IndraLab

Statements

STAMBPL1 affects Ubiquitin
| 4 16
STAMBPL1 binds Ubiquitin.
| 1 16
sparser
"The Oγ atom of AMSH’s Ser346 is pointing away from Glu64 of the proximal ubiquitin ( xref ), contrary to the equivalent residue in both free and ubiquitin-bound AMSH-LP, which are at distances of 2.4Å and 2.6Å from proximal ubiquitin’s Glu64, respectively."
21888914
sparser
"Cys282 is next to the active site, and in fact it makes a van der Waals contact with Leu73 of the distal ubiquitin in the structure of AMSH-LP DUB domain bound to Lys63-linked ubiquitin dimer. xref In the disulfide orientation, however, as seen in the model of AMSH244 bound to Lys63-linked diubiquitin (please see below), the contact is lost."
21888914
sparser
"Interestingly, in the structure of AMSH-LP DUB domain bound to Lys63-linked ubiquitin dimer, the corresponding residue pair is still seen in a similar position as the substrate-free form, xref suggesting that these residues close the active site during catalysis as well, perhaps to help position the scissile peptide bond or stabilize the transition state or both."
21888914
sparser
"It is known that Val328 and Phe332 of AMSH-LP interact with ubiquitin Ile44, but structural comparison shows that the equivalent positions in Rpn11 (Val83 and Phe87) are oriented in an opposite direction from AMSH-LP ( xref B)."
33498168
sparser
"Sato et al. resolved the crystal structure of AMSH-LP E292A -ubiquitin complex (PDB ID: 2ZNV) from H. sapiens and proposed the catalytic mechanism of JAMMs, which was probably similar to that of thermolysin ( xref H) [ xref , xref ]."
35883466
reach
"A structural study revealed that AMSH-LP directly binds Ub molecules to specifically cleave Ub chains ( Sato et al., 2008 )."
28525741
sparser
"A structural study revealed that AMSH-LP directly binds Ub molecules to specifically cleave Ub chains ( Sato et al., 2008 )."
28525741
sparser
"While the interaction between AMSH-LP with distal Ub domain is critical for binding affinity, the interaction of AMSH-LP with proximal Ub is critical for catalysis."
26899455
sparser
"The structural basis for this recognition was elucidated with the homologous protein, AMSH-LP, bound to Lys63-linked dimer of ubiquitin ( xref )."
24151880
sparser
"Using the AMSH-LP E292A -ubiquitin complex (PDB ID: 2ZNV) from Homo sapiens as an example, the C-terminal tail of the distal ubiquitin moiety binds the active site cleft and is stabilized with the Ins-1 segment by extensive hydrophobic interactions and hydrogen bonds, thus facilitating a scissile isopeptide bond for hydrolysis ( xref A,C) [ xref ]."
35883466
STAMBPL1 binds Ubiquitin and K63. 4 / 4
| 4
sparser
"The overall three-dimensional fold of Sst2 Δ220 –K63-Ub 2 is highly similar to the structure of the DUB domain of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) with an rmsd of 1.19 Å of Cα atoms over 266 residues from both Sst2 and K63-Ub 2 ."
24787148
sparser
"Figure xref d shows the superposition of Sst2 Δ220 –K63-Ub 2 and AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV( xref ))."
24787148
sparser
"Proximal ubiquitin binding is similar to that observed in the crystal structure of AMSH-LP bound to K63-Ub 2 ."
24787148
sparser
"The structure was determined by molecular replacement using a model of Sst2–K63-Ub 2 generated by superimposition of Sst2 cat with the structure of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV( xref )) and refined yielding satisfactory crystallographic, free R factors and good stereochemistry (Table xref )."
24787148
Rpn11 binds STAMBPL1 and Ubiquitin. 1 / 1
| 1
sparser
"Rpn11 and AMSH-LP bind ubiquitin in a similar orientation, but their interaction with the Ile44 hydrophobic patch is quite different."
33498168
BRCC36 binds STAMBPL1, Ubiquitin, and K63. 1 / 1
| 1
sparser
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly."
28587922
STAMBPL1 binds patch and Ubiquitin. 1 / 1
| 1
sparser
"AMSH-LP binds the distal ubiquitin via its Leu8/Ile44/Val70 hydrophobic patch conserved in NEDD8."
21288713
STAMBPL1 inhibits Ubiquitin.
| 1
STAMBPL1 inhibits Ubiquitin. 1 / 1
| 1
reach
"Particularly, sites 251-436 of STAMBPL1 interact with sites 228-605 of NRF2, facilitating DUB activity and eliminating ubiquitin molecules attached to NRF2, thus protecting it from proteasome-mediated degradation."
39706065
STAMBPL1 increases the amount of Ubiquitin.
| 1
STAMBPL1 increases the amount of Ubiquitin. 1 / 1
| 1
reach
"Since our data clearly indicate that STAMBPL1 affects Snail stability via the proteasome, we assessed if the levels of the main ubiquitin ligases or DUBs involved in the regulation of Snail half-life are modulated by STAMBPL1."
32636467
STAMBPL1 activates Ubiquitin.
| 1
STAMBPL1 activates Ubiquitin. 1 / 1
| 1
reach
"The observation that AMSH-LP causes partial cleavage of the first ubiquitin attached to some proteins has been noted previously [24]."
36408944
STAMBPL1 affects SESN2
2 | 9 12
STAMBPL1 binds SESN2.
2 | 2 12
STAMBPL1 binds SESN2. 10 / 16
2 | 2 12
sparser
"The results indicated that in the SMAD3 overexpression group, the binding of Sestrin2 to STAMBPL1 increased, whereas in the SMAD3 knockdown group, the binding of Sestrin2 to RNF167 was significantly enhanced (Fig.  xref C, D)."
40751214
sparser
"Inhibiting the interaction between STAMBPL1 and Sestrin2 thereby inactivating mTORC1 using a cell-permeable peptide could be a potential treatment approach for gastric and colorectal cancers [ xref ]."
39482684
reach
"The binding of RNF167 and STAMBPL1 to Sestrin2 is not mutually exclusive, as the interaction of one protein with Sestrin2 was not affected by deficiency or overexpression of the other protein ( Figure[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35114100
sparser
"Importantly, we demonstrated that disrupting the STAMBPL1-Sestrin2 interaction with a cell-penetrating peptide might serve as a potential strategy for colon cancer therapy."
35114100
sparser
"Moreover, a cell-permeable peptide that blocks STAMBPL1-Sestrin2 interaction suppresses mTOR signaling and anchorage-independent cell growth of human colon cancer cells."
35114100
reach
"Inhibiting the interaction between STAMBPL1 and Sestrin2 thereby inactivating mTORC1 using a cell-permeable peptide could be a potential treatment approach for gastric and colorectal cancers [141]."
39482684
sparser
"Next, we tested whether a cell-permeable peptide disrupting STAMBPL1-Sestrin2 interaction may suppress cancer development."
35114100
sparser
"Deleting the USP8_dimer domain or the linker region between the USP8_dimer domain and the JAB domain (UJ_linker) suppressed STAMBPL1-Sestrin2 interaction ( Figures S10 A and S10B)."
35114100
biogrid
No evidence text available
35114100
sparser
"The binding of leucine may alter Sestrin2 conformation, promoting Sestrin2-STAMBPL1 interaction and resulting in removal of the ubiquitin chain."
35114100
STAMBPL1 deubiquitinates SESN2.
| 5
STAMBPL1 deubiquitinates SESN2. 4 / 4
| 4
reach
"To test whether STAMBPL1 or STAMBP plays the dominant role in deubiquitinating Sestrin2 and regulating mTORC1 signaling, we knocked out STAMBPL1 on its own or in combination with STAMBP knockdown."
35114100
reach
"Interestingly, Wang et al. reported that gastric cancer and colorectal cancer downregulate an E3 ubiquitin ligase RING finger protein 167 (RNF167) and upregulate a deubiquitinase STAMBPL1 that can prevent the ubiquitination of Sestrin2, decrease Sestrin2-GATOR2 interaction and increase mTORC1 signaling [119]."
35527284
reach
"Deficiency of STAMBPL1 promoted Sestrin2 ubiquitination ( Figures 2 E and S3 H–S3J), prevented lysosomal localization of mTORC1 upon amino acid sufficiency and suppressed mTORC1 activity ( Figures 2 F[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35114100
reach
"These results indicate that STAMBPL1 plays a major role in deubiquitinating Sestrin2."
35114100
Mutated STAMBPL1 leads to the deubiquitination of SESN2. 1 / 1
| 1
reach
"Consistent with the above results, endogenous K405Rfs ∗ 21 mutation of STAMBPL1 promoted the deubiquitination of Sestrin2 and activated mTORC1 signaling ( Figures 6 D and 6E)."
35114100
STAMBPL1 ubiquitinates SESN2.
| 1
STAMBPL1 leads to the ubiquitination of SESN2. 1 / 1
| 1
reach
"Consistently, knockout of STAMBPL1 and subsequent increase in Sestrin2 ubiquitination markedly inhibited xenograft tumor growth [119]."
35527284
STAMBPL1 decreases the amount of SESN2.
| 1
STAMBPL1 decreases the amount of SESN2. 1 / 1
| 1
reach
"Knockout of STAMBPL1 greatly elevated the polyubiquitination level of Sestrin2 and suppressed mTORC1 activity ( Figures S3 D and S3E)."
35114100
STAMBPL1 affects CFLAR
1 | 1 14 7
STAMBPL1 binds CFLAR.
1 | 3 7
CFLAR binds STAMBPL1. 9 / 9
1 | 3 5
biogrid
No evidence text available
31817770
reach
"Specifically, when STAMBPL1 and c-FLIP bound together, STAMBPL1 deubiquitylated c-FLIP."
37511599
reach
"STAMBPL1 bound to c-FLIP and deubiqutylated c-FLIP protein."
37511599
sparser
"As DUBs remove ubiquitin chains by binding to the target protein and inhibiting ubiquitination, we performed an immunoprecipitation (IP) assay using the STAMBPL1 antibody and observed that endogenous STAMBPL1 interacts with c-FLIP ( xref C)."
37511599
sparser
"Additionally, we observed that STAMBPL1 endogenously interacts with c-FLIP ( xref C)."
37511599
sparser
"STAMBPL1 bound to c-FLIP and deubiqutylated c-FLIP protein."
37511599
sparser
"In addition, STAMBPL1 also bound endogenous c-FLIP in Caki cells ( xref D)."
31817770
reach
"STAMBPL1 interacted with survivin and c-FLIP, resulted in reduction of ubiquitination."
31817770
sparser
"Specifically, when STAMBPL1 and c-FLIP bound together, STAMBPL1 deubiquitylated c-FLIP."
37511599
STAMBPL1 binds BIRC5 and CFLAR. 2 / 2
| 2
sparser
"Thus, these data reveal that STAMBPL1 directly interacts with survivin and c-FLIP, resulting in stabilization of proteins."
31817770
sparser
"STAMBPL1 interacted with survivin and c-FLIP, resulted in reduction of ubiquitination."
31817770
STAMBPL1 activates CFLAR.
| 1 5
STAMBPL1 activates CFLAR. 6 / 6
| 1 5
reach
"Our findings provided that honokiol could overcome TRAIL resistance through survivin and c-FLIP degradation induced by inhibition of STAMBPL1 expression."
31817770
reach
"Knockdown of STAMBPL1 reduced survivin and c-FLIP protein levels, while overexpression of STAMBPL1 inhibited honokinol induced survivin and c-FLIP degradation."
31817770
reach
"STAMBPL1 stabilizes XIAP to inhibit apoptosis in prostate cancer cells (Chen et al., 2019) and confers resistance to honokiol-induced apoptosis in various cancer cell types by stabilizing Survivin and c-FLIP (Woo et al., 2019)."
40208233
reach
"Tubeimoside-1 Enhances TRAIL-Induced Apoptotic Cell Death through STAMBPL1-Mediated c-FLIP Downregulation."
37511599
eidos
"Mechanistically , TBMS-1 destabilized c-FLIP expression by downregulating STAMBPL1 , a deubiquitinase ( DUB ) ."
37511599
reach
"STAMBPL1 overexpression markedly prevented apoptosis induced by TBMS-1 and TRAIL combination therapy as well as c-FLIP degradation (Figure 4G)."
37511599
STAMBPL1 inhibits CFLAR.
| 3
STAMBPL1 inhibits CFLAR. 3 / 3
| 3
reach
"We previously reported the involvement of STAMBPL1-mediated c-FLIP degradation in TRAIL sensitization and showed that STABMPL1 overexpression reduces c-FLIP ubiquitination [19]."
37511599
reach
"This is achieved through the downregulation of anti-apoptotic proteins survivin and cFLIP, which are degraded by the deubiquitinase STAMBPL1."
38316367
reach
"This study demonstrated that TBMS-1 sensitizes cancer cells to the apoptosis effect of TRAIL via STAMBPL1-dependent downregulation of c-FLIP."
37511599
STAMBPL1 increases the amount of CFLAR.
| 1
STAMBPL1 increases the amount of CFLAR. 1 / 1
| 1
reach
"However, considering the observation that STAMBPL1 knockdown reduced c-FLIP expression, we proposed c-FLIP as a new substrate of STAMBPL1."
37511599
STAMBPL1 deubiquitinates CFLAR.
| 1
STAMBPL1 deubiquitinates CFLAR. 1 / 1
| 1
reach
"Specifically, when STAMBPL1 and c-FLIP bound together, STAMBPL1 deubiquitylated c-FLIP."
37511599
STAMBPL1 decreases the amount of CFLAR.
| 1
STAMBPL1 decreases the amount of CFLAR. 1 / 1
| 1
reach
"Knockdown of STAMBPL1 reduced survivin and c-FLIP protein levels, while overexpression of STAMBPL1 inhibited honokinol induced survivin and c-FLIP degradation."
31817770
Ubiquitin affects STAMBPL1
| 1 16
sparser
"The Oγ atom of AMSH’s Ser346 is pointing away from Glu64 of the proximal ubiquitin ( xref ), contrary to the equivalent residue in both free and ubiquitin-bound AMSH-LP, which are at distances of 2.4Å and 2.6Å from proximal ubiquitin’s Glu64, respectively."
21888914
sparser
"Cys282 is next to the active site, and in fact it makes a van der Waals contact with Leu73 of the distal ubiquitin in the structure of AMSH-LP DUB domain bound to Lys63-linked ubiquitin dimer. xref In the disulfide orientation, however, as seen in the model of AMSH244 bound to Lys63-linked diubiquitin (please see below), the contact is lost."
21888914
sparser
"Interestingly, in the structure of AMSH-LP DUB domain bound to Lys63-linked ubiquitin dimer, the corresponding residue pair is still seen in a similar position as the substrate-free form, xref suggesting that these residues close the active site during catalysis as well, perhaps to help position the scissile peptide bond or stabilize the transition state or both."
21888914
sparser
"It is known that Val328 and Phe332 of AMSH-LP interact with ubiquitin Ile44, but structural comparison shows that the equivalent positions in Rpn11 (Val83 and Phe87) are oriented in an opposite direction from AMSH-LP ( xref B)."
33498168
sparser
"Sato et al. resolved the crystal structure of AMSH-LP E292A -ubiquitin complex (PDB ID: 2ZNV) from H. sapiens and proposed the catalytic mechanism of JAMMs, which was probably similar to that of thermolysin ( xref H) [ xref , xref ]."
35883466
reach
"A structural study revealed that AMSH-LP directly binds Ub molecules to specifically cleave Ub chains ( Sato et al., 2008 )."
28525741
sparser
"A structural study revealed that AMSH-LP directly binds Ub molecules to specifically cleave Ub chains ( Sato et al., 2008 )."
28525741
sparser
"While the interaction between AMSH-LP with distal Ub domain is critical for binding affinity, the interaction of AMSH-LP with proximal Ub is critical for catalysis."
26899455
sparser
"The structural basis for this recognition was elucidated with the homologous protein, AMSH-LP, bound to Lys63-linked dimer of ubiquitin ( xref )."
24151880
sparser
"Using the AMSH-LP E292A -ubiquitin complex (PDB ID: 2ZNV) from Homo sapiens as an example, the C-terminal tail of the distal ubiquitin moiety binds the active site cleft and is stabilized with the Ins-1 segment by extensive hydrophobic interactions and hydrogen bonds, thus facilitating a scissile isopeptide bond for hydrolysis ( xref A,C) [ xref ]."
35883466
STAMBPL1 binds Ubiquitin and K63. 4 / 4
| 4
sparser
"The overall three-dimensional fold of Sst2 Δ220 –K63-Ub 2 is highly similar to the structure of the DUB domain of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) with an rmsd of 1.19 Å of Cα atoms over 266 residues from both Sst2 and K63-Ub 2 ."
24787148
sparser
"Figure xref d shows the superposition of Sst2 Δ220 –K63-Ub 2 and AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV( xref ))."
24787148
sparser
"Proximal ubiquitin binding is similar to that observed in the crystal structure of AMSH-LP bound to K63-Ub 2 ."
24787148
sparser
"The structure was determined by molecular replacement using a model of Sst2–K63-Ub 2 generated by superimposition of Sst2 cat with the structure of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV( xref )) and refined yielding satisfactory crystallographic, free R factors and good stereochemistry (Table xref )."
24787148
Rpn11 binds STAMBPL1 and Ubiquitin. 1 / 1
| 1
sparser
"Rpn11 and AMSH-LP bind ubiquitin in a similar orientation, but their interaction with the Ile44 hydrophobic patch is quite different."
33498168
BRCC36 binds STAMBPL1, Ubiquitin, and K63. 1 / 1
| 1
sparser
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly."
28587922
STAMBPL1 binds patch and Ubiquitin. 1 / 1
| 1
sparser
"AMSH-LP binds the distal ubiquitin via its Leu8/Ile44/Val70 hydrophobic patch conserved in NEDD8."
21288713
STAMBPL1 affects apoptotic process
| 2 18
STAMBPL1 inhibits apoptotic process.
| 2 14
STAMBPL1 inhibits apoptotic process. 10 / 16
| 2 14
reach
"In response to genotoxic stress, the degradation of STAMBPL1 augments apoptotic cell death."
35066747
reach
"Moreover, Chen et al. indicated that STAMBPL1 depletion increases cell death 72 h after shRNA treatment; however, our data did not show STAMBPL1 siRNA-induced apoptosis after treatment for 24 h (Figure 4G)."
37511599
reach
"We observed activation of caspase-9, -3 and -7, but not caspase-8, in STAMBPL1 silencing-induced apoptosis."
31004702
reach
"Here we show evidence that STAMBPL1 regulates X-linked inhibitor of apoptosis protein (XIAP) stability, thus modulates apoptosis in prostate cancer cells.XIAP is one of the Inhibitor of Apoptosis Prot[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31004702
reach
"Apoptosis of CRC was induced by silence of STAMBPL1."
38008943
reach
"STAMBPL1 overexpression markedly prevented apoptosis induced by TBMS-1 and TRAIL combination therapy as well as c-FLIP degradation (Figure 4G)."
37511599
reach
"STAMBPL1 depletion was found to induce apoptosis by promoting the degradation of the protein XIAP, suggesting that targeting STAMBPL1 might offer a promising therapeutic strategy for prostate cancer [23]."
38419066
eidos
"Recently , we reported the depletion of STAMBPL1 increases apoptotic cell death through accumulation of intracellular ROS and lysosome-dependent XIAP degradation in prostate cancer cells [ 34 ] , and we also reported that levels of STAMBPL1 is correlated with the expression of survivin in cepharanthine treated renal cancer cells [ 35 ] ."
31817770
reach
"We demonstrated that STAMBPL1 RNAi depletion induced apoptosis in PC3 and DU145 cells by promoting XIAP lysosomal degradation."
31004702
reach
"Necroptosis inhibitor Nec-1 and autophagy inhibitor CQ did not efficiently suppress cell death induced by STAMBPL1 targeting; whereas, addition of a caspase 3 inhibitor, Z-DEVD-FMK, to cells markedly [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31004702
STAMBPL1 activates apoptotic process.
| 4
STAMBPL1 activates apoptotic process. 4 / 4
| 4
reach
"Mechanistically, downregulation of STAMBPL1 upon H. pylori infection has been shown to promote apoptosis by circumventing the deubiquitinylation and hence stabilization of the antiapoptotic protein su[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37230895
reach
"STAMBPL1 stabilizes XIAP to inhibit apoptosis in prostate cancer cells (Chen et al., 2019) and confers resistance to honokiol-induced apoptosis in various cancer cell types by stabilizing Survivin and c-FLIP (Woo et al., 2019)."
40208233
reach
"Further, we demonstrated the involvement of STAMBPL1 in combined treatment-induced apoptosis using an overexpression or depletion system."
37511599
reach
"Recent studies have shown that excessive ROS generated in H. pylori infection induces direct degradation of STAMBPL1 by cullin 1-RING ubiquitin ligase and the 26S proteasome, while STAMBPL1 can lead to cell apoptosis by reducing the anti-apoptotic protein survivin (Chaithongyot and Naumann, 2022)."
38774627
STAMBPL1 affects BIRC5
3 | 13 4
STAMBPL1 binds BIRC5.
3 | 1 4
BIRC5 binds STAMBPL1. 6 / 6
3 | 1 2
sparser
"However, although cepharanthine reduces STAMBPL1 expression and overexpression of STAMBPL1 inhibits cepharanthine-mediated downregulation of survivin, interaction between STAMBPL1 and survivin was not investigated."
31817770
biogrid
No evidence text available
35066747
biogrid
No evidence text available
31817770
biogrid
No evidence text available
35066747
sparser
"As shown in xref C, we detected the interaction between STAMBPL1 and survivin."
31817770
reach
"STAMBPL1 interacted with survivin and c-FLIP, resulted in reduction of ubiquitination."
31817770
STAMBPL1 binds BIRC5 and CFLAR. 2 / 2
| 2
sparser
"Thus, these data reveal that STAMBPL1 directly interacts with survivin and c-FLIP, resulting in stabilization of proteins."
31817770
sparser
"STAMBPL1 interacted with survivin and c-FLIP, resulted in reduction of ubiquitination."
31817770
STAMBPL1 activates BIRC5.
| 5
STAMBPL1 activates BIRC5. 5 / 5
| 5
reach
"Mechanistically, downregulation of STAMBPL1 upon H. pylori infection has been shown to promote apoptosis by circumventing the deubiquitinylation and hence stabilization of the antiapoptotic protein su[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37230895
reach
"Knockdown of STAMBPL1 reduced survivin and c-FLIP protein levels, while overexpression of STAMBPL1 inhibited honokinol induced survivin and c-FLIP degradation."
