atoms over 266 residues from both Sst2 and K63-Ub 2."
24787148
STAMBPL1 affects Cell Survival
| 1
STAMBPL1 activates Cell Survival. 1 / 1
| 1
eidos
"In addition , STAMBPL1 deubiquitinylates the anti-apoptotic protein Survivin and thus ameliorates cell survival ."
35066747
STAMBPL1 affects CNTN2
| 1
STAMBPL1 leads to the deubiquitination of CNTN2. 1 / 1
| 1
reach
"The deubiquitination of Tax-1 can be also mediated by STAM binding protein like 1 (STAMBPL1), which was identified in an RNA interference screen XREF_BIBR."
25116307
STAMBPL1 affects CLTCL1
1 |
biogrid
No evidence text available
28514442
STAMBPL1 affects CEP72
1 |
biogrid
No evidence text available
25416956
STAMBPL1 affects CEP55
| 1
CEP55 binds YPEL3, STAMBPL1, and IGFBP1. 1 / 1
| 1
sparser
"These data suggest that STAMBPL1, CEP55, YPEL3 and IGFBP1 may be associated with the prognosis of patients with PAAD."
32565937
STAMBPL1 affects CDH1
| 1
STAMBPL1 increases the amount of CDH1. 1 / 1
| 1
reach
"These analyses showed that the KO of STAMBPL1 caused a significant restoration in the expression of E-cadherin, both transcriptionally and at protein levels, and a significant vimentin reduction."
32636467
STAMBPL1 affects CDC37
1 |
CDC37 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
21163940
STAMBPL1 affects CC2D2A
1 |
biogrid
No evidence text available
26638075
STAMBPL1 affects CAPZA2
1 |
CAPZA2 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
26496610
STAMBPL1 affects BRCC36
| 1
Ubiquitin binds STAMBPL1, K63, and BRCC36. 1 / 1
| 1
sparser
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly."
28587922
STAMBPL1 affects BRCC3
| 1
STAMBPL1 binds BRCC3. 1 / 1
| 1
reach
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly.Comparison of the BRCC36 homodimer and heterodimer structures suggests an explanation for the loss of catalytic activity in the homod[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28587922
STAMBPL1 affects BMP2K
1 |
biogrid
No evidence text available
28514442
STAMBPL1 affects AP1B1
1 |
biogrid
No evidence text available
28514442
STAMBPL1 affects A2M
1 |
STAMBPL1 binds A2M. 1 / 1
1 |
biogrid
No evidence text available
21163940
STAMBP affects SHBG
| 1
SHBG binds STAMBP and STAMBPL1. 1 / 1
| 1
sparser
"Hameed et al. developed a zinc chelating ABP that forms a tight complex with STAMBP and STAMBPL1 and inhibits the activity of the proteasomal DUB Rpn11 (PSMD14 in humans)."
35625630
STAMBP affects Clathrin
| 1
Clathrin binds STAMBP, CLTC, and STAMBPL1. 1 / 1
| 1
sparser
"We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins."
16716190
STAM2 affects GRB2
| 1
STAM binds STAM2, STAMBPL1, and GRB2. 1 / 1
| 1
sparser
"Consistent with this, coimmunoprecipitation analyses revealed that AMSH-LP could not bind to STAM1, STAM2, or Grb2, all of which contain an SH3 domain that interacts with AMSH [2,3,11] ."
12810066
STAM affects STAM2, and STAMBPL1
| 1
STAM binds STAM2 and STAMBPL1. 1 / 1
| 1
sparser
"Another STAM family protein, STAM2, did not bind to AMSH-LP either, although AMSH strongly binds to STAM2 (data not shown)."
12810066
STAM affects GRB2
| 1
STAM binds STAM2, STAMBPL1, and GRB2. 1 / 1
| 1
sparser
"Consistent with this, coimmunoprecipitation analyses revealed that AMSH-LP could not bind to STAM1, STAM2, or Grb2, all of which contain an SH3 domain that interacts with AMSH [2,3,11] ."
