IndraLab

Statements

ASXL1 affects BAP1
11 | 1 123 96
ASXL1 binds BAP1.
11 | 99 90
ASXL1 binds BAP1. 10 / 166
11 | 86 69
sparser
"In flies and humans, the Polycomb repressive deubiquitinase (PR-DUB) complex is formed through interactions of BAP1 and ASXL1 [ xref ]."
24455749
reach
"ASXL1 forms a complex with BRCA1 associated protein 1 (BAP1) that physically interacts with PRC2 and deubiquitinylates histone H2A [XREF_BIBR]."
| PMC
reach
"We investigated which BAP1 protein binding partners, and thus which regulatory complexes, mediate TRAIL sensitivity identifying the BAP1 and ASXL1 complex, the Polycomb repressive deubiquitinase (PR-DUB), as key."
29345617
reach
"BAP1 function is intimately linked with that of ASXL1, commonly mutated in CMML, and it was recently shown that the interaction between ASXL1 and BAP1 was restored in ASXL1-mutation corrected clones (Valletta et al, 2015)."
29797327
reach
"These data show that the specificity of the BAP1 and ASXL1 complex for the Polycomb site (K119) is not determined by the amino acids surrounding the scissile isopeptide bond, but at regions outside the ubiquitinated tail such as the nucleosome core."
26739236
reach
"The interaction between ASXL1 and BAP1 and the ubiquitin C-terminal hydrolase (UCH) domain of BAP1 are abso- lutely required for cooperation."
23850490
reach
"ASXL1 binds a deubiquitinase BAP1 to form a critical complex for H2A K119 deubiquitination through the catalysis of polycomb repressive complex 1 [XREF_BIBR, XREF_BIBR]."
28697759
reach
"BAP1 and ASXL1 recruitment and activation for H2A deubiquitination."
26739236
sparser
"The tumor suppressors BAP1 and ASXL1 interact to form a polycomb deubiquitinase complex that removes monoubiquitin from histone H2A lysine 119 (H2AK119Ub)."
| PMC
sparser
"Additional sex combs-like 1 (ASXL1) is frequently mutated in a variety of myeloid malignancies, resulting in expression of a C-terminal-truncated ASXL1 protein that confers gain of function on the ASXL1-BAP1 deubiquitinase (DUB) complex."
34186160
Mutated ASXL1 binds BAP1. 9 / 9
| 9
reach
"This hyperactive mutant ASXL1/BAP1 complex is thought to promote impairment of myeloid differentiation through inhibition of H2AK119ub at posterior HOXA genes and IRF8, encoding an essential transcription factor in myeloid lineages [18]."
33483612
reach
"This hyperactive mutant ASXL1 and BAP1 complex induces upregulation of posterior HOXA genes and IRF8 through inhibition of H2AK119ub, impairing multilineage differentiation of haematopoietic progenitors (except for that toward monocytes), and accelerates RUNX1-ETO-induced leukaemogenesis."
30013160
reach
"Mechanistically, the mutant ASXL1 and BAP1 complex induced the upregulation of HOXA5, HOXA7, HOXA9, and IRF8 via a reduction in H2AK119ub."
32378586
reach
"Cancer associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1 and BAP1 complex."
26095772
reach
"[Molecular mechanisms by which the mutant ASXL1 and BAP1 complex aggravates myeloid leukemia]."
32378586
reach
"We have examined the role of H2AK119Ub in regulating gene expression by using hyperactive mutations of the ASXL1 and BAP1 complex that allowed us to deplete ~ 90% of total H2AK119Ub."
26095772
reach
"Based of the possibility that ASXL1 truncations might act as gain-of-function mutations of the ASXL1 and BAP1 complex, we examined whether hyperactive ASXL-BAP1 complexes could alter the fate of haematopoietic cells in vivo."
26095772
reach
"The mutant ASXL1/BAP1 complex inhibits the differentiation of HSPCs toward multilineage except for immature monocytes, and promoted myeloid leukemogenesis induced by RUNX1-ETO, an oncogenic fusion protein frequently coexisting with ASXL1 mutations [72]."