31817770
reach
"Our findings provided that honokiol could overcome TRAIL resistance through survivin and c-FLIP degradation induced by inhibition of STAMBPL1 expression."
31817770
reach
"STAMBPL1 stabilizes XIAP to inhibit apoptosis in prostate cancer cells (Chen et al., 2019) and confers resistance to honokiol-induced apoptosis in various cancer cell types by stabilizing Survivin and c-FLIP (Woo et al., 2019)."
40208233
reach
"Recent studies have shown that excessive ROS generated in H. pylori infection induces direct degradation of STAMBPL1 by cullin 1-RING ubiquitin ligase and the 26S proteasome, while STAMBPL1 can lead to cell apoptosis by reducing the anti-apoptotic protein survivin (Chaithongyot and Naumann, 2022)."
38774627
STAMBPL1 inhibits BIRC5.
| 4
STAMBPL1 inhibits BIRC5. 4 / 4
| 4
reach
"This is achieved through the downregulation of anti-apoptotic proteins survivin and cFLIP, which are degraded by the deubiquitinase STAMBPL1."
38316367
reach
"Honokiol Enhances TRAIL Mediated Apoptosis through STAMBPL1 Induced Survivin and c-FLIP Degradation."
31817770
reach
"Ectopic expression of STAMBPL1 significantly inhibited CEP induced survivin downregulation (XREF_FIG F)."
30360403
reach
"Next, we investigated whether overexpression of STAMBPL1 prevents CEP induced survivin downregulation."
30360403
STAMBPL1 increases the amount of BIRC5.
| 2
STAMBPL1 increases the amount of BIRC5. 2 / 2
| 2
reach
"Cepharanthine Enhances TRAIL Mediated Apoptosis Through STAMBPL1 Mediated Downregulation of Survivin Expression in Renal Carcinoma Cells."
30360403
reach
"Exogenous expression of STAMBPL1 increased the percentage of cells in the S phase and upregulated the expressions of CyclinD1 and Survivin."
39150093
STAMBPL1 decreases the amount of BIRC5.
| 1
STAMBPL1 decreases the amount of BIRC5. 1 / 1
| 1
reach
"Knockdown of STAMBPL1 reduced survivin and c-FLIP protein levels, while overexpression of STAMBPL1 inhibited honokinol induced survivin and c-FLIP degradation."
31817770
SESN2 affects STAMBPL1
2 | 2 12
STAMBPL1 binds SESN2. 10 / 16
2 | 2 12
sparser
"The results indicated that in the SMAD3 overexpression group, the binding of Sestrin2 to STAMBPL1 increased, whereas in the SMAD3 knockdown group, the binding of Sestrin2 to RNF167 was significantly enhanced (Fig.  xref C, D)."
40751214
sparser
"Inhibiting the interaction between STAMBPL1 and Sestrin2 thereby inactivating mTORC1 using a cell-permeable peptide could be a potential treatment approach for gastric and colorectal cancers [ xref ]."
39482684
reach
"The binding of RNF167 and STAMBPL1 to Sestrin2 is not mutually exclusive, as the interaction of one protein with Sestrin2 was not affected by deficiency or overexpression of the other protein ( Figure[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35114100
sparser
"Importantly, we demonstrated that disrupting the STAMBPL1-Sestrin2 interaction with a cell-penetrating peptide might serve as a potential strategy for colon cancer therapy."
35114100
sparser
"Moreover, a cell-permeable peptide that blocks STAMBPL1-Sestrin2 interaction suppresses mTOR signaling and anchorage-independent cell growth of human colon cancer cells."
35114100
reach
"Inhibiting the interaction between STAMBPL1 and Sestrin2 thereby inactivating mTORC1 using a cell-permeable peptide could be a potential treatment approach for gastric and colorectal cancers [141]."
39482684
sparser
"Next, we tested whether a cell-permeable peptide disrupting STAMBPL1-Sestrin2 interaction may suppress cancer development."
35114100
sparser
"Deleting the USP8_dimer domain or the linker region between the USP8_dimer domain and the JAB domain (UJ_linker) suppressed STAMBPL1-Sestrin2 interaction ( Figures S10 A and S10B)."
35114100
biogrid
No evidence text available
35114100
sparser
"The binding of leucine may alter Sestrin2 conformation, promoting Sestrin2-STAMBPL1 interaction and resulting in removal of the ubiquitin chain."
35114100
TRAF2 affects STAMBPL1
| 6 6
TRAF2 binds STAMBPL1.
| 3 6
STAMBPL1 binds TRAF2. 9 / 9
| 3 6
reach
"The interaction between the TRAF2 (1-348), TRAF2 (74-496) fragments, and STAMBPL1 was verified (Fig. 8E)."
38419066
sparser
"STAMBPL1 directly interacts with TRAF2 and stabilize its protein stability."
38419066
reach
"The CO-IP experiment was further utilized to identify the interaction of STAMBPL1 and TRAF2 in HCCLM3 and Hep3B cell line, and the result showed that STAMBPL1 can interact with TRAF2 in both HCCLM3 and Hep3B cell line (Fig. 6B, C)."
38419066
sparser
"The 251–436 sites of STAMBPL1 particularly interact with the 294–496 sites of TRAF2, thereby exerting the function of DUB and removing the ubiquitin molecules attached to TRAF2."
38419066
sparser
"The CO-IP experiment was further utilized to identify the interaction of STAMBPL1 and TRAF2 in HCCLM3 and Hep3B cell line, and the result showed that STAMBPL1 can interact with TRAF2 in both HCCLM3 and Hep3B cell line (Fig.  xref B, C)."
38419066
sparser
"The specific binding sites of interaction between STAMBPL1 and TRAF2."
38419066
reach
"The specific binding sites of interaction between STAMBPL1 and TRAF2."
38419066
sparser
"Simultaneously, through IP experiments, it was further discovered that STAMBPL1 can interact with the TRAF2 (1-348), TRAF2 (74-496) fragments and undergo deubiquitination modification (Fig.  xref F)."
38419066
sparser
"IP assays confirmed the interaction between the STAMBPL1 (251-436) fragment and TRAF2 (Fig.  xref D)."
38419066
TRAF2 inhibits STAMBPL1.
| 3
TRAF2 inhibits STAMBPL1. 3 / 3
| 3
reach
"TRAF2 reversed the tumorigenic activity of STAMBPL1 in HCC cells."
38419066
reach
"The results from the colony formation assay suggested that TRAF2 can reverse the pro-proliferative ability of STAMBPL1 in HCC cells (Fig. 9E–F)."
38419066
reach
"TRAF2 can reverse the tumorigenic activity of STAMBPL1 in vitro at the same time (Fig. 11M–R)."
38419066
reach
"CCK-8 assays revealed that the inhibition of STAMBPL1 could reduce the proliferation of HCCLM3 and Hep3B (Fig. 3G)."
38419066
reach
"STAMBPL1 has been reported to promote cell proliferation and function as an oncogenic protein in gastric cancer ( Yu et al., 2019 )."
35114100
reach
"Additionally, the suppression of STAMBPL1 inhibits tumor growth and the proliferation in colorectal and gastric cancer cells [20,21]."
37511599
reach
"These findings highlight the diverse roles that deubiquitinases play in HCC, either by promoting or suppressing the disease, and suggest that they could be potential targets for therapeutic intervention in HCC.In the study, we identified one oncogene gene (STAMBPL1) which promote the proliferation and metastasis of HCC."
38419066
reach
"Functionally, STAMBPL1 notably enhances CCA cell proliferation and metastasis while impeding ferroptosis."
39706065
reach
"Knockdown of STAMBPL1 reduced cell viability of CRC and suppressed the proliferation, invasion, and migration."
38008943
reach
"Following STAMBPL1 knockdown by short hairpin RNA (sh)STAMBPL1, cell proliferation was significantly suppressed, the cell apoptosis rate was significantly upregulated, and the numbers of invasive AGS cells and the AGS wound healing rate were significantly decreased (P<0.01 and P<0.001, respectively), compared with those in the shControl group."
31611951
reach
"These results suggested that AGS cell proliferation was suppressed by STAMBPL1 knockdown."
31611951
reach
"STAMBPL1 promotes the ability of cell cloning and proliferation in LUAD."
37393834
reach
"Functionally, STAMBPL1 significantly promoted HCC cells proliferation and metastasis, and it interacts with TRAF2 and stabilize it via the deubiquitination at the K63 residue."
38419066
STAMBPL1 inhibits cell population proliferation. 2 / 2
| 2
reach
"Furthermore, knockdown of STAMBPL1 by shSTAMBPL1 resulted in STAMBPL1 downregulation, which in turn decreased the cell proliferation of AGS gastric cancer cells, increasing cell apoptosis, cell invasion and migration in vitro."
31611951
reach
"In addition, the results from the colony formation experiment demonstrated that the downregulation of STAMBPL1 suppressed the proliferation of hepatocellular carcinoma cells (Fig. 3H)."
38419066
STAMBPL1 affects STAMBP
2 | 4 6
STAMBPL1 binds STAMBP.
2 | 2 5
STAMBPL1 binds STAMBP. 8 / 8
2 | 2 4
sparser
"Unlike the monomer of AMSH or AMSH-LP with inherent DUB activity, BRCC36 must form a complex with other subunits to specifically cleave K63-linked polyubiquitin chains."
35883466
sparser
"To quantify the interaction of the UbVs with STAMBP and STAMBPL1 and to validate the key residues responsible for the tight binding, we used isothermal titration calorimetry (ITC) to measure the interaction thermodynamics ( xref )."
34425109
sparser
"Hameed et al. developed a zinc chelating ABP that forms a tight complex with STAMBP and STAMBPL1 and inhibits the activity of the proteasomal DUB Rpn11 (PSMD14 in humans)."
35625630
reach
"Both STAMBP and STAMBPL1 localize to early endosomes by binding to clathrin (31); however, STAMBPL1 fails to bind to STAM due to residue substitutions in the SBM-like motif, suggesting it may function in different signaling pathway from that of STAMBP (30) ."
| DOI
reach
"Both STAMBP and STAMBPL1 localize to early endosomes by binding to clathrin (31); however, STAMBPL1 fails to bind to STAM due to residue substitutions in the SBM-like motif, suggesting it may function in different signaling pathway from that of STAMBP (30)."
34425109
biogrid
No evidence text available
28514442
sparser
"Hence, it is possible that AMSH and AMSH-LP might be associated with a proteasome or other unknown large protein complex in the nucleus through their MPN domain."
12810066
biogrid
No evidence text available
33961781
STAMBP binds STAMBPL1, Clathrin, and CLTC. 1 / 1
| 1
sparser
"We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins."
16716190
STAMBPL1 inhibits STAMBP.
| 2
STAMBPL1 inhibits STAMBP. 2 / 2
| 2
reach
"Next, we compared the K63-diUb (FRET) cleavage inhibition by the UbVs with STAMBP JAMM to the inhibition of fulllength STAMBP activated by STAM protein and full-length STAMBPL1."
| DOI
reach
"Next, we compared the K63-diUb (FRET) cleavage inhibition by the UbVs with STAMBP to the inhibition of full-length STAMBP activated by STAM protein and full-length STAMBPL1."
34425109
STAMBPL1 activates STAMBP.
| 1
STAMBPL1 activates STAMBP. 1 / 1
| 1
sparser
"Next, we compared the K63-diUb (FRET) cleavage inhibition by the UbVs with STAMBP JAMM to the inhibition of full-length STAMBP activated by STAM protein and full-length STAMBPL1."
34425109
STAMBPL1 affects Neoplasms
| 12
STAMBPL1 activates Neoplasms.
| 11
STAMBPL1 activates Neoplasms. 10 / 10
| 10
reach
"Additionally, the suppression of STAMBPL1 inhibits tumor growth and the proliferation in colorectal and gastric cancer cells [20,21]."
37511599
reach
"Therefore, we investigated whether STAMBPL1 promotes tumor angiogenesis."
40208233
reach
"Deletion of STAMBPL1 or correction of the heterozygous STAMBPL1 mutation in a human colon cancer cell line suppresses xenograft tumor growth."
35114100
reach
"STAMBPL1 knockout or correction of the heterozygous STAMBPL1 mutation in a human colon cancer cell could suppress xenograft tumor growth [24]."
38419066
reach
"Notably, STAMBPL1 overexpression increased lipid accumulation in HCC cells and xenograft tumors."
39150093
reach
"STAMBPL1 knockout significantly suppressed mTORC1 activity, anchorage-independent cell growth, and xenograft tumor growth ( Figures 5 F–5J and S8 C–S8J) in all three cell lines."
35114100
reach
"Besides, upregulation of STAMBPL1 could significantly enhance the tumor growth rate and volume in nude mice (Fig. 11E–H)."
38419066
reach
"All these results hinted that the STAMBPL1 positively mediated tumor growth in vitro."
38419066
reach
"Suppression of STAMBPL1 function inhibits tumor growth and provides a potential option for colorectal cancer therapy."
35180426
reach
"Knocking down STAMBPL1 inhibited the growth of HCC1806 xenografts in mice (Figure 3G–I) and decreased the number of microvessels in tumor tissue (Figure 3J, K), indicating that STAMBPL1 promoted tumor angiogenesis."
40208233
Mutated STAMBPL1 activates Neoplasms. 1 / 1
| 1
reach
"STAMBPL1 knockout or correction of the heterozygous STAMBPL1 mutation in a human colon cancer cell could suppress xenograft tumor growth [24]."
38419066
STAMBPL1 inhibits Neoplasms.
| 1
STAMBPL1 inhibits Neoplasms. 1 / 1
| 1
reach
"Tumor growth of CRC was also suppressed by the silence of STAMBPL1."
38008943
STAMBPL1 affects FOXO1
| 3 9
STAMBPL1 binds FOXO1.
| 9
sparser
"This interaction between STAMBPL1 and FOXO1 does not necessarily affect the binding of FOXO1 with DNA, including the GRHL3 promoter."
40208233
sparser
"Additionally, an immunoprecipitation assay revealed an interaction between the FOXO1 protein (250–596 aa) and STAMBPL1 ( xref )."
40208233
sparser
"They demonstrate that STAMBPL1 interacts with FOXO1, define the required domains in each protein, and illustrate that this interaction facilitates FOXO1 transcriptional factor activity, which then activates GRHL3/HIF1a/VEGFA signaling."
40208233
sparser
"Because the authors find that STAMBPL1 and FOXO1 interact, they suggest that STAMBPL1 may promote the formation of an active transcriptional complex containing FOXO1, perhaps by facilitating the recruitment of transcriptional coactivators."
40208233
sparser
"Furthermore, it would be important to determine whether the STAMBPL1-FOXO1 interaction is essential for GRHL3 transcription."
40208233
sparser
"The study also shows that STAMBPL1 interacts with FOXO1 to promote GRHL3 transcription, which in turn activates HIF1A."
40208233
sparser
"The results of the GST pull-down assay indicated that the N-terminus (1–140 aa) of STAMBPL1 interacted with FOXO1 ( xref )."
40208233
sparser
"Since the interaction sites of STAMBPL1-FOXO1 have been mapped, a mutant disrupting the interaction would provide better insight into how STAMBPL1 promotes GRHL3 transcription by interacting with FOXO1."
40208233
sparser
"Additionally, we found that STAMBPL1 interacts with FOXO1 to facilitate the transcription of GRHL3/HIF1α/VEGFA."
40208233
STAMBPL1 activates FOXO1.
| 3
STAMBPL1 activates FOXO1. 3 / 3
| 3
reach
"However, the mechanism by which STAMBPL1 activates the transcriptional activity of FOXO1 has not been elucidated."
40208233
reach
"This suggests that STAMBPL1 enhances the transcriptional activity of FOXO1 on GRHL3 by interacting with nuclear FOXO1."
40208233
reach
"STAMBPL1 was shown to increase the transcriptional activation of FOXO1 at the GRHL3 promoter (Figure 7K), and it also bound to the GRHL3 promoter which could be disrupted by FOXO1 knockdown (Figure 7L)."
40208233
CFLAR affects STAMBPL1
1 | 4 7
CFLAR binds STAMBPL1.
1 | 3 7
CFLAR binds STAMBPL1. 9 / 9
1 | 3 5
biogrid
No evidence text available
31817770
reach
"Specifically, when STAMBPL1 and c-FLIP bound together, STAMBPL1 deubiquitylated c-FLIP."
37511599
reach
"STAMBPL1 bound to c-FLIP and deubiqutylated c-FLIP protein."
37511599
sparser
"As DUBs remove ubiquitin chains by binding to the target protein and inhibiting ubiquitination, we performed an immunoprecipitation (IP) assay using the STAMBPL1 antibody and observed that endogenous STAMBPL1 interacts with c-FLIP ( xref C)."
37511599
sparser
"Additionally, we observed that STAMBPL1 endogenously interacts with c-FLIP ( xref C)."
37511599
sparser
"STAMBPL1 bound to c-FLIP and deubiqutylated c-FLIP protein."
37511599
sparser
"In addition, STAMBPL1 also bound endogenous c-FLIP in Caki cells ( xref D)."
31817770
reach
"STAMBPL1 interacted with survivin and c-FLIP, resulted in reduction of ubiquitination."
31817770
sparser
"Specifically, when STAMBPL1 and c-FLIP bound together, STAMBPL1 deubiquitylated c-FLIP."
37511599
STAMBPL1 binds BIRC5 and CFLAR. 2 / 2
| 2
sparser
"Thus, these data reveal that STAMBPL1 directly interacts with survivin and c-FLIP, resulting in stabilization of proteins."
31817770
sparser
"STAMBPL1 interacted with survivin and c-FLIP, resulted in reduction of ubiquitination."
31817770
CFLAR inhibits STAMBPL1.
| 1
CFLAR inhibits STAMBPL1. 1 / 1
| 1
reach
"Moreover, STAMBPL1 knockdown markedly increased sensitivity to TRAIL by destabilizing c-FLIP."
37511599
STAMBPL1 affects TRAF2
| 5 6
STAMBPL1 binds TRAF2.
| 3 6
STAMBPL1 binds TRAF2. 9 / 9
| 3 6
reach
"The interaction between the TRAF2 (1-348), TRAF2 (74-496) fragments, and STAMBPL1 was verified (Fig. 8E)."
38419066
sparser
"STAMBPL1 directly interacts with TRAF2 and stabilize its protein stability."
38419066
reach
"The CO-IP experiment was further utilized to identify the interaction of STAMBPL1 and TRAF2 in HCCLM3 and Hep3B cell line, and the result showed that STAMBPL1 can interact with TRAF2 in both HCCLM3 and Hep3B cell line (Fig. 6B, C)."
38419066
sparser
"The 251–436 sites of STAMBPL1 particularly interact with the 294–496 sites of TRAF2, thereby exerting the function of DUB and removing the ubiquitin molecules attached to TRAF2."
38419066
sparser
"The CO-IP experiment was further utilized to identify the interaction of STAMBPL1 and TRAF2 in HCCLM3 and Hep3B cell line, and the result showed that STAMBPL1 can interact with TRAF2 in both HCCLM3 and Hep3B cell line (Fig.  xref B, C)."
38419066
sparser
"The specific binding sites of interaction between STAMBPL1 and TRAF2."
38419066
reach
"The specific binding sites of interaction between STAMBPL1 and TRAF2."
38419066
sparser
"Simultaneously, through IP experiments, it was further discovered that STAMBPL1 can interact with the TRAF2 (1-348), TRAF2 (74-496) fragments and undergo deubiquitination modification (Fig.  xref F)."
38419066
sparser
"IP assays confirmed the interaction between the STAMBPL1 (251-436) fragment and TRAF2 (Fig.  xref D)."
38419066
STAMBPL1 decreases the amount of TRAF2.
| 1
STAMBPL1 decreases the amount of TRAF2. 1 / 1
| 1
reach
"Meanwhile, the ubiquitination level of TRAF2 was also detected in control group and shSTAMBPL1 group, and it showed that the inhibition of STAMBPL1 can increasing the ubiquitination level of TRAF2 in both HCCLM3 and Hep3B cell (Fig. 7C, D)."
38419066
STAMBPL1 activates TRAF2.
| 1
STAMBPL1 activates TRAF2. 1 / 1
| 1
reach
"Especially STAMBPL1 could modulate the stability of TRAF2 protein and activate WNT/PI3K/NF-kb signalling pathway."
38419066
STAMBPL1 affects GRHL3
| 11
STAMBPL1 increases the amount of GRHL3.
| 8
STAMBPL1 increases the amount of GRHL3. 8 / 8
| 8
reach
"To investigate the mechanism by which STAMBPL1 promotes GRHL3 transcription through FOXO1, we conducted immunofluorescence and immunoprecipitation assays."
40208233
reach
"Furthermore, we discovered that STAMBPL1 regulates GRHL3 transcription by interacting with the transcription factor FOXO1."
40208233
reach
"Silencing of STAMBPL1 inhibited GRHL3 transcription in both HCC1806 and HCC1937 cells (Figure 4B, Figure 4—figure supplement 1B)."
40208233
reach
"Conversely, the overexpression of STAMBPL1 promoted GRHL3 transcription (Figure 4D, Figure 4—figure supplement 1D)."
40208233
reach
"STAMBPL1 mediates GRHL3 transcription by interacting with FOXO1."
40208233
reach
"Therefore, we aimed to investigate whether STAMBPL1 promotes GRHL3 transcription via FOXO1."
40208233
reach
"These findings suggest that STAMBPL1 promotes GRHL3 transcription by interacting with FOXO1."
40208233
reach
"Through RNA-seq analysis, we revealed that STAMBPL1 positively regulates the transcription of GRHL3."
40208233
STAMBPL1 activates GRHL3.
| 3
STAMBPL1 activates GRHL3. 3 / 3
| 3
reach
"These findings suggest that STAMBPL1 activates the HIF1α/VEGFA axis by upregulating GRHL3."
40208233
reach
"In summary, STAMBPL1 promoted TNBC angiogenesis by activating the GRHL3/HIF1α/VEGFA pathway via interacting with FOXO1 in a non-enzymatic manner."
