IndraLab

Statements

FAS binds STAMBPL1. 5 / 5
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"Seven of the nine fusions frequently detected in patients with HCC included: MAN2A1–FER (100%), SLC45A2–AMACR (62.3%), ZMPSTE24–ZMYM4 (62.3%), PTEN–NOLC1 (57.4%), CCNH–C5orf30 (55.7%), STAMBPL1–FAS (26.2%), and PCMTD1–SNTG1 (16.4%)."
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"STAMBPL1-FAS fusion isoform was identified in sample 1 M (metastasis cancer) and 2 M (the metastasis cancer): XM_011539985 from STAMBPL1 and XM_011539766.2 from FAS (Fig.  xref )."
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"However, subsequent analysis using Taqman qPCR showed that the STAMBPL1-FAS fusion isoform can be found in all 6 cancer samples (Supplementary Fig.  xref ), implying a wider distribution of this gene fusion in colon cancers."
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"The relatively low-frequency fusion transcripts were STAMBPL1–FAS (26.2%, 16/61), PCMTD1–SNTG1 (16.4%, 10/61), and ZNF124–SMYD3 (16.4%, 10/61)."
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"The Fisher exact test showed that seven fusion genes— MAN2A1–FER ( P  = 1.4 × 10 −19 ), CCNH–C5orf30 ( P  = 1.1 × 10 −5 ), SLC45A2–AMACR ( P  = 2.8 × 10 −9 ), ZMPSTE24–ZMYM4 ( P  = 9.3 × 10 −6 ), PTEN–NOLC1 ( P  = 1.8 × 10 −6 ), PCMTD1–SNTG1 ( P  = 0.006), and STAMBPL1–FAS ( P  = 0.01)—had significantly greater frequencies of expression in the serum samples of patients with HCC, suggesting that the detection of these fusion transcripts in the serum samples of patients with HCC likely predicts the risk for HCC."
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