IndraLab

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STAMBPL1 activates Neoplasms. 10 / 10
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"Additionally, the suppression of STAMBPL1 inhibits tumor growth and the proliferation in colorectal and gastric cancer cells [20,21]."
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"Therefore, we investigated whether STAMBPL1 promotes tumor angiogenesis."
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"Deletion of STAMBPL1 or correction of the heterozygous STAMBPL1 mutation in a human colon cancer cell line suppresses xenograft tumor growth."
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"STAMBPL1 knockout or correction of the heterozygous STAMBPL1 mutation in a human colon cancer cell could suppress xenograft tumor growth [24]."
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"Notably, STAMBPL1 overexpression increased lipid accumulation in HCC cells and xenograft tumors."
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"STAMBPL1 knockout significantly suppressed mTORC1 activity, anchorage-independent cell growth, and xenograft tumor growth ( Figures 5 F–5J and S8 C–S8J) in all three cell lines."
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"Besides, upregulation of STAMBPL1 could significantly enhance the tumor growth rate and volume in nude mice (Fig. 11E–H)."
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"All these results hinted that the STAMBPL1 positively mediated tumor growth in vitro."
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"Suppression of STAMBPL1 function inhibits tumor growth and provides a potential option for colorectal cancer therapy."
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"Knocking down STAMBPL1 inhibited the growth of HCC1806 xenografts in mice (Figure 3G–I) and decreased the number of microvessels in tumor tissue (Figure 3J, K), indicating that STAMBPL1 promoted tumor angiogenesis."
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