31673113
reach
"Our studies here raise the possibility that ASXL1 mutations may act as gain-of-function mutations of the ASXL1 and BAP1 complex."
26095772
ASXL1 binds EED and BAP1. 4 / 4
| 4
sparser
"In flies and humans, the Polycomb repressive deubiquitinase (PR-DUB) complex is formed through interactions of BAP1 and ASXL1 [ xref ]."
24455749
sparser
"BAP1 interacts with ASXL1 polycomb chromatin binding protein forming a polycomb repressive deubiquitinase complex that regulates histone H2A ubiquitination xref ."
25482724
sparser
"BAP1 also interacts with ASXL1 to form the Polycomb group repressive deubiquitinase complex (PR-DUB), which is involved in stem cell pluripotency and other developmental processes ( xref , xref )."
21051595
sparser
"8 BAP1 interacts with ASXL1 (MIM 612990 ) to form the Polycomb group Repressive Deubiquitinase complex (PR-DUB)."
23684012
ASXL1 binds ASXL2 and BAP1. 3 / 3
| 3
sparser
"Although both ASXL1 and ASXL2 have been identified to bind to BAP1, recent biochemical characterization of BAP1 complexes by xref suggest that BAP1 forms two mutually exclusive complexes with ASXL1 and ASXL2."
27527698
sparser
"Depletion of the PHD fingers did not affect the stability of ASXL1 or ASXL2, or the interaction between ASXL1, ASXL2, and BAP1 (Additional file xref : Fig. S2A, B)."
36180891
sparser
"Proteomic analysis of BAP1 interacting partners using this system revealed that BAP1 interacts with ASXL1 and ASXL2 in vivo as well as host cell factor 1 (HCF-1), O-GlcNAc transferase (OGT), and Forkhead box protein K1/2 (FOXK1/2) ( xref )."
27527698
ASXL1 binds BAP1 and PTEN. 2 / 2
| 2
sparser
"Then we performed ChIP-qPCR analyses in 32D cells to validate whether Asxl1 and Bap1 are bound to the Pten promoter and examined the accompanying changes of histone modifications in different conditions."
32236560
sparser
"As shown in xref , Asxl1 and Bap1 are specifically bound to the Pten promoter, and their enrichment is further induced by the absence of IL3 in WT cells."
32236560
ASXL1 binds BAP1 and ASXH domain. 2 / 2
| 2
reach
"As mentioned earlier, the interaction between BAP1 and ASXL1 occurs through the ASXH domain."
27527698
reach
"ASXL1 directly binds to BAP1 through the ASXH domain and its adjoining region."
33796551
ASXL1 binds PGR and BAP1. 2 / 2
| 2
sparser
"The K119 Ub-H2A is removed by the deubiquitinase complex PR-DUB (Polycomb Repressive-Deubiquitinase complex) formed by the proteins ASXL1 (Additional Sex Combs like 1) and BAP1 (BRAC1 Associated Protein 1) [ xref ]."
33198194
sparser
"Like Drosophila Calypso and ASX, human BAP1 and ASXL1 proteins could thus also be assembled into a stable PR-DUB complex ( xref , right, lane 8), demonstrating the evolutionary conservation of this interaction."
20436459
ASXL1 binds BAP1-L635A. 1 / 1
| 1
reach
"Performing equivalent experiments with the corresponding BAP1-ASXL1 complexes demonstrated that wild-type BAP1-ASXL1 readily shifted the nucleosome band, whereas the L635A BAP1 and ASXL1 complex had a dramatically impaired ability to induce nucleosome mobility shift at the same concentrations."
30258054
ASXL1 binds KDM1A and BAP1. 1 / 1
| 1
sparser
"The region around the ASXH domain of ASXL1 directly binds to BAP1 ( xref ) and KDM1A (LSD1; xref )."