40208233
reach
"Our study reveals for the first time that GRHL3 promotes transcriptional activity by binding to the promoter of the HIF1A gene.In this study, we utilized two TNBC cell lines, HCC1806 and HCC1937, along with human primary umbilical vein endothelial cells (HUVECs) and a nude mouse breast orthotopic transplantation tumor model to investigate the regulatory mechanism by which STAMBPL1 activates the GRHL3/HIF1α/VEGFA signaling pathway through its interaction with FOXO1, thereby promoting angiogenesis in TNBC."
40208233
UBD affects STAMBPL1
| 3 7
UBD binds STAMBPL1. 9 / 9
| 2 7
sparser
"How JAMM/MPNDUBs cleave ubiquitin chains with K63-linkage specificity has been explained by the crystal structure of AMSH-LP bound to K63-linked di-ubiquitin: Two insertion loops orient the distal and proximal ubiquitin in order to place the isopeptide bond at lysine 63 in direct proximity to the active site [ xref ]."
33142801
sparser
"The crystal structure of the catalytic domain of AMSH-LP bound to its substrate Lys63-linked diubiquitin (PBD ID: 2ZNV) reveals the flap adopting a closed position over the active site ( xref )."
26368668
sparser
"Only recently was Lys63-linkage specificity understood from the structural analysis of the DUB domain of AMSH-LP bound Lys63-linked diubiquitin. xref This structure reveals interactions between the enzyme and both the distal and proximal ubiquitins, but the basis for specificity arises from residues in the proximal site of the enzyme interacting with the proximal ubiquitin, despite a more extensive interaction with the distal ubiquitin (a significantly more accessible surface area is buried upon interaction with distal than proximal ubiquitin). xref Overall, AMSH adopts very similar interactions when modeled according to the ubiquitin-bound structure of AMSH-LP."
21888914
sparser
"However, this residue, in fact, the two-residue turn segment, Leu402-Phe403, needs to move apart relative to Thr316 to make room for the diubiquitin substrate to position itself correctly in the active site. (These observations are also true in the structure of AMSH-LP bound to diubiquitin.) It seems likely that the β-turn segment is dynamic, fluctuating between open and closed forms; the substrate binds to the open form, perhaps by conformational selection."
24787148
sparser
"Modeling of the catalytic domain of AMSH onto the structure of AMSH-LP bound to Lys63-linked diubiquitin revealed four residues within AMSH (Thr341, Phe343, Ser346, and Phe395) that could determine its specificity for Lys63-linked polyubiquitin chains by recognizing the tri-peptide sequence motif Gln62-Lys63-Glu64 within the proximal ubiquitin, which encompasses the acceptor Lys63 and its two immediate flanking residues."
24151880
reach
"Recent structure determination of the K63 linked diubiquitin bound to AMSH-LP revealed specific interactions between the proximal ubiquitin and the DUB catalytic core as well as an inserted motif."
22118673
sparser
"The crystal structure of the catalytic core domain of AMSH-LP bound to K63-linked diubiquitin has provided a molecular description of this specificity xref ."
19243136
reach
"(These observations are also true in the structure of AMSH-LP bound to diubiquitin.)"
24787148
sparser
"The structure of AMSH-LP bound to K63-linked diubiquitin demonstrates that the recognition of the proximal ubiquitin in diubiquitin determines AMSH-LP linkage selectivity xref ."
19243136
STAMBPL1 binds UBD and Phe403. 1 / 1
| 1
reach
"X-ray crystal structures of the DUB domains of both AMSH-LP and Sst2 bound to diubiquitin shows Phe403 collapsed onto the Lys63 side chain of the proximal ubiquitin; however, the flap residues appear to retain their mobility even in presence of bound substrate or product (indicated by relatively weak electron density enveloping these residues and higher B-factors than internal residues)."
26368668
STAMBPL1 affects DUSP1
3 | 5 2
STAMBPL1 binds DUSP1.
3 | 2 2
STAMBPL1 binds DUSP1. 7 / 7
3 | 2 2
sparser
"STAMBPL1 interacts with MKP-1 and stabilizes MKP-1 via deubiquitination."
35236965
reach
"STAMBPL1 interacts with MKP-1 and stabilizes MKP-1 via deubiquitination."
35236965
biogrid
No evidence text available
35236965
biogrid
No evidence text available
35236965
biogrid
No evidence text available
35236965
reach
"The study by Liu et al. (2022) found that STAMBPL1 interacts with MKP-1 and stabilizes MKP-1 via deubiquitination, further promoting breast cancer cell resistance to cisplatin."
36685836
sparser
"The study by xref found that STAMBPL1 interacts with MKP-1 and stabilizes MKP-1 via deubiquitination, further promoting breast cancer cell resistance to cisplatin."
36685836
STAMBPL1 activates DUSP1.
| 2
STAMBPL1 activates DUSP1. 2 / 2
| 2
reach
"Our previous research revealed that STAMBPL1, a deubiquitinase, promotes cisplatin resistance in TNBC by stabilizing MKP1 (Liu et al., 2022)."
40208233
reach
"Our previous research revealed that the deubiquitinase STAMBPL1 enhances the stability of MKP-1, thereby promoting cisplatin resistance in breast cancer."
40208233
STAMBPL1 increases the amount of DUSP1.
| 1
STAMBPL1 increases the amount of DUSP1. 1 / 1
| 1
reach
"STAMBPL1 promotes breast cancer cell resistance to cisplatin partially by stabilizing MKP-1 expression."
35236965
FOXO1 affects STAMBPL1
1 | 9
FOXO1 binds STAMBPL1.
| 9
sparser
"This interaction between STAMBPL1 and FOXO1 does not necessarily affect the binding of FOXO1 with DNA, including the GRHL3 promoter."
40208233
sparser
"Additionally, an immunoprecipitation assay revealed an interaction between the FOXO1 protein (250–596 aa) and STAMBPL1 ( xref )."
40208233
sparser
"They demonstrate that STAMBPL1 interacts with FOXO1, define the required domains in each protein, and illustrate that this interaction facilitates FOXO1 transcriptional factor activity, which then activates GRHL3/HIF1a/VEGFA signaling."
40208233
sparser
"Because the authors find that STAMBPL1 and FOXO1 interact, they suggest that STAMBPL1 may promote the formation of an active transcriptional complex containing FOXO1, perhaps by facilitating the recruitment of transcriptional coactivators."
40208233
sparser
"Furthermore, it would be important to determine whether the STAMBPL1-FOXO1 interaction is essential for GRHL3 transcription."
40208233
sparser
"The study also shows that STAMBPL1 interacts with FOXO1 to promote GRHL3 transcription, which in turn activates HIF1A."
40208233
sparser
"The results of the GST pull-down assay indicated that the N-terminus (1–140 aa) of STAMBPL1 interacted with FOXO1 ( xref )."
40208233
sparser
"Since the interaction sites of STAMBPL1-FOXO1 have been mapped, a mutant disrupting the interaction would provide better insight into how STAMBPL1 promotes GRHL3 transcription by interacting with FOXO1."
40208233
sparser
"Additionally, we found that STAMBPL1 interacts with FOXO1 to facilitate the transcription of GRHL3/HIF1α/VEGFA."
40208233
FOXO1 increases the amount of STAMBPL1.
1 |
Transcriptionally active FOXO1 increases the amount of STAMBPL1. 1 / 1
1 |
bel
"Supplemental Table S1. Transcripts found in Class I [activated by FKHR]"
12150827
TBMS-1 affects STAMBPL1
| 9
TBMS-1 decreases the amount of STAMBPL1.
| 5
TBMS-1 decreases the amount of STAMBPL1. 5 / 5
| 5
reach
"Interestingly, the results of this study showed that TBMS-1 only downregulates STAMBPL1 expression (Figure 4A,B)."
37511599
reach
"However, TBMS-1 significantly downregulated the expression of STAMBPL1, a DUB of c-FLIP, but had no effect on other DUBs (USP2, USP8, and USP9x) (Figure 4A)."
37511599
reach
"Additionally, TBMS-1 treatment downregulated c-FLIP and STAMBPL1 expression in HeLa and A549 cells; however, such effects were absent in normal EA.hy926 cells (Figure 4B)."
37511599
reach
"These findings were further confirmed in vivo using a xenograft model based on the observation that combined treatment with TBMS-1 and TRAIL decreased tumor volume and downregulated STAMBPL1 and c-FLIP expression levels."
37511599
reach
"Importantly, the combination of TBMS-1 and TRAIL therapy reduced the tumor volume and downregulated the expression levels of STAMBPL1 and c-FLIP in an in vivo xenograft model."
38003270
TBMS-1 inhibits STAMBPL1.
| 3
TBMS-1 inhibits STAMBPL1. 3 / 3
| 3
reach
"Particularly, pretreatment with CHX rapidly enhanced the degradation of STAMBPL1 by TBMS-1 (Figure 4F)."
37511599
reach
"Therefore, TBMS-1 downregulated STAMBPL1 at the post-translational regulation level."
37511599
reach
"Taken together, our findings indicated that TBMS-1 downregulates c-FLIP by downregulating STAMBPL1 deubiquitinating enzymes in various cancer cells."
37511599
TBMS-1 activates STAMBPL1.
| 1
TBMS-1 activates STAMBPL1. 1 / 1
| 1
reach
"Further mechanism studies have shown that TBMS-1 significantly increases sensitivity to TRAIL by downregulating the ubiquitinase STAMBPL1 (DUB) to disrupt c-FLIP expression."
38003270
STAMBPL1 affects mTORC1
| 9
STAMBPL1 activates mTORC1.
| 5
STAMBPL1 activates mTORC1. 5 / 5
| 5
reach
"When leucine is sufficient, STAM-binding-protein-like 1 (STAMBPL) removes the ubiquitin chain on Sestrin2 and activates the mTORC1 signal [80]."
40205401
reach
"STAMBPL1 knockout significantly suppressed mTORC1 activity, anchorage-independent cell growth, and xenograft tumor growth ( Figures 5 F–5J and S8 C–S8J) in all three cell lines."
35114100
reach
"When overexpressed in cells, STAMBPL1 catalyzed the deubiquitination of Sestrin2 ( Figure 2 C) and promoted mTORC1 activation ( Figure 2 D)."
35114100
reach
"Accordingly, STAMBPL1(K405Rfs ∗ 21) showed higher interaction level with Sestrin2, even in the absence of amino acids or leucine ( Figures 6 B and S9 C), and activated mTORC1 signaling ( Figure 6 C)."
35114100
reach
"To further test if the catalytic activity of STAMBPL1 is required to modulate mTORC1 signaling, we mutated the water-activating Glu 292 (E292A) and the Zn 2+ -coordinating Asp 360 (D360A) residues in [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35114100
STAMBPL1 inhibits mTORC1.
| 2
STAMBPL1 inhibits mTORC1. 1 / 1
| 1
reach
"Correction of the STAMBPL1(K405Rfs ∗ 21) mutation in LS174T colon cancer cells inhibited mTORC1 activity and suppressed anchorage-independent cell growth ( Figures 6 F, 6G, and S9 D)."
35114100
STAMBPL1 bound to SESN2 inhibits mTORC1. 1 / 1
| 1
reach
"Inhibiting the interaction between STAMBPL1 and Sestrin2 thereby inactivating mTORC1 using a cell-permeable peptide could be a potential treatment approach for gastric and colorectal cancers [141]."
39482684
STAMBPL1 ubiquitinates mTORC1.
| 1
STAMBPL1 leads to the ubiquitination of mTORC1. 1 / 1
| 1
reach
"Interestingly, Wang et al. reported that gastric cancer and colorectal cancer downregulate an E3 ubiquitin ligase RING finger protein 167 (RNF167) and upregulate a deubiquitinase STAMBPL1 that can prevent the ubiquitination of Sestrin2, decrease Sestrin2-GATOR2 interaction and increase mTORC1 signaling [119]."
35527284
STAMBPL1 deubiquitinates mTORC1.
| 1
Mutated STAMBPL1 leads to the deubiquitination of mTORC1. 1 / 1
| 1
reach
"Consistent with the above results, endogenous K405Rfs ∗ 21 mutation of STAMBPL1 promoted the deubiquitination of Sestrin2 and activated mTORC1 signaling ( Figures 6 D and 6E)."
35114100
STAMBPL1 affects HIF1
| 9
STAMBPL1 activates HIF1.
| 7
STAMBPL1 activates HIF1. 7 / 7
| 7
reach
"In summary, STAMBPL1 promoted TNBC angiogenesis by activating the GRHL3/HIF1α/VEGFA pathway via interacting with FOXO1 in a non-enzymatic manner."
40208233
reach
"In this study, we discovered that STAMBPL1 promotes angiogenesis in TNBC by activating the HIF1α/VEGFA pathway independently of its enzymatic activity."
40208233
reach
"Under normoxic conditions, both STAMBPL1 and its enzymatically mutated variant (E292A) can upregulate the protein expression of HIF1α (Figure 1F)."
40208233
reach
"To elucidate how STAMBPL1 upregulates HIF1α, we examined the transcription levels of HIF1A when STAMBPL1 was knocking down under hypoxia."
40208233
reach
"These findings suggest that STAMBPL1 activates the HIF1α/VEGFA axis in TNBC cells, leading to enhanced abilities of HUVECs through a paracrine pathway."
40208233
reach
"These findings suggest that STAMBPL1 activates the HIF1α/VEGFA axis by upregulating GRHL3."
40208233
reach
"Our study reveals for the first time that GRHL3 promotes transcriptional activity by binding to the promoter of the HIF1A gene.In this study, we utilized two TNBC cell lines, HCC1806 and HCC1937, along with human primary umbilical vein endothelial cells (HUVECs) and a nude mouse breast orthotopic transplantation tumor model to investigate the regulatory mechanism by which STAMBPL1 activates the GRHL3/HIF1α/VEGFA signaling pathway through its interaction with FOXO1, thereby promoting angiogenesis in TNBC."
40208233
STAMBPL1 increases the amount of HIF1.
| 2
STAMBPL1 increases the amount of HIF1. 2 / 2
| 2
reach
"These findings suggest that STAMBPL1 enhances the expression of HIF1α in breast cancer cells through a non-DUB enzyme activity mechanism."
40208233
reach
"In this study, we discovered that, independent of its deubiquitinating enzyme activity, STAMBPL1 upregulates HIF1α expression in TNBC cells."
40208233
STAMBP affects STAMBPL1
2 | 2 5
STAMBPL1 binds STAMBP. 8 / 8
2 | 2 4
sparser
"Unlike the monomer of AMSH or AMSH-LP with inherent DUB activity, BRCC36 must form a complex with other subunits to specifically cleave K63-linked polyubiquitin chains."
35883466
sparser
"To quantify the interaction of the UbVs with STAMBP and STAMBPL1 and to validate the key residues responsible for the tight binding, we used isothermal titration calorimetry (ITC) to measure the interaction thermodynamics ( xref )."
34425109
sparser
"Hameed et al. developed a zinc chelating ABP that forms a tight complex with STAMBP and STAMBPL1 and inhibits the activity of the proteasomal DUB Rpn11 (PSMD14 in humans)."
35625630
reach
"Both STAMBP and STAMBPL1 localize to early endosomes by binding to clathrin (31); however, STAMBPL1 fails to bind to STAM due to residue substitutions in the SBM-like motif, suggesting it may function in different signaling pathway from that of STAMBP (30) ."
| DOI
reach
"Both STAMBP and STAMBPL1 localize to early endosomes by binding to clathrin (31); however, STAMBPL1 fails to bind to STAM due to residue substitutions in the SBM-like motif, suggesting it may function in different signaling pathway from that of STAMBP (30)."
34425109
biogrid
No evidence text available
28514442
sparser
"Hence, it is possible that AMSH and AMSH-LP might be associated with a proteasome or other unknown large protein complex in the nucleus through their MPN domain."
12810066
biogrid
No evidence text available
33961781
STAMBP binds STAMBPL1, Clathrin, and CLTC. 1 / 1
| 1
sparser
"We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins."
16716190
STAMBPL1 is modified
6 | 3
STAMBPL1 is phosphorylated.
6 |
STAMBPL1 is phosphorylated on S242. 3 / 3
3 |
hprd
No evidence text available
17322306
hprd
No evidence text available
20068231
hprd
No evidence text available
18669648
STAMBPL1 is phosphorylated on S400. 1 / 1
1 |
hprd
No evidence text available
20068231
STAMBPL1 is phosphorylated on T392. 1 / 1
1 |
hprd
No evidence text available
20068231
STAMBPL1 is phosphorylated on S25. 1 / 1
1 |
hprd
No evidence text available
18669648
STAMBPL1 is methylated.
| 2
STAMBPL1 is methylated. 2 / 2
| 2
sparser
"We found that dysregulation of miR-29C, miR-34A, miR-98, and miR-215; and methylation of ANKRD1, ARID5B, CDCA2, PIF1, STAMBPL1, TROAP, ZNF165 , and HIST1H2AJ in HeLa cells could result in cell proliferation and anti-apoptosis through NFκB, TGF-β, and PI3K pathways."
27295129
sparser
"It has been reported that NUF2, TROAP, STAMBPL1 , and ARID5B can be methylated in cancers. xref Furthermore, we used the DNA methylation profile of human cervical cancer and ESCs to validate our findings."
27295129
STAMBPL1 is ubiquitinated.
| 1
STAMBPL1 is ubiquitinated. 1 / 1
| 1
sparser
"SMAD3 was shown to stabilize Sestrin2 protein levels by influencing the ubiquitination processes of STAMBPL1 and RNF167."
40751214
STAMBPL1 affects SNAI1
| 2 6
STAMBPL1 binds SNAI1.
| 6
SNAI1 binds STAMBPL1. 6 / 6
| 6
sparser
"A significant STAMBPL1-SNAI1 co-signature was observed across multiple tumour types."
32636467
sparser
"Altogether, these data highlight the prevalence of the identified STAMBPL1-SNAI1 association across an extensive number of tumours types."
32636467
sparser
"While our study does not address the mechanistic details on this regulation, we uncover a substantial STAMBPL1-SNAI1 link across multiple human tumours."
32636467
sparser
"Prevalence of a STAMBPL1-SNAI1 co-signature across a spectrum of tumour types."
32636467
sparser
"Hence, we analysed 35 additional human tumour types for a STAMBPL1-SNAI1 co-signature (Fig.  xref )."
32636467
sparser
"Importantly, we found that 24 tumour types showed a positive correlation, out of which >4000 samples in 12 TCGA tumours displayed a significant STAMBPL1-SNAI1 co-expression profile (Fig.  xref )."
32636467
STAMBPL1 inhibits SNAI1.
| 1
STAMBPL1 inhibits SNAI1. 1 / 1
| 1
reach
"By downregulating the level of Ubiquitin using RNA interference-mediated knockdown of Ubb and Ubc, we found that knockdown of UbC that instructs tandem units of ubiquitin with nine repeats resulted in more efficient attenuation of both K48 and total and mono-Ub levels without affecting STAMBPL1 levels (Supplementary Fig. S3e) and that downregulation of UbC effectively hindered STAMBPL1-mediated Snail protein reduction (Fig. 4i)."
32636467
STAMBPL1 activates SNAI1.
| 1
STAMBPL1 activates SNAI1. 1 / 1
| 1
reach
"Since STAMBPL1 has been shown to be an indirect activator of nuclear factor-κB) (NF-κB) signalling, and given that this pathway promotes Snail stabilisation through the synthesis of COP9 signalosome 2 protein (CSN2), we assessed if CSN2 is relevant for STAMBPL1 effect on Snail."
32636467
BIRC5 affects STAMBPL1
3 | 1 4
BIRC5 binds STAMBPL1. 6 / 6
3 | 1 2
sparser
"However, although cepharanthine reduces STAMBPL1 expression and overexpression of STAMBPL1 inhibits cepharanthine-mediated downregulation of survivin, interaction between STAMBPL1 and survivin was not investigated."
31817770
biogrid
No evidence text available
35066747
biogrid
No evidence text available
31817770
biogrid
No evidence text available
35066747
sparser
"As shown in xref C, we detected the interaction between STAMBPL1 and survivin."
31817770
reach
"STAMBPL1 interacted with survivin and c-FLIP, resulted in reduction of ubiquitination."
31817770
STAMBPL1 binds BIRC5 and CFLAR. 2 / 2
| 2
sparser
"Thus, these data reveal that STAMBPL1 directly interacts with survivin and c-FLIP, resulting in stabilization of proteins."
31817770
sparser
"STAMBPL1 interacted with survivin and c-FLIP, resulted in reduction of ubiquitination."
31817770
SNAI1 affects STAMBPL1
| 1 6
SNAI1 binds STAMBPL1.
| 6
SNAI1 binds STAMBPL1. 6 / 6
| 6
sparser
"A significant STAMBPL1-SNAI1 co-signature was observed across multiple tumour types."
32636467
sparser
"Altogether, these data highlight the prevalence of the identified STAMBPL1-SNAI1 association across an extensive number of tumours types."
32636467
sparser
"While our study does not address the mechanistic details on this regulation, we uncover a substantial STAMBPL1-SNAI1 link across multiple human tumours."
32636467
sparser
"Prevalence of a STAMBPL1-SNAI1 co-signature across a spectrum of tumour types."
32636467
sparser
"Hence, we analysed 35 additional human tumour types for a STAMBPL1-SNAI1 co-signature (Fig.  xref )."
32636467
sparser
"Importantly, we found that 24 tumour types showed a positive correlation, out of which >4000 samples in 12 TCGA tumours displayed a significant STAMBPL1-SNAI1 co-expression profile (Fig.  xref )."
32636467
SNAI1 inhibits STAMBPL1.
| 1
SNAI1 inhibits STAMBPL1. 1 / 1
| 1
reach
"By genetically depleting STAMBPL1 in these cells, we observed a primary effect on Snail protein levels (Fig. 4b)."
32636467
DUSP1 affects STAMBPL1
3 | 2 2
STAMBPL1 binds DUSP1. 7 / 7
3 | 2 2
sparser
"STAMBPL1 interacts with MKP-1 and stabilizes MKP-1 via deubiquitination."
35236965
reach
"STAMBPL1 interacts with MKP-1 and stabilizes MKP-1 via deubiquitination."
35236965
biogrid
No evidence text available
35236965
biogrid
No evidence text available
35236965
biogrid
No evidence text available
35236965
reach
"The study by Liu et al. (2022) found that STAMBPL1 interacts with MKP-1 and stabilizes MKP-1 via deubiquitination, further promoting breast cancer cell resistance to cisplatin."