12810066
SP1 affects STAMBPL1
| 1
SP1 binds STAMBPL1, E2F2, E2F6, and MAFF. 1 / 1
| 1
sparser
"While our study highlights and connect three key signalling pathways: mutant p53, EMT and DUBs, showing that STAMBPL1 is transcriptionally elevated in mutant p53-expressing cells, STAMBPL1 seems not to be under a direct regulation by p53 R175H . However, out of the known TFs that help recruit mutant p53 to the chromatin to upregulate genes, xref we found that E2F2, E2F6, MAFF and SP1 can bind to the core promoter region of STAMBPL1 by their motif search using Eukaryotic promoter database."
32636467
SNRPA1 affects STAMBPL1
1 |
biogrid
No evidence text available
19615732
SNP rs2862833 affects STAMBPL1
| 1
SNP rs2862833 increases the amount of STAMBPL1. 1 / 1
| 1
reach
"The protective SNP rs2862833, a downstream variant of the FAS gene, increased the expression of FAS (Z-score 10.8, P = 3.51 x10 -27) and the STAMBPL1 and ACTA2 locus (Z-score 38.25, P = 9.81 x10 -198)."
29142307
SMURF2 affects STAMBPL1
1 |
SMURF2 ubiquitinates STAMBPL1. 1 / 1
1 |
SMAP2 affects STAMBPL1
1 |
biogrid
No evidence text available
28514442
SMAD7 affects SMAD2
| 1
STAMBPL1 binds SMAD2 and SMAD7. 1 / 1
| 1
sparser
"Previous studies reported that although they did not investigate the DUB activity of STAMBPL1, STAMBPL1 interact with Smad2 and Smad7, followed by induction of TGF-β-mediated transcriptional activity [ xref ]."
31817770
SIPA1L1 affects STAMBPL1
1 |
biogrid
No evidence text available
28514442
SHBG affects STAMBPL1
| 1
SHBG binds STAMBP and STAMBPL1. 1 / 1
| 1
sparser
"Hameed et al. developed a zinc chelating ABP that forms a tight complex with STAMBP and STAMBPL1 and inhibits the activity of the proteasomal DUB Rpn11 (PSMD14 in humans)."
35625630
SESN2 affects STAMBPL1
| 1
SESN2 binds STAMBPL1. 1 / 1
| 1
sparser
"Lastly, a cell-permeable peptide that blocks the STAMBPL1-Sestrin2 interaction inhibits mTORC1 and provides a potential option for cancer therapy."
35114100
REPS1 affects STAMBPL1
1 |
biogrid
No evidence text available
28514442
Phe403 affects UBD
| 1
UBD binds STAMBPL1 and Phe403. 1 / 1
| 1
reach
"X-ray crystal structures of the DUB domains of both AMSH-LP and Sst2 bound to diubiquitin shows Phe403 collapsed onto the Lys63 side chain of the proximal ubiquitin; however, the flap residues appear to retain their mobility even in presence of bound substrate or product (indicated by relatively weak electron density enveloping these residues and higher B-factors than internal residues)."
26368668
PTCH1 affects Ubiquitin
| 1
Ubiquitin binds STAMBPL1 and PTCH1. 1 / 1
| 1
sparser
"AMSH-LP binds the distal ubiquitin via its Leu8/Ile44/Val70 hydrophobic patch conserved in NEDD8."
21288713
PSEN1 affects STAMBPL1
1 |
biogrid
No evidence text available
21163940
PNMA1 affects STAMBPL1
1 |
biogrid
No evidence text available
25416956
PIK3C2A affects STAMBPL1
1 |
STAMBPL1 binds PIK3C2A. 1 / 1
1 |
biogrid
No evidence text available
28514442
PICALM affects STAMBPL1
1 |
PICALM binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
28514442
OTUB1 affects STAMBPL1
1 |
biogrid
No evidence text available
19615732
NUMB affects STAMBPL1
1 |
STAMBPL1 binds NUMB. 1 / 1
1 |
biogrid
No evidence text available
28514442
N-nitrosodiethylamine increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
24535843
MYC affects STAMBPL1
| 1
MYC activates mutated STAMBPL1. 1 / 1
| 1
reach
"Second, defective intracellular trafficking and localization, originating from D406G germline mutation of STAMBPL1 and enhanced by MYC network activation, inhibit cell polarity establishment and cell differentiation, preventing cell cycle exit."
