IndraLab

Statements


STAMBPL1 binds K63-Ub 2. 5 / 5
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"Figure XREF_FIG d shows the superposition of Sst2 Delta220 -K63-Ub 2 and AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV)."

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"Proximal ubiquitin binding is similar to that observed in the crystal structure of AMSH-LP bound to K63-Ub 2."

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"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly.Comparison of the BRCC36 homodimer and heterodimer structures suggests an explanation for the loss of catalytic activity in the homod[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"The structure was determined by molecular replacement using a model of Sst2-K63-Ub 2 generated by superimposition of Sst2 cat with the structure of AMSH-LP bound to K63-Ub 2 (PDB entry 2ZNV) and refined yielding satisfactory crystallographic, free R factors and good stereochemistry."

reach
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly."