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STAMBPL1 inhibits apoptotic process. 16 / 16
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"In response to genotoxic stress, the degradation of STAMBPL1 augments apoptotic cell death."
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"Moreover, Chen et al. indicated that STAMBPL1 depletion increases cell death 72 h after shRNA treatment; however, our data did not show STAMBPL1 siRNA-induced apoptosis after treatment for 24 h (Figure 4G)."
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"We observed activation of caspase-9, -3 and -7, but not caspase-8, in STAMBPL1 silencing-induced apoptosis."
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"Here we show evidence that STAMBPL1 regulates X-linked inhibitor of apoptosis protein (XIAP) stability, thus modulates apoptosis in prostate cancer cells.XIAP is one of the Inhibitor of Apoptosis Prot[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Apoptosis of CRC was induced by silence of STAMBPL1."
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"STAMBPL1 overexpression markedly prevented apoptosis induced by TBMS-1 and TRAIL combination therapy as well as c-FLIP degradation (Figure 4G)."
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"STAMBPL1 depletion was found to induce apoptosis by promoting the degradation of the protein XIAP, suggesting that targeting STAMBPL1 might offer a promising therapeutic strategy for prostate cancer [23]."
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"We designed experiments to show that the percentage of apoptotic cells in A549 STAMBPL1 SI group (4.89% ± 0.33%, p<0.05) and H1299 STAMBPL1 SI (9.18% ± 0.51%, p<0.001) group increased significantly compared with A549 STAMBPL1 NC group (3.33% ± 0.41%) and H1299 STAMBPL1 NC group (2.91% ± 0.24%) (Fig. 2G, p<0.05, p<0.001), which proved that STAMBPL1 could reduce apoptosis of LUAD cells."
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"STAMBPL1 reduces apoptosis of LUAD cells."
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"In response to genotoxic stress , the degradation of STAMBPL1 augments apoptotic cell death ."
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"These results indicate that ROS accumulation is insufficient for maximal apoptosis in STAMBPL1-depleted cells.To determine the mechanism of STAMBPL1 depletion-induced apoptosis, we sought to monitor a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These data suggest that STAMBPL1 loss diverts the XIAP degradation from proteasome pathway to lysosome pathway, and drastically enhances XIAP degradation.In this study, we reported evidence that silen[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Recently , we reported the depletion of STAMBPL1 increases apoptotic cell death through accumulation of intracellular ROS and lysosome-dependent XIAP degradation in prostate cancer cells [ 34 ] , and we also reported that levels of STAMBPL1 is correlated with the expression of survivin in cepharanthine treated renal cancer cells [ 35 ] ."
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"We demonstrated that STAMBPL1 RNAi depletion induced apoptosis in PC3 and DU145 cells by promoting XIAP lysosomal degradation."
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"Necroptosis inhibitor Nec-1 and autophagy inhibitor CQ did not efficiently suppress cell death induced by STAMBPL1 targeting; whereas, addition of a caspase 3 inhibitor, Z-DEVD-FMK, to cells markedly [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, knockdown of STAMBPL1 by shSTAMBPL1 resulted in STAMBPL1 downregulation, which in turn decreased the cell proliferation of AGS gastric cancer cells, increasing cell apoptosis, cell invasion and migration in vitro."
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