30018743
MAST1 affects STAMBPL1
1 |
MAST1 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
21163940
MAGEA6 affects STAMBPL1
1 |
biogrid
No evidence text available
25416956
MAFF affects STAMBPL1
| 1
SP1 binds STAMBPL1, E2F2, E2F6, and MAFF. 1 / 1
| 1
sparser
"While our study highlights and connect three key signalling pathways: mutant p53, EMT and DUBs, showing that STAMBPL1 is transcriptionally elevated in mutant p53-expressing cells, STAMBPL1 seems not to be under a direct regulation by p53 R175H . However, out of the known TFs that help recruit mutant p53 to the chromatin to upregulate genes, xref we found that E2F2, E2F6, MAFF and SP1 can bind to the core promoter region of STAMBPL1 by their motif search using Eukaryotic promoter database."
32636467
LAX1 affects STAMBPL1
1 |
STAMBPL1 binds LAX1. 1 / 1
1 |
biogrid
No evidence text available
25416956
L-methionine affects STAMBPL1
1 |
L-methionine increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
20938992
K63-Ub 2 affects DUB domain
| 1
STAMBPL1 binds DUB domain and K63-Ub 2. 1 / 1
| 1
reach
"The overall three-dimensional fold of Sst2 Delta220 -K63-Ub 2 is highly similar to the structure of the DUB domain of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) with an rmsd of 1.19 A of Calpha atoms over 266 residues from both Sst2 and K63-Ub 2."
24787148
K63 affects sst2
| 1
STAMBPL1 binds K63 and sst2. 1 / 1
| 1
sparser
"In contrast, AMSH-LP and its yeast homolog Sst2 bind K63 diUb with K M of ~ 50 μM and k cat of ~ 1 s − 1 , substantiall[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28587922
K63 affects BRCC36
| 1
Ubiquitin binds STAMBPL1, K63, and BRCC36. 1 / 1
| 1
sparser
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly."
28587922
JAB affects STAMBPL1
| 1
STAMBPL1 binds JAB. 1 / 1
| 1
sparser
"1 / STAMBPL1 JAMM complex at 2.0 Å resolution (PDB:7L97, Fig. 2B and Table 1 ) in space group C 2 ."
34425109
INCA1 affects STAMBPL1
1 |
biogrid
No evidence text available
25416956
IKZF3 affects STAMBPL1
1 |
IKZF3 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
25416956
IGFBP1 affects YPEL3
| 1
CEP55 binds YPEL3, STAMBPL1, and IGFBP1. 1 / 1
| 1
sparser
"These data suggest that STAMBPL1, CEP55, YPEL3 and IGFBP1 may be associated with the prognosis of patients with PAAD."
32565937
HMX3 affects STAMBPL1
1 |
STAMBPL1 binds HMX3. 1 / 1
1 |
biogrid
No evidence text available
19615732
HIP1R affects STAMBPL1
1 |
biogrid
No evidence text available
28514442
GSK3 affects STAMBPL1
| 1
GSK3 decreases the amount of STAMBPL1. 1 / 1
| 1
reach
"Consistent with the effect of GSK-3 inhibition to stimulate the transcription of Snail, in this study, we show that GSK-3α/β inhibition can induce a significant STAMBPL1 expression in all cell lines tested, signifying that this stimulation is able to trigger similar STAMBPL1 molecular response in several cell and cancer types and suggest that GSK-3α/β inhibition may converge upon common signalling element in multiple carcinomas to activate STAMBPL1."
32636467
GRB2 affects STAMBPL1
| 1
STAM binds STAM2, STAMBPL1, and GRB2. 1 / 1
| 1
sparser
"Consistent with this, coimmunoprecipitation analyses revealed that AMSH-LP could not bind to STAM1, STAM2, or Grb2, all of which contain an SH3 domain that interacts with AMSH [2,3,11] ."