36685836
sparser
"The study by xref found that STAMBPL1 interacts with MKP-1 and stabilizes MKP-1 via deubiquitination, further promoting breast cancer cell resistance to cisplatin."
36685836
STAMBPL1 affects angiogenesis
| 6
STAMBPL1 activates angiogenesis. 6 / 6
| 6
reach
"In this study, we discovered that STAMBPL1 promotes angiogenesis in TNBC by activating the HIF1α/VEGFA pathway independently of its enzymatic activity."
40208233
reach
"STAMBPL1 activates the GRHL3/HIF1A/VEGFA axis through interaction with FOXO1 to promote angiogenesis in triple-negative breast cancer."
40208233
reach
"In summary, STAMBPL1 promoted TNBC angiogenesis by activating the GRHL3/HIF1α/VEGFA pathway via interacting with FOXO1 in a non-enzymatic manner."
40208233
reach
"Therefore, we investigated whether STAMBPL1 promotes tumor angiogenesis."
40208233
reach
"STAMBPL1 in TNBC cells enhances the activity of HUVECs and promotes TNBC angiogenesis."
40208233
reach
"Knocking down STAMBPL1 inhibited the growth of HCC1806 xenografts in mice (Figure 3G–I) and decreased the number of microvessels in tumor tissue (Figure 3J, K), indicating that STAMBPL1 promoted tumor angiogenesis."
40208233
STAMBPL1 affects XIAP
| 6
STAMBPL1 inhibits XIAP.
| 3
STAMBPL1 inhibits XIAP. 3 / 3
| 3
reach
"These data suggest that STAMBPL1 loss diverts the XIAP degradation from proteasome pathway to lysosome pathway, and drastically enhances XIAP degradation.In this study, we reported evidence that silen[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31004702
reach
"STAMBPL1 depletion was found to induce apoptosis by promoting the degradation of the protein XIAP, suggesting that targeting STAMBPL1 might offer a promising therapeutic strategy for prostate cancer [23]."
38419066
reach
"Of interest, XIAP protein was diminished by STAMBPL1 RNAi."
31004702
STAMBPL1 increases the amount of XIAP.
| 1
STAMBPL1 increases the amount of XIAP. 1 / 1
| 1
reach
"Albeit the sharp drop seen in XIAP protein level in STAMBPL1 depleted cells, we did not observe any change in XIAP mRNA level ( Fig. 6 A), indicating that regulation of XIAP expression by STAMBPL1 is [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31004702
STAMBPL1 deubiquitinates XIAP.
| 1
STAMBPL1 leads to the deubiquitination of XIAP. 1 / 1
| 1
reach
"We observed that STAMBPL1 depletion modulates XIAP ubiquitination status, which diverts the XIAP degradation from proteasome pathway to lysosome pathway."
31004702
STAMBPL1 activates XIAP.
| 1
STAMBPL1 activates XIAP. 1 / 1
| 1
reach
"We demonstrated that STAMBPL1 RNAi depletion induced apoptosis in PC3 and DU145 cells by promoting XIAP lysosomal degradation."
31004702
STAMBPL1 affects HIF1A
| 6
STAMBPL1 increases the amount of HIF1A.
| 5
STAMBPL1 increases the amount of HIF1A. 5 / 5
| 5
reach
"We demonstrated that STAMBPL1 increased HIF1A transcription in a non-enzymatic manner, thereby activating the HIF1alpha/VEGFA signaling pathway to facilitate triple-negative breast cancer angiogenesis."
40208233
reach
"STAMBPL1 promotes HIF1A transcription and activates the HIF1alpha/VEGFA axis."
40208233
reach
"Data showed that STAMBPL1 overexpression increased the transcription of HIF1A (Figure 4E, Figure 4—figure supplement 1E) and VEGFA (Figure 2E, G)."
40208233
reach
"These findings suggested that STAMBPL1 activated the HIF1α/VEGFA axis through enhancing the transcription of HIF1A."
40208233
reach
"By silencing the STAMBPL1 gene in HCC1806 cells subjected to 10 hr of hypoxia, we performed RNA-seq analysis to investigate the mechanism by which STAMBPL1 promotes HIF1A transcription."
40208233
STAMBPL1 activates HIF1A.
| 1
STAMBPL1 activates HIF1A. 1 / 1
| 1
reach
"STAMBPL1 upregulates HIF1alpha in a non-enzymatic manner in TNBC cells."
40208233
STAMBPL1 affects CLTC
5 | 1
STAMBPL1 binds CLTC. 5 / 5
5 |
biogrid
No evidence text available
16716190
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26496610
biogrid
No evidence text available
16716190
biogrid
No evidence text available
33961781
STAMBP binds STAMBPL1, Clathrin, and CLTC. 1 / 1
| 1
sparser
"We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins."
16716190
AXL affects STAMBPL1
| 6
AXL binds STAMBPL1.
| 5
STAMBPL1 binds AXL. 5 / 5
| 5
sparser
"DUBs employ diverse mechanisms and modes of interaction with their substrates to mediate the removal of mono‐ubiquitin or poly‐ubiquitin chains from the target protein. [ xref ] To ascertain the direct interaction between STAMBPL1 and AXL, Immunoprecipitation (IP) and in vitro pull‐down assays were performed."
39527690
sparser
"Based on their interaction, we next identified the critical region within STAMBPL1 that binds to AXL."
39527690
sparser
"Our results showed truncated mutant lacking USP8_dimer domain exhibited much lower binding affinity with AXL comparing with STAMBPL1‐WT, STAMBPL1‐ΔUJ_linker and STAMBPL1‐ΔJAB, indicating that STAMBPL1 interacts with AXL largely through USP8_dimer domain (Figure  xref )."
39527690
sparser
"First, our data showed that the interaction between STAMBPL1 and AXL proteins in KIRC cells was not affected upon GAS6 stimulation (Figure  xref )."
39527690
sparser
"Thus, STAMBPL1 binding to AXL will sterically block TRIM21 from recognizing the AXL and inhibit the subsequent ubiquitination of AXL."
39527690
AXL ubiquitinates STAMBPL1.
| 1
AXL ubiquitinates STAMBPL1. 1 / 1
| 1
sparser
"Of note, STAMBPL1 silencing failed to downregulate AXL protein level in TRIM21 KD 786‐O cells, implying that STAMBPL1 KD‐induced AXL ubiquitination and degradation was dependent on TRIM21 (Figure  xref )."
39527690
Valproic acid affects STAMBPL1
5 |
Valproic acid decreases the amount of STAMBPL1.
4 |
Valproic acid decreases the amount of STAMBPL1. 4 / 4
4 |
ctd
No evidence text available
23179753
ctd
No evidence text available
26272509
ctd
No evidence text available
24935251
ctd
No evidence text available
27188386
Valproic acid increases the amount of STAMBPL1.
1 |
Valproic acid increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
29154799
Ubiquitin affects K63
| 5
STAMBPL1 binds Ubiquitin and K63. 4 / 4
| 4
sparser
"The overall three-dimensional fold of Sst2 Δ220 –K63-Ub 2 is highly similar to the structure of the DUB domain of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) with an rmsd of 1.19 Å of Cα atoms over 266 residues from both Sst2 and K63-Ub 2 ."
24787148
sparser
"Figure xref d shows the superposition of Sst2 Δ220 –K63-Ub 2 and AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV( xref ))."
24787148
sparser
"Proximal ubiquitin binding is similar to that observed in the crystal structure of AMSH-LP bound to K63-Ub 2 ."
24787148
sparser
"The structure was determined by molecular replacement using a model of Sst2–K63-Ub 2 generated by superimposition of Sst2 cat with the structure of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV( xref )) and refined yielding satisfactory crystallographic, free R factors and good stereochemistry (Table xref )."
24787148
BRCC36 binds STAMBPL1, Ubiquitin, and K63. 1 / 1
| 1
sparser
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly."
28587922
STAMBPL1 affects cell growth
| 5
STAMBPL1 activates cell growth.
| 4
STAMBPL1 activates cell growth. 4 / 4
| 4
reach
"Knockdown of STAMBPL1 inhibited cell growth and metastasis of CRC through inactivation of the NF-κB pathway."
38008943
reach
"Our findings indicated that STAMBPL1 overexpression enhanced breast cancer cell growth in vivo."
40208233
reach
"STAMBPL1 knockout significantly suppressed mTORC1 activity, anchorage-independent cell growth, and xenograft tumor growth ( Figures 5 F–5J and S8 C–S8J) in all three cell lines."
35114100
reach
"We also showed that knockout of STAMBPL1 in HEK293T cells activated the catabolic autophagy pathway ( Figures S7 A and S7B), reduced the cell size ( Figure S7 C), and suppressed anchorage-independent [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35114100
STAMBPL1 inhibits cell growth.
| 1
STAMBPL1 inhibits cell growth. 1 / 1
| 1
reach
"Correction of the STAMBPL1(K405Rfs ∗ 21) mutation in LS174T colon cancer cells inhibited mTORC1 activity and suppressed anchorage-independent cell growth ( Figures 6 F, 6G, and S9 D)."
35114100
STAMBPL1 affects STAM
| 5
STAMBPL1 binds STAM. 3 / 3
| 3
sparser
"We observed a significant enhancement of IL-2-mediated c- myc induction in AMSH-LP-transfected cells as well as AMSH-transfected cells, although AMSH-LP did not associate physically with either STAM [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12810066
sparser
"We addressed whether the SBM-like motif of AMSH-LP could bind STAM1."
12810066
sparser
"These results indicate that, unlike AMSH, AMSH-LP cannot bind to the STAMs."
12810066
STAMBPL1 binds STAM, STAM2, and GRB2. 1 / 1
| 1
sparser
"Consistent with this, coimmunoprecipitation analyses revealed that AMSH-LP could not bind to STAM1, STAM2, or Grb2, all of which contain an SH3 domain that interacts with AMSH [2,3,11] ."
12810066
STAM2 binds STAM and STAMBPL1. 1 / 1
| 1
sparser
"Another STAM family protein, STAM2, did not bind to AMSH-LP either, although AMSH strongly binds to STAM2 (data not shown)."
12810066
STAMBPL1 affects K63-Ub 2
| 5
STAMBPL1 binds K63-Ub 2. 4 / 4
| 4
reach
"Proximal ubiquitin binding is similar to that observed in the crystal structure of AMSH-LP bound to K63-Ub 2."
24787148
reach
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly."
28587922
reach
"Figure XREF_FIG d shows the superposition of Sst2 Delta220 -K63-Ub 2 and AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV)."
24787148
reach
"The structure was determined by molecular replacement using a model of Sst2-K63-Ub 2 generated by superimposition of Sst2 cat with the structure of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) and refined yielding satisfactory crystallographic, free R factors and good stereochemistry."
24787148
STAMBPL1 binds K63-Ub 2 and DUB domain. 1 / 1
| 1
reach
"The overall three-dimensional fold of Sst2 Delta220 -K63-Ub 2 is highly similar to the structure of the DUB domain of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) with an rmsd of 1.19 A of Calpha atoms over 266 residues from both Sst2 and K63-Ub 2."
24787148
STAMBPL1 affects K63
| 5
STAMBPL1 binds Ubiquitin and K63. 4 / 4
| 4
sparser
"The overall three-dimensional fold of Sst2 Δ220 –K63-Ub 2 is highly similar to the structure of the DUB domain of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) with an rmsd of 1.19 Å of Cα atoms over 266 residues from both Sst2 and K63-Ub 2 ."
24787148
sparser
"Figure xref d shows the superposition of Sst2 Δ220 –K63-Ub 2 and AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV( xref ))."
24787148
sparser
"Proximal ubiquitin binding is similar to that observed in the crystal structure of AMSH-LP bound to K63-Ub 2 ."
24787148
sparser
"The structure was determined by molecular replacement using a model of Sst2–K63-Ub 2 generated by superimposition of Sst2 cat with the structure of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV( xref )) and refined yielding satisfactory crystallographic, free R factors and good stereochemistry (Table xref )."
24787148
BRCC36 binds STAMBPL1, Ubiquitin, and K63. 1 / 1
| 1
sparser
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly."
28587922
STAMBPL1 affects HYCC1
| 5
STAMBPL1 activates HYCC1. 5 / 5
| 5
reach
"These findings highlight the diverse roles that deubiquitinases play in HCC, either by promoting or suppressing the disease, and suggest that they could be potential targets for therapeutic intervention in HCC.In the study, we identified one oncogene gene (STAMBPL1) which promote the proliferation and metastasis of HCC."
38419066
reach
"Through the analysis of TCGA expression symbol and clinicopathological information, it was found that the expression of STAMBPL1 increased with the variation of tumor stage (Fig. 1K) and grade (Fig. 1M) in HCC."
38419066
reach
"Additionally, the EDU staining also demonstrated that suppression of STAMBPL1 expression could reduce the proportion of proliferative HCC cells (Fig. 3I, J)."
38419066
reach
"Additionally, the EDU staining also demonstrated that overexpression of STAMBPL1 expression could enhance the proportion of proliferative HCC cells (Fig. 4G)."
38419066
reach
"Functionally, STAMBPL1 significantly promoted HCC cells proliferation and metastasis, and it interacts with TRAF2 and stabilize it via the deubiquitination at the K63 residue."
38419066
STAMBPL1 affects FAS
| 5
FAS binds STAMBPL1. 5 / 5
| 5
sparser
"Seven of the nine fusions frequently detected in patients with HCC included: MAN2A1–FER (100%), SLC45A2–AMACR (62.3%), ZMPSTE24–ZMYM4 (62.3%), PTEN–NOLC1 (57.4%), CCNH–C5orf30 (55.7%), STAMBPL1–FAS (26.2%), and PCMTD1–SNTG1 (16.4%)."
38537933
sparser
"STAMBPL1-FAS fusion isoform was identified in sample 1 M (metastasis cancer) and 2 M (the metastasis cancer): XM_011539985 from STAMBPL1 and XM_011539766.2 from FAS (Fig.  xref )."
33907296
sparser
"However, subsequent analysis using Taqman qPCR showed that the STAMBPL1-FAS fusion isoform can be found in all 6 cancer samples (Supplementary Fig.  xref ), implying a wider distribution of this gene fusion in colon cancers."
33907296
sparser
"The relatively low-frequency fusion transcripts were STAMBPL1–FAS (26.2%, 16/61), PCMTD1–SNTG1 (16.4%, 10/61), and ZNF124–SMYD3 (16.4%, 10/61)."
38537933
sparser
"The Fisher exact test showed that seven fusion genes— MAN2A1–FER ( P  = 1.4 × 10 −19 ), CCNH–C5orf30 ( P  = 1.1 × 10 −5 ), SLC45A2–AMACR ( P  = 2.8 × 10 −9 ), ZMPSTE24–ZMYM4 ( P  = 9.3 × 10 −6 ), PTEN–NOLC1 ( P  = 1.8 × 10 −6 ), PCMTD1–SNTG1 ( P  = 0.006), and STAMBPL1–FAS ( P  = 0.01)—had significantly greater frequencies of expression in the serum samples of patients with HCC, suggesting that the detection of these fusion transcripts in the serum samples of patients with HCC likely predicts the risk for HCC."
38537933
STAMBPL1 affects AXL
| 5
STAMBPL1 binds AXL. 5 / 5
| 5
sparser
"DUBs employ diverse mechanisms and modes of interaction with their substrates to mediate the removal of mono‐ubiquitin or poly‐ubiquitin chains from the target protein. [ xref ] To ascertain the direct interaction between STAMBPL1 and AXL, Immunoprecipitation (IP) and in vitro pull‐down assays were performed."
39527690
sparser
"Based on their interaction, we next identified the critical region within STAMBPL1 that binds to AXL."
39527690
sparser
"Our results showed truncated mutant lacking USP8_dimer domain exhibited much lower binding affinity with AXL comparing with STAMBPL1‐WT, STAMBPL1‐ΔUJ_linker and STAMBPL1‐ΔJAB, indicating that STAMBPL1 interacts with AXL largely through USP8_dimer domain (Figure  xref )."
39527690
sparser
"First, our data showed that the interaction between STAMBPL1 and AXL proteins in KIRC cells was not affected upon GAS6 stimulation (Figure  xref )."
39527690
sparser
"Thus, STAMBPL1 binding to AXL will sterically block TRIM21 from recognizing the AXL and inhibit the subsequent ubiquitination of AXL."
39527690
STAM affects STAMBPL1
| 5
STAMBPL1 binds STAM. 3 / 3
| 3
sparser
"We observed a significant enhancement of IL-2-mediated c- myc induction in AMSH-LP-transfected cells as well as AMSH-transfected cells, although AMSH-LP did not associate physically with either STAM [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12810066
sparser
"We addressed whether the SBM-like motif of AMSH-LP could bind STAM1."
12810066
sparser
"These results indicate that, unlike AMSH, AMSH-LP cannot bind to the STAMs."
12810066
STAMBPL1 binds STAM, STAM2, and GRB2. 1 / 1
| 1
sparser
"Consistent with this, coimmunoprecipitation analyses revealed that AMSH-LP could not bind to STAM1, STAM2, or Grb2, all of which contain an SH3 domain that interacts with AMSH [2,3,11] ."
12810066
STAM2 binds STAM and STAMBPL1. 1 / 1
| 1
sparser
"Another STAM family protein, STAM2, did not bind to AMSH-LP either, although AMSH strongly binds to STAM2 (data not shown)."
12810066
K63-Ub 2 affects STAMBPL1
| 5
STAMBPL1 binds K63-Ub 2. 4 / 4
| 4
reach
"Proximal ubiquitin binding is similar to that observed in the crystal structure of AMSH-LP bound to K63-Ub 2."
24787148
reach
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly."
28587922
reach
"Figure XREF_FIG d shows the superposition of Sst2 Delta220 -K63-Ub 2 and AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV)."
24787148
reach
"The structure was determined by molecular replacement using a model of Sst2-K63-Ub 2 generated by superimposition of Sst2 cat with the structure of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) and refined yielding satisfactory crystallographic, free R factors and good stereochemistry."
24787148
STAMBPL1 binds K63-Ub 2 and DUB domain. 1 / 1
| 1
reach
"The overall three-dimensional fold of Sst2 Delta220 -K63-Ub 2 is highly similar to the structure of the DUB domain of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) with an rmsd of 1.19 A of Calpha atoms over 266 residues from both Sst2 and K63-Ub 2."
24787148
K63 affects Ubiquitin
| 5
STAMBPL1 binds Ubiquitin and K63. 4 / 4
| 4
sparser
"The overall three-dimensional fold of Sst2 Δ220 –K63-Ub 2 is highly similar to the structure of the DUB domain of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) with an rmsd of 1.19 Å of Cα atoms over 266 residues from both Sst2 and K63-Ub 2 ."
24787148
sparser
"Figure xref d shows the superposition of Sst2 Δ220 –K63-Ub 2 and AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV( xref ))."
24787148
sparser
"Proximal ubiquitin binding is similar to that observed in the crystal structure of AMSH-LP bound to K63-Ub 2 ."
24787148
sparser
"The structure was determined by molecular replacement using a model of Sst2–K63-Ub 2 generated by superimposition of Sst2 cat with the structure of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV( xref )) and refined yielding satisfactory crystallographic, free R factors and good stereochemistry (Table xref )."
24787148
BRCC36 binds STAMBPL1, Ubiquitin, and K63. 1 / 1
| 1
sparser
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly."
28587922
FAS affects STAMBPL1
| 5
FAS binds STAMBPL1. 5 / 5
| 5
sparser
"Seven of the nine fusions frequently detected in patients with HCC included: MAN2A1–FER (100%), SLC45A2–AMACR (62.3%), ZMPSTE24–ZMYM4 (62.3%), PTEN–NOLC1 (57.4%), CCNH–C5orf30 (55.7%), STAMBPL1–FAS (26.2%), and PCMTD1–SNTG1 (16.4%)."
38537933
sparser
"STAMBPL1-FAS fusion isoform was identified in sample 1 M (metastasis cancer) and 2 M (the metastasis cancer): XM_011539985 from STAMBPL1 and XM_011539766.2 from FAS (Fig.  xref )."
33907296
sparser
"However, subsequent analysis using Taqman qPCR showed that the STAMBPL1-FAS fusion isoform can be found in all 6 cancer samples (Supplementary Fig.  xref ), implying a wider distribution of this gene fusion in colon cancers."
33907296
sparser
"The relatively low-frequency fusion transcripts were STAMBPL1–FAS (26.2%, 16/61), PCMTD1–SNTG1 (16.4%, 10/61), and ZNF124–SMYD3 (16.4%, 10/61)."
38537933
sparser
"The Fisher exact test showed that seven fusion genes— MAN2A1–FER ( P  = 1.4 × 10 −19 ), CCNH–C5orf30 ( P  = 1.1 × 10 −5 ), SLC45A2–AMACR ( P  = 2.8 × 10 −9 ), ZMPSTE24–ZMYM4 ( P  = 9.3 × 10 −6 ), PTEN–NOLC1 ( P  = 1.8 × 10 −6 ), PCMTD1–SNTG1 ( P  = 0.006), and STAMBPL1–FAS ( P  = 0.01)—had significantly greater frequencies of expression in the serum samples of patients with HCC, suggesting that the detection of these fusion transcripts in the serum samples of patients with HCC likely predicts the risk for HCC."
38537933
STAMBPL1 affects cell death
| 4
STAMBPL1 inhibits cell death.
| 2
reach
"Taken together, these data indicate that inhibition of STAMBPL1 in prostate cancer cells triggers caspase-dependent apoptosis.Considering that caspase 8 is the predominant initiator caspase in the cel[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31004702
reach
"To elucidate the machinery of STAMBPL1 depletion-induced cell death, we tested necroptosis inhibitor necrostatin-1 (Nec-1), autophagy inhibitor chloroquine (CQ) and caspase 3 inhibitor Z-DEVD-FMK for [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31004702
STAMBPL1 activates cell death.
| 2
STAMBPL1 activates cell death. 2 / 2
| 2
reach
"Accordingly, overexpression of XIAP in STAMBPL1-silenced cells rescued cell death, supporting the notion that decreasing XIAP is the major mechanism underlying the cell death caused by STAMBPL1 downre[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31004702
reach
"Necroptosis inhibitor Nec-1 and autophagy inhibitor CQ did not efficiently suppress cell death induced by STAMBPL1 targeting; whereas, addition of a caspase 3 inhibitor, Z-DEVD-FMK, to cells markedly [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31004702
reach
"Functionally, STAMBPL1 notably enhances CCA cell proliferation and metastasis while impeding ferroptosis."
