IndraLab

Statements

BAP1 activates ASXL1. 5 / 5
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"Guo and her colleagues found that deletion of one allele of Bap1 in Asxl1 -truncated mice prevented ASXL1 truncation-driven myeloid malignancy [ 38 ]."
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"Reduced BAP1 activity prevents ASXL1 truncation driven myeloid malignancy in vivo."
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"Truncated ASXL1 increases BAP1 protein stability, enhances BAP1 recruitment to chromatin and promotes the expression of a pro-leukemic transcriptional signature."
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"RNA sequencing analyses revealed that reduced BAP1 expression suppressed ASXL1 Y591X -induced upregulation of the transcription factors activator protein 1 ( AP-1 ) and early growth response 1/2 ( EGR[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Strikingly, these include both loss-of-function mutations in Bap1 and Asxl1/2 and gain-of-function mutations in which truncated ASXL1 increases BAP1 stability."
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