12810066
GPRIN1 affects STAMBPL1
1 |
STAMBPL1 binds GPRIN1. 1 / 1
1 |
biogrid
No evidence text available
28514442
GOLGA2 affects STAMBPL1
1 |
biogrid
No evidence text available
25416956
GNPTAB affects STAMBPL1
1 |
biogrid
No evidence text available
25416956
FOXO1 affects STAMBPL1
1 |
Transcriptionally active FOXO1 increases the amount of STAMBPL1. 1 / 1
1 |
bel
"Supplemental Table S1. Transcripts found in Class I [activated by FKHR]"
12150827
EPS15 affects STAMBPL1
1 |
STAMBPL1 binds EPS15. 1 / 1
1 |
biogrid
No evidence text available
28514442
ECSIT affects STAMBPL1
1 |
STAMBPL1 binds ECSIT. 1 / 1
1 |
biogrid
No evidence text available
21163940
E7 affects STAMBPL1
1 |
STAMBPL1 binds E7. 1 / 1
1 |
virhostnet
No evidence text available
22810586
E2F6 affects STAMBPL1
| 1
SP1 binds STAMBPL1, E2F2, E2F6, and MAFF. 1 / 1
| 1
sparser
"While our study highlights and connect three key signalling pathways: mutant p53, EMT and DUBs, showing that STAMBPL1 is transcriptionally elevated in mutant p53-expressing cells, STAMBPL1 seems not to be under a direct regulation by p53 R175H . However, out of the known TFs that help recruit mutant p53 to the chromatin to upregulate genes, xref we found that E2F2, E2F6, MAFF and SP1 can bind to the core promoter region of STAMBPL1 by their motif search using Eukaryotic promoter database."
32636467
DUB domain affects STAMBPL1
| 1
STAMBPL1 binds DUB domain and K63-Ub 2. 1 / 1
| 1
reach
"The overall three-dimensional fold of Sst2 Delta220 -K63-Ub 2 is highly similar to the structure of the DUB domain of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) with an rmsd of 1.19 A of Calpha atoms over 266 residues from both Sst2 and K63-Ub 2."
24787148
Cuprizone affects STAMBPL1
1 |
Cuprizone decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
26577399
Clathrin affects STAMBP
| 1
Clathrin binds STAMBP, CLTC, and STAMBPL1. 1 / 1
| 1
sparser
"We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins."
16716190
CLTCL1 affects STAMBPL1
1 |
biogrid
No evidence text available
28514442
CLTC affects STAMBP
| 1
Clathrin binds STAMBP, CLTC, and STAMBPL1. 1 / 1
| 1
sparser
"We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins."
16716190
CEP72 affects STAMBPL1
1 |
biogrid
No evidence text available
25416956
CEP55 affects YPEL3
| 1
CEP55 binds YPEL3, STAMBPL1, and IGFBP1. 1 / 1
| 1
sparser
"These data suggest that STAMBPL1, CEP55, YPEL3 and IGFBP1 may be associated with the prognosis of patients with PAAD."
32565937
CDC37 affects STAMBPL1
1 |
CDC37 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
21163940
CC2D2A affects STAMBPL1
1 |
biogrid
No evidence text available
26638075
CAPZA2 affects STAMBPL1
1 |
CAPZA2 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
26496610
BRCC36 affects Ubiquitin
| 1
Ubiquitin binds STAMBPL1, K63, and BRCC36. 1 / 1
| 1
sparser
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly."
28587922
BMP2K affects STAMBPL1
1 |
biogrid
No evidence text available
28514442
Aroclor 1254 affects STAMBPL1
1 |
Aroclor 1254 decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
23650126
Air Pollutants affects STAMBPL1
1 |
Air Pollutants increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
21757418
AZM551248 affects STAMBPL1
1 |
AZM551248 increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
22323515
AP1B1 affects STAMBPL1
1 |
biogrid
No evidence text available
28514442
A2M affects STAMBPL1
1 |
STAMBPL1 binds A2M. 1 / 1
1 |
biogrid
No evidence text available
21163940
4-hydroxyphenyl retinamide increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
28973697
2-hydroxypropanoic acid decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
30851411
2-butoxyethanol decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
19812364
ctd
No evidence text available
32109520
17beta-estradiol decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
20660070
1-methylanthracene increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
28329830
1,1-dichloroethene increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
26682919
(-)-epigallocatechin 3-gallate decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
22079256
(-)-demecolcine decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
23649840