
IndraLab
Statements
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"While our study highlights and connect three key signalling pathways: mutant p53, EMT and DUBs, showing that STAMBPL1 is transcriptionally elevated in mutant p53-expressing cells, STAMBPL1 seems not to be under a direct regulation by p53 R175H . However, out of the known TFs that help recruit mutant p53 to the chromatin to upregulate genes, xref we found that E2F2, E2F6, MAFF and SP1 can bind to the core promoter region of STAMBPL1 by their motif search using Eukaryotic promoter database."