IndraLab

Statements

ASXL1 affects BAP1
28 | 1 185 144
ASXL1 binds BAP1.
28 | 148 134
BAP1 binds ASXL1. 10 / 270
28 | 129 113
reach
"The mammalian homologue of Calypso, BAP1, directly associates with ASXL1, and the mammalian BAP1 and ASXL1 complex was shown to possess deubiquitinase activity in vitro 39."
23009937
biogrid
No evidence text available
32683582
reach
"OGT improves ASXL1 stability by inducing O-GlcNAcylation at the ASXL1 Ser199 site [127], while ASXL1 interacts with and activates BAP1 [66]."
38931332
reach
"BAP1 interacts with the polycomb factors ASXL1 and 2 and its substrates HCF-1 and OGT, but the precise mechanism how its loss of function bypasses growth arrest in BRAF mutated nevi remains to be elucidated."
24460190
reach
"8 BAP1 interacts with ASXL1 (MIM 612990) to form the Polycomb group Repressive Deubiquitinase complex (PR-DUB)."
23684012
sparser
"ASXL1 forms a complex with the deubiquitination enzyme BAP1 and removes monoubiquitin from H2AK119Ub, to derepress genes targeted by PRC1 [ xref ]."
| PMC
sparser
"The endogenous BAP1 interaction with ASXL1 was confirmed by IP and WB analysis ( Supplemental Fig. 2B )."
28802580
biogrid
No evidence text available
26437366
biogrid
No evidence text available
32669118
sparser
"Using the same strategy, we found that human BAP1 also forms a stable complex with the N-terminal domain of human ASXL1 (ASXL1(2–365)) but not with the human PcG proteins BMI1 or RING1A ( xref , right, lanes 8–10)."
20436459
Mutated ASXL1 binds BAP1. 10 / 11
| 11
reach
"This hyperactive mutant ASXL1/BAP1 complex is thought to promote impairment of myeloid differentiation through inhibition of H2AK119ub at posterior HOXA genes and IRF8, encoding an essential transcription factor in myeloid lineages [18]."
33483612
reach
"Cancer associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1 and BAP1 complex."
26095772
reach
"The mutant ASXL1/BAP1 complex inhibits the differentiation of HSPCs toward multilineage except for immature monocytes, and promoted myeloid leukemogenesis induced by RUNX1-ETO, an oncogenic fusion protein frequently coexisting with ASXL1 mutations [72]."
31673113
reach
"This hyperactive mutant ASXL1 and BAP1 complex induces upregulation of posterior HOXA genes and IRF8 through inhibition of H2AK119ub, impairing multilineage differentiation of haematopoietic progenitors (except for that toward monocytes), and accelerates RUNX1-ETO-induced leukaemogenesis."
30013160
reach
"Based of the possibility that ASXL1 truncations might act as gain-of-function mutations of the ASXL1 and BAP1 complex, we examined whether hyperactive ASXL-BAP1 complexes could alter the fate of haematopoietic cells in vivo."
26095772
reach
"Our studies here raise the possibility that ASXL1 mutations may act as gain-of-function mutations of the ASXL1 and BAP1 complex."
26095772
reach
"We have examined the role of H2AK119Ub in regulating gene expression by using hyperactive mutations of the ASXL1 and BAP1 complex that allowed us to deplete ~ 90% of total H2AK119Ub."
26095772
reach
"Mechanistically, mutant ASXL1 interacted with and stabilized BAP1 (BRCA1 Associated Protein 1), a nuclear ubiquitin carboxy-terminal hydrolase, resulting in the deubiquitination and activation of AKT,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38039845
reach
"The overactive mutant ASXL1/BAP1 complex aberrantly de-ubiquitinated H2AK119Ub, followed by de-repression of its target genes including posterior HOXA genes and IRF8 , leading to leukemic transformati[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31945396
reach
"[Molecular mechanisms by which the mutant ASXL1 and BAP1 complex aggravates myeloid leukemia]."