23736028
ASXL1 binds H2AC20 and BAP1. 1 / 1
| 1
sparser
"Interestingly, the polycomb group protein ASXL1 that forms a functional H2A-DUB complex with BAP1 ( Scheuermann et al., 2010 ) also acts as a tumor suppressor and is frequently mutated in human myeloi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24647359
ASXL1 binds KDM1A, NCOA1, and BAP1. 1 / 1
| 1
sparser
"ASXL1 directly interacts with BAP1, KDM1A (LSD1), NCOA1 and nuclear hormone receptors (NHRs), such as retinoic acid receptors, oestrogen receptor and androgen receptor."
23736028
sparser
"Here, we report that BAP1 forms two mutually exclusive complexes with the transcriptional regulators ASXL1 and ASXL2, which are necessary for maintaining proper protein levels of this DUB."
26416890
ASXL1 binds FOXK2, PGR, and BAP1. 1 / 1
| 1
sparser
"Similarly, we were able to verify FOXK2 interactions with the PR-DUB complex components BAP1 and ASXL1 but were only able to detect weaker co-associations with HCFC1 in co-IP experiments (Figure xref )."
24748658
SUZ12 binds ASXL1, ASXL2, and BAP1. 1 / 1
| 1
sparser
"Despite evidence of clear physical interaction between ASXL1, ASXL2, and BAP1 (as previously reported xref ) as well as ASXL1 and the core PRC2 member SUZ12 (also previously reported xref ), interaction between ASXL2 and PRC2 members were not evident ( xref )."
28516957
ASXL1 binds BAP1 and UCH domain. 1 / 1
| 1
reach
"In addition, we demonstrated that both ASXL1 binding to BAP1 and the UCH domain of BAP1 are required for RAR repression."
23850490
AKT binds ASXL1 and BAP1. 1 / 1
| 1
sparser
"We found that wild-type/mutant ASXL1 and BAP1 bound to AKT in both cytoplasm and nucleus in 293T cells, suggesting that they form a complex (Fig.  xref a, xref , and Supplementary Fig.  xref )."
33758188
ASXL1 binds HCFC1 and BAP1. 1 / 1
| 1
sparser
"Together, these data suggest that wild-type ASXL1 forms a complex with HCF-1 and FOXK1/K2 independent of BAP1, and that the C-terminally truncated mutant ASXL1 can bind to BAP1 but loses interaction with FOXK1/K2."
32683582
ASXL1 binds ASXL2, EED, and BAP1. 1 / 1
| 1
sparser
"BAP1 forms a complex with Polycomb group proteins ASXL1 and ASXL2, and deubiquitinates histone H2AK119ub to antagonize PRC1-mediated gene silencing ( xref – xref )."
33912157
ASXL1 binds BAP1 and ULD. 1 / 1
| 1
sparser
"At the C-terminus, apart from YY1 interactions, ASXL1 also interacts with the ULD domain of BAP1 to drive the H2A deubiquitination reaction [ xref ]."
31635116
ASXL1 activates BAP1.
| 1 23 6
ASXL1 activates BAP1. 10 / 29
| 1 22 6
reach
"In this paper we describe that similar to the homologous UCH-L5 and RPN13 DEU complex, the DEUBAD domains of ASXL1, ASXL2 and ASXL3 can activate BAP1 by increasing BAP1 's affinity specifically for the ubiquitin in the substrate, through a combination of mild effects."
26739236
reach
"Like UCH37, BAP1 associates with a partner protein, ASXL1, which activates BAP1 and is required for the BAP1 mediated deubiquitylation of H2A in nucleosomes."
25702872
reach
"As part of the Polycomb repression machinery, BAP1 is activated by the deubiquitinase adaptor domain of ASXL1 mediating gene repression by cleaving ubiquitin (Ub) from histone H2A in nucleosomes."
30639226
reach
"BAP1 is activated by ASXL1 to deubiquitinate mono-ubiquitinated H2A at K119 in Polycomb gene repression, but the mechanism of this reaction remains poorly defined."
26739236
sparser
"A recent study suggests that ASXL1 might activate Bap1 in a similar manner xref ."
27012468
sparser
"BAP1 is activated by ASXL1 to deubiquitinate mono-ubiquitinated H2A at K119 in Polycomb gene repression, but the mechanism of this reaction remains poorly defined."