39706065
reach
"Functionally, STAMBPL1 significantly promoted HCC cells proliferation and metastasis, and it interacts with TRAF2 and stabilize it via the deubiquitination at the K63 residue."
38419066
reach
"These findings highlight the diverse roles that deubiquitinases play in HCC, either by promoting or suppressing the disease, and suggest that they could be potential targets for therapeutic intervention in HCC.In the study, we identified one oncogene gene (STAMBPL1) which promote the proliferation and metastasis of HCC."
38419066
reach
"Knockdown of STAMBPL1 inhibited cell growth and metastasis of CRC through inactivation of the NF-κB pathway."
38008943
reach
"STAMBPL1 promotes cell migration and invasion in LUAD."
37393834
reach
"Knockdown of STAMBPL1 reduced cell viability of CRC and suppressed the proliferation, invasion, and migration."
38008943
reach
"Cell invasion showed that the number of cells in A549 and H1299 of the STAMBPL1 SI group was lower than that of A549 STAMBPL1 NC and H1299 STAMBPL1 NC group, suggesting that STAMBPL1 promoted the cell invasion ability of LUAD (Fig. 2D, p<0.001, p<0.01)."
37393834
reach
"Furthermore, knockdown of STAMBPL1 by shSTAMBPL1 resulted in STAMBPL1 downregulation, which in turn decreased the cell proliferation of AGS gastric cancer cells, increasing cell apoptosis, cell invasion and migration in vitro."
31611951
STAMBPL1 affects NFkappaB
| 3
STAMBPL1 activates NFkappaB. 2 / 3
| 2
reach
"These data ruled out the dependence of cell death on caspase 8 activation, indicating cell-extrinsic pathway is not a mechanism underlying the STAMBPL1 depletion induced apoptosis.It was reported that[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31004702
reach
"Silencing of STAMBPL1 with siRNA inhibits Tax activation of both the canonical and noncanonical NF-kappaB signaling pathways."
| PMC
Modified STAMBPL1 activates NFkappaB. 1 / 1
| 1
reach
"Overexpression of wild-type STAMBPL1, but not a catalytically inactive mutant, enhances Tax mediated NF-kappaB activation and the induction of NF-kappaB target genes."
| PMC
STAMBPL1 affects DHRS2
| 4
STAMBPL1 increases the amount of DHRS2.
| 3
STAMBPL1 increases the amount of DHRS2. 3 / 3
| 3
reach
"STAMBPL1 promotes NSCLC progression by regulating DHRS2 expression."
37393834
reach
"STAMBPL1 promotes the progression of lung adenocarcinoma by inhibiting DHRS2 expression."
37393834
reach
"Besides, we found that the expression of DHRS2 in the primary tumor was lower than in normal samples in the TCGA-LUAD database (Fig. 3E), while the expression of STAMBPL1 in the primary tumor was higher than in normal samples (Fig. 3F), so we carried out the hypothesis that STAMBPL1 promotes the progression of lung adenocarcinoma by inhibiting DHRS2 expression."
37393834
STAMBPL1 decreases the amount of DHRS2.
| 1
STAMBPL1 decreases the amount of DHRS2. 1 / 1
| 1
reach
"Combined with microarray sequencing, qPCR, and WB results, we proved that knockdown of STAMBPL1 in LUAD A549 and H1299 cell lines could up-regulate DHRS2 gene expression."
37393834
K63 affects STAMBPL1, and Ubiquitin
| 4
STAMBPL1 binds Ubiquitin and K63. 4 / 4
| 4
sparser
"The overall three-dimensional fold of Sst2 Δ220 –K63-Ub 2 is highly similar to the structure of the DUB domain of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) with an rmsd of 1.19 Å of Cα atoms over 266 residues from both Sst2 and K63-Ub 2 ."
24787148
sparser
"Figure xref d shows the superposition of Sst2 Δ220 –K63-Ub 2 and AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV( xref ))."
24787148
sparser
"Proximal ubiquitin binding is similar to that observed in the crystal structure of AMSH-LP bound to K63-Ub 2 ."
24787148
sparser
"The structure was determined by molecular replacement using a model of Sst2–K63-Ub 2 generated by superimposition of Sst2 cat with the structure of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV( xref )) and refined yielding satisfactory crystallographic, free R factors and good stereochemistry (Table xref )."
24787148
Honokiol affects STAMBPL1
| 4
Honokiol inhibits STAMBPL1. 4 / 4
| 4
eidos
"Honokiol decreased STAMBPL1 expression , resulting in degradation of survivin and c-FLIP protein ."
31817770
eidos
"Therefore , we tested alteration of various DUBs expression and discovered that honokiol only decreased STAMBPL1 which is classified as JAMM family ( Figure 5B ) ."
31817770
eidos
"In our study , the honokiol inhibited STAMBPL1 expression ( Figure 5B ) ."
31817770
eidos
"Honokiol induced STAMBPL1 downregulation in tested cancer cells ( ACHN , A498 , A549 , and Hela cells ) ( Figure 6E ) ."
31817770
Cyclosporin A affects STAMBPL1
3 |
Cyclosporin A increases the amount of STAMBPL1. 3 / 3
3 |
ctd
No evidence text available
27989131
ctd
No evidence text available
25562108
ctd
No evidence text available
20106945
Bisphenol A affects STAMBPL1
3 |
Bisphenol A methylates STAMBPL1.
1 |
Bisphenol A methylates STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
31601247
Bisphenol A increases the amount of STAMBPL1.
1 |
Bisphenol A increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
25181051
Bisphenol A decreases the amount of STAMBPL1.
1 |
Bisphenol A decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
29275510
Aflatoxin B1 affects STAMBPL1
3 |
Aflatoxin B1 increases the amount of STAMBPL1.
2 |
Aflatoxin B1 increases the amount of STAMBPL1. 2 / 2
2 |
ctd
No evidence text available
33354967
ctd
No evidence text available
22100608
Aflatoxin B1 methylates STAMBPL1.
1 |
Aflatoxin B1 methylates STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
27153756
TP53 affects STAMBPL1
| 2 1
TP53 activates STAMBPL1.
| 1 1
Mutated TP53 activates STAMBPL1. 1 / 1
| 1
reach
"Thus, the mechanism by which mutant p53 might activate STAMBPL1 is therefore likely through its interaction with these TFs, which possess responsive to mutant p53."
32636467
TP53 activates STAMBPL1. 1 / 1
| 1
sparser
"Thus, the mechanism by which mutant p53 might activate STAMBPL1 is therefore likely through its interaction with these TFs, which possess responsive to mutant p53. xref – xref Although future studies are needed to delineate whether other DUBs are involved in mutant p53-induced EMT or to other mutant p53-mediated oncogenic pro-survival benefits (ref. xref , xref ), our findings suggest an involvement of mutant p53 in driving the expression of STAMBPL1 as a novel pro-EMT GOF, providing further rationale to investigate DUB expression by other oncoproteins."
32636467
TP53 increases the amount of STAMBPL1.
| 1
TP53 increases the amount of STAMBPL1. 1 / 1
| 1
reach
"While ChIP assay revealed p53 enrichment on MDM2 and CDKN1A promoters in p53 -expressing cells (up to ~4% and ~10% of input), no significant (>1%) occupancy on any of the six predicted was detected for either WT or p53 (Supplementary Fig. S5c), indicating that the expression of STAMBPL1 gene is not directly regulated by p53 ."
32636467
TNFSF10 affects STAMBPL1
| 3
TNFSF10 decreases the amount of STAMBPL1.
| 2
TNFSF10 decreases the amount of STAMBPL1. 2 / 2
| 2
reach
"These findings were further confirmed in vivo using a xenograft model based on the observation that combined treatment with TBMS-1 and TRAIL decreased tumor volume and downregulated STAMBPL1 and c-FLIP expression levels."
37511599
reach
"Importantly, the combination of TBMS-1 and TRAIL therapy reduced the tumor volume and downregulated the expression levels of STAMBPL1 and c-FLIP in an in vivo xenograft model."
38003270
TNFSF10 inhibits STAMBPL1.
| 1
TNFSF10 inhibits STAMBPL1. 1 / 1
| 1
reach
"Further mechanism studies have shown that TBMS-1 significantly increases sensitivity to TRAIL by downregulating the ubiquitinase STAMBPL1 (DUB) to disrupt c-FLIP expression."
38003270
STAMBPL1 affects VEGFA
| 2 1
STAMBPL1 increases the amount of VEGFA. 3 / 3
| 2 1
sparser
"For Fig.7G-H, our experimental objective was to determine whether the activation of HIF1A / VEGFA transcription by STAMBPL1 via FOXO1."
40208233
reach
"Data showed that STAMBPL1 overexpression increased the transcription of HIF1A (Figure 4E, Figure 4—figure supplement 1E) and VEGFA (Figure 2E, G)."
40208233
reach
"The ability of STAMBPL1 to induce VEGFA transcription was blocked by HIF1α knockdown (Figure 2D–G)."
40208233
STAMBPL1 affects Tax
| 3
STAMBPL1 activates Tax.
| 2
STAMBPL1 activates Tax. 2 / 2
| 2
reach
"Furthermore, overexpression of STAMBPL1 enhances the stability of Tax by blocking its proteasomal degradation, whereas siRNA silencing of STAMBPL1 promotes Tax degradation."
| PMC
reach
"Silencing of STAMBPL1 with siRNA inhibits Tax activation of both the canonical and noncanonical NF-kappaB signaling pathways."
| PMC
STAMBPL1 deubiquitinates Tax.
| 1
STAMBPL1 leads to the deubiquitination of Tax. 1 / 1
| 1
reach
"Importantly, STAMBPL1 does not induce Tax de-ubiquitination but protects Tax from degradation."
22035054
STAMBPL1 affects SMAD7
1 | 1 1
STAMBPL1 binds SMAD7.
1 | 1
STAMBPL1 binds SMAD2 and SMAD7. 1 / 1
| 1
sparser
"Previous studies reported that although they did not investigate the DUB activity of STAMBPL1, STAMBPL1 interact with Smad2 and Smad7, followed by induction of TGF-β-mediated transcriptional activity [ xref ]."
31817770
STAMBPL1 binds SMAD7. 1 / 1
1 |
hprd
No evidence text available
14728725
STAMBPL1 inhibits SMAD7.
| 1
STAMBPL1 inhibits SMAD7. 1 / 1
| 1
reach
"Similarly, AMSH-LP has been reported to sequester SMAD7, thereby exerting a positive impact on the TGFbeta pathway (XREF_FIG C) XREF_BIBR."
25007997
STAMBPL1 affects RAB2A
3 |
RAB2A binds STAMBPL1. 3 / 3
3 |
biogrid
No evidence text available
32296183
biogrid
No evidence text available
21516116
biogrid
No evidence text available
25416956
STAMBPL1 affects MAGEA3
3 |
biogrid
No evidence text available
32296183
biogrid
No evidence text available
33961781
biogrid
No evidence text available
33961781
STAMBPL1 affects GTSE1
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26496610
STAMBPL1 affects GST
| 3
STAMBPL1 binds GST. 3 / 3
| 3
sparser
"The GST‐STAMBPL1 or GST‐TRIM21 fusion proteins were produced in Escherichia coli (BL21) cells and purified using a GST‐Tag Protein Purification Kit (Sangon Biotech, Shanghai, China)."
39527690
sparser
"Indeed, endogenous binding between STAMBPL1 and AXL was observed in multiple KIRC cell lines (786‐O, 769‐P and Caki‐1), and the glutathione S‐transferase (GST) pull‐down experiments showed that AXL interacted with purified GST‐STAMBPL1, but not GST alone ( Figure xref ; Figure xref , Supporting Information)."
39527690
sparser
"Prokaryotic plasmids encoding GST‐STAMBPL1 or GST‐TRIM21 fusion protein were constructed in pGEX‐4T. The PD‐L1 wild‐type or mutant promoter sequence was constructed into pGL3‐basic firefly luciferase reporter vector."
39527690
STAMBPL1 affects GAK
3 |
GAK binds STAMBPL1. 3 / 3
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26496610
STAMBPL1 affects Clathrin
| 2 1
reach
"Both STAMBP and STAMBPL1 localize to early endosomes by binding to clathrin (31); however, STAMBPL1 fails to bind to STAM due to residue substitutions in the SBM-like motif, suggesting it may function in different signaling pathway from that of STAMBP (30)."
34425109
reach
"Both STAMBP and STAMBPL1 localize to early endosomes by binding to clathrin (31); however, STAMBPL1 fails to bind to STAM due to residue substitutions in the SBM-like motif, suggesting it may function in different signaling pathway from that of STAMBP (30) ."
| DOI
STAMBP binds STAMBPL1, Clathrin, and CLTC. 1 / 1
| 1
sparser
"We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins."
16716190
STAMBPL1 affects CLINT1
3 |
STAMBPL1 binds CLINT1. 3 / 3
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
biogrid
No evidence text available
19615732
RAB2A affects STAMBPL1
3 |
RAB2A binds STAMBPL1. 3 / 3
3 |
biogrid
No evidence text available
32296183
biogrid
No evidence text available
21516116
biogrid
No evidence text available
25416956
MAGEA3 affects STAMBPL1
3 |
biogrid
No evidence text available
32296183
biogrid
No evidence text available
33961781
biogrid
No evidence text available
33961781
GTSE1 affects STAMBPL1
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26496610
GST affects STAMBPL1
| 3
STAMBPL1 binds GST. 3 / 3
| 3
sparser
"The GST‐STAMBPL1 or GST‐TRIM21 fusion proteins were produced in Escherichia coli (BL21) cells and purified using a GST‐Tag Protein Purification Kit (Sangon Biotech, Shanghai, China)."
39527690
sparser
"Indeed, endogenous binding between STAMBPL1 and AXL was observed in multiple KIRC cell lines (786‐O, 769‐P and Caki‐1), and the glutathione S‐transferase (GST) pull‐down experiments showed that AXL interacted with purified GST‐STAMBPL1, but not GST alone ( Figure xref ; Figure xref , Supporting Information)."
39527690
sparser
"Prokaryotic plasmids encoding GST‐STAMBPL1 or GST‐TRIM21 fusion protein were constructed in pGEX‐4T. The PD‐L1 wild‐type or mutant promoter sequence was constructed into pGL3‐basic firefly luciferase reporter vector."
39527690
GAK affects STAMBPL1
3 |
GAK binds STAMBPL1. 3 / 3
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26496610
Clathrin affects STAMBPL1
| 2 1
reach
"Both STAMBP and STAMBPL1 localize to early endosomes by binding to clathrin (31); however, STAMBPL1 fails to bind to STAM due to residue substitutions in the SBM-like motif, suggesting it may function in different signaling pathway from that of STAMBP (30)."
34425109
reach
"Both STAMBP and STAMBPL1 localize to early endosomes by binding to clathrin (31); however, STAMBPL1 fails to bind to STAM due to residue substitutions in the SBM-like motif, suggesting it may function in different signaling pathway from that of STAMBP (30) ."
| DOI
STAMBP binds STAMBPL1, Clathrin, and CLTC. 1 / 1
| 1
sparser
"We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins."
16716190
CLINT1 affects STAMBPL1
3 |
STAMBPL1 binds CLINT1. 3 / 3
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
biogrid
No evidence text available
19615732
Air Pollutants affects STAMBPL1
3 |
Air Pollutants increases the amount of STAMBPL1.
2 |
Air Pollutants increases the amount of STAMBPL1. 2 / 2
2 |
ctd
No evidence text available
21757418
ctd
No evidence text available
37586242
Air Pollutants decreases the amount of STAMBPL1.
1 |
Air Pollutants decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
37586242
Silicon dioxide increases the amount of STAMBPL1.
1 |
Silicon dioxide increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
25895662
Silicon dioxide decreases the amount of STAMBPL1.
1 |
Silicon dioxide decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
23806026
Paracetamol affects STAMBPL1
2 |
Paracetamol decreases the amount of STAMBPL1. 2 / 2
2 |
ctd
No evidence text available
33387578
ctd
No evidence text available
21420995
Folic acid affects STAMBPL1
2 |
Folic acid increases the amount of STAMBPL1. 2 / 2
2 |
ctd
No evidence text available
20938992
ctd
No evidence text available
25629700
Cisplatin affects STAMBPL1
2 |
Cisplatin increases the amount of STAMBPL1.
1 |
Cisplatin increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
27594783
Cisplatin decreases the amount of STAMBPL1.
1 |
Cisplatin decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
27392435
Benzo[a]pyrene affects STAMBPL1
2 |
Benzo[a]pyrene increases the amount of STAMBPL1. 2 / 2
2 |
ctd
No evidence text available
22228805
ctd
No evidence text available
32234424
Atrazine affects STAMBPL1
2 |
Atrazine decreases the amount of STAMBPL1. 2 / 2
2 |
ctd
No evidence text available
36841081
ctd
No evidence text available
29505797
ZNF106 affects STAMBPL1
2 |
STAMBPL1 binds ZNF106. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
WNK1 affects STAMBPL1
2 |
STAMBPL1 binds WNK1. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
VTI1B affects STAMBPL1
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
UBC affects STAMBPL1
2 |
STAMBPL1 binds UBC. 2 / 2
2 |
biogrid
No evidence text available
18758443
biogrid
No evidence text available
32636467
Tobacco Smoke Pollution decreases the amount of STAMBPL1. 2 / 2
2 |
ctd
No evidence text available
33660061
ctd
No evidence text available
28065790
TRIP13 affects STAMBPL1
1 1 |
TRIP13 binds STAMBPL1. 2 / 2
1 1 |
hprd
No evidence text available
16189514
biogrid
No evidence text available
16189514
TRIM27 affects STAMBPL1
2 |
TRIM27 binds STAMBPL1. 2 / 2
2 |
biogrid
No evidence text available
25416956
biogrid
No evidence text available
32296183
STX8 affects STAMBPL1
2 |
STAMBPL1 binds STX8. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
reach
"Especially STAMBPL1 could modulate the stability of TRAF2 protein and activate WNT/PI3K/NF-kb signalling pathway."
38419066
reach
"Our study reveals for the first time that GRHL3 promotes transcriptional activity by binding to the promoter of the HIF1A gene.In this study, we utilized two TNBC cell lines, HCC1806 and HCC1937, along with human primary umbilical vein endothelial cells (HUVECs) and a nude mouse breast orthotopic transplantation tumor model to investigate the regulatory mechanism by which STAMBPL1 activates the GRHL3/HIF1α/VEGFA signaling pathway through its interaction with FOXO1, thereby promoting angiogenesis in TNBC."
40208233
STAMBPL1 affects pathway
| 2
STAMBPL1 activates pathway. 2 / 2
| 2
sparser
"Mechanistically, STAMBPL1 activated Wnt/β-catenin pathway and increased the expression of downstream cancer-promoting genes."
39150093
sparser
"Mechanistically, STAMBPL1 activates the Wnt/β-catenin pathway, increasing the expression of downstream oncogenes."
40607251
STAMBPL1 affects cell migration
| 2
reach
"Cell migration showed that the number of A549 and H1299 cells in the STAMBPL1 SI group was lower than that in A549 STAMBPL1 NC and H1299 STAMBPL1 NC group, indicating that STAMBPL1 promoted cell migration of LUAD (Fig. 2C, p<0.001, p<0.001)."
37393834
reach
"STAMBPL1 promotes cell migration and invasion in LUAD."
37393834
STAMBPL1 affects ZNF106
2 |
STAMBPL1 binds ZNF106. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
STAMBPL1 affects WNK1
2 |
STAMBPL1 binds WNK1. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
STAMBPL1 affects VTI1B
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
STAMBPL1 affects UBC
2 |
STAMBPL1 binds UBC. 2 / 2
2 |
biogrid
No evidence text available
18758443
biogrid
No evidence text available
32636467
STAMBPL1 affects TRIP13
1 1 |
TRIP13 binds STAMBPL1. 2 / 2
1 1 |
hprd
No evidence text available
16189514
biogrid
No evidence text available
16189514
STAMBPL1 affects TRIM27
2 |
TRIM27 binds STAMBPL1. 2 / 2
2 |
biogrid
No evidence text available
25416956
biogrid
No evidence text available
32296183
STAMBPL1 affects TNFSF10
| 2
STAMBPL1 inhibits TNFSF10. 2 / 2
| 2
reach
"Conversely, STAMBPL1 knockdown enhanced sensitivity to TRAIL (Figure 4H)."
37511599
reach
"Moreover, STAMBPL1 knockdown markedly increased sensitivity to TRAIL by destabilizing c-FLIP."
37511599
STAMBPL1 affects TNBC
| 2
STAMBPL1 activates TNBC. 2 / 2
| 2
reach
"In this study, we discovered that STAMBPL1 promotes angiogenesis in TNBC by activating the HIF1α/VEGFA pathway independently of its enzymatic activity."
40208233
reach
"In summary, STAMBPL1 promoted TNBC angiogenesis by activating the GRHL3/HIF1α/VEGFA pathway via interacting with FOXO1 in a non-enzymatic manner."
40208233
STAMBPL1 affects TGFB
| 2
STAMBPL1 activates TGFB. 2 / 2
| 2
reach
"Finally, AMSH-LP and UCHL5 promote TGF-beta responses through their interaction with inhibitory I-SMADs [XREF_BIBR, XREF_BIBR]."
25972356
reach
"One further link between this pathway and endosomes concerns the parallel findings that the endosomal DUBs AMSH and AMSH-LP positively regulate the related bone morphogenic protein (BMP) and TGFβ sign[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22975321
STAMBPL1 affects STX8
2 |
STAMBPL1 binds STX8. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
STAMBPL1 affects STAM2
| 2
STAMBPL1 binds STAM, STAM2, and GRB2. 1 / 1
| 1
sparser
"Consistent with this, coimmunoprecipitation analyses revealed that AMSH-LP could not bind to STAM1, STAM2, or Grb2, all of which contain an SH3 domain that interacts with AMSH [2,3,11] ."
12810066
STAM2 binds STAM and STAMBPL1. 1 / 1
| 1
sparser
"Another STAM family protein, STAM2, did not bind to AMSH-LP either, although AMSH strongly binds to STAM2 (data not shown)."