32378586
BAP1 binds ASXL1 and H2AK119Ub. 4 / 4
| 4
reach
"The images were collected with an exposure of 0.04 seconds per frame; the total exposure time was 2 seconds for the BAP1/ASXL1-H2AK119Ub complex, for a total of 50 frames."
36865140
reach
"In the BAP1/ASXL1-H2AK119Ub complex, we centered a spherical mask with a 60 Å pixels radius on the BAP1/ASXL1 moiety, which resulted in a clearly resolved BAP1/ASXL1 on the nucleosome at 5."
36865140
reach
"Using the best-scoring particles, we ran Non-Uniform Refinement, which yielded the BAP1/ASXL1-H2AK119Ub complex at 3."
36865140
reach
"For the BAP1/ASXL1-H2AK119Ub complex, available X-ray crystal structures were used for initial rigid body fit into our cryo-EM maps."
36865140
EED binds BAP1 and ASXL1. 4 / 4
| 4
sparser
"In flies and humans, the Polycomb repressive deubiquitinase (PR-DUB) complex is formed through interactions of BAP1 and ASXL1 [ xref ]."
24455749
sparser
"BAP1 interacts with ASXL1 polycomb chromatin binding protein forming a polycomb repressive deubiquitinase complex that regulates histone H2A ubiquitination xref ."
25482724
sparser
"8 BAP1 interacts with ASXL1 (MIM 612990 ) to form the Polycomb group Repressive Deubiquitinase complex (PR-DUB)."
23684012
sparser
"BAP1 also interacts with ASXL1 to form the Polycomb group repressive deubiquitinase complex (PR-DUB), which is involved in stem cell pluripotency and other developmental processes ( xref , xref )."
21051595
BAP1 binds ASXL1 and ASXL2. 3 / 3
| 3
sparser
"Although both ASXL1 and ASXL2 have been identified to bind to BAP1, recent biochemical characterization of BAP1 complexes by xref suggest that BAP1 forms two mutually exclusive complexes with ASXL1 and ASXL2."
27527698
sparser
"Proteomic analysis of BAP1 interacting partners using this system revealed that BAP1 interacts with ASXL1 and ASXL2 in vivo as well as host cell factor 1 (HCF-1), O-GlcNAc transferase (OGT), and Forkhead box protein K1/2 (FOXK1/2) ( xref )."
27527698
sparser
"Depletion of the PHD fingers did not affect the stability of ASXL1 or ASXL2, or the interaction between ASXL1, ASXL2, and BAP1 (Additional file xref : Fig. S2A, B)."
36180891
ASXL1 binds BAP1 and PTEN. 2 / 2
| 2
sparser
"Then we performed ChIP-qPCR analyses in 32D cells to validate whether Asxl1 and Bap1 are bound to the Pten promoter and examined the accompanying changes of histone modifications in different conditions."
32236560
sparser
"As shown in xref , Asxl1 and Bap1 are specifically bound to the Pten promoter, and their enrichment is further induced by the absence of IL3 in WT cells."
32236560
BAP1 binds ASXL1 and ASXH domain. 2 / 2
| 2
reach
"ASXL1 directly binds to BAP1 through the ASXH domain and its adjoining region."
33796551
reach
"As mentioned earlier, the interaction between BAP1 and ASXL1 occurs through the ASXH domain."
27527698
BAP1 binds ASXL1 and PGR. 2 / 2
| 2
sparser
"The K119 Ub-H2A is removed by the deubiquitinase complex PR-DUB (Polycomb Repressive-Deubiquitinase complex) formed by the proteins ASXL1 (Additional Sex Combs like 1) and BAP1 (BRAC1 Associated Protein 1) [ xref ]."
33198194
sparser
"Like Drosophila Calypso and ASX, human BAP1 and ASXL1 proteins could thus also be assembled into a stable PR-DUB complex ( xref , right, lane 8), demonstrating the evolutionary conservation of this interaction."
20436459
BAP1-L635A binds ASXL1. 1 / 1
| 1
reach
"Performing equivalent experiments with the corresponding BAP1-ASXL1 complexes demonstrated that wild-type BAP1-ASXL1 readily shifted the nucleosome band, whereas the L635A BAP1 and ASXL1 complex had a dramatically impaired ability to induce nucleosome mobility shift at the same concentrations."