26739236
reach
"ASXL1 DEU stimulates BAP1 by lowering the K M on Ub-AMC (XREF_SUPPLEMENTARY)."
26739236
reach
"A previous report showed that the deubiquitinase adapter (DEUBAD) domain of ASXL1 increases BAP1 's affinity for ubiquitin on H2A 15, and we showed that monoubiquitinated ASXL1-MT enhances nuclear retention of BAP1."
30013160
reach
"BAP1 is activated by ASXL1 in a similar manner where the DEUBAD domain of ASXL1 increases affinity of BAP1 for the ubiquitinated substrate [98]."
28624371
reach
"In summary, we have shown that ASXL1 DEU activates BAP1 by increasing the affinity for ubiquitin through a combination of mild effects including stabilization of the BAP1 ULD anchor."
26739236
Mutated ASXL1 activates BAP1. 1 / 1
| 1
reach
"Monoubiquitination of mutant ASXL1 enhanced the catalytic function of BAP1, resulting in a profound reduction in H2AK119ub by counteracting the PRC1 complex."
32378586
ASXL1 inhibits BAP1.
| 1
ASXL1 inhibits BAP1. 1 / 1
| 1
reach
"ASXL1 Modulates DUB Activity of BAP1 and RAR Repression In Vivo The physiological relevance of ASXL1 cooperation with BAP1 was addressed by using MEFs derived from Asxl1 null mice."
23850490
BAP1 affects ASXL1
11 | 104 90
BAP1 binds ASXL1.
11 | 99 90
ASXL1 binds BAP1. 10 / 166
11 | 86 69
sparser
"In flies and humans, the Polycomb repressive deubiquitinase (PR-DUB) complex is formed through interactions of BAP1 and ASXL1 [ xref ]."
24455749
reach
"ASXL1 forms a complex with BRCA1 associated protein 1 (BAP1) that physically interacts with PRC2 and deubiquitinylates histone H2A [XREF_BIBR]."
| PMC
reach
"We investigated which BAP1 protein binding partners, and thus which regulatory complexes, mediate TRAIL sensitivity identifying the BAP1 and ASXL1 complex, the Polycomb repressive deubiquitinase (PR-DUB), as key."
29345617
reach
"BAP1 function is intimately linked with that of ASXL1, commonly mutated in CMML, and it was recently shown that the interaction between ASXL1 and BAP1 was restored in ASXL1-mutation corrected clones (Valletta et al, 2015)."
29797327
reach
"These data show that the specificity of the BAP1 and ASXL1 complex for the Polycomb site (K119) is not determined by the amino acids surrounding the scissile isopeptide bond, but at regions outside the ubiquitinated tail such as the nucleosome core."
26739236
reach
"The interaction between ASXL1 and BAP1 and the ubiquitin C-terminal hydrolase (UCH) domain of BAP1 are abso- lutely required for cooperation."
23850490
reach
"ASXL1 binds a deubiquitinase BAP1 to form a critical complex for H2A K119 deubiquitination through the catalysis of polycomb repressive complex 1 [XREF_BIBR, XREF_BIBR]."
28697759
reach
"BAP1 and ASXL1 recruitment and activation for H2A deubiquitination."
26739236
sparser
"The tumor suppressors BAP1 and ASXL1 interact to form a polycomb deubiquitinase complex that removes monoubiquitin from histone H2A lysine 119 (H2AK119Ub)."
| PMC
sparser
"Additional sex combs-like 1 (ASXL1) is frequently mutated in a variety of myeloid malignancies, resulting in expression of a C-terminal-truncated ASXL1 protein that confers gain of function on the ASXL1-BAP1 deubiquitinase (DUB) complex."
34186160
Mutated ASXL1 binds BAP1. 9 / 9
| 9
reach
"This hyperactive mutant ASXL1/BAP1 complex is thought to promote impairment of myeloid differentiation through inhibition of H2AK119ub at posterior HOXA genes and IRF8, encoding an essential transcription factor in myeloid lineages [18]."
