IndraLab

Statements

STAMBPL1 binds STAMBP. 6 / 8
2 | 2 4
reach
"Both STAMBP and STAMBPL1 localize to early endosomes by binding to clathrin (31); however, STAMBPL1 fails to bind to STAM due to residue substitutions in the SBM-like motif, suggesting it may function in different signaling pathway from that of STAMBP (30)."
34425109
sparser
"Unlike the monomer of AMSH or AMSH-LP with inherent DUB activity, BRCC36 must form a complex with other subunits to specifically cleave K63-linked polyubiquitin chains."
35883466
sparser
"To quantify the interaction of the UbVs with STAMBP and STAMBPL1 and to validate the key residues responsible for the tight binding, we used isothermal titration calorimetry (ITC) to measure the interaction thermodynamics ( xref )."
34425109
sparser
"Hameed et al. developed a zinc chelating ABP that forms a tight complex with STAMBP and STAMBPL1 and inhibits the activity of the proteasomal DUB Rpn11 (PSMD14 in humans)."
35625630
reach
"Both STAMBP and STAMBPL1 localize to early endosomes by binding to clathrin (31); however, STAMBPL1 fails to bind to STAM due to residue substitutions in the SBM-like motif, suggesting it may function in different signaling pathway from that of STAMBP (30) ."
| DOI
sparser
"Hence, it is possible that AMSH and AMSH-LP might be associated with a proteasome or other unknown large protein complex in the nucleus through their MPN domain."
12810066