30258054
ASXL1 binds BAP1 and KDM1A. 1 / 1
| 1
sparser
"The region around the ASXH domain of ASXL1 directly binds to BAP1 ( xref ) and KDM1A (LSD1; xref )."
23736028
ASXL1 binds BAP1 and H2AC20. 1 / 1
| 1
sparser
"Interestingly, the polycomb group protein ASXL1 that forms a functional H2A-DUB complex with BAP1 ( Scheuermann et al., 2010 ) also acts as a tumor suppressor and is frequently mutated in human myeloi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24647359
ASXL1 binds BAP1, KDM1A, and NCOA1. 1 / 1
| 1
sparser
"ASXL1 directly interacts with BAP1, KDM1A (LSD1), NCOA1 and nuclear hormone receptors (NHRs), such as retinoic acid receptors, oestrogen receptor and androgen receptor."
23736028
sparser
"Here, we report that BAP1 forms two mutually exclusive complexes with the transcriptional regulators ASXL1 and ASXL2, which are necessary for maintaining proper protein levels of this DUB."
26416890
PGR binds BAP1, ASXL1, and FOXK2. 1 / 1
| 1
sparser
"Similarly, we were able to verify FOXK2 interactions with the PR-DUB complex components BAP1 and ASXL1 but were only able to detect weaker co-associations with HCFC1 in co-IP experiments (Figure xref )."
24748658
ASXL2 binds BAP1, ASXL1, and SUZ12. 1 / 1
| 1
sparser
"Despite evidence of clear physical interaction between ASXL1, ASXL2, and BAP1 (as previously reported xref ) as well as ASXL1 and the core PRC2 member SUZ12 (also previously reported xref ), interaction between ASXL2 and PRC2 members were not evident ( xref )."
28516957
ASXL1 binds BAP1 and UCH domain. 1 / 1
| 1
reach
"In addition, we demonstrated that both ASXL1 binding to BAP1 and the UCH domain of BAP1 are required for RAR repression."
23850490
ASXL1 binds BAP1 and AKT. 1 / 1
| 1
sparser
"We found that wild-type/mutant ASXL1 and BAP1 bound to AKT in both cytoplasm and nucleus in 293T cells, suggesting that they form a complex (Fig.  xref a, xref , and Supplementary Fig.  xref )."
33758188
ASXL1 binds BAP1 and HCFC1. 1 / 1
| 1
sparser
"Together, these data suggest that wild-type ASXL1 forms a complex with HCF-1 and FOXK1/K2 independent of BAP1, and that the C-terminally truncated mutant ASXL1 can bind to BAP1 but loses interaction with FOXK1/K2."
32683582
BAP1 binds EED, ASXL1, and ASXL2. 1 / 1
| 1
sparser
"BAP1 forms a complex with Polycomb group proteins ASXL1 and ASXL2, and deubiquitinates histone H2AK119ub to antagonize PRC1-mediated gene silencing ( xref – xref )."
33912157
ASXL1 binds BAP1 and ULD. 1 / 1
| 1
sparser
"At the C-terminus, apart from YY1 interactions, ASXL1 also interacts with the ULD domain of BAP1 to drive the H2A deubiquitination reaction [ xref ]."
31635116
ASXL1 activates BAP1.
| 1 36 10
ASXL1 activates BAP1. 10 / 40
| 1 29 10
reach
"Because of the strong conservation of key elements between UCH-L5 and RPN13 DEU and BAP1 and ASXL1, we anticipate that the ASXL1 DEUBAD domain employs similar strategies to activate BAP1."
25702870
reach
"Increasing concentrations of TG2-179-1 were incubated with H2A-Ub nucleosomes containing the DEUBAD domain of ASXL1 (ASXL1 ), which activates BAP1 by increasing its affinity for the ubiquitin moiety of H2A-Ub ."