12810066
STAMBPL1 affects SMAD2
1 | 1
STAMBPL1 binds SMAD2 and SMAD7. 1 / 1
| 1
sparser
"Previous studies reported that although they did not investigate the DUB activity of STAMBPL1, STAMBPL1 interact with Smad2 and Smad7, followed by induction of TGF-β-mediated transcriptional activity [ xref ]."
31817770
hprd
No evidence text available
14728725
STAMBPL1 affects SIPA1L1
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
STAMBPL1 affects RNF32
2 |
biogrid
No evidence text available
21163940
biogrid
No evidence text available
21163940
STAMBPL1 affects REPS1
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
STAMBPL1 affects PIK3C2A
2 |
STAMBPL1 binds PIK3C2A. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
STAMBPL1 affects PICALM
2 |
STAMBPL1 binds PICALM. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
STAMBPL1 affects NUMB
2 |
STAMBPL1 binds NUMB. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
STAMBPL1 affects NFE2L2
| 1 1
STAMBPL1 binds NFE2L2.
| 1
sparser
"Particularly, sites 251-436 of STAMBPL1 interact with sites 228-605 of NRF2, facilitating DUB activity and eliminating ubiquitin molecules attached to NRF2, thus protecting it from proteasome-mediated degradation."
39706065
STAMBPL1 activates NFE2L2.
| 1
STAMBPL1 activates NFE2L2. 1 / 1
| 1
reach
"This study firstly reveals that STAMBPL1 promotes cholangiocarcinoma progression by upregulating NRF2, indicating that targeting the STAMBPL1/NRF2 axis is a novel therapeutic strategy."
39706065
STAMBPL1 affects MAGEA6
2 |
biogrid
No evidence text available
32296183
biogrid
No evidence text available
25416956
STAMBPL1 affects JAG1
| 2
STAMBPL1 inhibits JAG1.
| 1
STAMBPL1 inhibits JAG1. 1 / 1
| 1
reach
"Furthermore, knockdown of STAMBPL1 by shSTAMBPL1 resulted in STAMBPL1 downregulation, which in turn decreased the cell proliferation of AGS gastric cancer cells, increasing cell apoptosis, cell invasion and migration in vitro."
31611951
STAMBPL1 activates JAG1.
| 1
STAMBPL1 activates JAG1. 1 / 1
| 1
reach
"These results suggested that AGS cell proliferation was suppressed by STAMBPL1 knockdown."
31611951
STAMBPL1 affects HIP1R
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
STAMBPL1 affects GPRIN1
2 |
STAMBPL1 binds GPRIN1. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
STAMBPL1 affects EPS15
2 |
STAMBPL1 binds EPS15. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
STAMBPL1 affects EGFR
| 2
STAMBPL1 activates EGFR. 2 / 2
| 2
reach
"STAMBPL1 augments RNA efficient splicing of EGFR to avoid intron retention by activating cleavage of the K63-linked ubiquitin chain on the target of EGR1 protein 1 (TOE1)."
39388352
reach
"Previous studies suggested that STAMBPL1 enhances the trafficking of EGFR to the cell surface by removing Lys 63-linked polyubiquitin chains [ 5 , 7 , 8 ]."
31004702
STAMBPL1 affects E7
1 1 |
E7 binds STAMBPL1. 2 / 2
1 1 |
biogrid
No evidence text available
22810586
virhostnet
No evidence text available
22810586
STAMBPL1 affects Cell Survival
| 1 1
STAMBPL1 activates Cell Survival. 2 / 2
| 1 1
eidos
"In addition , STAMBPL1 deubiquitinylates the anti-apoptotic protein Survivin and thus ameliorates cell survival ."
35066747
reach
"Knockdown of STAMBPL1 reduced cell viability of CRC and suppressed the proliferation, invasion, and migration."
38008943
reach
"In addition, the results from the colony formation experiment demonstrated that the downregulation of STAMBPL1 suppressed the proliferation of hepatocellular carcinoma cells (Fig. 3H)."
38419066
reach
"STAMBPL1, transcriptionally regulated by SREBP1, promotes malignant behaviors of hepatocellular carcinoma cells via Wnt/β-catenin signaling pathway."
39150093
STAMBPL1 affects CRC
| 2
STAMBPL1 activates CRC. 2 / 2
| 2
reach
"Knockdown of STAMBPL1 reduced cell viability of CRC and suppressed the proliferation, invasion, and migration."
38008943
reach
"Knockdown of STAMBPL1 inhibited cell growth and metastasis of CRC through inactivation of the NF-κB pathway."
38008943
STAMBPL1 affects CLTCL1
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
STAMBPL1 affects CEP72
2 |
biogrid
No evidence text available
25416956
biogrid
No evidence text available
32296183
STAMBPL1 affects CDH1
1 | 1
STAMBPL1 increases the amount of CDH1.
| 1
STAMBPL1 increases the amount of CDH1. 1 / 1
| 1
reach
"These analyses showed that the KO of STAMBPL1 caused a significant restoration in the expression of E-cadherin, both transcriptionally and at protein levels, and a significant vimentin reduction."
32636467
STAMBPL1 binds CDH1.
1 |
CDH1 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
37756605
STAMBPL1 affects BMP2K
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
STAM2 affects STAMBPL1
| 2
STAMBPL1 binds STAM, STAM2, and GRB2. 1 / 1
| 1
sparser
"Consistent with this, coimmunoprecipitation analyses revealed that AMSH-LP could not bind to STAM1, STAM2, or Grb2, all of which contain an SH3 domain that interacts with AMSH [2,3,11] ."
12810066
STAM2 binds STAM and STAMBPL1. 1 / 1
| 1
sparser
"Another STAM family protein, STAM2, did not bind to AMSH-LP either, although AMSH strongly binds to STAM2 (data not shown)."
12810066
SMAD7 affects STAMBPL1
1 | 1
STAMBPL1 binds SMAD2 and SMAD7. 1 / 1
| 1
sparser
"Previous studies reported that although they did not investigate the DUB activity of STAMBPL1, STAMBPL1 interact with Smad2 and Smad7, followed by induction of TGF-β-mediated transcriptional activity [ xref ]."
31817770
STAMBPL1 binds SMAD7. 1 / 1
1 |
hprd
No evidence text available
14728725
SMAD2 affects STAMBPL1
1 | 1
STAMBPL1 binds SMAD2 and SMAD7. 1 / 1
| 1
sparser
"Previous studies reported that although they did not investigate the DUB activity of STAMBPL1, STAMBPL1 interact with Smad2 and Smad7, followed by induction of TGF-β-mediated transcriptional activity [ xref ]."
31817770
hprd
No evidence text available
14728725
SIPA1L1 affects STAMBPL1
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
Reactive Oxygen Species inhibits STAMBPL1. 2 / 2
| 2
reach
"Thus, H. pylori infection causes excessive OS and produces redundant ROS, which in turn downregulates the STAMBPL1 and contributes to the survival of GBC cells."
38774627
reach
"Recent studies have shown that excessive ROS generated in H. pylori infection induces direct degradation of STAMBPL1 by cullin 1-RING ubiquitin ligase and the 26S proteasome, while STAMBPL1 can lead to cell apoptosis by reducing the anti-apoptotic protein survivin (Chaithongyot and Naumann, 2022)."
38774627
RNF32 affects STAMBPL1
2 |
biogrid
No evidence text available
21163940
biogrid
No evidence text available
21163940
REPS1 affects STAMBPL1
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
Particulate Matter increases the amount of STAMBPL1.
1 |
Particulate Matter increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
37586242
Particulate Matter decreases the amount of STAMBPL1.
1 |
Particulate Matter decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
37586242
PIK3C2A affects STAMBPL1
2 |
STAMBPL1 binds PIK3C2A. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
PICALM affects STAMBPL1
2 |
STAMBPL1 binds PICALM. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
Neoplasm Invasiveness decreases the amount of STAMBPL1.
| 1
Neoplasm Invasiveness decreases the amount of STAMBPL1. 1 / 1
| 1
reach
"The transwell assays were used to evaluate the influence on invasion and metastasis abilities of HCC cells by reducing the expression of STAMBPL1."
38419066
Neoplasm Invasiveness activates STAMBPL1. 1 / 1
| 1
reach
"The transwell assays and cell scratch assay both validated the influence of STAMBPL1 on migration and invasion ability of HCCLM3 and Hep3B cells, The migration and invasion ability of HCCLM3 and Hep3B cells was enhanced in the STAMBPL1-overexpressed group (Fig. 4I–J)."
38419066
NUMB affects STAMBPL1
2 |
STAMBPL1 binds NUMB. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
NPRL2 affects STAMBPL1
| 2
NPRL2 inhibits STAMBPL1. 2 / 2
| 2
reach
"Knockout of GATOR1 component DEPDC5 or NPRL2 in WT or STAMBPL1-null LS174T cells ( Figures S8 K and S8L) restored anchorage-independent cell growth and xenograft tumor growth in STAMBPL1-deficient cel[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35114100
reach
"Knockout of GATOR1 component DEPDC5 or NPRL2 restored mTORC1 activity and promoted anchorage-independent cell growth in STAMBPL1(K405Rfs ∗ 21) mutation-corrected LS174T cells ( Figures 6 G and S9 E–S9[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35114100
NFkappaB affects STAMBPL1
| 2
NFkappaB inhibits STAMBPL1.
| 1
NFkappaB inhibits STAMBPL1. 1 / 1
| 1
reach
"Overexpression of wild-type STAMBPL1, but not a catalytically inactive mutant, enhanced Tax mediated NF-kappaB activation, whereas silencing of STAMBPL1 with siRNA impaired Tax activation of both the canonical and noncanonical NF-kappaB signaling pathways."
22258247
NFkappaB activates STAMBPL1.
| 1
NFkappaB activates STAMBPL1. 1 / 1
| 1
reach
"Overexpression of wild-type STAMBPL1, but not a catalytically inactive mutant, enhanced Tax mediated NF-kappaB activation, whereas silencing of STAMBPL1 with siRNA impaired Tax activation of both the canonical and noncanonical NF-kappaB signaling pathways."
22258247
MAGEA6 affects STAMBPL1
2 |
biogrid
No evidence text available
32296183
biogrid
No evidence text available
25416956
HIP1R affects STAMBPL1
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
GPRIN1 affects STAMBPL1
2 |
STAMBPL1 binds GPRIN1. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
EPS15 affects STAMBPL1
2 |
STAMBPL1 binds EPS15. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
E7 affects STAMBPL1
1 1 |
E7 binds STAMBPL1. 2 / 2
1 1 |
biogrid
No evidence text available
22810586
virhostnet
No evidence text available
22810586
DEPDC5 affects STAMBPL1
| 2
DEPDC5 inhibits STAMBPL1. 2 / 2
| 2
reach
"Knockout of GATOR1 component DEPDC5 or NPRL2 in WT or STAMBPL1-null LS174T cells ( Figures S8 K and S8L) restored anchorage-independent cell growth and xenograft tumor growth in STAMBPL1-deficient cel[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35114100
reach
"Knockout of GATOR1 component DEPDC5 or NPRL2 restored mTORC1 activity and promoted anchorage-independent cell growth in STAMBPL1(K405Rfs ∗ 21) mutation-corrected LS174T cells ( Figures 6 G and S9 E–S9[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35114100
CLTCL1 affects STAMBPL1
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
CFLAR affects BIRC5
| 2
STAMBPL1 binds BIRC5 and CFLAR. 2 / 2
| 2
sparser
"Thus, these data reveal that STAMBPL1 directly interacts with survivin and c-FLIP, resulting in stabilization of proteins."
31817770
sparser
"STAMBPL1 interacted with survivin and c-FLIP, resulted in reduction of ubiquitination."
31817770
CEP72 affects STAMBPL1
2 |
biogrid
No evidence text available
25416956
biogrid
No evidence text available
32296183
BMP2K affects STAMBPL1
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
BIRC5 affects CFLAR, and STAMBPL1
| 2
STAMBPL1 binds BIRC5 and CFLAR. 2 / 2
| 2
sparser
"Thus, these data reveal that STAMBPL1 directly interacts with survivin and c-FLIP, resulting in stabilization of proteins."
31817770
sparser
"STAMBPL1 interacted with survivin and c-FLIP, resulted in reduction of ubiquitination."
31817770
2,3,7,8-tetrachlorodibenzodioxine increases the amount of STAMBPL1.
1 |
ctd
No evidence text available
33387578
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of STAMBPL1.
1 |
ctd
No evidence text available
32109520
17beta-estradiol increases the amount of STAMBPL1.
1 |
17beta-estradiol increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
31614463
17beta-estradiol decreases the amount of STAMBPL1.
1 |
17beta-estradiol decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
20660070
(+)-JQ1 compound decreases the amount of STAMBPL1. 2 / 2
2 |
ctd
No evidence text available
25307878
ctd
No evidence text available
27432991
Urethane affects STAMBPL1
1 |
Urethane decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
28818685
Tunicamycin affects STAMBPL1
1 |
Tunicamycin increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
22378314
Triadimefon affects STAMBPL1
1 |
Triadimefon increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
28263823
Trametinib affects STAMBPL1
1 |
Trametinib decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
36139627
Topotecan affects STAMBPL1
1 |
Topotecan decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
25729387
Titanium dioxide demethylates STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
35295148
Thioacetamide affects STAMBPL1
1 |
Thioacetamide increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
34492290
Thapsigargin affects STAMBPL1
1 |
Thapsigargin increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
22378314
Sulforaphane affects STAMBPL1
1 |
Sulforaphane increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
31838189
Sst2 affects STAMBPL1
| 1
STAMBPL1 binds sst2. 1 / 1
| 1
reach
"In contrast, AMSH-LP and its yeast homologue Sst2 bind K63 diUb with K M ~ 50 muM, and k cat ~ 1 s -1, substantially below the catalytic proficiency associated with cleavage of some small peptides by thermolysin."
28587922
Sotorasib affects STAMBPL1
1 |
Sotorasib decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
36139627
Sorafenib affects STAMBPL1
| 1
STAMBPL1 binds sorafenib. 1 / 1
| 1
reach
"The binding energies for each interaction were recorded, and statistical analyses were performed to draw meaningful conclusions regarding the potential binding of STAMBPL1 with sorafenib, regorafenib, lenvatinib, and cabozantinib."
38419066
Sodium arsenite decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
38568856
ShSTAMBPL1 affects STAMBPL1
| 1
ShSTAMBPL1 inhibits STAMBPL1. 1 / 1
| 1
reach
"Furthermore, knockdown of STAMBPL1 by shSTAMBPL1 resulted in STAMBPL1 downregulation, which in turn decreased the cell proliferation of AGS gastric cancer cells, increasing cell apoptosis, cell invasion and migration in vitro."
31611951
ShSTAMBPL1#2 affects STAMBPL1
| 1
ShSTAMBPL1#2 decreases the amount of STAMBPL1. 1 / 1
| 1
reach
"The collective findings demonstrate that shSTAMBPL1#1 and shSTAMBPL1#2 inhibited the expression of STAMBPL1 effectively (Fig. 3C–F)."
38419066
ShSTAMBPL1#1 affects STAMBPL1
| 1
ShSTAMBPL1#1 decreases the amount of STAMBPL1. 1 / 1
| 1
reach
"The collective findings demonstrate that shSTAMBPL1#1 and shSTAMBPL1#2 inhibited the expression of STAMBPL1 effectively (Fig. 3C–F)."
38419066
Rpn11 affects Ubiquitin
| 1
Rpn11 binds STAMBPL1 and Ubiquitin. 1 / 1
| 1
sparser
"Rpn11 and AMSH-LP bind ubiquitin in a similar orientation, but their interaction with the Ile44 hydrophobic patch is quite different."
33498168
Rotenone affects STAMBPL1
1 |
Rotenone increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
39786591
Resveratrol affects STAMBPL1
1 |
Resveratrol increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
25505154
Propiconazole affects STAMBPL1
1 |
Propiconazole increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
28970091
Progesterone affects STAMBPL1
1 |
Progesterone decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
20660070
Potassium chromate decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
22079256
Polyubiquitin affects STAMBPL1
| 1
STAMBPL1 binds polyubiquitin. 1 / 1
| 1
sparser
"Thus, the structure of the AMSH-LP domain bound to K63-linked polyubiquitin reveals one mode by which DUBs discriminate between polyubiquitin isoforms."
19243136
Phorbol 13-acetate 12-myristate increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
25613284
Permethrin affects STAMBPL1
1 |
Permethrin demethylates STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
33148267
Perfluorooctane-1-sulfonic acid increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
36331819
Patch affects Ubiquitin
| 1
STAMBPL1 binds patch and Ubiquitin. 1 / 1
| 1
sparser
"AMSH-LP binds the distal ubiquitin via its Leu8/Ile44/Val70 hydrophobic patch conserved in NEDD8."
21288713
Oxaliplatin affects STAMBPL1
1 |
Oxaliplatin decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
25729387
Okadaic acid affects STAMBPL1
1 |
Okadaic acid increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
38832940
Nickel sulfate affects STAMBPL1
1 |
Nickel sulfate decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
22714537
Nickel atom affects STAMBPL1
1 |
Nickel atom increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
25583101
Methyl methanesulfonate decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
23649840
Methamphetamine decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
29802913
Melphalan affects STAMBPL1
1 |
Melphalan decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
22363485
Lead diacetate affects STAMBPL1
1 |
Lead diacetate decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
21829687
Jinfukang affects STAMBPL1
1 |
Jinfukang decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
27392435
Ivermectin affects STAMBPL1
1 |
Ivermectin decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
32959892
Ionomycin affects STAMBPL1
1 |
Ionomycin increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
25613284
Hsa-mir-23c affects STAMBPL1
1 |
Hsa-mir-23c decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-941 affects STAMBPL1
1 |
Hsa-miR-941 decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-885-5p affects STAMBPL1
1 |
Hsa-miR-885-5p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-766-3p affects STAMBPL1
1 |
Hsa-miR-766-3p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-6868-3p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-6849-3p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-6837-3p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-6754-3p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-6720-5p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-6512-3p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-5197-5p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-508-5p affects STAMBPL1
1 |
Hsa-miR-508-5p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-4778-3p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-4633-5p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-412-3p affects STAMBPL1
1 |
Hsa-miR-412-3p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-23b-3p affects STAMBPL1
1 |
Hsa-miR-23b-3p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-23a-3p affects STAMBPL1
1 |
Hsa-miR-23a-3p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-215-5p affects STAMBPL1
1 |
Hsa-miR-215-5p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19074876
Hsa-miR-192-5p affects STAMBPL1
1 |
Hsa-miR-192-5p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19074876
Hsa-miR-130a-5p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-1237-3p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-103a-3p decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hexabromocyclododecane decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
29177809
Formaldehyde affects STAMBPL1
1 |
Formaldehyde decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
23649840
Flutamide affects STAMBPL1
1 |
Flutamide increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
24136188
Flusilazole affects STAMBPL1
1 |
Flusilazole increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
28263823
Fluoranthene affects STAMBPL1
1 |
Fluoranthene increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
28329830
Fenarimol affects STAMBPL1
1 |
Fenarimol increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
28970091
Ethyl methanesulfonate decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
23649840
Ethanol affects STAMBPL1
1 |
Ethanol increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
19167417
Entinostat affects STAMBPL1
1 |
Entinostat decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
27188386
Endosulfan affects STAMBPL1
1 |
Endosulfan increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
26615145
Ectopic following affects STAMBPL1
| 1
Ectopic following activates STAMBPL1. 1 / 1
| 1
eidos
"A 137 number of novel host factors have been confirmed to facilitate SARS-CoV-2 pseudovirus entry ,138 151HEK293T cells , besides ACE2 and CTSL , the ectopic expression of any of the following genes could 152 effectively enable SARS-CoV-2 infection , CLEC4G , CPLX1 , LDLRAD3 , TMEM30A , and STAMBPL1 153 ( Fig. 3B ) ."
| DOI
Doxorubicin affects STAMBPL1
1 |
Doxorubicin decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
29803840
Dorsomorphin affects STAMBPL1
1 |
Dorsomorphin decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
27188386
DiUb affects STAMBPL1
| 1
DiUb binds STAMBPL1. 1 / 1
| 1
reach
"(E) A comparison of the diUb/STAMBPL1 complex structure (left) and UbV/STAMBPL1 structure overlaid with diUb (right)."
| DOI
Deoxynivalenol affects STAMBPL1
1 |
Deoxynivalenol decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
35307453
Deltamethrin affects STAMBPL1
1 |
Deltamethrin increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
37019170
Cyanoginosin LR decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
34863901
Choline affects STAMBPL1
1 |
Choline increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
20938992
Cepharanthine affects STAMBPL1
| 1
eidos
"However , although cepharanthine reduces STAMBPL1 expression and overexpression of STAMBPL1 inhibits cepharanthine-mediated downregulation of survivin , interaction between STAMBPL1 and survivin was not investigated ."
31817770
Camptothecin affects STAMBPL1
1 |
Camptothecin methylates STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
30720231
Calcitriol affects STAMBPL1
1 |
Calcitriol increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
16002434
Butanal affects STAMBPL1
1 |
Butanal increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
26079696
Bis(2-ethylhexyl) phthalate decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
31163220
Beta-D-glucose affects STAMBPL1
1 |
Beta-D-glucose increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
36331819
Benzo[a]pyrene diol epoxide I decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
19150397
All-trans-retinoic acid increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
21934132
Acetamide affects STAMBPL1
1 |
Acetamide increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
31881176
Abrine affects STAMBPL1
1 |
Abrine increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
31054353
ZRANB1 affects STAMBPL1
1 |
biogrid
No evidence text available
32296183
ZNF835 affects STAMBPL1
1 |
biogrid
No evidence text available
32296183
YPEL3 affects STAMBPL1
| 1
STAMBPL1 binds CEP55, YPEL3, and IGFBP1. 1 / 1
| 1
sparser
"These data suggest that STAMBPL1, CEP55, YPEL3 and IGFBP1 may be associated with the prognosis of patients with PAAD."
32565937
Vincristine affects STAMBPL1
1 |
Vincristine decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
23649840
Ubiquitin affects rpn11
| 1
Rpn11 binds STAMBPL1 and Ubiquitin. 1 / 1
| 1
sparser
"Rpn11 and AMSH-LP bind ubiquitin in a similar orientation, but their interaction with the Ile44 hydrophobic patch is quite different."
