IndraLab

Statements

Mutated ASXL1 activates BAP1. 6 / 6
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"ASXL1 mutations found in AML aberrantly enhance the DUB activity of BAP-1 and thus, deplete the levels of H3K27me 3."
27451124
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"Simultaneous overexpression of BAP1 and mutant ASXL1 promotes the deubiquitinase activity of BAP1, leading to the loss of H2AK119Ub followed by H3K27me3 reduction (Balasubramani et al., 2015)."
29643185
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"In our model, BAP1 mRNA did not change in KI mice, and physiological expression of Asxl1 mutant seemed to mildly support Bap1 function, which is not sufficient for global H3K27me3 reduction."
29643185
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"However, recent studies have reported that hyperactive catalytic function of BAP1 caused by ASXL1 mutation in haematopoietic cells disturbs normal haematopoiesis and promotes myeloid leukaemogenesis i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34186160
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"Mechanistically, BAP1 mono-ubiquitinated and stabilized mutant ASXL1, which in turn enhanced the DUB activity of BAP1."
31945396
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"Monoubiquitination of mutant ASXL1 enhanced the catalytic function of BAP1, resulting in a profound reduction in H2AK119ub by counteracting the PRC1 complex."
32378586