36754982
reach
"As part of the Polycomb repression machinery, BAP1 is activated by the deubiquitinase adaptor domain of ASXL1 mediating gene repression by cleaving ubiquitin (Ub) from histone H2A in nucleosomes."
30639226
reach
"The molecular mechanism of BAP1 activation by ASXL1 remains elusive, as no structures are available for either BAP1 or ASXL1."
30639226
reach
"BAP1 is activated by ASXL1 in a similar manner where the DEUBAD domain of ASXL1 increases affinity of BAP1 for the ubiquitinated substrate [98]."
28624371
sparser
"A recent study suggests that ASXL1 might activate Bap1 in a similar manner xref ."
27012468
reach
"Several studies reported that ASXL1 truncation enhanced the catalytic deubiquitinating activity of BAP1 towards mono-ubiquitinated H2AK119 [ 20 , 36 ]."
34186160
sparser
"The molecular mechanism of BAP1 activation by ASXL1 remains elusive, as no structures are available for either BAP1 or ASXL1."
30639226
reach
"A previous report showed that the deubiquitinase adapter (DEUBAD) domain of ASXL1 increases BAP1 's affinity for ubiquitin on H2A 15, and we showed that monoubiquitinated ASXL1-MT enhances nuclear retention of BAP1."
30013160
reach
"To further confirm that GGNBP2 loss could affect the activation of BAP1 by ASXL1 in deubiquitinating H2A, Ggnbp2KO cells were transfected with ASXL1 siRNA together with Ggnbp2 overexpression plasmids."
39109527
Mutated ASXL1 activates BAP1. 6 / 6
| 6
reach
"ASXL1 mutations found in AML aberrantly enhance the DUB activity of BAP-1 and thus, deplete the levels of H3K27me 3."
27451124
reach
"Monoubiquitination of mutant ASXL1 enhanced the catalytic function of BAP1, resulting in a profound reduction in H2AK119ub by counteracting the PRC1 complex."
32378586
reach
"Simultaneous overexpression of BAP1 and mutant ASXL1 promotes the deubiquitinase activity of BAP1, leading to the loss of H2AK119Ub followed by H3K27me3 reduction (Balasubramani et al., 2015)."
29643185
reach
"In our model, BAP1 mRNA did not change in KI mice, and physiological expression of Asxl1 mutant seemed to mildly support Bap1 function, which is not sufficient for global H3K27me3 reduction."
29643185
reach
"However, recent studies have reported that hyperactive catalytic function of BAP1 caused by ASXL1 mutation in haematopoietic cells disturbs normal haematopoiesis and promotes myeloid leukaemogenesis i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34186160
reach
"Mechanistically, BAP1 mono-ubiquitinated and stabilized mutant ASXL1, which in turn enhanced the DUB activity of BAP1."
31945396
ASXL1 bound to BAP1 activates BAP1. 1 / 1
| 1
reach
"The results showed that GGNBP2 loss reduced deubiquitinase activity by disrupting ASXL1/BAP1 binding and preventing BAP1 from entering the nucleus."
39109527
ASXL1 inhibits BAP1.
| 1
ASXL1 inhibits BAP1. 1 / 1
| 1
reach
"ASXL1 Modulates DUB Activity of BAP1 and RAR Repression In Vivo The physiological relevance of ASXL1 cooperation with BAP1 was addressed by using MEFs derived from Asxl1 null mice."
23850490
BAP1 affects ASXL1
28 | 159 134
BAP1 binds ASXL1.
28 | 148 134
BAP1 binds ASXL1. 10 / 270
28 | 129 113
reach
"The mammalian homologue of Calypso, BAP1, directly associates with ASXL1, and the mammalian BAP1 and ASXL1 complex was shown to possess deubiquitinase activity in vitro 39."
23009937
biogrid
No evidence text available
32683582
reach
"OGT improves ASXL1 stability by inducing O-GlcNAcylation at the ASXL1 Ser199 site [127], while ASXL1 interacts with and activates BAP1 [66]."