33483612
reach
"This hyperactive mutant ASXL1 and BAP1 complex induces upregulation of posterior HOXA genes and IRF8 through inhibition of H2AK119ub, impairing multilineage differentiation of haematopoietic progenitors (except for that toward monocytes), and accelerates RUNX1-ETO-induced leukaemogenesis."
30013160
reach
"Mechanistically, the mutant ASXL1 and BAP1 complex induced the upregulation of HOXA5, HOXA7, HOXA9, and IRF8 via a reduction in H2AK119ub."
32378586
reach
"Cancer associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1 and BAP1 complex."
26095772
reach
"[Molecular mechanisms by which the mutant ASXL1 and BAP1 complex aggravates myeloid leukemia]."
32378586
reach
"We have examined the role of H2AK119Ub in regulating gene expression by using hyperactive mutations of the ASXL1 and BAP1 complex that allowed us to deplete ~ 90% of total H2AK119Ub."
26095772
reach
"Based of the possibility that ASXL1 truncations might act as gain-of-function mutations of the ASXL1 and BAP1 complex, we examined whether hyperactive ASXL-BAP1 complexes could alter the fate of haematopoietic cells in vivo."
26095772
reach
"The mutant ASXL1/BAP1 complex inhibits the differentiation of HSPCs toward multilineage except for immature monocytes, and promoted myeloid leukemogenesis induced by RUNX1-ETO, an oncogenic fusion protein frequently coexisting with ASXL1 mutations [72]."
31673113
reach
"Our studies here raise the possibility that ASXL1 mutations may act as gain-of-function mutations of the ASXL1 and BAP1 complex."
26095772
ASXL1 binds EED and BAP1. 4 / 4
| 4
sparser
"In flies and humans, the Polycomb repressive deubiquitinase (PR-DUB) complex is formed through interactions of BAP1 and ASXL1 [ xref ]."
24455749
sparser
"BAP1 interacts with ASXL1 polycomb chromatin binding protein forming a polycomb repressive deubiquitinase complex that regulates histone H2A ubiquitination xref ."
25482724
sparser
"BAP1 also interacts with ASXL1 to form the Polycomb group repressive deubiquitinase complex (PR-DUB), which is involved in stem cell pluripotency and other developmental processes ( xref , xref )."
21051595
sparser
"8 BAP1 interacts with ASXL1 (MIM 612990 ) to form the Polycomb group Repressive Deubiquitinase complex (PR-DUB)."
23684012
ASXL1 binds ASXL2 and BAP1. 3 / 3
| 3
sparser
"Although both ASXL1 and ASXL2 have been identified to bind to BAP1, recent biochemical characterization of BAP1 complexes by xref suggest that BAP1 forms two mutually exclusive complexes with ASXL1 and ASXL2."
27527698
sparser
"Depletion of the PHD fingers did not affect the stability of ASXL1 or ASXL2, or the interaction between ASXL1, ASXL2, and BAP1 (Additional file xref : Fig. S2A, B)."
36180891
sparser
"Proteomic analysis of BAP1 interacting partners using this system revealed that BAP1 interacts with ASXL1 and ASXL2 in vivo as well as host cell factor 1 (HCF-1), O-GlcNAc transferase (OGT), and Forkhead box protein K1/2 (FOXK1/2) ( xref )."
27527698
ASXL1 binds BAP1 and PTEN. 2 / 2
| 2
sparser
"Then we performed ChIP-qPCR analyses in 32D cells to validate whether Asxl1 and Bap1 are bound to the Pten promoter and examined the accompanying changes of histone modifications in different conditions."
32236560
sparser
"As shown in xref , Asxl1 and Bap1 are specifically bound to the Pten promoter, and their enrichment is further induced by the absence of IL3 in WT cells."
32236560
ASXL1 binds BAP1 and ASXH domain. 2 / 2
| 2
reach
"As mentioned earlier, the interaction between BAP1 and ASXL1 occurs through the ASXH domain."
27527698
reach
"ASXL1 directly binds to BAP1 through the ASXH domain and its adjoining region."
