IndraLab

Statements

STAMBPL1 activates CFLAR. 6 / 6
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"Knockdown of STAMBPL1 reduced survivin and c-FLIP protein levels, while overexpression of STAMBPL1 inhibited honokinol induced survivin and c-FLIP degradation."
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"Our findings provided that honokiol could overcome TRAIL resistance through survivin and c-FLIP degradation induced by inhibition of STAMBPL1 expression."
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"STAMBPL1 stabilizes XIAP to inhibit apoptosis in prostate cancer cells (Chen et al., 2019) and confers resistance to honokiol-induced apoptosis in various cancer cell types by stabilizing Survivin and c-FLIP (Woo et al., 2019)."
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"Tubeimoside-1 Enhances TRAIL-Induced Apoptotic Cell Death through STAMBPL1-Mediated c-FLIP Downregulation."
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"Mechanistically , TBMS-1 destabilized c-FLIP expression by downregulating STAMBPL1 , a deubiquitinase ( DUB ) ."
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"STAMBPL1 overexpression markedly prevented apoptosis induced by TBMS-1 and TRAIL combination therapy as well as c-FLIP degradation (Figure 4G)."
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