38931332
reach
"BAP1 interacts with the polycomb factors ASXL1 and 2 and its substrates HCF-1 and OGT, but the precise mechanism how its loss of function bypasses growth arrest in BRAF mutated nevi remains to be elucidated."
24460190
reach
"8 BAP1 interacts with ASXL1 (MIM 612990) to form the Polycomb group Repressive Deubiquitinase complex (PR-DUB)."
23684012
sparser
"ASXL1 forms a complex with the deubiquitination enzyme BAP1 and removes monoubiquitin from H2AK119Ub, to derepress genes targeted by PRC1 [ xref ]."
| PMC
sparser
"The endogenous BAP1 interaction with ASXL1 was confirmed by IP and WB analysis ( Supplemental Fig. 2B )."
28802580
biogrid
No evidence text available
26437366
biogrid
No evidence text available
32669118
sparser
"Using the same strategy, we found that human BAP1 also forms a stable complex with the N-terminal domain of human ASXL1 (ASXL1(2–365)) but not with the human PcG proteins BMI1 or RING1A ( xref , right, lanes 8–10)."
20436459
Mutated ASXL1 binds BAP1. 10 / 11
| 11
reach
"This hyperactive mutant ASXL1/BAP1 complex is thought to promote impairment of myeloid differentiation through inhibition of H2AK119ub at posterior HOXA genes and IRF8, encoding an essential transcription factor in myeloid lineages [18]."
33483612
reach
"Cancer associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1 and BAP1 complex."
26095772
reach
"The mutant ASXL1/BAP1 complex inhibits the differentiation of HSPCs toward multilineage except for immature monocytes, and promoted myeloid leukemogenesis induced by RUNX1-ETO, an oncogenic fusion protein frequently coexisting with ASXL1 mutations [72]."
31673113
reach
"This hyperactive mutant ASXL1 and BAP1 complex induces upregulation of posterior HOXA genes and IRF8 through inhibition of H2AK119ub, impairing multilineage differentiation of haematopoietic progenitors (except for that toward monocytes), and accelerates RUNX1-ETO-induced leukaemogenesis."
30013160
reach
"Based of the possibility that ASXL1 truncations might act as gain-of-function mutations of the ASXL1 and BAP1 complex, we examined whether hyperactive ASXL-BAP1 complexes could alter the fate of haematopoietic cells in vivo."
26095772
reach
"Our studies here raise the possibility that ASXL1 mutations may act as gain-of-function mutations of the ASXL1 and BAP1 complex."
26095772
reach
"We have examined the role of H2AK119Ub in regulating gene expression by using hyperactive mutations of the ASXL1 and BAP1 complex that allowed us to deplete ~ 90% of total H2AK119Ub."
26095772
reach
"Mechanistically, mutant ASXL1 interacted with and stabilized BAP1 (BRCA1 Associated Protein 1), a nuclear ubiquitin carboxy-terminal hydrolase, resulting in the deubiquitination and activation of AKT,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38039845
reach
"The overactive mutant ASXL1/BAP1 complex aberrantly de-ubiquitinated H2AK119Ub, followed by de-repression of its target genes including posterior HOXA genes and IRF8 , leading to leukemic transformati[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31945396
reach
"[Molecular mechanisms by which the mutant ASXL1 and BAP1 complex aggravates myeloid leukemia]."
32378586
BAP1 binds ASXL1 and H2AK119Ub. 4 / 4
| 4
reach
"The images were collected with an exposure of 0.04 seconds per frame; the total exposure time was 2 seconds for the BAP1/ASXL1-H2AK119Ub complex, for a total of 50 frames."
36865140
reach
"In the BAP1/ASXL1-H2AK119Ub complex, we centered a spherical mask with a 60 Å pixels radius on the BAP1/ASXL1 moiety, which resulted in a clearly resolved BAP1/ASXL1 on the nucleosome at 5."
36865140
reach
"Using the best-scoring particles, we ran Non-Uniform Refinement, which yielded the BAP1/ASXL1-H2AK119Ub complex at 3."
36865140
reach
"For the BAP1/ASXL1-H2AK119Ub complex, available X-ray crystal structures were used for initial rigid body fit into our cryo-EM maps."