33498168
Ubiquitin affects patch
| 1
STAMBPL1 binds patch and Ubiquitin. 1 / 1
| 1
sparser
"AMSH-LP binds the distal ubiquitin via its Leu8/Ile44/Val70 hydrophobic patch conserved in NEDD8."
21288713
Ubiquitin affects BRCC36
| 1
BRCC36 binds STAMBPL1, Ubiquitin, and K63. 1 / 1
| 1
sparser
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly."
28587922
UbV affects STAMBPL1
| 1
STAMBPL1 binds UbV. 1 / 1
| 1
reach
"A strong hydrogen bond network is then formed between the Arg72 guanidinium and the backbone carbonyl group of Glu326 in ins-1 and between the amide group of Gln49 of UbV with the backbone carbonyl and amide of Val328 and Glu326, thus stabilizing the interaction between the STAMBPL1 and UbV (Fig. 2G)."
34425109
UbV SP.1 affects STAMBPL1
| 1
UbV SP.1 inhibits STAMBPL1. 1 / 1
| 1
reach
"In addition, UbV SP.1 appeared to inhibit STAMBPL1 to some extent, whereas UbV SP.3 showed no inhibitory effect with STAMBPL1 (Fig. S2A) ."
| DOI
USP49 affects STAMBPL1
1 |
STAMBPL1 binds USP49. 1 / 1
1 |
biogrid
No evidence text available
19615732
ULK1 affects STAMBPL1
1 |
STAMBPL1 binds ULK1. 1 / 1
1 |
biogrid
No evidence text available
32453962
UBE2N affects STAMBPL1
1 |
biogrid
No evidence text available
19615732
UBD affects Phe403
| 1
STAMBPL1 binds UBD and Phe403. 1 / 1
| 1
reach
"X-ray crystal structures of the DUB domains of both AMSH-LP and Sst2 bound to diubiquitin shows Phe403 collapsed onto the Lys63 side chain of the proximal ubiquitin; however, the flap residues appear to retain their mobility even in presence of bound substrate or product (indicated by relatively weak electron density enveloping these residues and higher B-factors than internal residues)."
26368668
TRIM67 affects STAMBPL1
1 |
biogrid
No evidence text available
36215168
TRIM21 affects STAMBPL1
| 1
STAMBPL1 binds TRIM21. 1 / 1
| 1
sparser
"However, the interaction of STAMBPL1 and TRIM21 was not detected in KIRC cell lines (786‐O, 769‐P and Caki‐1) (Figure xref , Supporting Information)."
39527690
TCF4 affects STAMBPL1
1 |
TCF4 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
25416956
TBMS-1- affects STAMBPL1
| 1
TBMS-1- decreases the amount of STAMBPL1. 1 / 1
| 1
reach
"Moreover, TBMS-1- or CHX-only treatments downregulated STAMBPL1 protein expression levels from 9 h (Figure 4E,F)."
37511599
STAMBPL1 affects survivin c-FLIP protein
| 1
STAMBPL1 activates survivin c-FLIP protein. 1 / 1
| 1
eidos
"Knockdown of STAMBPL1 reduced survivin and c-FLIP protein levels , while overexpression of STAMBPL1 inhibited honokinol-induced survivin and c-FLIP degradation ."
31817770
STAMBPL1 affects sst2
| 1
STAMBPL1 binds sst2. 1 / 1
| 1
reach
"In contrast, AMSH-LP and its yeast homologue Sst2 bind K63 diUb with K M ~ 50 muM, and k cat ~ 1 s -1, substantially below the catalytic proficiency associated with cleavage of some small peptides by thermolysin."
28587922
STAMBPL1 affects sorafenib
| 1
STAMBPL1 binds sorafenib. 1 / 1
| 1
reach
"The binding energies for each interaction were recorded, and statistical analyses were performed to draw meaningful conclusions regarding the potential binding of STAMBPL1 with sorafenib, regorafenib, lenvatinib, and cabozantinib."
38419066
STAMBPL1 affects sensitization
| 1
STAMBPL1 activates sensitization. 1 / 1
| 1
reach
"Collectively, our findings suggested that STAMBPL1 contributes to c-FLIP degradation and TRAIL sensitization by TBMS-1."
37511599
STAMBPL1 affects rpn11
| 1
Rpn11 binds STAMBPL1 and Ubiquitin. 1 / 1
| 1
sparser
"Rpn11 and AMSH-LP bind ubiquitin in a similar orientation, but their interaction with the Ile44 hydrophobic patch is quite different."
33498168
STAMBPL1 activates regulation of cellular amino acid metabolic process. 1 / 1
| 1
reach
"Multi-omics studies demonstrate that Gamabufotalin exerts anti-HCC effects through STAMBPL1-mediated regulation of amino acid metabolism (Zheng, et al., 2024)."
40303979
STAMBPL1 affects polyubiquitin
| 1
STAMBPL1 binds polyubiquitin. 1 / 1
| 1
sparser
"Thus, the structure of the AMSH-LP domain bound to K63-linked polyubiquitin reveals one mode by which DUBs discriminate between polyubiquitin isoforms."
19243136
STAMBPL1 affects peptide
| 1
STAMBPL1 bound to SESN2 inhibits peptide. 1 / 1
| 1
reach
"Inhibiting the interaction between STAMBPL1 and Sestrin2 thereby inactivating mTORC1 using a cell-permeable peptide could be a potential treatment approach for gastric and colorectal cancers [141]."
39482684
STAMBPL1 affects patch
| 1
STAMBPL1 binds patch and Ubiquitin. 1 / 1
| 1
sparser
"AMSH-LP binds the distal ubiquitin via its Leu8/Ile44/Val70 hydrophobic patch conserved in NEDD8."
21288713
STAMBPL1 affects messenger RNA
| 1
STAMBPL1 increases the amount of messenger RNA. 1 / 1
| 1
reach
"qPCR results revealed, beyond the knockdown efficiency, that depletion of STAMBPL1 causes an elevation of CDH1 and a reduction of VIM messenger RNA (mRNA) levels (Fig. 2b)."
32636467
STAMBPL1 affects ferroptosis
| 1
reach
"Functionally, STAMBPL1 notably enhances CCA cell proliferation and metastasis while impeding ferroptosis."
39706065
reach
"STAMBPL1 expression contributes to EMT."
32636467
STAMBPL1 affects diUb
| 1
DiUb binds STAMBPL1. 1 / 1
| 1
reach
"(E) A comparison of the diUb/STAMBPL1 complex structure (left) and UbV/STAMBPL1 structure overlaid with diUb (right)."
| DOI
STAMBPL1 affects cisplatin
| 1
STAMBPL1 activates cisplatin. 1 / 1
| 1
reach
"Our previous research demonstrated that STAMBPL1 enhances cisplatin resistance in TNBC cells through the stabilization of MKP-1 (Liu et al., 2022)."
40208233
STAMBPL1 affects cepharanthine-mediated survivin
| 1
STAMBPL1 activates cepharanthine-mediated survivin. 1 / 1
| 1
eidos
"However , although cepharanthine reduces STAMBPL1 expression and overexpression of STAMBPL1 inhibits cepharanthine-mediated downregulation of survivin , interaction between STAMBPL1 and survivin was not investigated ."
31817770
STAMBPL1 affects breast cancer cell resistance cisplatin
| 1
STAMBPL1 activates breast cancer cell resistance cisplatin. 1 / 1
| 1
eidos
"STAMBPL1 promotes breast cancer cell resistance to cisplatin partially by stabilizing MKP-1 expression ."
35236965
STAMBPL1 affects autophagy
| 1
STAMBPL1 inhibits autophagy. 1 / 1
| 1
reach
"We also showed that knockout of STAMBPL1 in HEK293T cells activated the catabolic autophagy pathway ( Figures S7 A and S7B), reduced the cell size ( Figure S7 C), and suppressed anchorage-independent [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35114100
STAMBPL1 affects ZRANB1
1 |
biogrid
No evidence text available
32296183
STAMBPL1 affects ZNF835
1 |
biogrid
No evidence text available
32296183
STAMBPL1 affects YPEL3
| 1
STAMBPL1 binds CEP55, YPEL3, and IGFBP1. 1 / 1
| 1
sparser
"These data suggest that STAMBPL1, CEP55, YPEL3 and IGFBP1 may be associated with the prognosis of patients with PAAD."
32565937
STAMBPL1 affects Wnt/β-catenin
| 1
STAMBPL1 activates Wnt/β-catenin. 1 / 1
| 1
reach
"Mechanistically, STAMBPL1 activated Wnt/β-catenin pathway and increased the expression of downstream cancer-promoting genes."
39150093
STAMBPL1 affects WNT/PI3K/NF-kb
| 1
STAMBPL1 activates WNT/PI3K/NF-kb. 1 / 1
| 1
reach
"Especially STAMBPL1 could modulate the stability of TRAF2 protein and activate WNT/PI3K/NF-kb signalling pathway."
38419066
STAMBPL1 affects VIM
| 1
STAMBPL1 increases the amount of VIM. 1 / 1
| 1
reach
"qPCR results revealed, beyond the knockdown efficiency, that depletion of STAMBPL1 causes an elevation of CDH1 and a reduction of VIM messenger RNA (mRNA) levels (Fig. 2b)."
32636467
STAMBPL1 affects Ubiquitin, and rpn11
| 1
Rpn11 binds STAMBPL1 and Ubiquitin. 1 / 1
| 1
sparser
"Rpn11 and AMSH-LP bind ubiquitin in a similar orientation, but their interaction with the Ile44 hydrophobic patch is quite different."
33498168
STAMBPL1 affects Ubiquitin, and patch
| 1
STAMBPL1 binds patch and Ubiquitin. 1 / 1
| 1
sparser
"AMSH-LP binds the distal ubiquitin via its Leu8/Ile44/Val70 hydrophobic patch conserved in NEDD8."
21288713
STAMBPL1 affects UbV
| 1
STAMBPL1 binds UbV. 1 / 1
| 1
reach
"A strong hydrogen bond network is then formed between the Arg72 guanidinium and the backbone carbonyl group of Glu326 in ins-1 and between the amide group of Gln49 of UbV with the backbone carbonyl and amide of Val328 and Glu326, thus stabilizing the interaction between the STAMBPL1 and UbV (Fig. 2G)."
34425109
STAMBPL1 affects USP49
1 |
STAMBPL1 binds USP49. 1 / 1
1 |
biogrid
No evidence text available
19615732
STAMBPL1 affects ULK1
1 |
STAMBPL1 binds ULK1. 1 / 1
1 |
biogrid
No evidence text available
32453962
STAMBPL1 affects UBE2N
1 |
biogrid
No evidence text available
19615732
STAMBPL1 affects TRIM67
1 |
biogrid
No evidence text available
36215168
STAMBPL1 affects TRIM21
| 1
STAMBPL1 binds TRIM21. 1 / 1
| 1
sparser
"However, the interaction of STAMBPL1 and TRIM21 was not detected in KIRC cell lines (786‐O, 769‐P and Caki‐1) (Figure xref , Supporting Information)."
39527690
STAMBPL1 affects TP53
| 1
STAMBPL1 activates mutated TP53. 1 / 1
| 1
reach
"Concomitantly, we observed that STAMBPL1 expression was elevated in cells with mutant p53-elicited EMT (Fig. 6c)."
32636467
STAMBPL1 affects TCF4
1 |
TCF4 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
25416956
STAMBPL1 affects Sestrin2-GATOR2
| 1
STAMBPL1 leads to the ubiquitination of Sestrin2-GATOR2. 1 / 1
| 1
reach
"Interestingly, Wang et al. reported that gastric cancer and colorectal cancer downregulate an E3 ubiquitin ligase RING finger protein 167 (RNF167) and upregulate a deubiquitinase STAMBPL1 that can prevent the ubiquitination of Sestrin2, decrease Sestrin2-GATOR2 interaction and increase mTORC1 signaling [119]."
35527284
STAMBPL1 affects SYT1
| 1
STAMBPL1 activates SYT1. 1 / 1
| 1
reach
"The ICC/IF experiment showed the expression of STAMBPL1 could mediate the P65 protein to transfer to the nucleus (Fig. 5I, J)."
38419066
STAMBPL1 affects STAMBPL1
| 1
STAMBPL1 increases the amount of STAMBPL1. 1 / 1
| 1
reach
"We further constructed stable STAMBPL1 over-expressed cells (including HCCLM3 and Hep3B), and the efficiency of overexpression STAMBPL1 were examined by qRT-PCR and WB, the results showed that overexpression STAMBPL1 can upregulate the STAMBPL1 expression in HCCLM3 cells and Hep3B cells (Fig. 4A–D)."
38419066
STAMBPL1 affects SP1
| 1
E2F2 binds E2F6, MAFF, SP1, and STAMBPL1. 1 / 1
| 1
sparser
"While our study highlights and connect three key signalling pathways: mutant p53, EMT and DUBs, showing that STAMBPL1 is transcriptionally elevated in mutant p53-expressing cells, STAMBPL1 seems not to be under a direct regulation by p53 R175H . However, out of the known TFs that help recruit mutant p53 to the chromatin to upregulate genes, xref we found that E2F2, E2F6, MAFF and SP1 can bind to the core promoter region of STAMBPL1 by their motif search using Eukaryotic promoter database."
32636467
STAMBPL1 affects SNRPA1
1 |
biogrid
No evidence text available
19615732
STAMBPL1 affects SMAP2
1 |
biogrid
No evidence text available
28514442
STAMBPL1 affects SF3B5
1 |
biogrid
No evidence text available
32296183
STAMBPL1 affects SEC16A
1 |
biogrid
No evidence text available
33961781
STAMBPL1 affects S7B
| 1
STAMBPL1 inhibits S7B. 1 / 1
| 1
reach
"We also showed that knockout of STAMBPL1 in HEK293T cells activated the catabolic autophagy pathway ( Figures S7 A and S7B), reduced the cell size ( Figure S7 C), and suppressed anchorage-independent [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35114100
STAMBPL1 affects RPN11
| 1
STAMBPL1 inhibits RPN11. 1 / 1
| 1
reach
"In fact, whereas the Ins-2 loop of AMSH-LP contacts the proximal ubiquitin, restricting linkage specificity [44], in Rpn11, it anchors the enzyme to the proteasome [45,66]."
28988953
STAMBPL1 affects RNF167
| 1
reach
"The binding of RNF167 and STAMBPL1 to Sestrin2 is not mutually exclusive, as the interaction of one protein with Sestrin2 was not affected by deficiency or overexpression of the other protein ( Figure[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35114100
STAMBPL1 affects REL
1 |
STAMBPL1 binds REL. 1 / 1
1 |
biogrid
No evidence text available
32296183
STAMBPL1 affects RBM47
1 |
biogrid
No evidence text available
33961781
STAMBPL1 affects RAB2B
1 |
biogrid
No evidence text available
32296183
STAMBPL1 affects Phe403
| 1
STAMBPL1 binds UBD and Phe403. 1 / 1
| 1
reach
"X-ray crystal structures of the DUB domains of both AMSH-LP and Sst2 bound to diubiquitin shows Phe403 collapsed onto the Lys63 side chain of the proximal ubiquitin; however, the flap residues appear to retain their mobility even in presence of bound substrate or product (indicated by relatively weak electron density enveloping these residues and higher B-factors than internal residues)."
26368668
STAMBPL1 affects PSEN1
1 |
biogrid
No evidence text available
21163940
STAMBPL1 affects PNMA1
1 |
biogrid
No evidence text available
25416956
STAMBPL1 affects PLEKHF2
1 |
STAMBPL1 binds PLEKHF2. 1 / 1
1 |
biogrid
No evidence text available
32296183
STAMBPL1 affects OTUB1
1 |
biogrid
No evidence text available
19615732
STAMBPL1 affects NSCLC
| 1
STAMBPL1 activates NSCLC. 1 / 1
| 1
reach
"The results suggested that STAMBPL1 promoting NSCLC progression in A549 and H1299 LUAD cell lines is partly achieved by inhibiting the expression of DHRS2 (Fig. 5B-E)."
37393834
STAMBPL1 affects MYC
| 1
STAMBPL1 decreases the amount of MYC. 1 / 1
| 1
reach
"It is of great interest that the C-terminal-half-deleted mutants of AMSH and AMSH-LP, which lack the JAMM motifs, are unable to induce the IL-2-mediated c- myc expression."
12810066
STAMBPL1 affects MORN5
1 |
biogrid
No evidence text available
32296183
STAMBPL1 affects MAST1
1 |
MAST1 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
21163940
STAMBPL1 affects MAFF
| 1
E2F2 binds E2F6, MAFF, SP1, and STAMBPL1. 1 / 1
| 1
sparser
"While our study highlights and connect three key signalling pathways: mutant p53, EMT and DUBs, showing that STAMBPL1 is transcriptionally elevated in mutant p53-expressing cells, STAMBPL1 seems not to be under a direct regulation by p53 R175H . However, out of the known TFs that help recruit mutant p53 to the chromatin to upregulate genes, xref we found that E2F2, E2F6, MAFF and SP1 can bind to the core promoter region of STAMBPL1 by their motif search using Eukaryotic promoter database."
32636467
STAMBPL1 affects Lys63-Ub 2
| 1
STAMBPL1 binds Lys63-Ub 2. 1 / 1
| 1
reach
"The 10 best structures of the best cluster in terms of Haddock score were retained.The proposed structure of the STAM2/AMSH/Lys63-Ub 3 ternary complex has been obtained by assembling the SH3/AMSH stru[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
STAMBPL1 affects Liu et al., 2022
| 1
STAMBPL1 activates Liu et al., 2022. 1 / 1
| 1
reach
"Our previous research revealed that STAMBPL1, a deubiquitinase, promotes cisplatin resistance in TNBC by stabilizing MKP1 (Liu et al., 2022)."
40208233
STAMBPL1 affects LUAD
| 1
STAMBPL1 activates LUAD. 1 / 1
| 1
reach
"Cell migration showed that the number of A549 and H1299 cells in the STAMBPL1 SI group was lower than that in A549 STAMBPL1 NC and H1299 STAMBPL1 NC group, indicating that STAMBPL1 promoted cell migration of LUAD (Fig. 2C, p<0.001, p<0.001)."
37393834
STAMBPL1 affects LCOR
1 |
LCOR binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
35914814
STAMBPL1 affects LAX1
1 |
LAX1 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
25416956
STAMBPL1 affects INCA1
1 |
biogrid
No evidence text available
25416956
STAMBPL1 affects IKZF3
1 |
IKZF3 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
25416956
STAMBPL1 affects IGFBP1
| 1
STAMBPL1 binds CEP55, YPEL3, and IGFBP1. 1 / 1
| 1
sparser
"These data suggest that STAMBPL1, CEP55, YPEL3 and IGFBP1 may be associated with the prognosis of patients with PAAD."
32565937
STAMBPL1 affects Hypoxia
| 1
STAMBPL1 activates Hypoxia. 1 / 1
| 1
reach
"In this study, we discovered that STAMBPL1 could upregulate the expression of the hypoxia-inducible factor HIF1alpha in breast cancer cells."
40208233
STAMBPL1 affects HMX3
1 |
STAMBPL1 binds HMX3. 1 / 1
1 |
biogrid
No evidence text available
19615732
STAMBPL1 affects GRB2
| 1
STAMBPL1 binds STAM, STAM2, and GRB2. 1 / 1
| 1
sparser
"Consistent with this, coimmunoprecipitation analyses revealed that AMSH-LP could not bind to STAM1, STAM2, or Grb2, all of which contain an SH3 domain that interacts with AMSH [2,3,11] ."
12810066
STAMBPL1 affects GOLGA6L9
1 |
biogrid
No evidence text available
32296183
STAMBPL1 affects GOLGA2
1 |
biogrid
No evidence text available
25416956
STAMBPL1 affects GNPTAB
1 |
biogrid
No evidence text available
25416956
STAMBPL1 affects GCSAML
1 |
biogrid
No evidence text available
32296183
STAMBPL1 affects Flag
| 1
STAMBPL1 binds Flag. 1 / 1
| 1
sparser
"The Flag-STAMBPL1 plasmid were well constructed and transferred to HCCLM3 and Hep3B cell, including (Control, Flag-STAMBPL1-2ug, Flag-STAMBPL1-3ug, Flag-STAMBPL1-4ug), The findings indicated that elevated STAMBPL1 levels led to a decrease in the ubiquitination levels of TRAF2 in both HCCLM3 and Hep3B cells (Fig.  xref A, B)."
38419066
STAMBPL1 affects FBXL6
1 |
biogrid
No evidence text available
37267103
STAMBPL1 affects FBN2
| 1
STAMBPL1 activates FBN2. 1 / 1
| 1
reach
"Functionally, STAMBPL1 notably enhances CCA cell proliferation and metastasis while impeding ferroptosis."
39706065
STAMBPL1 affects ENOX2
1 |
STAMBPL1 binds ENOX2. 1 / 1
1 |
biogrid
No evidence text available
32296183
STAMBPL1 affects ECSIT
1 |
ECSIT binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
21163940
STAMBPL1 affects E2F6
| 1
E2F2 binds E2F6, MAFF, SP1, and STAMBPL1. 1 / 1
| 1
sparser
"While our study highlights and connect three key signalling pathways: mutant p53, EMT and DUBs, showing that STAMBPL1 is transcriptionally elevated in mutant p53-expressing cells, STAMBPL1 seems not to be under a direct regulation by p53 R175H . However, out of the known TFs that help recruit mutant p53 to the chromatin to upregulate genes, xref we found that E2F2, E2F6, MAFF and SP1 can bind to the core promoter region of STAMBPL1 by their motif search using Eukaryotic promoter database."
32636467
STAMBPL1 affects Deubiquitinase
| 1
STAMBPL1 deubiquitinates Deubiquitinase on K63. 1 / 1
| 1
reach
"Structure of the Zn-dependent AMSH-LP deubiquitinating enzyme (DUB) in complex with Lys63-linked diubiquitins provided the first evidence for recognition of an isopeptide bond-linked ubiquitin chain [[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22569095
STAMBPL1 affects Death
| 1
STAMBPL1 inhibits Death. 1 / 1
| 1
reach
"Chen et al. reported that the silencing of STAMBPL1 using shRNA triggers caspase-dependent death via XIAP degradation in prostate cancer cells [35]."
