IndraLab

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"Mechanistically, downregulation of STAMBPL1 upon H. pylori infection has been shown to promote apoptosis by circumventing the deubiquitinylation and hence stabilization of the antiapoptotic protein su[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"STAMBPL1 stabilizes XIAP to inhibit apoptosis in prostate cancer cells (Chen et al., 2019) and confers resistance to honokiol-induced apoptosis in various cancer cell types by stabilizing Survivin and c-FLIP (Woo et al., 2019)."

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"Further, we demonstrated the involvement of STAMBPL1 in combined treatment-induced apoptosis using an overexpression or depletion system."

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"Recent studies have shown that excessive ROS generated in H. pylori infection induces direct degradation of STAMBPL1 by cullin 1-RING ubiquitin ligase and the 26S proteasome, while STAMBPL1 can lead to cell apoptosis by reducing the anti-apoptotic protein survivin (Chaithongyot and Naumann, 2022)."