36865140
EED binds BAP1 and ASXL1. 4 / 4
| 4
sparser
"In flies and humans, the Polycomb repressive deubiquitinase (PR-DUB) complex is formed through interactions of BAP1 and ASXL1 [ xref ]."
24455749
sparser
"BAP1 interacts with ASXL1 polycomb chromatin binding protein forming a polycomb repressive deubiquitinase complex that regulates histone H2A ubiquitination xref ."
25482724
sparser
"8 BAP1 interacts with ASXL1 (MIM 612990 ) to form the Polycomb group Repressive Deubiquitinase complex (PR-DUB)."
23684012
sparser
"BAP1 also interacts with ASXL1 to form the Polycomb group repressive deubiquitinase complex (PR-DUB), which is involved in stem cell pluripotency and other developmental processes ( xref , xref )."
21051595
BAP1 binds ASXL1 and ASXL2. 3 / 3
| 3
sparser
"Although both ASXL1 and ASXL2 have been identified to bind to BAP1, recent biochemical characterization of BAP1 complexes by xref suggest that BAP1 forms two mutually exclusive complexes with ASXL1 and ASXL2."
27527698
sparser
"Proteomic analysis of BAP1 interacting partners using this system revealed that BAP1 interacts with ASXL1 and ASXL2 in vivo as well as host cell factor 1 (HCF-1), O-GlcNAc transferase (OGT), and Forkhead box protein K1/2 (FOXK1/2) ( xref )."
27527698
sparser
"Depletion of the PHD fingers did not affect the stability of ASXL1 or ASXL2, or the interaction between ASXL1, ASXL2, and BAP1 (Additional file xref : Fig. S2A, B)."
36180891
ASXL1 binds BAP1 and PTEN. 2 / 2
| 2
sparser
"Then we performed ChIP-qPCR analyses in 32D cells to validate whether Asxl1 and Bap1 are bound to the Pten promoter and examined the accompanying changes of histone modifications in different conditions."
32236560
sparser
"As shown in xref , Asxl1 and Bap1 are specifically bound to the Pten promoter, and their enrichment is further induced by the absence of IL3 in WT cells."
32236560
BAP1 binds ASXL1 and ASXH domain. 2 / 2
| 2
reach
"ASXL1 directly binds to BAP1 through the ASXH domain and its adjoining region."
33796551
reach
"As mentioned earlier, the interaction between BAP1 and ASXL1 occurs through the ASXH domain."
27527698
BAP1 binds ASXL1 and PGR. 2 / 2
| 2
sparser
"The K119 Ub-H2A is removed by the deubiquitinase complex PR-DUB (Polycomb Repressive-Deubiquitinase complex) formed by the proteins ASXL1 (Additional Sex Combs like 1) and BAP1 (BRAC1 Associated Protein 1) [ xref ]."
33198194
sparser
"Like Drosophila Calypso and ASX, human BAP1 and ASXL1 proteins could thus also be assembled into a stable PR-DUB complex ( xref , right, lane 8), demonstrating the evolutionary conservation of this interaction."
20436459
BAP1-L635A binds ASXL1. 1 / 1
| 1
reach
"Performing equivalent experiments with the corresponding BAP1-ASXL1 complexes demonstrated that wild-type BAP1-ASXL1 readily shifted the nucleosome band, whereas the L635A BAP1 and ASXL1 complex had a dramatically impaired ability to induce nucleosome mobility shift at the same concentrations."
30258054
ASXL1 binds BAP1 and KDM1A. 1 / 1
| 1
sparser
"The region around the ASXH domain of ASXL1 directly binds to BAP1 ( xref ) and KDM1A (LSD1; xref )."
