IndraLab

Statements

Mutated ASXL1 binds BAP1. 9 / 9
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"This hyperactive mutant ASXL1/BAP1 complex is thought to promote impairment of myeloid differentiation through inhibition of H2AK119ub at posterior HOXA genes and IRF8, encoding an essential transcription factor in myeloid lineages [18]."
33483612
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"This hyperactive mutant ASXL1 and BAP1 complex induces upregulation of posterior HOXA genes and IRF8 through inhibition of H2AK119ub, impairing multilineage differentiation of haematopoietic progenitors (except for that toward monocytes), and accelerates RUNX1-ETO-induced leukaemogenesis."
30013160
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"Mechanistically, the mutant ASXL1 and BAP1 complex induced the upregulation of HOXA5, HOXA7, HOXA9, and IRF8 via a reduction in H2AK119ub."
32378586
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"Cancer associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1 and BAP1 complex."
26095772
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"[Molecular mechanisms by which the mutant ASXL1 and BAP1 complex aggravates myeloid leukemia]."
32378586
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"We have examined the role of H2AK119Ub in regulating gene expression by using hyperactive mutations of the ASXL1 and BAP1 complex that allowed us to deplete ~ 90% of total H2AK119Ub."
26095772
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"Based of the possibility that ASXL1 truncations might act as gain-of-function mutations of the ASXL1 and BAP1 complex, we examined whether hyperactive ASXL-BAP1 complexes could alter the fate of haematopoietic cells in vivo."
26095772
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"The mutant ASXL1/BAP1 complex inhibits the differentiation of HSPCs toward multilineage except for immature monocytes, and promoted myeloid leukemogenesis induced by RUNX1-ETO, an oncogenic fusion protein frequently coexisting with ASXL1 mutations [72]."
31673113
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"Our studies here raise the possibility that ASXL1 mutations may act as gain-of-function mutations of the ASXL1 and BAP1 complex."
26095772