33796551
ASXL1 binds PGR and BAP1. 2 / 2
| 2
sparser
"The K119 Ub-H2A is removed by the deubiquitinase complex PR-DUB (Polycomb Repressive-Deubiquitinase complex) formed by the proteins ASXL1 (Additional Sex Combs like 1) and BAP1 (BRAC1 Associated Protein 1) [ xref ]."
33198194
sparser
"Like Drosophila Calypso and ASX, human BAP1 and ASXL1 proteins could thus also be assembled into a stable PR-DUB complex ( xref , right, lane 8), demonstrating the evolutionary conservation of this interaction."
20436459
ASXL1 binds BAP1-L635A. 1 / 1
| 1
reach
"Performing equivalent experiments with the corresponding BAP1-ASXL1 complexes demonstrated that wild-type BAP1-ASXL1 readily shifted the nucleosome band, whereas the L635A BAP1 and ASXL1 complex had a dramatically impaired ability to induce nucleosome mobility shift at the same concentrations."
30258054
ASXL1 binds KDM1A and BAP1. 1 / 1
| 1
sparser
"The region around the ASXH domain of ASXL1 directly binds to BAP1 ( xref ) and KDM1A (LSD1; xref )."
23736028
ASXL1 binds H2AC20 and BAP1. 1 / 1
| 1
sparser
"Interestingly, the polycomb group protein ASXL1 that forms a functional H2A-DUB complex with BAP1 ( Scheuermann et al., 2010 ) also acts as a tumor suppressor and is frequently mutated in human myeloi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24647359
ASXL1 binds KDM1A, NCOA1, and BAP1. 1 / 1
| 1
sparser
"ASXL1 directly interacts with BAP1, KDM1A (LSD1), NCOA1 and nuclear hormone receptors (NHRs), such as retinoic acid receptors, oestrogen receptor and androgen receptor."
23736028
sparser
"Here, we report that BAP1 forms two mutually exclusive complexes with the transcriptional regulators ASXL1 and ASXL2, which are necessary for maintaining proper protein levels of this DUB."
26416890
ASXL1 binds FOXK2, PGR, and BAP1. 1 / 1
| 1
sparser
"Similarly, we were able to verify FOXK2 interactions with the PR-DUB complex components BAP1 and ASXL1 but were only able to detect weaker co-associations with HCFC1 in co-IP experiments (Figure xref )."
24748658
SUZ12 binds ASXL1, ASXL2, and BAP1. 1 / 1
| 1
sparser
"Despite evidence of clear physical interaction between ASXL1, ASXL2, and BAP1 (as previously reported xref ) as well as ASXL1 and the core PRC2 member SUZ12 (also previously reported xref ), interaction between ASXL2 and PRC2 members were not evident ( xref )."
28516957
ASXL1 binds BAP1 and UCH domain. 1 / 1
| 1
reach
"In addition, we demonstrated that both ASXL1 binding to BAP1 and the UCH domain of BAP1 are required for RAR repression."
23850490
AKT binds ASXL1 and BAP1. 1 / 1
| 1
sparser
"We found that wild-type/mutant ASXL1 and BAP1 bound to AKT in both cytoplasm and nucleus in 293T cells, suggesting that they form a complex (Fig.  xref a, xref , and Supplementary Fig.  xref )."
33758188
ASXL1 binds HCFC1 and BAP1. 1 / 1
| 1
sparser
"Together, these data suggest that wild-type ASXL1 forms a complex with HCF-1 and FOXK1/K2 independent of BAP1, and that the C-terminally truncated mutant ASXL1 can bind to BAP1 but loses interaction with FOXK1/K2."
32683582
ASXL1 binds ASXL2, EED, and BAP1. 1 / 1
| 1
sparser
"BAP1 forms a complex with Polycomb group proteins ASXL1 and ASXL2, and deubiquitinates histone H2AK119ub to antagonize PRC1-mediated gene silencing ( xref – xref )."
33912157
ASXL1 binds BAP1 and ULD. 1 / 1
| 1
sparser
"At the C-terminus, apart from YY1 interactions, ASXL1 also interacts with the ULD domain of BAP1 to drive the H2A deubiquitination reaction [ xref ]."