23736028
ASXL1 binds BAP1 and H2AC20. 1 / 1
| 1
sparser
"Interestingly, the polycomb group protein ASXL1 that forms a functional H2A-DUB complex with BAP1 ( Scheuermann et al., 2010 ) also acts as a tumor suppressor and is frequently mutated in human myeloi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24647359
ASXL1 binds BAP1, KDM1A, and NCOA1. 1 / 1
| 1
sparser
"ASXL1 directly interacts with BAP1, KDM1A (LSD1), NCOA1 and nuclear hormone receptors (NHRs), such as retinoic acid receptors, oestrogen receptor and androgen receptor."
23736028
sparser
"Here, we report that BAP1 forms two mutually exclusive complexes with the transcriptional regulators ASXL1 and ASXL2, which are necessary for maintaining proper protein levels of this DUB."
26416890
PGR binds BAP1, ASXL1, and FOXK2. 1 / 1
| 1
sparser
"Similarly, we were able to verify FOXK2 interactions with the PR-DUB complex components BAP1 and ASXL1 but were only able to detect weaker co-associations with HCFC1 in co-IP experiments (Figure xref )."
24748658
ASXL2 binds BAP1, ASXL1, and SUZ12. 1 / 1
| 1
sparser
"Despite evidence of clear physical interaction between ASXL1, ASXL2, and BAP1 (as previously reported xref ) as well as ASXL1 and the core PRC2 member SUZ12 (also previously reported xref ), interaction between ASXL2 and PRC2 members were not evident ( xref )."
28516957
ASXL1 binds BAP1 and UCH domain. 1 / 1
| 1
reach
"In addition, we demonstrated that both ASXL1 binding to BAP1 and the UCH domain of BAP1 are required for RAR repression."
23850490
ASXL1 binds BAP1 and AKT. 1 / 1
| 1
sparser
"We found that wild-type/mutant ASXL1 and BAP1 bound to AKT in both cytoplasm and nucleus in 293T cells, suggesting that they form a complex (Fig.  xref a, xref , and Supplementary Fig.  xref )."
33758188
ASXL1 binds BAP1 and HCFC1. 1 / 1
| 1
sparser
"Together, these data suggest that wild-type ASXL1 forms a complex with HCF-1 and FOXK1/K2 independent of BAP1, and that the C-terminally truncated mutant ASXL1 can bind to BAP1 but loses interaction with FOXK1/K2."
32683582
BAP1 binds EED, ASXL1, and ASXL2. 1 / 1
| 1
sparser
"BAP1 forms a complex with Polycomb group proteins ASXL1 and ASXL2, and deubiquitinates histone H2AK119ub to antagonize PRC1-mediated gene silencing ( xref – xref )."
33912157
ASXL1 binds BAP1 and ULD. 1 / 1
| 1
sparser
"At the C-terminus, apart from YY1 interactions, ASXL1 also interacts with the ULD domain of BAP1 to drive the H2A deubiquitination reaction [ xref ]."
31635116
BAP1 activates ASXL1.
| 7
BAP1 activates ASXL1. 5 / 5
| 5
reach
"Reduced BAP1 activity prevents ASXL1 truncation driven myeloid malignancy in vivo."
29743720
reach
"Truncated ASXL1 increases BAP1 protein stability, enhances BAP1 recruitment to chromatin and promotes the expression of a pro-leukemic transcriptional signature."
35122023
reach
"RNA sequencing analyses revealed that reduced BAP1 expression suppressed ASXL1 Y591X -induced upregulation of the transcription factors activator protein 1 ( AP-1 ) and early growth response 1/2 ( EGR[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34186160
reach
"Strikingly, these include both loss-of-function mutations in Bap1 and Asxl1/2 and gain-of-function mutations in which truncated ASXL1 increases BAP1 stability."
36460465
reach
"Guo and her colleagues found that deletion of one allele of Bap1 in Asxl1 -truncated mice prevented ASXL1 truncation-driven myeloid malignancy [ 38 ]."
34186160
BAP1 activates mutated ASXL1. 2 / 2
| 2
reach
"Mutant ASXL1 was reported to drive response to the BCL2 inhibitor venetoclax in vitro and a small molecule inhibitor of BAP1 inhibited mutant ASXL1-driven leukemic gene expression and impaired tumor growth in vivo."