37511599
STAMBPL1 affects DUB domain
| 1
STAMBPL1 binds K63-Ub 2 and DUB domain. 1 / 1
| 1
reach
"The overall three-dimensional fold of Sst2 Delta220 -K63-Ub 2 is highly similar to the structure of the DUB domain of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) with an rmsd of 1.19 A of Calpha atoms over 266 residues from both Sst2 and K63-Ub 2."
24787148
STAMBPL1 inhibits DNA-templated transcription. 1 / 1
| 1
reach
"As a result, viral transcription and replication are greatly suppressed by either LEF1 or STAMBPL1, resulting in selective viral replication in LEF1 and STAMPBPL1 low expressing cells."
27901484
STAMBPL1 affects DMD
| 1
STAMBPL1 binds DMD. 1 / 1
| 1
sparser
"Furthermore, by transcriptomic analysis we were able to identify 10 fusions compatible with inter-chromosomal translocations not previously showed by conventional methods ( PAX5::POM121C, IK::FBXW2, ZNF444::HLA-B, NFX1::DICER1, DCAF8::ZNF836, DMD::STAMBPL1, SLFNL1::SMPD2, RP11-148O21.2::ATG4B, TMEM263::CD47,INPP5A::SETD7 ) and 6 intra-chromosomal events involving distant genes ( NUP214::ABL1, MAEA::CTBP1, ZC3H12D::RP11-445F6.2, MAML2::FAT3, MNT::CLUH, TSKS::ARRDC2 ) ( xref )."
35884588
reach
"This study firstly reveals that STAMBPL1 promotes cholangiocarcinoma progression by upregulating NRF2, indicating that targeting the STAMBPL1/NRF2 axis is a novel therapeutic strategy."
39706065
STAMBPL1 affects Caspase
| 1
STAMBPL1 inhibits Caspase. 1 / 1
| 1
reach
"Chen et al. reported that the silencing of STAMBPL1 using shRNA triggers caspase-dependent death via XIAP degradation in prostate cancer cells [35]."
37511599
STAMBPL1 activates Carcinoma, Non-Small-Cell Lung. 1 / 1
| 1
eidos
"A rescue experiment was conducted to certify that STAMBPL1 promotes NSCLC progression by regulating DHRS2 expression ."
37393834
STAMBPL1 affects Carcinogenesis
| 1
reach
"STAMBPL1 deficiency attenuates liver tumorigenesis in vitro and in vivo."
39388352
STAMBPL1 affects CUL1
| 1
STAMBPL1 inhibits CUL1. 1 / 1
| 1
reach
"Recent studies have shown that excessive ROS generated in H. pylori infection induces direct degradation of STAMBPL1 by cullin 1-RING ubiquitin ligase and the 26S proteasome, while STAMBPL1 can lead to cell apoptosis by reducing the anti-apoptotic protein survivin (Chaithongyot and Naumann, 2022)."
38774627
STAMBPL1 affects COPS6
1 |
biogrid
No evidence text available
35066747
STAMBPL1 affects COPS5
1 |
STAMBPL1 binds COPS5. 1 / 1
1 |
biogrid
No evidence text available
35066747
STAMBPL1 affects CNTN2
| 1
STAMBPL1 leads to the deubiquitination of CNTN2. 1 / 1
| 1
reach
"The deubiquitination of Tax-1 can be also mediated by STAM binding protein like 1 (STAMBPL1), which was identified in an RNA interference screen XREF_BIBR."
25116307
STAMBPL1 affects CEP55
| 1
STAMBPL1 binds CEP55, YPEL3, and IGFBP1. 1 / 1
| 1
sparser
"These data suggest that STAMBPL1, CEP55, YPEL3 and IGFBP1 may be associated with the prognosis of patients with PAAD."
32565937
STAMBPL1 affects CDC37
1 |
CDC37 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
21163940
STAMBPL1 affects CD274
| 1
STAMBPL1 increases the amount of CD274. 1 / 1
| 1
reach
"In addition, STAMBPL1 enhanced PD-L1 transcription via facilitating nuclear translocation of p65, and knockdown (KD) of STAMBPL1 augmented antitumor effects of PD-1 blockade."
39527690
STAMBPL1 affects CCND1
| 1
STAMBPL1 increases the amount of CCND1. 1 / 1
| 1
reach
"Exogenous expression of STAMBPL1 increased the percentage of cells in the S phase and upregulated the expressions of CyclinD1 and Survivin."
39150093
STAMBPL1 affects CC2D2A
1 |
biogrid
No evidence text available
26638075
STAMBPL1 affects CAPZA2
1 |
CAPZA2 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
26496610
STAMBPL1 affects CALCOCO2
1 |
CALCOCO2 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
32296183
STAMBPL1 affects C10orf88
1 |
C10orf88 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
33961781
STAMBPL1 affects BRCC36
| 1
BRCC36 binds STAMBPL1, Ubiquitin, and K63. 1 / 1
| 1
sparser
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly."
28587922
STAMBPL1 activates Adenocarcinoma of Lung. 1 / 1
| 1
eidos
"STAMBPL1 promotes the progression of lung adenocarcinoma by inhibiting DHRS2 expression ."
37393834
STAMBPL1 affects Actb
1 |
Actb binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
26496610
STAMBPL1 affects AP1B1
1 |
biogrid
No evidence text available
28514442
STAMBPL1 affects ANXA5
| 1
STAMBPL1 inhibits ANXA5. 1 / 1
| 1
reach
"STAMBPL1 knockdown in both PC3 and DU145 cells significantly increased Annexin V-positive cell population ( Fig. 1 H), as well as accumulation of dead cells in sub-G1 phase ( Fig. 1 I)."
31004702
STAMBPL1 affects A2M
1 |
A2M binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
21163940
STAMBP affects Clathrin
| 1
STAMBP binds STAMBPL1, Clathrin, and CLTC. 1 / 1
| 1
sparser
"We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins."
16716190
STAM2 affects GRB2
| 1
STAMBPL1 binds STAM, STAM2, and GRB2. 1 / 1
| 1
sparser
"Consistent with this, coimmunoprecipitation analyses revealed that AMSH-LP could not bind to STAM1, STAM2, or Grb2, all of which contain an SH3 domain that interacts with AMSH [2,3,11] ."
12810066
STAM affects STAM2, and STAMBPL1
| 1
STAM2 binds STAM and STAMBPL1. 1 / 1
| 1
sparser
"Another STAM family protein, STAM2, did not bind to AMSH-LP either, although AMSH strongly binds to STAM2 (data not shown)."
12810066
STAM affects GRB2
| 1
STAMBPL1 binds STAM, STAM2, and GRB2. 1 / 1
| 1
sparser
"Consistent with this, coimmunoprecipitation analyses revealed that AMSH-LP could not bind to STAM1, STAM2, or Grb2, all of which contain an SH3 domain that interacts with AMSH [2,3,11] ."
12810066
SP1 affects STAMBPL1
| 1
E2F2 binds E2F6, MAFF, SP1, and STAMBPL1. 1 / 1
| 1
sparser
"While our study highlights and connect three key signalling pathways: mutant p53, EMT and DUBs, showing that STAMBPL1 is transcriptionally elevated in mutant p53-expressing cells, STAMBPL1 seems not to be under a direct regulation by p53 R175H . However, out of the known TFs that help recruit mutant p53 to the chromatin to upregulate genes, xref we found that E2F2, E2F6, MAFF and SP1 can bind to the core promoter region of STAMBPL1 by their motif search using Eukaryotic promoter database."
32636467
SNRPA1 affects STAMBPL1
1 |
biogrid
No evidence text available
19615732
SNP rs2862833 affects STAMBPL1
| 1
SNP rs2862833 increases the amount of STAMBPL1. 1 / 1
| 1
reach
"The protective SNP rs2862833, a downstream variant of the FAS gene, increased the expression of FAS (Z-score 10.8, P = 3.51 x10 -27) and the STAMBPL1 and ACTA2 locus (Z-score 38.25, P = 9.81 x10 -198)."
29142307
SMURF2 affects STAMBPL1
1 |
SMAP2 affects STAMBPL1
1 |
biogrid
No evidence text available
28514442
SMAD7 affects SMAD2
| 1
STAMBPL1 binds SMAD2 and SMAD7. 1 / 1
| 1
sparser
"Previous studies reported that although they did not investigate the DUB activity of STAMBPL1, STAMBPL1 interact with Smad2 and Smad7, followed by induction of TGF-β-mediated transcriptional activity [ xref ]."
31817770
SF3B5 affects STAMBPL1
1 |
biogrid
No evidence text available
32296183
SEC16A affects STAMBPL1
1 |
biogrid
No evidence text available
33961781
S-(1,2-dichlorovinyl)-L-cysteine decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
35811015
RNF167 affects STAMBPL1
| 1
reach
"The binding of RNF167 and STAMBPL1 to Sestrin2 is not mutually exclusive, as the interaction of one protein with Sestrin2 was not affected by deficiency or overexpression of the other protein ( Figure[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35114100
REL affects STAMBPL1
1 |
STAMBPL1 binds REL. 1 / 1
1 |
biogrid
No evidence text available
32296183
RBM47 affects STAMBPL1
1 |
biogrid
No evidence text available
33961781
RAB2B affects STAMBPL1
1 |
biogrid
No evidence text available
32296183
Phe403 affects UBD
| 1
STAMBPL1 binds UBD and Phe403. 1 / 1
| 1
reach
"X-ray crystal structures of the DUB domains of both AMSH-LP and Sst2 bound to diubiquitin shows Phe403 collapsed onto the Lys63 side chain of the proximal ubiquitin; however, the flap residues appear to retain their mobility even in presence of bound substrate or product (indicated by relatively weak electron density enveloping these residues and higher B-factors than internal residues)."
26368668
PSEN1 affects STAMBPL1
1 |
biogrid
No evidence text available
21163940
PNMA1 affects STAMBPL1
1 |
biogrid
No evidence text available
25416956
PLEKHF2 affects STAMBPL1
1 |
STAMBPL1 binds PLEKHF2. 1 / 1
1 |
biogrid
No evidence text available
32296183
OTUB1 affects STAMBPL1
1 |
biogrid
No evidence text available
19615732
Neoplasm Metastasis decreases the amount of STAMBPL1. 1 / 1
| 1
reach
"The transwell assays were used to evaluate the influence on invasion and metastasis abilities of HCC cells by reducing the expression of STAMBPL1."
38419066
NVP-BKM120 affects STAMBPL1
1 |
NVP-BKM120 decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
36139627
NFE2L2 affects STAMBPL1
| 1
sparser
"Particularly, sites 251-436 of STAMBPL1 interact with sites 228-605 of NRF2, facilitating DUB activity and eliminating ubiquitin molecules attached to NRF2, thus protecting it from proteasome-mediated degradation."
39706065
N-nitrosodiethylamine increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
24535843
N,N-diethyl-m-toluamide demethylates STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
33148267
MYC affects STAMBPL1
| 1
MYC activates mutated STAMBPL1. 1 / 1
| 1
reach
"Second, defective intracellular trafficking and localization, originating from D406G germline mutation of STAMBPL1 and enhanced by MYC network activation, inhibit cell polarity establishment and cell differentiation, preventing cell cycle exit."
30018743
MORN5 affects STAMBPL1
1 |
biogrid
No evidence text available
32296183
MIR548P affects STAMBPL1
1 |
MIR548P decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
MIR1248 affects STAMBPL1
1 |
MIR1248 decreases the amount of STAMBPL1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
MIOS affects STAMBPL1
| 1
MIOS decreases the amount of STAMBPL1. 1 / 1
| 1
reach
"Knockdown of the GATOR2 subunit Mios completely blocked the effect of RNF167 deficiency or STAMBPL1 overexpression on mTORC1 activity ( Figures S5 A and S5B), which suggests that GATOR2 functions down[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35114100
MAST1 affects STAMBPL1
1 |
MAST1 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
21163940
MAFF affects STAMBPL1
| 1
E2F2 binds E2F6, MAFF, SP1, and STAMBPL1. 1 / 1
| 1
sparser
"While our study highlights and connect three key signalling pathways: mutant p53, EMT and DUBs, showing that STAMBPL1 is transcriptionally elevated in mutant p53-expressing cells, STAMBPL1 seems not to be under a direct regulation by p53 R175H . However, out of the known TFs that help recruit mutant p53 to the chromatin to upregulate genes, xref we found that E2F2, E2F6, MAFF and SP1 can bind to the core promoter region of STAMBPL1 by their motif search using Eukaryotic promoter database."
32636467
Lys63-Ub 2 affects STAMBPL1
| 1
STAMBPL1 binds Lys63-Ub 2. 1 / 1
| 1
reach
"The 10 best structures of the best cluster in terms of Haddock score were retained.The proposed structure of the STAM2/AMSH/Lys63-Ub 3 ternary complex has been obtained by assembling the SH3/AMSH stru[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
Lipopolysaccharides decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
35811015
LCOR affects STAMBPL1
1 |
LCOR binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
35914814
LAX1 affects STAMBPL1
1 |
LAX1 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
25416956
L-methionine affects STAMBPL1
1 |
L-methionine increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
20938992
K63-Ub 2 affects DUB domain
| 1
STAMBPL1 binds K63-Ub 2 and DUB domain. 1 / 1
| 1
reach
"The overall three-dimensional fold of Sst2 Delta220 -K63-Ub 2 is highly similar to the structure of the DUB domain of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) with an rmsd of 1.19 A of Calpha atoms over 266 residues from both Sst2 and K63-Ub 2."
24787148
K63 affects BRCC36
| 1
BRCC36 binds STAMBPL1, Ubiquitin, and K63. 1 / 1
| 1
sparser
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly."
28587922
JAG1 affects STAMBPL1
| 1
JAG1 inhibits STAMBPL1. 1 / 1
| 1
reach
"In cultured human gastric adenocarcinoma epithelial cell lines AGS and NCI-N87, H. pylori -induced production of ROS caused the degradation of the deubiquitinylase STAM-binding protein-like 1 (STAMBPL[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37230895
INCA1 affects STAMBPL1
1 |
biogrid
No evidence text available
25416956
IKZF3 affects STAMBPL1
1 |
IKZF3 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
25416956
IGFBP1 affects YPEL3
| 1
STAMBPL1 binds CEP55, YPEL3, and IGFBP1. 1 / 1
| 1
sparser
"These data suggest that STAMBPL1, CEP55, YPEL3 and IGFBP1 may be associated with the prognosis of patients with PAAD."
32565937
HMX3 affects STAMBPL1
1 |
STAMBPL1 binds HMX3. 1 / 1
1 |
biogrid
No evidence text available
19615732
HIF1A affects STAMBPL1
| 1
HIF1A increases the amount of STAMBPL1. 1 / 1
| 1
sparser
"The difference between HIF-1a expression upon FOXO1 silencing should be compared in the presence or absence of STAMBPL1 overexpression to understand if FOXO1 impacts HIF-1a transcription dependently or independently of STAMBPL1."
40208233
GSK3 affects STAMBPL1
| 1
GSK3 decreases the amount of STAMBPL1. 1 / 1
| 1
reach
"Consistent with the effect of GSK-3 inhibition to stimulate the transcription of Snail, in this study, we show that GSK-3α/β inhibition can induce a significant STAMBPL1 expression in all cell lines tested, signifying that this stimulation is able to trigger similar STAMBPL1 molecular response in several cell and cancer types and suggest that GSK-3α/β inhibition may converge upon common signalling element in multiple carcinomas to activate STAMBPL1."
32636467
GRB2 affects STAMBPL1
| 1
STAMBPL1 binds STAM, STAM2, and GRB2. 1 / 1
| 1
sparser
"Consistent with this, coimmunoprecipitation analyses revealed that AMSH-LP could not bind to STAM1, STAM2, or Grb2, all of which contain an SH3 domain that interacts with AMSH [2,3,11] ."
12810066
GOLGA6L9 affects STAMBPL1
1 |
biogrid
No evidence text available
32296183
GOLGA2 affects STAMBPL1
1 |
biogrid
No evidence text available
25416956
GNPTAB affects STAMBPL1
1 |
biogrid
No evidence text available
25416956
GCSAML affects STAMBPL1
1 |
biogrid
No evidence text available
32296183
Flag affects STAMBPL1
| 1
STAMBPL1 binds Flag. 1 / 1
| 1
sparser
"The Flag-STAMBPL1 plasmid were well constructed and transferred to HCCLM3 and Hep3B cell, including (Control, Flag-STAMBPL1-2ug, Flag-STAMBPL1-3ug, Flag-STAMBPL1-4ug), The findings indicated that elevated STAMBPL1 levels led to a decrease in the ubiquitination levels of TRAF2 in both HCCLM3 and Hep3B cells (Fig.  xref A, B)."
38419066
FBXL6 affects STAMBPL1
1 |
biogrid
No evidence text available
37267103
ENOX2 affects STAMBPL1
1 |
STAMBPL1 binds ENOX2. 1 / 1
1 |
biogrid
No evidence text available
32296183
ECSIT affects STAMBPL1
1 |
ECSIT binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
21163940
E2F6 affects STAMBPL1
| 1
E2F2 binds E2F6, MAFF, SP1, and STAMBPL1. 1 / 1
| 1
sparser
"While our study highlights and connect three key signalling pathways: mutant p53, EMT and DUBs, showing that STAMBPL1 is transcriptionally elevated in mutant p53-expressing cells, STAMBPL1 seems not to be under a direct regulation by p53 R175H . However, out of the known TFs that help recruit mutant p53 to the chromatin to upregulate genes, xref we found that E2F2, E2F6, MAFF and SP1 can bind to the core promoter region of STAMBPL1 by their motif search using Eukaryotic promoter database."
32636467
DUB domain affects STAMBPL1
| 1
STAMBPL1 binds K63-Ub 2 and DUB domain. 1 / 1
| 1
reach
"The overall three-dimensional fold of Sst2 Delta220 -K63-Ub 2 is highly similar to the structure of the DUB domain of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) with an rmsd of 1.19 A of Calpha atoms over 266 residues from both Sst2 and K63-Ub 2."
24787148
DMD affects STAMBPL1
| 1
STAMBPL1 binds DMD. 1 / 1
| 1
sparser
"Furthermore, by transcriptomic analysis we were able to identify 10 fusions compatible with inter-chromosomal translocations not previously showed by conventional methods ( PAX5::POM121C, IK::FBXW2, ZNF444::HLA-B, NFX1::DICER1, DCAF8::ZNF836, DMD::STAMBPL1, SLFNL1::SMPD2, RP11-148O21.2::ATG4B, TMEM263::CD47,INPP5A::SETD7 ) and 6 intra-chromosomal events involving distant genes ( NUP214::ABL1, MAEA::CTBP1, ZC3H12D::RP11-445F6.2, MAML2::FAT3, MNT::CLUH, TSKS::ARRDC2 ) ( xref )."
35884588
Cuprizon affects STAMBPL1
1 |
Cuprizon decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
26577399
Clathrin affects STAMBP
| 1
STAMBP binds STAMBPL1, Clathrin, and CLTC. 1 / 1
| 1
sparser
"We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins."
16716190
Caspase affects STAMBPL1
| 1
Caspase activates STAMBPL1. 1 / 1
| 1
reach
"Necroptosis inhibitor Nec-1 and autophagy inhibitor CQ did not efficiently suppress cell death induced by STAMBPL1 targeting; whereas, addition of a caspase 3 inhibitor, Z-DEVD-FMK, to cells markedly [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31004702
COPS6 affects STAMBPL1
1 |
biogrid
No evidence text available
35066747
COPS5 affects STAMBPL1
1 |
STAMBPL1 binds COPS5. 1 / 1
1 |
biogrid
No evidence text available
35066747
CLTC affects STAMBP
| 1
STAMBP binds STAMBPL1, Clathrin, and CLTC. 1 / 1
| 1
sparser
"We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins."
16716190
CEP55 affects YPEL3
| 1
STAMBPL1 binds CEP55, YPEL3, and IGFBP1. 1 / 1
| 1
sparser
"These data suggest that STAMBPL1, CEP55, YPEL3 and IGFBP1 may be associated with the prognosis of patients with PAAD."
32565937
CDH1 affects STAMBPL1
1 |
CDH1 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
37756605
CDC37 affects STAMBPL1
1 |
CDC37 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
21163940
CC2D2A affects STAMBPL1
1 |
biogrid
No evidence text available
26638075
CASP8 affects STAMBPL1
| 1
CASP8 inhibits STAMBPL1. 1 / 1
| 1
reach
"Taken together, these data indicate that inhibition of STAMBPL1 in prostate cancer cells triggers caspase-dependent apoptosis.Considering that caspase 8 is the predominant initiator caspase in the cel[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31004702
CAPZA2 affects STAMBPL1
1 |
CAPZA2 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
26496610
CALCOCO2 affects STAMBPL1
1 |
CALCOCO2 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
32296183
C10orf88 affects STAMBPL1
1 |
C10orf88 binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
33961781
BRCC36 affects Ubiquitin
| 1
BRCC36 binds STAMBPL1, Ubiquitin, and K63. 1 / 1
| 1
sparser
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly."
28587922
BRCC3 affects STAMBPL1
| 1
BRCC3 deubiquitinates STAMBPL1. 1 / 1
| 1
reach
"To identify the DUB associated with NALP7, we over-expressed plasmids expressing several candidate DUBs including BRCC3, which deubiquitinates NALP3, COPS5, STAMBPL1, USP7 and the endosome associated DUBs, STAMBP and USP8."
28492230
Aroclor 1254 affects STAMBPL1
1 |
Aroclor 1254 decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
23650126
Actb affects STAMBPL1
1 |
Actb binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
26496610
AZM551248 affects STAMBPL1
1 |
AZM551248 increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
22323515
AP1B1 affects STAMBPL1
1 |
biogrid
No evidence text available
28514442
A2M affects STAMBPL1
1 |
A2M binds STAMBPL1. 1 / 1
1 |
biogrid
No evidence text available
21163940
4-hydroxyphenyl retinamide increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
28973697
2-palmitoylglycerol increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
37199045
2-hydroxypropanoic acid decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
30851411
2-butoxyethanol decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
19812364
ctd
No evidence text available
39104825
1-methylanthracene increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
28329830
1,1-dichloroethene increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
26682919
(-)-epigallocatechin 3-gallate decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
22079256
(-)-demecolcine decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
23649840
4,4'-sulfonyldiphenol decreases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
39298647
2,2',5,5'-tetrachlorobiphenyl increases the amount of STAMBPL1. 1 / 1
1 |
ctd
No evidence text available
36804509