31635116
BAP1 ubiquitinates ASXL1.
| 2
BAP1 leads to the ubiquitination of mutated ASXL1. 2 / 2
| 2
reach
"BAP1 induces stabilization and monoubiquitination of mutant ASXL1, and monoubiquitinated ASXL1-MT increases the catalytic function of BAP1."
30013160
reach
"BAP1 induces monoubiquitination of mutant ASXL1."
30013160
BAP1 activates ASXL1.
| 2
BAP1 activates ASXL1. 2 / 2
| 2
reach
"Truncated ASXL1 increases BAP1 protein stability, enhances BAP1 recruitment to chromatin and promotes the expression of a pro-leukemic transcriptional signature."
35122023
reach
"Reduced BAP1 activity prevents ASXL1 truncation driven myeloid malignancy in vivo."
29743720
BAP1 decreases the amount of ASXL1.
| 1
BAP1 decreases the amount of mutated ASXL1. 1 / 1
| 1
reach
"Importantly, BAP1 depletion inhibited the leukemogenicity of mutant ASXL1 expressing myeloid leukemia cells and MLL rearranged leukemia cells by reducing the expression levels of HOXA5, HOXA7, and HOXA9."
32378586
ASXL1 affects BAP1, FOXK1, FOXK2, Flag, and HCFC1
| 1
ASXL1 binds FOXK1, HCFC1, FOXK2, BAP1, and Flag. 1 / 1
| 1
sparser
"Moreover, we observed that Flag-ASXL1 interacted with endogenous HCF-1, FOXK1 and FOXK2 in BAP1 knockdown HEK293T cells (Fig.  xref G), and that Flag-BAP1 interacted with endogenous HCF-1, FOXK1, and FOXK2 in ASXL1 knockdown HEK293T cells (Fig.  xref H)."
32683582
sparser
"Here, we report that BAP1 forms two mutually exclusive complexes with the transcriptional regulators ASXL1 and ASXL2, which are necessary for maintaining proper protein levels of this DUB."
26416890
ASXL1 affects ASXL2, BAP1, and SUZ12
| 1
SUZ12 binds ASXL1, ASXL2, and BAP1. 1 / 1
| 1
sparser
"Despite evidence of clear physical interaction between ASXL1, ASXL2, and BAP1 (as previously reported xref ) as well as ASXL1 and the core PRC2 member SUZ12 (also previously reported xref ), interaction between ASXL2 and PRC2 members were not evident ( xref )."
28516957
ASXL1 affects ASXL2, BAP1, EED, HCFC1, and transferase
| 1
sparser
"In a whole animal murine model, BAP1 also interacted with the cell cycle regulator host cell factor-1 (HCF-1), the signal transduction modulator O-linked N-acetylglucosamine transferase (OGT), and the Polycomb group proteins ASXL1 and ASXL2."
33144689
ASXL1 affects ASXL2, BAP1, EED, HCFC1, and OGT
| 1
ASXL1 binds ASXL2, EED, HCFC1, OGT, and BAP1. 1 / 1
| 1
sparser
"Knock-in mice expressing Bap1 revealed that BAP1 interacts with HCF1, OGT, and polycomb group proteins ASXL1 and ASXL2 in vivo ( xref )."
29284740
ASXL1 affects ASXL2, BAP1, and EED
| 1
ASXL1 binds ASXL2, EED, and BAP1. 1 / 1
| 1
sparser
"BAP1 forms a complex with Polycomb group proteins ASXL1 and ASXL2, and deubiquitinates histone H2AK119ub to antagonize PRC1-mediated gene silencing ( xref – xref )."
33912157
ASXL1 affects AKT
| 1
AKT binds ASXL1 and BAP1. 1 / 1
| 1
sparser
"We found that wild-type/mutant ASXL1 and BAP1 bound to AKT in both cytoplasm and nucleus in 293T cells, suggesting that they form a complex (Fig.  xref a, xref , and Supplementary Fig.  xref )."
33758188