36951160
reach
"Then, these effects were observed in primary leukaemia samples with ASXL1 mutation that BAP1 reduction significantly decreased the colony-forming capacity and promoted the differentiation of blast cel[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34186160
BAP1 ubiquitinates ASXL1.
| 2
BAP1 leads to the ubiquitination of mutated ASXL1. 2 / 2
| 2
reach
"BAP1 induces stabilization and monoubiquitination of mutant ASXL1, and monoubiquitinated ASXL1-MT increases the catalytic function of BAP1."
30013160
reach
"BAP1 induces monoubiquitination of mutant ASXL1."
30013160
BAP1 inhibits ASXL1.
| 1
BAP1 inhibits ASXL1. 1 / 1
| 1
reach
"Recently, BAP1 catalytic inhibitors have been developed that inhibit ASXL1‐driven leukaemic gene signatures and impaired tumour progression in an in vivo model of ASXL1 AML [22]."
37872885
BAP1 decreases the amount of ASXL1.
| 1
BAP1 decreases the amount of mutated ASXL1. 1 / 1
| 1
reach
"Importantly, BAP1 depletion inhibited the leukemogenicity of mutant ASXL1 expressing myeloid leukemia cells and MLL rearranged leukemia cells by reducing the expression levels of HOXA5, HOXA7, and HOXA9."
32378586
ASXL1 affects BAP1, FOXK1, FOXK2, Flag, and HCFC1
| 1
BAP1 binds Flag, ASXL1, HCFC1, FOXK1, and FOXK2. 1 / 1
| 1
sparser
"Moreover, we observed that Flag-ASXL1 interacted with endogenous HCF-1, FOXK1 and FOXK2 in BAP1 knockdown HEK293T cells (Fig.  xref G), and that Flag-BAP1 interacted with endogenous HCF-1, FOXK1, and FOXK2 in ASXL1 knockdown HEK293T cells (Fig.  xref H)."
32683582
sparser
"Here, we report that BAP1 forms two mutually exclusive complexes with the transcriptional regulators ASXL1 and ASXL2, which are necessary for maintaining proper protein levels of this DUB."
26416890
ASXL1 affects ASXL2, BAP1, and SUZ12
| 1
ASXL2 binds BAP1, ASXL1, and SUZ12. 1 / 1
| 1
sparser
"Despite evidence of clear physical interaction between ASXL1, ASXL2, and BAP1 (as previously reported xref ) as well as ASXL1 and the core PRC2 member SUZ12 (also previously reported xref ), interaction between ASXL2 and PRC2 members were not evident ( xref )."
28516957
ASXL1 affects ASXL2, BAP1, EED, HCFC1, and transferase
| 1
sparser
"In a whole animal murine model, BAP1 also interacted with the cell cycle regulator host cell factor-1 (HCF-1), the signal transduction modulator O-linked N-acetylglucosamine transferase (OGT), and the Polycomb group proteins ASXL1 and ASXL2."
33144689
ASXL1 affects ASXL2, BAP1, EED, HCFC1, and OGT
| 1
BAP1 binds HCFC1, OGT, EED, ASXL1, and ASXL2. 1 / 1
| 1
sparser
"Knock-in mice expressing Bap1 revealed that BAP1 interacts with HCF1, OGT, and polycomb group proteins ASXL1 and ASXL2 in vivo ( xref )."
29284740
ASXL1 affects ASXL2, BAP1, and EED
| 1
BAP1 binds EED, ASXL1, and ASXL2. 1 / 1
| 1
sparser
"BAP1 forms a complex with Polycomb group proteins ASXL1 and ASXL2, and deubiquitinates histone H2AK119ub to antagonize PRC1-mediated gene silencing ( xref – xref )."
33912157
ASXL1 affects AKT
| 1
ASXL1 binds BAP1 and AKT. 1 / 1
| 1
sparser
"We found that wild-type/mutant ASXL1 and BAP1 bound to AKT in both cytoplasm and nucleus in 293T cells, suggesting that they form a complex (Fig.  xref a, xref , and Supplementary Fig.  xref )."
33758188